SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5tqm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1868_0
(FPRA)		 5tqm CINNAMOYL-COA
REDUCTASE
(Sorghum
bicolor) 		3 / 3 ALA A 256
HIS A 257
VAL A 260
 None
 0.45A 1lqtB-5tqmA:
5.3		 1lqtB-5tqmA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1425_0
(FPRA)		 5tqm CINNAMOYL-COA
REDUCTASE
(Sorghum
bicolor) 		3 / 3 ALA A 256
HIS A 257
VAL A 260
 None
 0.45A 1lquB-5tqmA:
4.5		 1lquB-5tqmA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHC_B_AB1B9001_2
(PROTEASE RETROPEPSIN)		 5tqm CINNAMOYL-COA
REDUCTASE
(Sorghum
bicolor) 		5 / 12 GLY A 127
ASP A  89
GLY A  38
VAL A 100
ILE A  96
 None
NAP  A 401 (-2.8A)
NAP  A 401 ( 3.2A)
None
None
 1.04A 2qhcB-5tqmA:
undetectable		 2qhcB-5tqmA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDB_A_NPSA1591_1
(SERUM ALBUMIN)		 5tqm CINNAMOYL-COA
REDUCTASE
(Sorghum
bicolor) 		4 / 8 ILE A 150
LEU A 271
PHE A 312
TYR A 310
 DTT  A 403 (-4.5A)
None
None
None
 0.83A 2vdbA-5tqmA:
undetectable		 2vdbA-5tqmA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E68_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5tqm CINNAMOYL-COA
REDUCTASE
(Sorghum
bicolor) 		3 / 3 ARG A 325
ILE A  43
TRP A  46
 None
NAP  A 401 (-3.5A)
None
 1.14A 3e68A-5tqmA:
undetectable		 3e68A-5tqmA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AF0_A_MOAA1526_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 5tqm CINNAMOYL-COA
REDUCTASE
(Sorghum
bicolor) 		4 / 8 SER A 149
ASN A 209
ARG A 269
GLY A 186
 DTT  A 403 ( 2.6A)
None
None
None
 0.99A 4af0A-5tqmA:
undetectable		 4af0A-5tqmA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_A_RKEA401_1
(PROTON-GATED ION
CHANNEL)		 5tqm CINNAMOYL-COA
REDUCTASE
(Sorghum
bicolor) 		4 / 8 TYR A  42
ASP A 249
VAL A 229
LEU A 217
 NAP  A 401 (-4.5A)
None
None
None
 0.83A 4f8hA-5tqmA:
undetectable
4f8hB-5tqmA:
undetectable		 4f8hA-5tqmA:
22.53
4f8hB-5tqmA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_B_RKEB401_1
(PROTON-GATED ION
CHANNEL)		 5tqm CINNAMOYL-COA
REDUCTASE
(Sorghum
bicolor) 		4 / 8 TYR A  42
ASP A 249
VAL A 229
LEU A 217
 NAP  A 401 (-4.5A)
None
None
None
 0.80A 4f8hB-5tqmA:
undetectable
4f8hC-5tqmA:
undetectable		 4f8hB-5tqmA:
22.53
4f8hC-5tqmA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_C_RKEC401_1
(PROTON-GATED ION
CHANNEL)		 5tqm CINNAMOYL-COA
REDUCTASE
(Sorghum
bicolor) 		4 / 8 TYR A  42
ASP A 249
VAL A 229
LEU A 217
 NAP  A 401 (-4.5A)
None
None
None
 0.81A 4f8hC-5tqmA:
undetectable
4f8hD-5tqmA:
undetectable		 4f8hC-5tqmA:
22.53
4f8hD-5tqmA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_D_RKED401_1
(PROTON-GATED ION
CHANNEL)		 5tqm CINNAMOYL-COA
REDUCTASE
(Sorghum
bicolor) 		4 / 8 TYR A  42
ASP A 249
VAL A 229
LEU A 217
 NAP  A 401 (-4.5A)
None
None
None
 0.82A 4f8hD-5tqmA:
undetectable
4f8hE-5tqmA:
undetectable		 4f8hD-5tqmA:
22.53
4f8hE-5tqmA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_E_RKEE401_1
(PROTON-GATED ION
CHANNEL)		 5tqm CINNAMOYL-COA
REDUCTASE
(Sorghum
bicolor) 		4 / 8 VAL A 229
LEU A 217
TYR A  42
ASP A 249
 None
None
NAP  A 401 (-4.5A)
None
 0.82A 4f8hA-5tqmA:
undetectable
4f8hE-5tqmA:
undetectable		 4f8hA-5tqmA:
22.53
4f8hE-5tqmA:
22.53