SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5tr3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OHR_A_1UNA201_1
(ASPARTYLPROTEASE)		 5tr3 DIHYDROLIPOYL
DEHYDROGENASE
(Pseudomonas
putida) 		5 / 11 GLY A 188
ALA A 189
GLY A 197
THR A 233
ILE A 239
 None
 0.89A 1ohrA-5tr3A:
undetectable		 1ohrA-5tr3A:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDU_B_MK1B902_2
(PROTEASE RETROPEPSIN)		 5tr3 DIHYDROLIPOYL
DEHYDROGENASE
(Pseudomonas
putida) 		5 / 12 GLY A 173
ASP A 170
ILE A 192
GLY A  53
VAL A 199
 None
None
FAD  A 501 (-4.4A)
FAD  A 501 (-3.4A)
None
 1.10A 1sduB-5tr3A:
undetectable		 1sduB-5tr3A:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UKB_A_BEZA1300_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)		 5tr3 DIHYDROLIPOYL
DEHYDROGENASE
(Pseudomonas
putida) 		5 / 11 GLY A  15
ALA A  19
ALA A  20
VAL A 337
VAL A 338
 FAD  A 501 (-3.8A)
None
None
None
None
 1.13A 1ukbA-5tr3A:
undetectable		 1ukbA-5tr3A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VID_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 5tr3 DIHYDROLIPOYL
DEHYDROGENASE
(Pseudomonas
putida) 		4 / 5 SER A  64
GLU A 195
TYR A 358
SER A 171
 None
FAD  A 501 ( 4.6A)
FAD  A 501 (-4.1A)
FAD  A 501 (-3.5A)
 1.07A 1vidA-5tr3A:
undetectable		 1vidA-5tr3A:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_B_RALB600_2
(ESTROGEN RECEPTOR)		 5tr3 DIHYDROLIPOYL
DEHYDROGENASE
(Pseudomonas
putida) 		4 / 5 LEU A 415
ASP A 412
LEU A 352
HIS A 418
 None
 1.32A 2qxsB-5tr3A:
undetectable		 2qxsB-5tr3A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1162_1
(ALLERGEN ARG R 1)		 5tr3 DIHYDROLIPOYL
DEHYDROGENASE
(Pseudomonas
putida) 		3 / 3 GLU A 456
HIS A 471
GLU A 460
 None
 0.85A 2x45B-5tr3A:
undetectable		 2x45B-5tr3A:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AXZ_A_ADNA401_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 5tr3 DIHYDROLIPOYL
DEHYDROGENASE
(Pseudomonas
putida) 		5 / 12 GLY A  13
GLY A  46
ILE A 335
GLY A  16
GLY A  15
 FAD  A 501 (-3.4A)
None
None
None
FAD  A 501 (-3.8A)
 1.03A 3axzA-5tr3A:
undetectable		 3axzA-5tr3A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_A_ECLA600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5tr3 DIHYDROLIPOYL
DEHYDROGENASE
(Pseudomonas
putida) 		4 / 8 LEU A 213
GLY A 193
ALA A 276
ILE A 158
 None
 0.81A 3jusA-5tr3A:
undetectable		 3jusA-5tr3A:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_A_ECNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5tr3 DIHYDROLIPOYL
DEHYDROGENASE
(Pseudomonas
putida) 		4 / 8 LEU A 213
GLY A 193
ALA A 276
ILE A 158
 None
 0.81A 3jusA-5tr3A:
undetectable		 3jusA-5tr3A:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_A_CELA682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5tr3 DIHYDROLIPOYL
DEHYDROGENASE
(Pseudomonas
putida) 		5 / 12 ALA A 144
VAL A   9
GLY A  11
ALA A 150
SER A 151
 None
None
FAD  A 501 (-3.4A)
None
FAD  A 501 (-4.6A)
 1.08A 3ln1A-5tr3A:
undetectable		 3ln1A-5tr3A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5tr3 DIHYDROLIPOYL
DEHYDROGENASE
(Pseudomonas
putida) 		5 / 12 ALA A 144
VAL A   9
GLY A  11
ALA A 150
SER A 151
 None
None
FAD  A 501 (-3.4A)
None
FAD  A 501 (-4.6A)
 1.08A 3ln1C-5tr3A:
3.0		 3ln1C-5tr3A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_D_NCTD501_1
(CYTOCHROME P450 2A6)		 5tr3 DIHYDROLIPOYL
DEHYDROGENASE
(Pseudomonas
putida) 		4 / 7 GLY A 193
ILE A 239
LEU A 232
PHE A 216
 None
 0.72A 4ejjD-5tr3A:
undetectable		 4ejjD-5tr3A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L6V_1_PQN12001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
FUSION PROTEIN OF
PHOTOSYSTEM I
SUBUNIT III AND
SUBUNIT IX)		 5tr3 DIHYDROLIPOYL
DEHYDROGENASE
(Pseudomonas
putida) 		5 / 11 GLY A  93
ARG A  94
ALA A  59
GLY A  97
ALA A 330
 None
None
None
None
FAD  A 501 ( 3.8A)
 1.08A 4l6v1-5tr3A:
undetectable
4l6v6-5tr3A:
undetectable		 4l6v1-5tr3A:
21.73
4l6v6-5tr3A:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5tr3 DIHYDROLIPOYL
DEHYDROGENASE
(Pseudomonas
putida) 		4 / 7 LEU A 175
PRO A  56
LEU A 196
GLU A 195
 None
None
None
FAD  A 501 ( 4.6A)
 1.04A 4z4fA-5tr3A:
undetectable		 4z4fA-5tr3A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHR_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 5tr3 DIHYDROLIPOYL
DEHYDROGENASE
(Pseudomonas
putida) 		4 / 5 SER A  64
GLU A 195
TYR A 358
SER A 171
 None
FAD  A 501 ( 4.6A)
FAD  A 501 (-4.1A)
FAD  A 501 (-3.5A)
 1.09A 5fhrA-5tr3A:
undetectable		 5fhrA-5tr3A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_D_SAMD501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 5tr3 DIHYDROLIPOYL
DEHYDROGENASE
(Pseudomonas
putida) 		5 / 10 LEU A 149
ILE A  10
GLY A  11
GLY A  16
VAL A   7
 None
FAD  A 501 (-4.8A)
FAD  A 501 (-3.4A)
None
None
 1.01A 5o96C-5tr3A:
2.2
5o96D-5tr3A:
3.0		 5o96C-5tr3A:
20.12
5o96D-5tr3A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_A_RBFA502_1
(RIBOFLAVIN LYASE)		 5tr3 DIHYDROLIPOYL
DEHYDROGENASE
(Pseudomonas
putida) 		5 / 12 ALA A 469
GLY A 431
ALA A 434
VAL A 405
THR A 439
 None
 0.97A 5w4zA-5tr3A:
undetectable		 5w4zA-5tr3A:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_B_RBFB502_1
(RIBOFLAVIN LYASE)		 5tr3 DIHYDROLIPOYL
DEHYDROGENASE
(Pseudomonas
putida) 		5 / 12 ALA A 469
GLY A 431
ALA A 434
VAL A 405
THR A 439
 None
 0.96A 5w4zB-5tr3A:
undetectable		 5w4zB-5tr3A:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BP4_B_SAMB505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 5tr3 DIHYDROLIPOYL
DEHYDROGENASE
(Pseudomonas
putida) 		5 / 12 GLY A 193
ILE A 274
CYH A  54
LEU A 175
GLY A 173
 None
None
FAD  A 501 (-3.2A)
None
None
 1.49A 6bp4B-5tr3A:
undetectable		 6bp4B-5tr3A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_B_DAHB123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 5tr3 DIHYDROLIPOYL
DEHYDROGENASE
(Pseudomonas
putida) 		5 / 10 PHE A 437
THR A 439
ASP A 443
GLY A 431
ILE A 433
 TRS  A 502 ( 4.2A)
None
None
None
None
 1.13A 6ebpB-5tr3A:
undetectable		 6ebpB-5tr3A:
9.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_C_DAHC123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 5tr3 DIHYDROLIPOYL
DEHYDROGENASE
(Pseudomonas
putida) 		5 / 10 PHE A 437
THR A 439
ASP A 443
GLY A 431
ILE A 433
 TRS  A 502 ( 4.2A)
None
None
None
None
 1.14A 6ebpC-5tr3A:
undetectable		 6ebpC-5tr3A:
9.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_D_DAHD123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 5tr3 DIHYDROLIPOYL
DEHYDROGENASE
(Pseudomonas
putida) 		5 / 10 PHE A 437
THR A 439
ASP A 443
GLY A 431
ILE A 433
 TRS  A 502 ( 4.2A)
None
None
None
None
 1.08A 6ebpD-5tr3A:
undetectable		 6ebpD-5tr3A:
9.00