SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5tpk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D55_C_DVAC8_0
(ACTINOMYCIN D)		 5tpk PROTOCADHERIN-15
(Mus
musculus) 		3 / 3 PRO A 723
THR A 721
PRO A 694
 None
 0.81A 2d55C-5tpkA:
undetectable		 2d55C-5tpkA:
7.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KOT_A_ANWA99_0
(PROTEIN S100-A13)		 5tpk PROTOCADHERIN-15
(Mus
musculus) 		4 / 7 VAL A 891
THR A 890
PHE A 873
ARG A 836
 None
 1.02A 2kotA-5tpkA:
undetectable		 2kotA-5tpkA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE510_3
(PHOSPHOLIPASE A2)		 5tpk PROTOCADHERIN-15
(Mus
musculus) 		4 / 5 VAL A 805
VAL A 806
THR A 815
THR A 892
 None
 1.23A 3bjwG-5tpkA:
undetectable		 3bjwG-5tpkA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_1
(PHOSPHOLIPASE A2)		 5tpk PROTOCADHERIN-15
(Mus
musculus) 		4 / 5 VAL A 805
VAL A 806
THR A 815
THR A 892
 None
 1.23A 3bjwC-5tpkA:
undetectable		 3bjwC-5tpkA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH511_2
(PHOSPHOLIPASE A2)		 5tpk PROTOCADHERIN-15
(Mus
musculus) 		4 / 5 VAL A 805
VAL A 806
THR A 815
THR A 892
 None
 1.29A 3bjwD-5tpkA:
undetectable		 3bjwD-5tpkA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_C_ACTC800_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 5tpk PROTOCADHERIN-15
(Mus
musculus) 		3 / 3 ASP A 772
ARG A 778
ALA A 774
 CA  A1004 (-3.7A)
None
None
 0.80A 3mbgC-5tpkA:
undetectable		 3mbgC-5tpkA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		 5tpk PROTOCADHERIN-15
(Mus
musculus) 		4 / 6 ASP A 826
ASP A 824
ALA A 877
ASP A 792
 CA  A1002 ( 3.2A)
CA  A1003 (-2.2A)
None
CA  A1003 (-2.9A)
 1.14A 4mdaA-5tpkA:
undetectable		 4mdaA-5tpkA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		 5tpk PROTOCADHERIN-15
(Mus
musculus) 		4 / 6 ASP A 826
ASP A 824
ALA A 877
ASP A 792
 CA  A1002 ( 3.2A)
CA  A1003 (-2.2A)
None
CA  A1003 (-2.9A)
 1.11A 4mdbA-5tpkA:
undetectable		 4mdbA-5tpkA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_B_ADNB401_2
(ADENOSINE KINASE)		 5tpk PROTOCADHERIN-15
(Mus
musculus) 		4 / 5 LEU A 782
LEU A 766
LEU A 700
ASN A 737
 None
 1.25A 4n09B-5tpkA:
undetectable		 4n09B-5tpkA:
21.26