SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5tqw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_B_RTLB501_0
(RETINOL DEHYDRATASE)		 5tqw INHIBITOR OF NUCLEAR
FACTOR KAPPA-B
KINASE SUBUNIT ALPHA
(Homo
sapiens) 		5 / 12 ILE A 215
LEU A 122
LEU A 125
HIS A 432
ILE A 268
 None
 1.20A 1fmlB-5tqwA:
undetectable		 1fmlB-5tqwA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_A_NCAA506_0
(NAD-DEPENDENT
DEACETYLASE 2)		 5tqw INHIBITOR OF NUCLEAR
FACTOR KAPPA-B
KINASE SUBUNIT ALPHA
(Homo
sapiens) 		4 / 6 ALA A 189
SER A 206
ILE A 141
ASP A 203
 None
 0.95A 1yc2A-5tqwA:
undetectable		 1yc2A-5tqwA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OLS_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 5tqw INHIBITOR OF NUCLEAR
FACTOR KAPPA-B
KINASE SUBUNIT ALPHA
(Homo
sapiens) 		5 / 12 LEU A 537
ALA A 539
GLU A 543
LEU A 544
ILE A 618
 None
 1.27A 3olsB-5tqwA:
undetectable		 3olsB-5tqwA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_C_SUEC1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 5tqw INHIBITOR OF NUCLEAR
FACTOR KAPPA-B
KINASE SUBUNIT ALPHA
(Homo
sapiens) 		4 / 5 TYR A 441
ILE A 315
LEU A 386
LYS A 383
 None
 1.32A 3sueC-5tqwA:
undetectable		 3sueC-5tqwA:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KN2_C_LYAC304_2
(FOLATE RECEPTOR BETA)		 5tqw INHIBITOR OF NUCLEAR
FACTOR KAPPA-B
KINASE SUBUNIT ALPHA
(Homo
sapiens) 		3 / 3 TYR A 204
GLN A 285
TRP A 205
 None
 1.04A 4kn2C-5tqwA:
undetectable		 4kn2C-5tqwA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_A_0LIA1776_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 5tqw INHIBITOR OF NUCLEAR
FACTOR KAPPA-B
KINASE SUBUNIT ALPHA
(Homo
sapiens) 		5 / 12 ALA A  42
GLU A  61
MET A  65
LEU A 135
HIS A 142
 None
 0.80A 4v01A-5tqwA:
14.3		 4v01A-5tqwA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_B_0LIB1770_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 5tqw INHIBITOR OF NUCLEAR
FACTOR KAPPA-B
KINASE SUBUNIT ALPHA
(Homo
sapiens) 		5 / 12 ALA A  42
GLU A  61
MET A  65
LEU A 135
HIS A 142
 None
 0.73A 4v01B-5tqwA:
14.5		 4v01B-5tqwA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OTR_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 5tqw INHIBITOR OF NUCLEAR
FACTOR KAPPA-B
KINASE SUBUNIT ALPHA
(Homo
sapiens) 		4 / 5 TYR A 198
VAL A 202
PRO A 284
ALA A 189
 None
 1.06A 5otrA-5tqwA:
10.7		 5otrA-5tqwA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH8_A_ACTA302_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5tqw INHIBITOR OF NUCLEAR
FACTOR KAPPA-B
KINASE SUBUNIT ALPHA
(Homo
sapiens) 		3 / 3 CYH A 300
MET A 279
ASN A 281
 None
 1.13A 5qh8A-5tqwA:
undetectable		 5qh8A-5tqwA:
15.64