SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5tph'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5tph DE NOVO NTF2
HOMODIMER
(synthetic
construct) 		4 / 8 PHE A  42
VAL A  37
MET A  89
GLU A  47
 None
 1.01A 4a97D-5tphA:
undetectable		 4a97D-5tphA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_J_ZPCJ1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5tph DE NOVO NTF2
HOMODIMER
(synthetic
construct) 		4 / 8 PHE A  42
VAL A  37
MET A  89
ILE A 107
 None
 0.94A 4a97I-5tphA:
undetectable		 4a97I-5tphA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2O_A_8N6A501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5tph DE NOVO NTF2
HOMODIMER
(synthetic
construct) 		5 / 12 LEU A  55
PHE A  91
MET A  89
LEU A  13
LEU A  29
 None
 1.33A 5y2oA-5tphA:
undetectable		 5y2oA-5tphA:
19.67