SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5tpc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I1E_A_DM2A3001_1
(BOTULINUM NEUROTOXIN
TYPE B)		 5tpc BOTULINUM NEUROTOXIN
TYPE A
(Clostridium
botulinum) 		5 / 9 GLU A1203
GLY A1251
HIS A1253
SER A1264
TYR A1267
 NGA  A1303 (-3.1A)
None
GAL  A1304 (-3.7A)
GAL  A1304 (-2.7A)
GAL  A1304 ( 4.2A)
 0.59A 1i1eA-5tpcA:
29.7		 1i1eA-5tpcA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I1E_A_DM2A3001_1
(BOTULINUM NEUROTOXIN
TYPE B)		 5tpc BOTULINUM NEUROTOXIN
TYPE A
(Clostridium
botulinum) 		5 / 9 GLU A1203
GLY A1251
SER A1264
TRP A1266
TYR A1267
 NGA  A1303 (-3.1A)
None
GAL  A1304 (-2.7A)
GAL  A1304 ( 4.1A)
GAL  A1304 ( 4.2A)
 0.66A 1i1eA-5tpcA:
29.7		 1i1eA-5tpcA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LHV_A_NOGA301_1
(SEX HORMONE-BINDING
GLOBULIN)		 5tpc BOTULINUM NEUROTOXIN
TYPE A
(Clostridium
botulinum) 		4 / 8 SER A 922
ASP A 910
PHE A 906
ASN A 912
 None
 1.07A 1lhvA-5tpcA:
8.9		 1lhvA-5tpcA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_B_VIBB503_1
(YKOF)		 5tpc BOTULINUM NEUROTOXIN
TYPE A
(Clostridium
botulinum) 		4 / 7 SER A1027
ILE A 983
ILE A1029
THR A1020
 None
 0.81A 1sbrB-5tpcA:
undetectable		 1sbrB-5tpcA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D0K_A_FOLA1161_0
(DIHYDROFOLATE
REDUCTASE)		 5tpc BOTULINUM NEUROTOXIN
TYPE A
(Clostridium
botulinum) 		6 / 12 ILE A 965
LEU A 916
PHE A1055
ILE A 898
LEU A 881
ILE A1053
 None
 1.36A 2d0kA-5tpcA:
undetectable		 2d0kA-5tpcA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_P_CHDP1265_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5tpc BOTULINUM NEUROTOXIN
TYPE A
(Clostridium
botulinum) 		4 / 5 PHE A 945
PHE A1072
LEU A1074
PHE A 941
 None
 1.36A 2y69P-5tpcA:
undetectable
2y69W-5tpcA:
undetectable		 2y69P-5tpcA:
18.91
2y69W-5tpcA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFB_A_ACTA501_0
(METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER)		 5tpc BOTULINUM NEUROTOXIN
TYPE A
(Clostridium
botulinum) 		4 / 7 ASP A1171
ARG A1175
ILE A1096
TYR A1107
 None
 1.04A 2yfbA-5tpcA:
undetectable		 2yfbA-5tpcA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGQ_A_PCFA1275_0
(WNT INHIBITORY
FACTOR 1)		 5tpc BOTULINUM NEUROTOXIN
TYPE A
(Clostridium
botulinum) 		6 / 12 ILE A1053
LEU A 928
ILE A 965
ILE A 878
PHE A1072
VAL A1017
 None
 1.42A 2ygqA-5tpcA:
undetectable		 2ygqA-5tpcA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_B_SAMB801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 5tpc BOTULINUM NEUROTOXIN
TYPE A
(Clostridium
botulinum) 		4 / 8 ILE A 878
ASN A1073
SER A 944
ASP A 875
 None
 1.12A 2zw9B-5tpcA:
undetectable		 2zw9B-5tpcA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_B_SAMB1000_1
(UNCHARACTERIZED
PROTEIN MJ0100)		 5tpc BOTULINUM NEUROTOXIN
TYPE A
(Clostridium
botulinum) 		3 / 3 ASN A 935
ASN A1051
GLU A 969
 None
 0.75A 3kpdC-5tpcA:
undetectable		 3kpdC-5tpcA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_C_SAMC1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 5tpc BOTULINUM NEUROTOXIN
TYPE A
(Clostridium
botulinum) 		3 / 3 ASN A 935
ASN A1051
GLU A 969
 None
 0.87A 3kpdB-5tpcA:
undetectable		 3kpdB-5tpcA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_B_NCAB192_0
(NICOTINAMIDASE)		 5tpc BOTULINUM NEUROTOXIN
TYPE A
(Clostridium
botulinum) 		5 / 11 LEU A 928
ASP A 890
LEU A1074
ILE A 878
SER A 877
 None
 1.44A 3o94B-5tpcA:
undetectable		 3o94B-5tpcA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_C_NCAC192_0
(NICOTINAMIDASE)		 5tpc BOTULINUM NEUROTOXIN
TYPE A
(Clostridium
botulinum) 		5 / 11 LEU A 928
ASP A 890
LEU A1074
ILE A 878
SER A 877
 None
 1.42A 3o94C-5tpcA:
undetectable		 3o94C-5tpcA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_D_NCAD192_0
(NICOTINAMIDASE)		 5tpc BOTULINUM NEUROTOXIN
TYPE A
(Clostridium
botulinum) 		5 / 11 LEU A 928
ASP A 890
LEU A1074
ILE A 878
SER A 877
 None
 1.41A 3o94D-5tpcA:
undetectable		 3o94D-5tpcA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_E_PFLE319_1
(GLR4197 PROTEIN)		 5tpc BOTULINUM NEUROTOXIN
TYPE A
(Clostridium
botulinum) 		4 / 7 ILE A 984
TYR A 962
THR A 963
ILE A 964
 None
 0.98A 3p50E-5tpcA:
undetectable		 3p50E-5tpcA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_B_9PLB501_1
(CYTOCHROME P450 2A6)		 5tpc BOTULINUM NEUROTOXIN
TYPE A
(Clostridium
botulinum) 		5 / 9 PHE A1055
PHE A1072
ASN A 966
ILE A1053
THR A 943
 None
 1.33A 3t3rB-5tpcA:
undetectable		 3t3rB-5tpcA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_C_9PLC501_1
(CYTOCHROME P450 2A6)		 5tpc BOTULINUM NEUROTOXIN
TYPE A
(Clostridium
botulinum) 		5 / 9 PHE A1055
PHE A1072
ASN A 966
ILE A1053
THR A 943
 None
 1.33A 3t3rC-5tpcA:
undetectable		 3t3rC-5tpcA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5tpc BOTULINUM NEUROTOXIN
TYPE A
(Clostridium
botulinum) 		5 / 12 TYR A1001
ILE A1015
SER A 957
ILE A 964
LEU A1057
 None
 1.10A 3w67C-5tpcA:
undetectable		 3w67C-5tpcA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGA_A_ACTA1131_0
(LYSOZYME C)		 5tpc BOTULINUM NEUROTOXIN
TYPE A
(Clostridium
botulinum) 		3 / 3 ASN A1238
ASP A1246
ASN A1268
 None
 0.75A 4agaA-5tpcA:
undetectable		 4agaA-5tpcA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLM_A_198A1001_2
(ANDROGEN RECEPTOR)		 5tpc BOTULINUM NEUROTOXIN
TYPE A
(Clostridium
botulinum) 		4 / 6 MET A1004
ILE A 983
ILE A 984
VAL A 998
 None
 1.02A 4olmA-5tpcA:
undetectable		 4olmA-5tpcA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)		 5tpc BOTULINUM NEUROTOXIN
TYPE A
(Clostridium
botulinum) 		3 / 3 TRP A 974
MET A 968
ASN A 966
 None
 1.32A 5uc1B-5tpcA:
undetectable		 5uc1B-5tpcA:
11.22