SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5tpv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA350_2
(PROTEIN (ADENOSINE
KINASE))		 5tpv WLARA,
TDP-FUCOSE-3,4-KETOI
SOMERASE
(Campylobacter
jejuni) 		3 / 3 LEU A 106
SER A  64
ASN A  99
 None
 0.81A 1bx4A-5tpvA:
undetectable		 1bx4A-5tpvA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3478_1
(NEURAMINIDASE)		 5tpv WLARA,
TDP-FUCOSE-3,4-KETOI
SOMERASE
(Campylobacter
jejuni) 		4 / 8 ASP A 115
SER A  54
ASN A  51
LYS A  32
 None
 1.11A 2cmlC-5tpvA:
undetectable		 2cmlC-5tpvA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4478_1
(NEURAMINIDASE)		 5tpv WLARA,
TDP-FUCOSE-3,4-KETOI
SOMERASE
(Campylobacter
jejuni) 		4 / 8 ASP A 115
SER A  54
ASN A  51
LYS A  32
 None
 1.08A 2cmlD-5tpvA:
undetectable		 2cmlD-5tpvA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 5tpv WLARA,
TDP-FUCOSE-3,4-KETOI
SOMERASE
(Campylobacter
jejuni) 		3 / 3 TYR A  98
MET A  97
ILE A  59
 None
 0.90A 4c8bB-5tpvA:
undetectable		 4c8bB-5tpvA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGJ_A_1PQA304_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5tpv WLARA,
TDP-FUCOSE-3,4-KETOI
SOMERASE
(Campylobacter
jejuni) 		4 / 8 PHE A  56
ILE A  93
PHE A  58
GLY A  47
 None
None
None
TYD  A 201 (-3.5A)
 0.96A 4fgjA-5tpvA:
undetectable
4fgjB-5tpvA:
undetectable		 4fgjA-5tpvA:
20.43
4fgjB-5tpvA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_B_ACTB701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 5tpv WLARA,
TDP-FUCOSE-3,4-KETOI
SOMERASE
(Campylobacter
jejuni) 		3 / 3 HIS A  21
GLY A  86
ILE A  57
 None
 0.64A 4k50A-5tpvA:
undetectable		 4k50A-5tpvA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_B_ACTB701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 5tpv WLARA,
TDP-FUCOSE-3,4-KETOI
SOMERASE
(Campylobacter
jejuni) 		3 / 3 HIS A  21
GLY A  86
ILE A  59
 None
 0.61A 4k50A-5tpvA:
undetectable		 4k50A-5tpvA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_J_ACTJ701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 5tpv WLARA,
TDP-FUCOSE-3,4-KETOI
SOMERASE
(Campylobacter
jejuni) 		3 / 3 HIS A  21
GLY A  86
ILE A  59
 None
 0.59A 4k50I-5tpvA:
undetectable		 4k50I-5tpvA:
14.63