SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5tqi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JB0_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 5tqi PYRIDOXAL KINASE
PDXY
(Burkholderia
multivorans) 		5 / 9 SER A  19
GLY A  17
ALA A 225
LEU A 222
GLY A 218
 None
 1.43A 1jb0A-5tqiA:
undetectable		 1jb0A-5tqiA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_2
(ISOLEUCYL-TRNA
SYNTHETASE)		 5tqi PYRIDOXAL KINASE
PDXY
(Burkholderia
multivorans) 		3 / 3 GLU A 242
TRP A 203
LYS A  -1
 None
 1.42A 1qu2A-5tqiA:
undetectable		 1qu2A-5tqiA:
15.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TD2_A_PXLA288_1
(PYRIDOXAMINE KINASE)		 5tqi PYRIDOXAL KINASE
PDXY
(Burkholderia
multivorans) 		6 / 10 SER A   9
ALA A  16
HIS A  43
GLN A  45
VAL A 217
ASP A 221
 None
 0.76A 1td2A-5tqiA:
21.8		 1td2A-5tqiA:
50.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TD2_A_PXLA288_1
(PYRIDOXAMINE KINASE)		 5tqi PYRIDOXAL KINASE
PDXY
(Burkholderia
multivorans) 		6 / 10 SER A   9
VAL A  11
ALA A  16
HIS A  43
VAL A 217
ASP A 221
 None
 0.38A 1td2A-5tqiA:
21.8		 1td2A-5tqiA:
50.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TD2_B_PXLB289_1
(PYRIDOXAMINE KINASE)		 5tqi PYRIDOXAL KINASE
PDXY
(Burkholderia
multivorans) 		5 / 9 SER A   9
ALA A  16
HIS A  43
VAL A 217
ASP A 221
 None
 0.38A 1td2B-5tqiA:
43.7		 1td2B-5tqiA:
50.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_C_SC2C1289_1
(FICOLIN-2)		 5tqi PYRIDOXAL KINASE
PDXY
(Burkholderia
multivorans) 		4 / 6 ASP A 111
SER A 142
LEU A 222
GLY A 220
 None
 1.01A 2j2pA-5tqiA:
undetectable
2j2pC-5tqiA:
undetectable		 2j2pA-5tqiA:
21.31
2j2pC-5tqiA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1289_1
(FICOLIN-2)		 5tqi PYRIDOXAL KINASE
PDXY
(Burkholderia
multivorans) 		4 / 6 ASP A 111
SER A 142
LEU A 222
GLY A 220
 None
 1.03A 2j2pD-5tqiA:
undetectable
2j2pF-5tqiA:
undetectable		 2j2pD-5tqiA:
21.31
2j2pF-5tqiA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 5tqi PYRIDOXAL KINASE
PDXY
(Burkholderia
multivorans) 		5 / 12 ALA A 254
VAL A 251
PHE A  23
ILE A 272
ASP A 270
 None
 1.34A 2v95A-5tqiA:
undetectable		 2v95A-5tqiA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB1_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 5tqi PYRIDOXAL KINASE
PDXY
(Burkholderia
multivorans) 		6 / 12 ALA A  20
ASP A 111
PRO A 112
ALA A 113
ILE A 226
PRO A 143
 None
 1.16A 3jb1A-5tqiA:
undetectable		 3jb1A-5tqiA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB1_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 5tqi PYRIDOXAL KINASE
PDXY
(Burkholderia
multivorans) 		6 / 12 ALA A  21
ASP A 111
PRO A 112
ALA A 113
ILE A 226
PRO A 143
 None
 1.47A 3jb1A-5tqiA:
undetectable		 3jb1A-5tqiA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PCQ_A_PQNA847_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 5tqi PYRIDOXAL KINASE
PDXY
(Burkholderia
multivorans) 		5 / 9 SER A  19
GLY A  17
ALA A 225
LEU A 222
GLY A 218
 None
 1.43A 3pcqA-5tqiA:
undetectable		 3pcqA-5tqiA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5tqi PYRIDOXAL KINASE
PDXY
(Burkholderia
multivorans) 		4 / 4 PRO A 143
LEU A 148
ILE A 156
ARG A 154
 None
 1.43A 3w1wA-5tqiA:
3.6		 3w1wA-5tqiA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A83_A_DXCA1160_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 5tqi PYRIDOXAL KINASE
PDXY
(Burkholderia
multivorans) 		5 / 12 PHE A  23
PRO A  24
LEU A  28
ILE A 226
ALA A 268
 None
 1.37A 4a83A-5tqiA:
undetectable		 4a83A-5tqiA:
20.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EOH_A_TEPA402_1
(PYRIDOXAL KINASE)		 5tqi PYRIDOXAL KINASE
PDXY
(Burkholderia
multivorans) 		4 / 5 SER A   9
GLY A  17
VAL A 217
ASP A 221
 None
 0.66A 4eohA-5tqiA:
37.6		 4eohA-5tqiA:
31.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EOH_B_TEPB402_1
(PYRIDOXAL KINASE)		 5tqi PYRIDOXAL KINASE
PDXY
(Burkholderia
multivorans) 		4 / 5 SER A   9
HIS A  43
VAL A 217
ASP A 221
 None
 0.66A 4eohB-5tqiA:
37.5		 4eohB-5tqiA:
31.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA3_L_ACTL301_0
(C2095 HEAVY CHAIN
C2095 LIGHT CHAIN)		 5tqi PYRIDOXAL KINASE
PDXY
(Burkholderia
multivorans) 		3 / 3 PRO A  34
ASN A  36
HIS A  10
 None
CL  A 300 (-4.1A)
None
 0.90A 4ma3H-5tqiA:
undetectable
4ma3L-5tqiA:
undetectable		 4ma3H-5tqiA:
19.93
4ma3L-5tqiA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 5tqi PYRIDOXAL KINASE
PDXY
(Burkholderia
multivorans) 		5 / 9 LEU A 195
VAL A 197
VAL A 179
ILE A 156
ASP A 164
 None
 1.19A 5yf9X-5tqiA:
undetectable		 5yf9X-5tqiA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_A_SUEA1202_1
(NS3 PROTEASE)		 5tqi PYRIDOXAL KINASE
PDXY
(Burkholderia
multivorans) 		5 / 9 VAL A 248
HIS A 249
ALA A 240
VAL A 237
SER A 236
 None
 1.23A 6c2mA-5tqiA:
undetectable		 6c2mA-5tqiA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_1
(NS3 PROTEASE)		 5tqi PYRIDOXAL KINASE
PDXY
(Burkholderia
multivorans) 		5 / 9 VAL A 248
HIS A 249
ALA A 240
VAL A 237
SER A 236
 None
 1.21A 6c2mB-5tqiA:
undetectable		 6c2mB-5tqiA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_B_EY4B500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 5tqi PYRIDOXAL KINASE
PDXY
(Burkholderia
multivorans) 		4 / 6 VAL A 251
PRO A 216
ALA A 247
THR A 244
 None
 1.05A 6cduB-5tqiA:
undetectable
6cduC-5tqiA:
undetectable		 6cduB-5tqiA:
23.86
6cduC-5tqiA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GB9_A_ACTA508_0
(MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1)		 5tqi PYRIDOXAL KINASE
PDXY
(Burkholderia
multivorans) 		3 / 3 VAL A 217
ALA A  16
GLN A  45
 None
 0.48A 6gb9A-5tqiA:
3.0		 6gb9A-5tqiA:
21.29