SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5tpz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_E_TRPE81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5tpz GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B
(Rattus
norvegicus) 		4 / 6 GLY D  96
THR D 119
THR D 121
ILE D 123
 None
 0.85A 1gtnD-5tpzD:
undetectable
1gtnE-5tpzD:
undetectable		 1gtnD-5tpzD:
11.46
1gtnE-5tpzD:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_G_TRPG81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5tpz GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B
(Rattus
norvegicus) 		4 / 7 GLY D  96
THR D 119
THR D 121
ILE D 123
 None
 0.91A 1gtnF-5tpzD:
undetectable
1gtnG-5tpzD:
undetectable		 1gtnF-5tpzD:
11.46
1gtnG-5tpzD:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_K_TRPK81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5tpz GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B
(Rattus
norvegicus) 		4 / 7 GLY D  96
THR D 119
THR D 121
ILE D 123
 None
 0.86A 1gtnJ-5tpzD:
undetectable
1gtnK-5tpzD:
undetectable		 1gtnJ-5tpzD:
11.46
1gtnK-5tpzD:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 5tpz GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B
(Rattus
norvegicus) 		5 / 11 GLY D 147
PRO D 148
GLY D 125
GLN D 145
ILE D 300
 None
 1.26A 1jzsA-5tpzD:
undetectable		 1jzsA-5tpzD:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2201_1
(PROTEIN (METHIONINE
REPRESSOR))		 5tpz GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B
(Rattus
norvegicus) 		4 / 4 HIS D 127
ALA D 100
PHE D  99
GLY D 128
 None
 1.39A 1mj2B-5tpzD:
undetectable		 1mj2B-5tpzD:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC1200_1
(PROTEIN (METHIONINE
REPRESSOR))		 5tpz GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B
(Rattus
norvegicus) 		4 / 4 HIS D 127
ALA D 100
PHE D  99
GLY D 128
 None
 1.33A 1mj2D-5tpzD:
undetectable		 1mj2D-5tpzD:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_A_SAMA199_1
(METHIONINE REPRESSOR)		 5tpz GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B
(Rattus
norvegicus) 		4 / 4 HIS D 127
ALA D 100
PHE D  99
GLY D 128
 None
 1.37A 1mjoB-5tpzD:
undetectable		 1mjoB-5tpzD:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_B_SAMB200_0
(METHIONINE REPRESSOR)		 5tpz GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B
(Rattus
norvegicus) 		4 / 4 HIS D 127
ALA D 100
PHE D  99
GLY D 128
 None
 1.36A 1mjoA-5tpzD:
undetectable		 1mjoA-5tpzD:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_D_SAMD200_1
(METHIONINE REPRESSOR)		 5tpz GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B
(Rattus
norvegicus) 		4 / 4 HIS D 127
ALA D 100
PHE D  99
GLY D 128
 None
 1.37A 1mjoD-5tpzD:
undetectable		 1mjoD-5tpzD:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5tpz GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B
(Rattus
norvegicus) 		5 / 12 PHE D 182
ILE D 186
VAL D 376
LEU D 366
ILE D 364
 None
 1.35A 3em0B-5tpzD:
undetectable		 3em0B-5tpzD:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEL_B_QELB1_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)		 5tpz GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B
(Rattus
norvegicus) 		6 / 11 ALA D 107
GLN D 110
PHE D 114
THR D 174
PRO D 177
GLU D 236
 None
 0.46A 3qelA-5tpzD:
28.6
3qelB-5tpzD:
51.9		 3qelA-5tpzD:
25.36
3qelB-5tpzD:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QEL_D_QELD2_2
(GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)		 5tpz GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B
(Rattus
norvegicus) 		5 / 9 ALA D 109
GLN D 110
PHE D 114
PHE D 176
PRO D 177
 None
 1.46A 3qelD-5tpzD:
50.4		 3qelD-5tpzD:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QEL_D_QELD2_2
(GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)		 5tpz GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B
(Rattus
norvegicus) 		8 / 9 PRO D  78
ALA D 107
GLN D 110
PHE D 114
THR D 174
PHE D 176
PRO D 177
GLU D 236
 None
 0.43A 3qelD-5tpzD:
50.4		 3qelD-5tpzD:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H2G_A_ADNA603_1
(5'-NUCLEOTIDASE)		 5tpz GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B
(Rattus
norvegicus) 		5 / 9 GLY D 125
PHE D 143
GLY D 128
PHE D  99
ASP D 101
 None
 1.10A 4h2gA-5tpzD:
2.5		 4h2gA-5tpzD:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PE5_B_QELB920_1
(GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 1
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 5tpz GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B
(Rattus
norvegicus) 		5 / 10 ALA D 107
GLN D 110
PHE D 114
PRO D 177
GLU D 236
 None
 0.55A 4pe5A-5tpzD:
28.3
4pe5B-5tpzD:
23.2		 4pe5A-5tpzD:
18.70
4pe5B-5tpzD:
99.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PE5_C_QELC939_1
(GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 1
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 5tpz GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B
(Rattus
norvegicus) 		5 / 10 ALA D 107
GLN D 110
PHE D 114
PRO D 177
GLU D 236
 None
 0.51A 4pe5C-5tpzD:
13.4
4pe5D-5tpzD:
51.8		 4pe5C-5tpzD:
18.70
4pe5D-5tpzD:
99.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWJ_B_QELB503_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 5tpz GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B
(Rattus
norvegicus) 		6 / 11 PRO D  78
ALA D 107
GLN D 110
PHE D 114
PRO D 177
GLU D 236
 None
 0.42A 5ewjA-5tpzD:
28.6
5ewjB-5tpzD:
51.7		 5ewjA-5tpzD:
24.88
5ewjB-5tpzD:
99.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWJ_D_QELD503_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 5tpz GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B
(Rattus
norvegicus) 		7 / 12 PRO D  78
ALA D 107
GLN D 110
PHE D 114
THR D 174
PRO D 177
GLU D 236
 None
 0.45A 5ewjC-5tpzD:
19.9
5ewjD-5tpzD:
29.5		 5ewjC-5tpzD:
24.88
5ewjD-5tpzD:
99.72