SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5tpx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGX_A_SALA102_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 5tpx HISTONE
ACETYLTRANSFERASE
GCN5
(Plasmodium
falciparum) 		4 / 7 MET A1406
TYR A1457
ILE A1453
GLN A1450
 None
 1.02A 3hgxA-5tpxA:
undetectable		 3hgxA-5tpxA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3REM_A_SALA301_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 5tpx HISTONE
ACETYLTRANSFERASE
GCN5
(Plasmodium
falciparum) 		4 / 8 MET A1406
TYR A1457
ILE A1453
GLN A1450
 None
 1.03A 3remA-5tpxA:
undetectable		 3remA-5tpxA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3REM_B_SALB301_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 5tpx HISTONE
ACETYLTRANSFERASE
GCN5
(Plasmodium
falciparum) 		4 / 8 MET A1406
TYR A1457
ILE A1453
GLN A1450
 None
 0.99A 3remB-5tpxA:
undetectable		 3remB-5tpxA:
22.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3U5K_A_08JA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 5tpx HISTONE
ACETYLTRANSFERASE
GCN5
(Plasmodium
falciparum) 		4 / 8 TRP A1379
PRO A1380
VAL A1385
ASN A1436
 None
None
7H7  A1505 (-4.0A)
7H7  A1505 (-3.1A)
 0.67A 3u5kA-5tpxA:
15.9		 3u5kA-5tpxA:
30.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3U5K_B_08JB2_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 5tpx HISTONE
ACETYLTRANSFERASE
GCN5
(Plasmodium
falciparum) 		4 / 7 TRP A1379
PRO A1380
VAL A1385
ASN A1436
 None
None
7H7  A1505 (-4.0A)
7H7  A1505 (-3.1A)
 0.62A 3u5kB-5tpxA:
15.8		 3u5kB-5tpxA:
30.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3U5K_C_08JC3_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 5tpx HISTONE
ACETYLTRANSFERASE
GCN5
(Plasmodium
falciparum) 		4 / 8 TRP A1379
PRO A1380
VAL A1385
ASN A1436
 None
None
7H7  A1505 (-4.0A)
7H7  A1505 (-3.1A)
 0.69A 3u5kC-5tpxA:
15.9		 3u5kC-5tpxA:
30.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3U5K_D_08JD4_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 5tpx HISTONE
ACETYLTRANSFERASE
GCN5
(Plasmodium
falciparum) 		4 / 8 TRP A1379
PRO A1380
VAL A1385
ASN A1436
 None
None
7H7  A1505 (-4.0A)
7H7  A1505 (-3.1A)
 0.70A 3u5kD-5tpxA:
15.9		 3u5kD-5tpxA:
30.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5PBE_A_TYLA2001_1
(BROMODOMAIN ADJACENT
TO ZINC FINGER
DOMAIN PROTEIN 2B)		 5tpx HISTONE
ACETYLTRANSFERASE
GCN5
(Plasmodium
falciparum) 		4 / 6 PRO A1380
VAL A1385
TYR A1393
ASN A1436
 None
7H7  A1505 (-4.0A)
None
7H7  A1505 (-3.1A)
 0.68A 5pbeA-5tpxA:
16.6		 5pbeA-5tpxA:
37.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Y1Y_A_HNQA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 5tpx HISTONE
ACETYLTRANSFERASE
GCN5
(Plasmodium
falciparum) 		5 / 8 PRO A1380
VAL A1385
CYH A1432
TYR A1435
ASN A1436
 None
7H7  A1505 (-4.0A)
7H7  A1505 ( 3.7A)
None
7H7  A1505 (-3.1A)
 0.67A 5y1yA-5tpxA:
15.9		 5y1yA-5tpxA:
30.95