SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5tpm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1DMA_B_NCAB700_0 (EXOTOXIN A)	5tpm	PYRUVATE DEHYDROGENASE COMPLEX REPRESSOR (Escherichia coli)	4 / 6	HIS A 222 GLY A 109 ALA A 217 GLU A 215	None	0.97A	1dmaB-5tpmA: undetectable	1dmaB-5tpmA: 21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3N58_C_ADNC500_2 (ADENOSYLHOMOCYSTEINA SE)	5tpm	PYRUVATE DEHYDROGENASE COMPLEX REPRESSOR (Escherichia coli)	4 / 5	LEU A 167 GLN A 154 GLU A 159 HIS A 162	None	1.49A	3n58C-5tpmA: undetectable	3n58C-5tpmA: 16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FU8_A_ACTA302_0 (UROKINASE-TYPE PLASMINOGEN ACTIVATOR)	5tpm	PYRUVATE DEHYDROGENASE COMPLEX REPRESSOR (Escherichia coli)	4 / 5	TYR A 189 GLN A 138 GLY A 141 SER A 140	None	1.30A	4fu8A-5tpmA: undetectable	4fu8A-5tpmA: 18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4OKN_B_KANB403_1 (L-LACTATE DEHYDROGENASE A CHAIN)	5tpm	PYRUVATE DEHYDROGENASE COMPLEX REPRESSOR (Escherichia coli)	5 / 9	ALA A 217 ARG A 223 ILE A 205 PHE A 206 ILE A 209	None	1.39A	4oknB-5tpmA: undetectable	4oknB-5tpmA: 19.23

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1DMA_B_NCAB700_0","EXOTOXIN A","5tpm","PYRUVATE DEHYDROGENASE COMPLEX REPRESSOR","Escherichia coli",4,"HIS A 222;GLY A 109;ALA A 217;GLU A 215","None","0.97A","1dmaB-5tpmA:undetectable","1dmaB-5tpmA:21.33"],["3N58_C_ADNC500_2","ADENOSYLHOMOCYSTEINASE","5tpm","PYRUVATE DEHYDROGENASE COMPLEX REPRESSOR","Escherichia coli",4,"LEU A 167;GLN A 154;GLU A 159;HIS A 162","None","1.49A","3n58C-5tpmA:undetectable","3n58C-5tpmA:16.15"],["4FU8_A_ACTA302_0","UROKINASE-TYPE PLASMINOGEN ACTIVATOR","5tpm","PYRUVATE DEHYDROGENASE COMPLEX REPRESSOR","Escherichia coli",4,"TYR A 189;GLN A 138;GLY A 141;SER A 140","None","1.30A","4fu8A-5tpmA:undetectable","4fu8A-5tpmA:18.70"],["4OKN_B_KANB403_1","L-LACTATE DEHYDROGENASE A CHAIN","5tpm","PYRUVATE DEHYDROGENASE COMPLEX REPRESSOR","Escherichia coli",5,"ALA A 217;ARG A 223;ILE A 205;PHE A 206;ILE A 209","None","1.39A","4oknB-5tpmA:undetectable","4oknB-5tpmA:19.23"]]