SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5tqr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_D_DVAD6_0
(GRAMICIDIN A)		 5tqr POLYCOMB PROTEIN EED
(Chaetomium
thermophilum) 		3 / 3 TRP A 268
ALA A 316
VAL A 266
 None
 0.93A 1c4dC-5tqrA:
undetectable
1c4dD-5tqrA:
undetectable		 1c4dC-5tqrA:
2.38
1c4dD-5tqrA:
2.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_A_DOLA300_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		 5tqr POLYCOMB PROTEIN EED
(Chaetomium
thermophilum) 		5 / 11 TYR A 502
ILE A 511
HIS A 340
LEU A  11
LEU A 357
 None
 1.34A 1mrlA-5tqrA:
undetectable
1mrlB-5tqrA:
undetectable		 1mrlA-5tqrA:
15.66
1mrlB-5tqrA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5tqr POLYCOMB PROTEIN EED
(Chaetomium
thermophilum) 		3 / 3 LYS A 121
ASP A  23
ASN A  95
 None
 0.93A 2bm9A-5tqrA:
undetectable		 2bm9A-5tqrA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FCN_A_DVAA35_0
(UBIQUITIN)		 5tqr POLYCOMB PROTEIN EED
(Chaetomium
thermophilum) 		4 / 4 GLN A 175
GLU A 225
ILE A 226
PRO A 227
 None
 1.14A 2fcnA-5tqrA:
undetectable		 2fcnA-5tqrA:
9.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		 5tqr POLYCOMB PROTEIN EED
(Chaetomium
thermophilum) 		5 / 12 VAL A 538
PHE A  45
THR A  60
LEU A 111
LEU A  70
 None
 1.19A 2jn3A-5tqrA:
undetectable		 2jn3A-5tqrA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 5tqr POLYCOMB PROTEIN EED
(Chaetomium
thermophilum) 		5 / 12 ILE A 230
ASN A 212
SER A 204
GLY A 183
GLY A 185
 None
 1.14A 2zw9A-5tqrA:
12.8		 2zw9A-5tqrA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_A_SAMA301_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 5tqr POLYCOMB PROTEIN EED
(Chaetomium
thermophilum) 		4 / 6 TYR A 188
GLY A 140
THR A 161
GLU A 117
 None
 1.07A 3fpjA-5tqrA:
undetectable		 3fpjA-5tqrA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_B_PZIB802_0
(GLUTAMATE RECEPTOR 2)		 5tqr POLYCOMB PROTEIN EED
(Chaetomium
thermophilum) 		3 / 3 SER A  34
ASP A  22
ASN A 544
 None
 0.82A 3lsfB-5tqrA:
undetectable
3lsfE-5tqrA:
undetectable		 3lsfB-5tqrA:
19.34
3lsfE-5tqrA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_E_PZIE802_0
(GLUTAMATE RECEPTOR 2)		 5tqr POLYCOMB PROTEIN EED
(Chaetomium
thermophilum) 		3 / 3 ASP A  22
ASN A 544
SER A  34
 None
 0.82A 3lsfB-5tqrA:
undetectable
3lsfE-5tqrA:
undetectable		 3lsfB-5tqrA:
19.34
3lsfE-5tqrA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_B_478B200_2
(HIV-1 PROTEASE)		 5tqr POLYCOMB PROTEIN EED
(Chaetomium
thermophilum) 		5 / 10 ASP A  23
ALA A  38
ASP A  36
GLY A 541
VAL A 540
 None
 1.09A 3oxvB-5tqrA:
undetectable		 3oxvB-5tqrA:
10.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_C_478C200_2
(HIV-1 PROTEASE)		 5tqr POLYCOMB PROTEIN EED
(Chaetomium
thermophilum) 		5 / 11 ASP A  23
ALA A  38
ASP A  36
GLY A 541
VAL A 540
 None
 1.08A 3oxvD-5tqrA:
undetectable		 3oxvD-5tqrA:
10.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_B_KKKB413_1
(FLAVOHEMOGLOBIN)		 5tqr POLYCOMB PROTEIN EED
(Chaetomium
thermophilum) 		5 / 12 GLN A 388
GLN A 386
ALA A 410
LEU A 412
HIS A 340
 None
 1.14A 3ozwB-5tqrA:
undetectable		 3ozwB-5tqrA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5tqr POLYCOMB PROTEIN EED
(Chaetomium
thermophilum) 		3 / 3 SER A 101
TYR A 152
PRO A  47
 None
 0.97A 4kanB-5tqrA:
undetectable		 4kanB-5tqrA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_A_AG2A505_1
(HOMOSPERMIDINE
SYNTHASE)		 5tqr POLYCOMB PROTEIN EED
(Chaetomium
thermophilum) 		4 / 8 ASP A 246
PHE A 328
VAL A 193
ASP A 143
 None
 1.08A 4xqgA-5tqrA:
undetectable		 4xqgA-5tqrA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 5tqr POLYCOMB PROTEIN EED
(Chaetomium
thermophilum) 		4 / 8 ASP A 246
PHE A 328
VAL A 193
ASP A 143
 None
 1.07A 4xqgB-5tqrA:
undetectable		 4xqgB-5tqrA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_F_Z80F401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 5tqr POLYCOMB PROTEIN EED
(Chaetomium
thermophilum) 		5 / 10 ILE A  67
ILE A  87
THR A  60
ASN A  95
ILE A 113
 None
 1.30A 5lg3F-5tqrA:
undetectable		 5lg3F-5tqrA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_G_Z80G401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 5tqr POLYCOMB PROTEIN EED
(Chaetomium
thermophilum) 		5 / 10 ILE A  67
ILE A  87
THR A  60
ASN A  95
ILE A 113
 None
 1.27A 5lg3G-5tqrA:
undetectable		 5lg3G-5tqrA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_H_Z80H401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 5tqr POLYCOMB PROTEIN EED
(Chaetomium
thermophilum) 		5 / 10 ILE A  67
ILE A  87
THR A  60
ASN A  95
ILE A 113
 None
 1.24A 5lg3H-5tqrA:
undetectable		 5lg3H-5tqrA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5tqr POLYCOMB PROTEIN EED
(Chaetomium
thermophilum) 		5 / 10 LEU A 111
SER A  98
LEU A 144
ASP A 143
PRO A  47
 None
 1.30A 6dlzB-5tqrA:
undetectable
6dlzC-5tqrA:
undetectable		 6dlzB-5tqrA:
8.43
6dlzC-5tqrA:
8.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5tqr POLYCOMB PROTEIN EED
(Chaetomium
thermophilum) 		5 / 11 PRO A  47
LEU A 111
SER A  98
LEU A 144
ASP A 143
 None
 1.30A 6dlzA-5tqrA:
undetectable
6dlzD-5tqrA:
undetectable		 6dlzA-5tqrA:
8.43
6dlzD-5tqrA:
8.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5tqr POLYCOMB PROTEIN EED
(Chaetomium
thermophilum) 		5 / 10 LEU A 111
SER A  98
LEU A 144
ASP A 143
PRO A  47
 None
 1.30A 6dm1B-5tqrA:
undetectable
6dm1C-5tqrA:
undetectable		 6dm1B-5tqrA:
8.43
6dm1C-5tqrA:
8.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5tqr POLYCOMB PROTEIN EED
(Chaetomium
thermophilum) 		5 / 11 PRO A  47
LEU A 111
SER A  98
LEU A 144
ASP A 143
 None
 1.29A 6dm1A-5tqrA:
undetectable
6dm1D-5tqrA:
undetectable		 6dm1A-5tqrA:
8.43
6dm1D-5tqrA:
8.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5tqr POLYCOMB PROTEIN EED
(Chaetomium
thermophilum) 		5 / 10 LEU A 111
SER A  98
LEU A 144
ASP A 143
PRO A  47
 None
 1.33A 6dm2B-5tqrA:
undetectable
6dm2C-5tqrA:
undetectable		 6dm2B-5tqrA:
8.43
6dm2C-5tqrA:
8.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5tqr POLYCOMB PROTEIN EED
(Chaetomium
thermophilum) 		5 / 10 PRO A  47
LEU A 111
SER A  98
LEU A 144
ASP A 143
 None
 1.33A 6dm2A-5tqrA:
undetectable
6dm2D-5tqrA:
undetectable		 6dm2A-5tqrA:
8.43
6dm2D-5tqrA:
8.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA825_0
(GEPHYRIN)		 5tqr POLYCOMB PROTEIN EED
(Chaetomium
thermophilum) 		3 / 3 LYS A 408
VAL A 383
ASP A 385
 None
 0.45A 6fgdA-5tqrA:
undetectable		 6fgdA-5tqrA:
21.31