SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5tqa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2OZ7_A_CA4A1_2 (ANDROGEN RECEPTOR)	5tqa	DH270.6 FAB HEAVY CHAIN (Homo sapiens)	4 / 6	TRP H 36 MET H 81 MET H 70 LEU H 83	None	1.44A	2oz7A-5tqaH: undetectable	2oz7A-5tqaH: 17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3JWQ_B_VIAB901_1 (CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE CATALYTIC DOMAIN, CONE CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE SUBUNIT ALPHA CHIMERA)	5tqa	DH270.6 FAB HEAVY CHAIN (Homo sapiens)	5 / 11	TYR H 159 HIS H 214 LEU H 122 ALA H 182 THR H 91	None	1.17A	3jwqB-5tqaH: undetectable 3jwqC-5tqaH: undetectable	3jwqB-5tqaH: 18.29 3jwqC-5tqaH: 18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5TL8_A_X2NA502_1 (PROTEIN CYP51)	5tqa	DH270.6 FAB HEAVY CHAIN (Homo sapiens)	5 / 12	ALA H 16 PHE H 160 TYR H 159 LEU H 122 THR H 87	None	1.25A	5tl8A-5tqaH: undetectable	5tl8A-5tqaH: 19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DRZ_A_H8JA1206_0 (5HT2B RECEPTOR, BRIL CHIMERA)	5tqa	DH270.6 FAB HEAVY CHAIN (Homo sapiens)	5 / 12	VAL H 221 THR H 219 VAL H 225 GLY H 132 VAL H 166	None	1.10A	6drzA-5tqaH: undetectable	6drzA-5tqaH: 17.23

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2OZ7_A_CA4A1_2","ANDROGEN RECEPTOR","5tqa","DH270.6 FAB HEAVY CHAIN","Homo sapiens",4,"TRP H  36;MET H  81;MET H  70;LEU H  83","None","1.44A","2oz7A-5tqaH:undetectable","2oz7A-5tqaH:17.56"],["3JWQ_B_VIAB901_1","CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE CATALYTIC DOMAIN, CONE CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE SUBUNIT ALPHA CHIMERA;CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE CATALYTIC DOMAIN, CONE CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE SUBUNIT ALPHA CHIMERA","5tqa","DH270.6 FAB HEAVY CHAIN","Homo sapiens",5,"TYR H 159;HIS H 214;LEU H 122;ALA H 182;THR H  91","None","1.17A","3jwqB-5tqaH:undetectable;3jwqC-5tqaH:undetectable","3jwqB-5tqaH:18.29;3jwqC-5tqaH:18.29"],["5TL8_A_X2NA502_1","PROTEIN CYP51","5tqa","DH270.6 FAB HEAVY CHAIN","Homo sapiens",5,"ALA H  16;PHE H 160;TYR H 159;LEU H 122;THR H  87","None","1.25A","5tl8A-5tqaH:undetectable","5tl8A-5tqaH:19.36"],["6DRZ_A_H8JA1206_0","5HT2B RECEPTOR, BRIL CHIMERA","5tqa","DH270.6 FAB HEAVY CHAIN","Homo sapiens",5,"VAL H 221;THR H 219;VAL H 225;GLY H 132;VAL H 166","None","1.10A","6drzA-5tqaH:undetectable","6drzA-5tqaH:17.23"]]