SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5tpt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM9_A_9CRA201_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5tpt AMYLOID-LIKE PROTEIN
2
(Homo
sapiens) 		3 / 3 GLN A 480
ILE A 557
HIS A 487
 None
 0.72A 1fm9A-5tptA:
undetectable		 1fm9A-5tptA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K74_A_9CRA463_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5tpt AMYLOID-LIKE PROTEIN
2
(Homo
sapiens) 		3 / 3 GLN A 480
ILE A 557
HIS A 487
 None
 0.75A 1k74A-5tptA:
undetectable		 1k74A-5tptA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_A_ACTA1470_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 5tpt AMYLOID-LIKE PROTEIN
2
(Homo
sapiens) 		4 / 5 ARG A 459
ALA A 382
ASP A 383
GLU A 386
 None
 1.20A 2xrzA-5tptA:
undetectable		 2xrzA-5tptA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_4
(HIV-1 PROTEASE)		 5tpt AMYLOID-LIKE PROTEIN
2
(Homo
sapiens) 		3 / 3 ARG A 540
VAL A 529
THR A 507
 None
 0.83A 3k4vD-5tptA:
undetectable		 3k4vD-5tptA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_B_ECNB403_1
(FLAVOHEMOGLOBIN)		 5tpt AMYLOID-LIKE PROTEIN
2
(Homo
sapiens) 		5 / 11 ILE A 561
ALA A 492
LEU A 493
VAL A 497
LEU A 544
 None
 1.04A 4g1bB-5tptA:
5.3		 4g1bB-5tptA:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3U_B_SVRB102_1
(CHROMOBOX PROTEIN
HOMOLOG 7)		 5tpt AMYLOID-LIKE PROTEIN
2
(Homo
sapiens) 		3 / 3 LYS A 394
ARG A 459
VAL A 460
 None
 1.01A 4x3uA-5tptA:
undetectable
4x3uB-5tptA:
undetectable		 4x3uA-5tptA:
22.62
4x3uB-5tptA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8F_A_ACTA803_0
(UNCHARACTERIZED
PROTEIN)		 5tpt AMYLOID-LIKE PROTEIN
2
(Homo
sapiens) 		3 / 3 GLU A 461
LEU A 464
ARG A 468
 None
 0.74A 6d8fA-5tptA:
undetectable		 6d8fA-5tptA:
undetectable