SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5tpr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_A_T3A1_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 5tpr 3-DEHYDROQUINATE
SYNTHASE
(Trichormus
variabilis) 		5 / 12 ILE A 238
ALA A 246
LEU A 242
LEU A 145
ILE A 149
 None
 1.11A 1bsxA-5tprA:
undetectable		 1bsxA-5tprA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_B_T3B2_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 5tpr 3-DEHYDROQUINATE
SYNTHASE
(Trichormus
variabilis) 		5 / 12 ILE A 238
ALA A 246
LEU A 242
LEU A 145
ILE A 149
 None
 1.11A 1bsxB-5tprA:
undetectable		 1bsxB-5tprA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DB1_A_VDXA428_2
(VITAMIN D NUCLEAR
RECEPTOR)		 5tpr 3-DEHYDROQUINATE
SYNTHASE
(Trichormus
variabilis) 		4 / 6 LEU A  80
ILE A  33
TYR A  45
VAL A  59
 None
None
None
NAD  A 503 (-4.9A)
 1.06A 1db1A-5tprA:
undetectable		 1db1A-5tprA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5tpr 3-DEHYDROQUINATE
SYNTHASE
(Trichormus
variabilis) 		5 / 12 ILE A  85
GLY A 126
ALA A 173
GLY A 117
LEU A  27
 None
None
None
NAD  A 503 ( 4.6A)
None
 1.10A 1kiaC-5tprA:
2.9		 1kiaC-5tprA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S19_A_MC9A500_1
(VITAMIN D3 RECEPTOR)		 5tpr 3-DEHYDROQUINATE
SYNTHASE
(Trichormus
variabilis) 		4 / 5 TYR A 138
SER A 152
HIS A 271
HIS A 287
 None
None
ZN  A 501 (-3.3A)
NAD  A 503 (-3.1A)
 1.44A 1s19A-5tprA:
undetectable		 1s19A-5tprA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA502_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 5tpr 3-DEHYDROQUINATE
SYNTHASE
(Trichormus
variabilis) 		3 / 3 LEU A 378
HIS A 381
LYS A 382
 None
 1.05A 1y7iA-5tprA:
3.2		 1y7iA-5tprA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_2
(PROTEASE)		 5tpr 3-DEHYDROQUINATE
SYNTHASE
(Trichormus
variabilis) 		3 / 3 ARG A  61
VAL A 116
THR A 143
 None
None
NAD  A 503 (-3.4A)
 0.81A 2nmzA-5tprA:
undetectable		 2nmzA-5tprA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQY_A_PARA1201_1
(AAC(6')-IB)		 5tpr 3-DEHYDROQUINATE
SYNTHASE
(Trichormus
variabilis) 		5 / 12 GLY A 118
GLU A 278
VAL A 291
ASP A 150
ASP A 123
 NAD  A 503 ( 3.2A)
NAD  A 503 ( 4.7A)
None
NAD  A 503 ( 2.3A)
NAD  A 503 (-2.1A)
 1.16A 2vqyA-5tprA:
undetectable		 2vqyA-5tprA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_A_SALA257_1
(TRANSCRIPTIONAL
REGULATOR)		 5tpr 3-DEHYDROQUINATE
SYNTHASE
(Trichormus
variabilis) 		4 / 8 ALA A 354
THR A 341
ILE A 344
THR A 272
 None
 0.92A 3bpxA-5tprA:
undetectable
3bpxB-5tprA:
undetectable		 3bpxA-5tprA:
14.65
3bpxB-5tprA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EBZ_B_017B201_1
(PROTEASE)		 5tpr 3-DEHYDROQUINATE
SYNTHASE
(Trichormus
variabilis) 		5 / 11 ASP A  89
ILE A  85
ILE A  99
ILE A  54
ILE A  83
 None
 1.10A 3ebzA-5tprA:
undetectable		 3ebzA-5tprA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_B_BCZB468_1
(NEURAMINIDASE)		 5tpr 3-DEHYDROQUINATE
SYNTHASE
(Trichormus
variabilis) 		3 / 3 ARG A  79
GLU A 111
TYR A 132
 None
 0.85A 3k37B-5tprA:
undetectable		 3k37B-5tprA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA302_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 5tpr 3-DEHYDROQUINATE
SYNTHASE
(Trichormus
variabilis) 		4 / 6 LEU A 279
GLU A  87
PRO A  88
HIS A 287
 None
NAD  A 503 (-2.2A)
None
NAD  A 503 (-3.1A)
 1.39A 3ltwA-5tprA:
undetectable		 3ltwA-5tprA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UUD_B_ESTB600_1
(ESTROGEN RECEPTOR)		 5tpr 3-DEHYDROQUINATE
SYNTHASE
(Trichormus
variabilis) 		5 / 10 ALA A 296
LEU A 327
LEU A 325
MET A 285
LEU A 332
 None
 1.40A 3uudB-5tprA:
undetectable		 3uudB-5tprA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1004_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 5tpr 3-DEHYDROQUINATE
SYNTHASE
(Trichormus
variabilis) 		5 / 11 VAL A  55
ALA A  53
LEU A  62
LEU A  78
GLY A  64
 None
None
NAD  A 503 (-4.7A)
None
None
 0.89A 3zosA-5tprA:
undetectable
3zosB-5tprA:
undetectable		 3zosA-5tprA:
20.62
3zosB-5tprA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_C_MXMC606_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5tpr 3-DEHYDROQUINATE
SYNTHASE
(Trichormus
variabilis) 		3 / 3 LEU A 346
ARG A 348
MET A 356
 SO4  A 505 (-4.7A)
None
None
 0.90A 4m11C-5tprA:
0.6		 4m11C-5tprA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7L_A_SHHA709_1
(LEUKOTRIENE A-4
HYDROLASE)		 5tpr 3-DEHYDROQUINATE
SYNTHASE
(Trichormus
variabilis) 		5 / 12 ALA A 203
HIS A 287
HIS A 271
GLU A 198
LEU A 242
 None
NAD  A 503 (-3.1A)
ZN  A 501 (-3.3A)
ZN  A 501 (-2.6A)
None
 1.28A 4r7lA-5tprA:
undetectable		 4r7lA-5tprA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_A_0HKA2001_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 5tpr 3-DEHYDROQUINATE
SYNTHASE
(Trichormus
variabilis) 		5 / 12 TYR A 388
SER A 321
THR A 300
ALA A 299
ALA A 296
 None
 1.43A 4u15A-5tprA:
undetectable		 4u15A-5tprA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_ACTA605_0
(SERUM ALBUMIN)		 5tpr 3-DEHYDROQUINATE
SYNTHASE
(Trichormus
variabilis) 		4 / 6 TYR A 398
HIS A 329
GLY A 394
GLU A 393
 None
 1.03A 4zbqA-5tprA:
undetectable		 4zbqA-5tprA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_ACTA608_0
(SERUM ALBUMIN)		 5tpr 3-DEHYDROQUINATE
SYNTHASE
(Trichormus
variabilis) 		3 / 3 LYS A 163
ARG A 162
HIS A 161
 None
 1.05A 4zbrA-5tprA:
1.2		 4zbrA-5tprA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_1
(ESTROGEN RECEPTOR)		 5tpr 3-DEHYDROQUINATE
SYNTHASE
(Trichormus
variabilis) 		5 / 12 THR A 186
LEU A 187
LEU A 148
ILE A  33
GLY A  32
 NAD  A 503 (-4.0A)
NAD  A 503 (-4.4A)
None
None
None
 1.16A 5gs4A-5tprA:
undetectable		 5gs4A-5tprA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HYR_B_ESTB601_1
(ESTROGEN RECEPTOR)		 5tpr 3-DEHYDROQUINATE
SYNTHASE
(Trichormus
variabilis) 		5 / 11 ALA A 296
LEU A 327
LEU A 325
MET A 285
LEU A 332
 None
 1.43A 5hyrB-5tprA:
undetectable		 5hyrB-5tprA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_A_08JA602_1
(CYTOCHROME P450 3A4)		 5tpr 3-DEHYDROQUINATE
SYNTHASE
(Trichormus
variabilis) 		4 / 7 ALA A 239
THR A 243
ILE A 149
LEU A 199
 None
 0.84A 5te8A-5tprA:
undetectable		 5te8A-5tprA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB308_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 5tpr 3-DEHYDROQUINATE
SYNTHASE
(Trichormus
variabilis) 		3 / 3 LEU A 258
ILE A  23
TYR A 138
 None
 0.58A 5uunB-5tprA:
undetectable		 5uunB-5tprA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_B_SAMB501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 5tpr 3-DEHYDROQUINATE
SYNTHASE
(Trichormus
variabilis) 		5 / 12 ALA A 203
LYS A 249
ILE A 316
ASP A 294
GLY A 270
 None
 1.16A 5wwsB-5tprA:
undetectable		 5wwsB-5tprA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_E_PCFE202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5tpr 3-DEHYDROQUINATE
SYNTHASE
(Trichormus
variabilis) 		4 / 8 ILE A 344
ALA A 354
VAL A 366
ARG A 353
 None
 0.94A 6hu9a-5tprA:
1.3
6hu9e-5tprA:
undetectable		 6hu9a-5tprA:
22.72
6hu9e-5tprA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_E_PCFE202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5tpr 3-DEHYDROQUINATE
SYNTHASE
(Trichormus
variabilis) 		4 / 8 ILE A 344
ALA A 354
VAL A 366
ASP A 262
 None
 0.87A 6hu9a-5tprA:
1.3
6hu9e-5tprA:
undetectable		 6hu9a-5tprA:
22.72
6hu9e-5tprA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_Q_PCFQ202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5tpr 3-DEHYDROQUINATE
SYNTHASE
(Trichormus
variabilis) 		4 / 6 ILE A 344
ALA A 354
ARG A 353
ASP A 262
 None
 0.99A 6hu9m-5tprA:
undetectable
6hu9q-5tprA:
undetectable		 6hu9m-5tprA:
22.72
6hu9q-5tprA:
14.35