SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5tr1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D8C_A_SORA4000_0
(MALATE SYNTHASE G)		 5tr1 CHLORIDE CHANNEL
PROTEIN
(Bos
taurus) 		3 / 3 GLN A 513
HIS A 480
PRO A 517
 None
 0.74A 1d8cA-5tr1A:
undetectable		 1d8cA-5tr1A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FFY_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 5tr1 CHLORIDE CHANNEL
PROTEIN
(Bos
taurus) 		5 / 12 PRO A 420
GLY A 122
SER A 328
GLY A 424
VAL A 170
 None
 1.17A 1ffyA-5tr1A:
undetectable		 1ffyA-5tr1A:
21.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1H8S_A_AICA1000_1
(MUTANT AL2 6E7P9G)		 5tr1 MONOCLONAL ANTIBODY,
FAB FRAGMENT, HEAVY
CHAIN
MONOCLONAL ANTIBODY,
FAB FRAGMENT, LIGHT
CHAIN
(Mus
musculus) 		6 / 12 TYR L  36
GLN L  89
TYR L  94
LEU L  96
PHE L  98
TRP H 103
 None
 0.53A 1h8sA-5tr1L:
20.9		 1h8sA-5tr1L:
85.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2200_0
(PROTEIN (METHIONINE
REPRESSOR))		 5tr1 CHLORIDE CHANNEL
PROTEIN
(Bos
taurus) 		5 / 12 ALA A 349
PHE A 405
GLY A 345
LEU A 361
LEU A 352
 None
 1.22A 1mj2A-5tr1A:
undetectable
1mj2B-5tr1A:
undetectable		 1mj2A-5tr1A:
9.09
1mj2B-5tr1A:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_B_THAB2_1
(LIVER
CARBOXYLESTERASE I)		 5tr1 CHLORIDE CHANNEL
PROTEIN
(Bos
taurus) 		5 / 11 LEU A 618
VAL A 631
LEU A 590
LEU A 599
LEU A 558
 None
 1.36A 1mx1B-5tr1A:
undetectable		 1mx1B-5tr1A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 5tr1 CHLORIDE CHANNEL
PROTEIN
(Bos
taurus) 		5 / 12 PRO A 420
GLY A 122
SER A 328
GLY A 424
VAL A 170
 None
 1.17A 1qu2A-5tr1A:
undetectable		 1qu2A-5tr1A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_B_DVAB8_0
(GRAMICIDIN A)		 5tr1 CHLORIDE CHANNEL
PROTEIN
(Bos
taurus) 		4 / 5 VAL A  71
GLY A  72
VAL A  74
TRP A  80
 None
 1.34A 1tkqB-5tr1A:
undetectable		 1tkqB-5tr1A:
3.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOS_A_VIAA1_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 5tr1 CHLORIDE CHANNEL
PROTEIN
MONOCLONAL ANTIBODY,
FAB FRAGMENT, LIGHT
CHAIN
(Bos
taurus;
Mus
musculus) 		5 / 12 TYR L  94
LEU A 370
SER L  26
MET L   4
GLN L  89
 None
 1.47A 1xosA-5tr1L:
undetectable		 1xosA-5tr1L:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOT_A_VDNA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 5tr1 CHLORIDE CHANNEL
PROTEIN
MONOCLONAL ANTIBODY,
FAB FRAGMENT, LIGHT
CHAIN
(Bos
taurus;
Mus
musculus) 		5 / 12 TYR L  94
LEU A 370
SER L  26
MET L   4
GLN L  89
 None
 1.20A 1xotA-5tr1L:
undetectable		 1xotA-5tr1L:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AB2_A_SNLA502_1
(MINERALOCORTICOID
RECEPTOR)		 5tr1 MONOCLONAL ANTIBODY,
FAB FRAGMENT, LIGHT
CHAIN
(Mus
musculus) 		5 / 12 LEU L 104
ALA L  74
ARG L  54
PHE L  62
THR L  13
 None
 1.40A 2ab2A-5tr1L:
undetectable		 2ab2A-5tr1L:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AB2_B_SNLB503_1
(MINERALOCORTICOID
RECEPTOR)		 5tr1 MONOCLONAL ANTIBODY,
FAB FRAGMENT, LIGHT
CHAIN
(Mus
musculus) 		5 / 12 LEU L 104
ALA L  74
ARG L  54
PHE L  62
THR L  13
 None
 1.41A 2ab2B-5tr1L:
undetectable		 2ab2B-5tr1L:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CL5_B_SAMB1217_1
(CATECHOL
O-METHYLTRANSFERASE)		 5tr1 MONOCLONAL ANTIBODY,
FAB FRAGMENT, HEAVY
CHAIN
MONOCLONAL ANTIBODY,
FAB FRAGMENT, LIGHT
CHAIN
(Mus
musculus;
Mus
musculus) 		4 / 6 SER H  63
SER L 100
GLN L   6
ASP L   1
 None
 1.34A 2cl5B-5tr1H:
undetectable		 2cl5B-5tr1H:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_A_BEZA352_0
(D-AMINO-ACID OXIDASE)		 5tr1 CHLORIDE CHANNEL
PROTEIN
(Bos
taurus) 		4 / 6 LEU A 139
TYR A 138
ILE A 129
GLY A 204
 None
 0.94A 2du8A-5tr1A:
undetectable		 2du8A-5tr1A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_B_BEZB1352_0
(D-AMINO-ACID OXIDASE)		 5tr1 CHLORIDE CHANNEL
PROTEIN
(Bos
taurus) 		4 / 6 LEU A 139
TYR A 138
ILE A 129
GLY A 204
 None
 0.91A 2du8B-5tr1A:
undetectable		 2du8B-5tr1A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA2_A_SCKA901_1
(ACETYLCHOLINESTERASE)		 5tr1 CHLORIDE CHANNEL
PROTEIN
MONOCLONAL ANTIBODY,
FAB FRAGMENT, HEAVY
CHAIN
(Bos
taurus;
Mus
musculus) 		4 / 8 TYR H  54
ASP H  32
TYR A 392
HIS A 393
 None
 1.50A 2ha2A-5tr1H:
undetectable		 2ha2A-5tr1H:
11.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O01_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 5tr1 CHLORIDE CHANNEL
PROTEIN
(Bos
taurus) 		4 / 8 MET A 421
SER A 107
ALA A 156
LEU A 155
 None
 1.07A 2o01A-5tr1A:
undetectable		 2o01A-5tr1A:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		 5tr1 CHLORIDE CHANNEL
PROTEIN
(Bos
taurus) 		4 / 6 PHE A 222
PHE A 213
GLY A 424
GLY A 164
 None
 0.95A 2qr2A-5tr1A:
undetectable
2qr2B-5tr1A:
undetectable		 2qr2A-5tr1A:
16.67
2qr2B-5tr1A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B236_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		 5tr1 CHLORIDE CHANNEL
PROTEIN
(Bos
taurus) 		4 / 5 GLY A 424
GLY A 164
PHE A 222
PHE A 213
 None
 0.89A 2qr2A-5tr1A:
undetectable
2qr2B-5tr1A:
undetectable		 2qr2A-5tr1A:
16.67
2qr2B-5tr1A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 5tr1 CHLORIDE CHANNEL
PROTEIN
(Bos
taurus) 		5 / 12 VAL A 227
PHE A 222
THR A 211
VAL A 166
GLY A 167
 None
 1.25A 2x2iA-5tr1A:
undetectable		 2x2iA-5tr1A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_B_X2NB1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 5tr1 CHLORIDE CHANNEL
PROTEIN
(Bos
taurus) 		5 / 12 MET A 427
PHE A 426
ALA A 488
THR A 492
LEU A 362
 None
 1.17A 2x2nB-5tr1A:
undetectable		 2x2nB-5tr1A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5tr1 CHLORIDE CHANNEL
PROTEIN
MONOCLONAL ANTIBODY,
FAB FRAGMENT, LIGHT
CHAIN
(Bos
taurus;
Mus
musculus) 		4 / 8 TYR L  94
GLN L  27
ILE L   2
SER A 366
 None
 1.12A 2xz5B-5tr1L:
undetectable
2xz5E-5tr1L:
undetectable		 2xz5B-5tr1L:
21.62
2xz5E-5tr1L:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZVJ_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 5tr1 MONOCLONAL ANTIBODY,
FAB FRAGMENT, HEAVY
CHAIN
MONOCLONAL ANTIBODY,
FAB FRAGMENT, LIGHT
CHAIN
(Mus
musculus;
Mus
musculus) 		4 / 6 SER H  63
SER L 100
GLN L   6
ASP L   1
 None
 1.38A 2zvjA-5tr1H:
undetectable		 2zvjA-5tr1H:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE503_1
(PHOSPHOLIPASE A2)		 5tr1 CHLORIDE CHANNEL
PROTEIN
(Bos
taurus) 		5 / 11 VAL A 334
LEU A 335
SER A 105
PRO A 325
SER A 108
 None
 1.34A 3bjwE-5tr1A:
undetectable		 3bjwE-5tr1A:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_A_H3PA552_1
(GLUTAMATE
DEHYDROGENASE)		 5tr1 CHLORIDE CHANNEL
PROTEIN
(Bos
taurus) 		4 / 6 ILE A 129
TYR A 531
ILE A 123
HIS A 171
 None
 1.06A 3eteA-5tr1A:
undetectable
3eteE-5tr1A:
undetectable		 3eteA-5tr1A:
21.47
3eteE-5tr1A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC554_1
(GLUTAMATE
DEHYDROGENASE)		 5tr1 CHLORIDE CHANNEL
PROTEIN
(Bos
taurus) 		4 / 5 ILE A 129
TYR A 531
ILE A 123
HIS A 171
 None
 1.05A 3eteB-5tr1A:
undetectable
3eteC-5tr1A:
undetectable		 3eteB-5tr1A:
21.47
3eteC-5tr1A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_F_H3PF552_1
(GLUTAMATE
DEHYDROGENASE)		 5tr1 CHLORIDE CHANNEL
PROTEIN
(Bos
taurus) 		4 / 7 ILE A 123
HIS A 171
ILE A 129
TYR A 531
 None
 1.06A 3eteD-5tr1A:
undetectable
3eteF-5tr1A:
undetectable		 3eteD-5tr1A:
21.47
3eteF-5tr1A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_B_PNNB301_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 5tr1 CHLORIDE CHANNEL
PROTEIN
MONOCLONAL ANTIBODY,
FAB FRAGMENT, LIGHT
CHAIN
(Bos
taurus;
Mus
musculus) 		5 / 12 GLY L  30
ASN A 386
GLY L  68
SER L  67
GLY L  66
 None
 0.82A 3huoB-5tr1L:
undetectable		 3huoB-5tr1L:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_B_ECNB602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5tr1 CHLORIDE CHANNEL
PROTEIN
(Bos
taurus) 		5 / 9 PHE A 519
GLY A 120
ALA A 423
THR A 154
ILE A 161
 None
 1.30A 3jusB-5tr1A:
0.7		 3jusB-5tr1A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_F_TFPF201_1
(PROTEIN S100-A4)		 5tr1 CHLORIDE CHANNEL
PROTEIN
(Bos
taurus) 		4 / 5 MET A 412
PHE A 162
PHE A 432
PHE A 405
 None
 1.35A 3ko0F-5tr1A:
undetectable
3ko0G-5tr1A:
undetectable		 3ko0F-5tr1A:
9.94
3ko0G-5tr1A:
9.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LS4_H_TCIH220_2
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT
LIGHT CHAIN OF
ANTIBODY FAB
FRAGMENT)		 5tr1 MONOCLONAL ANTIBODY,
FAB FRAGMENT, LIGHT
CHAIN
(Mus
musculus) 		4 / 5 TYR L  36
GLN L  89
LEU L  96
PHE L  98
 None
 0.62A 3ls4L-5tr1L:
20.8		 3ls4L-5tr1L:
58.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P5N_A_RBFA190_1
(RIBOFLAVIN UPTAKE
PROTEIN)		 5tr1 CHLORIDE CHANNEL
PROTEIN
(Bos
taurus) 		5 / 12 THR A 492
GLY A 465
ALA A 467
ALA A 434
LEU A 361
 None
 1.09A 3p5nA-5tr1A:
undetectable		 3p5nA-5tr1A:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P5N_B_RBFB190_1
(RIBOFLAVIN UPTAKE
PROTEIN)		 5tr1 CHLORIDE CHANNEL
PROTEIN
(Bos
taurus) 		5 / 12 THR A 492
GLY A 465
ALA A 467
ALA A 434
LEU A 361
 None
 1.08A 3p5nB-5tr1A:
2.8		 3p5nB-5tr1A:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PMZ_E_TUBE220_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5tr1 CHLORIDE CHANNEL
PROTEIN
MONOCLONAL ANTIBODY,
FAB FRAGMENT, LIGHT
CHAIN
(Bos
taurus;
Mus
musculus) 		4 / 6 GLN L  90
MET L   4
ILE L   2
SER A 366
 None
 1.33A 3pmzD-5tr1L:
undetectable		 3pmzD-5tr1L:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_D_ACTD4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 5tr1 CHLORIDE CHANNEL
PROTEIN
(Bos
taurus) 		4 / 5 LEU A 413
LEU A 163
GLY A 164
GLY A 424
 None
 0.84A 3si7C-5tr1A:
undetectable
3si7D-5tr1A:
undetectable		 3si7C-5tr1A:
17.46
3si7D-5tr1A:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_A_C2FA1100_1
(GLYCINE
N-METHYLTRANSFERASE)		 5tr1 CHLORIDE CHANNEL
PROTEIN
(Bos
taurus) 		3 / 3 LEU A 172
HIS A 171
MET A 175
 None
 0.88A 3thrD-5tr1A:
undetectable		 3thrD-5tr1A:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZS3_A_ACTA1224_0
(THAUMATIN-LIKE
PROTEIN)		 5tr1 CHLORIDE CHANNEL
PROTEIN
(Bos
taurus) 		4 / 5 SER A 481
THR A 479
TYR A 520
ASP A 521
 None
 1.29A 3zs3A-5tr1A:
undetectable		 3zs3A-5tr1A:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5tr1 CHLORIDE CHANNEL
PROTEIN
(Bos
taurus) 		4 / 7 ILE A 524
PHE A 519
HIS A 171
VAL A 212
 None
 1.04A 4a97A-5tr1A:
2.5		 4a97A-5tr1A:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFT_D_QMRD301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5tr1 CHLORIDE CHANNEL
PROTEIN
(Bos
taurus) 		4 / 8 TYR A 531
VAL A 227
VAL A 202
ILE A 129
 None
 1.13A 4aftD-5tr1A:
undetectable
4aftE-5tr1A:
undetectable		 4aftD-5tr1A:
14.90
4aftE-5tr1A:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FE1_A_PQNA846_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 5tr1 CHLORIDE CHANNEL
PROTEIN
(Bos
taurus) 		5 / 10 MET A 421
SER A 107
ALA A 156
LEU A 155
ALA A 434
 None
 1.11A 4fe1A-5tr1A:
2.1
4fe1J-5tr1A:
undetectable		 4fe1A-5tr1A:
23.93
4fe1J-5tr1A:
5.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5tr1 CHLORIDE CHANNEL
PROTEIN
(Bos
taurus) 		4 / 8 ASN A 509
GLY A 476
PHE A 426
PHE A 213
 None
 0.94A 4fglD-5tr1A:
undetectable		 4fglD-5tr1A:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J14_A_X2NA602_1
(CHOLESTEROL
24-HYDROXYLASE)		 5tr1 CHLORIDE CHANNEL
PROTEIN
(Bos
taurus) 		5 / 10 ALA A 177
LEU A  56
ILE A  63
ALA A  61
ALA A 210
 None
 0.97A 4j14A-5tr1A:
0.0		 4j14A-5tr1A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L6V_1_PQN12001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
FUSION PROTEIN OF
PHOTOSYSTEM I
SUBUNIT III AND
SUBUNIT IX)		 5tr1 CHLORIDE CHANNEL
PROTEIN
(Bos
taurus) 		5 / 11 MET A 421
SER A 107
ALA A 156
LEU A 155
ALA A 434
 None
 1.11A 4l6v1-5tr1A:
1.5
4l6v6-5tr1A:
1.3		 4l6v1-5tr1A:
23.26
4l6v6-5tr1A:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L6V_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
FUSION PROTEIN OF
PHOTOSYSTEM I
SUBUNIT III AND
SUBUNIT IX)		 5tr1 CHLORIDE CHANNEL
PROTEIN
(Bos
taurus) 		5 / 9 MET A 421
SER A 107
ALA A 156
LEU A 155
ALA A 434
 None
 1.11A 4l6va-5tr1A:
undetectable
4l6vf-5tr1A:
undetectable		 4l6va-5tr1A:
23.26
4l6vf-5tr1A:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 2)		 5tr1 CHLORIDE CHANNEL
PROTEIN
(Bos
taurus) 		3 / 3 PHE A 474
THR A 523
LEU A 413
 None
 0.78A 4qztA-5tr1A:
undetectable		 4qztA-5tr1A:
9.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_A_15UA301_1
(THROMBIN HEAVY CHAIN)		 5tr1 CHLORIDE CHANNEL
PROTEIN
(Bos
taurus) 		6 / 10 TYR A 138
LEU A 126
LEU A  56
ALA A 242
ALA A 177
GLY A 208
 None
 1.40A 4rn6A-5tr1A:
undetectable		 4rn6A-5tr1A:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 5tr1 CHLORIDE CHANNEL
PROTEIN
(Bos
taurus) 		4 / 7 MET A 421
SER A 107
ALA A 156
LEU A 155
 None
 0.93A 4xk8A-5tr1A:
undetectable		 4xk8A-5tr1A:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA845_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 5tr1 CHLORIDE CHANNEL
PROTEIN
(Bos
taurus) 		4 / 8 MET A 421
SER A 107
ALA A 156
LEU A 155
 None
 0.98A 4xk8a-5tr1A:
undetectable		 4xk8a-5tr1A:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPM_A_BO2A801_1
(LON PROTEASE)		 5tr1 CHLORIDE CHANNEL
PROTEIN
(Bos
taurus) 		5 / 12 ALA A 368
THR A 371
THR A 401
GLY A 441
SER A 445
 None
 1.00A 4ypmA-5tr1A:
3.1		 4ypmA-5tr1A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_D_PAUD601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 5tr1 CHLORIDE CHANNEL
PROTEIN
(Bos
taurus) 		4 / 8 VAL A 220
ALA A 206
GLY A 204
GLY A  57
 None
 0.85A 5e26C-5tr1A:
undetectable
5e26D-5tr1A:
undetectable		 5e26C-5tr1A:
20.21
5e26D-5tr1A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWU_A_BEZA1401_0
(MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC)		 5tr1 CHLORIDE CHANNEL
PROTEIN
(Bos
taurus) 		4 / 6 GLY A 208
THR A 211
SER A 173
VAL A 207
 None
 1.14A 5ewuA-5tr1A:
undetectable		 5ewuA-5tr1A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHR_B_SAMB303_1
(CATECHOL
O-METHYLTRANSFERASE)		 5tr1 MONOCLONAL ANTIBODY,
FAB FRAGMENT, HEAVY
CHAIN
MONOCLONAL ANTIBODY,
FAB FRAGMENT, LIGHT
CHAIN
(Mus
musculus;
Mus
musculus) 		4 / 5 SER H  63
SER L 100
GLN L   6
ASP L   1
 None
 1.33A 5fhrB-5tr1H:
undetectable		 5fhrB-5tr1H:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5tr1 CHLORIDE CHANNEL
PROTEIN
(Bos
taurus) 		5 / 12 VAL A 226
LEU A  56
VAL A 174
GLY A 204
ALA A 205
 None
 0.85A 5iktA-5tr1A:
undetectable		 5iktA-5tr1A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND3_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 5tr1 CHLORIDE CHANNEL
PROTEIN
(Bos
taurus) 		5 / 12 GLU A 490
LEU A  56
ALA A 210
THR A  54
ARG A 238
 None
None
None
None
Y01  A 701 (-4.1A)
 0.99A 5nd3B-5tr1A:
undetectable		 5nd3B-5tr1A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND3_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 5tr1 CHLORIDE CHANNEL
PROTEIN
(Bos
taurus) 		5 / 12 GLU A 490
LEU A  56
THR A  54
ARG A 238
PRO A 216
 None
None
None
Y01  A 701 (-4.1A)
None
 1.15A 5nd3B-5tr1A:
undetectable		 5nd3B-5tr1A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUI_B_CTCB405_0
(TETRACYCLINE
DESTRUCTASE TET(50))		 5tr1 CHLORIDE CHANNEL
PROTEIN
(Bos
taurus) 		5 / 12 GLY A 433
PHE A 474
VAL A 166
LEU A 413
GLY A 164
 None
 1.05A 5tuiB-5tr1A:
undetectable		 5tuiB-5tr1A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_A_7V7A202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 5tr1 CHLORIDE CHANNEL
PROTEIN
(Bos
taurus) 		5 / 12 VAL A 478
ALA A 508
PRO A 428
ALA A 477
GLY A 476
 None
 1.12A 5tzoA-5tr1A:
undetectable		 5tzoA-5tr1A:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7P_A_SAMA501_0
(OXAC)		 5tr1 CHLORIDE CHANNEL
PROTEIN
(Bos
taurus) 		5 / 12 ALA A 471
GLY A 470
VAL A 501
PHE A 430
ARG A 438
 None
 1.17A 5w7pA-5tr1A:
undetectable		 5w7pA-5tr1A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5tr1 CHLORIDE CHANNEL
PROTEIN
(Bos
taurus) 		4 / 5 LEU A 641
PHE A 550
LEU A 673
PHE A 648
 None
 0.97A 5x19C-5tr1A:
2.8
5x19J-5tr1A:
undetectable		 5x19C-5tr1A:
15.99
5x19J-5tr1A:
5.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_0
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 5tr1 CHLORIDE CHANNEL
PROTEIN
(Bos
taurus) 		5 / 12 GLY A 470
ALA A 467
ALA A 504
ALA A 472
ALA A 485
 None
 1.04A 5zw4A-5tr1A:
undetectable		 5zw4A-5tr1A:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_0
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 5tr1 CHLORIDE CHANNEL
PROTEIN
(Bos
taurus) 		6 / 12 ILE A 431
GLY A 470
ALA A 434
ALA A 504
ALA A 472
ALA A 485
 None
 1.18A 5zw4A-5tr1A:
undetectable		 5zw4A-5tr1A:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_A_8NUA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 5tr1 CHLORIDE CHANNEL
PROTEIN
(Bos
taurus) 		5 / 12 SER A 360
SER A 159
THR A 160
ILE A 161
LEU A 402
 None
 1.35A 6a93A-5tr1A:
3.6		 6a93A-5tr1A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CNK_A_NCTA405_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4)		 5tr1 CHLORIDE CHANNEL
PROTEIN
(Bos
taurus) 		4 / 6 TYR A  82
TRP A  96
THR A  97
THR A 160
 None
 1.35A 6cnkA-5tr1A:
2.0
6cnkB-5tr1A:
2.3		 6cnkA-5tr1A:
10.54
6cnkB-5tr1A:
10.54