SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5tr9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_A_NIOA604_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5tr9 FERREDOXIN-NADP
REDUCTASE
(Neisseria
gonorrhoeae) 		4 / 5 SER A 158
THR A 192
GLU A 162
GLY A 129
 None
None
EDO  A 304 ( 3.8A)
EDO  A 304 (-3.3A)
 1.33A 1icrA-5tr9A:
undetectable
1icrB-5tr9A:
undetectable		 1icrA-5tr9A:
21.36
1icrB-5tr9A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_B_NIOB602_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5tr9 FERREDOXIN-NADP
REDUCTASE
(Neisseria
gonorrhoeae) 		4 / 5 GLU A 162
GLY A 129
SER A 158
THR A 192
 EDO  A 304 ( 3.8A)
EDO  A 304 (-3.3A)
None
None
 1.33A 1icrA-5tr9A:
undetectable
1icrB-5tr9A:
undetectable		 1icrA-5tr9A:
21.36
1icrB-5tr9A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_D_NIOD706_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5tr9 FERREDOXIN-NADP
REDUCTASE
(Neisseria
gonorrhoeae) 		4 / 5 GLU A 162
GLY A 129
SER A 158
THR A 192
 EDO  A 304 ( 3.8A)
EDO  A 304 (-3.3A)
None
None
 1.32A 1icvC-5tr9A:
undetectable
1icvD-5tr9A:
undetectable		 1icvC-5tr9A:
21.36
1icvD-5tr9A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_A_30BA500_1
(GENOME POLYPROTEIN)		 5tr9 FERREDOXIN-NADP
REDUCTASE
(Neisseria
gonorrhoeae) 		5 / 12 GLY A 266
GLY A 129
SER A 130
PHE A  80
ALA A  81
 FAD  A 301 (-4.9A)
EDO  A 304 (-3.3A)
FAD  A 301 (-2.8A)
None
FAD  A 301 (-3.8A)
 1.13A 3keeA-5tr9A:
undetectable		 3keeA-5tr9A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_C_ADNC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 5tr9 FERREDOXIN-NADP
REDUCTASE
(Neisseria
gonorrhoeae) 		4 / 5 LEU A  32
THR A  29
GLU A 162
HIS A 155
 EDO  A 304 ( 4.8A)
None
EDO  A 304 ( 3.8A)
CL  A 307 (-4.1A)
 1.29A 3n58C-5tr9A:
undetectable		 3n58C-5tr9A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5tr9 FERREDOXIN-NADP
REDUCTASE
(Neisseria
gonorrhoeae) 		5 / 12 GLY A 266
GLY A 129
SER A 130
PHE A  80
ALA A  81
 FAD  A 301 (-4.9A)
EDO  A 304 (-3.3A)
FAD  A 301 (-2.8A)
None
FAD  A 301 (-3.8A)
 1.16A 3sueB-5tr9A:
undetectable		 3sueB-5tr9A:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5tr9 FERREDOXIN-NADP
REDUCTASE
(Neisseria
gonorrhoeae) 		5 / 12 GLY A 266
GLY A 129
SER A 130
PHE A  80
ALA A  81
 FAD  A 301 (-4.9A)
EDO  A 304 (-3.3A)
FAD  A 301 (-2.8A)
None
FAD  A 301 (-3.8A)
 1.18A 3sueD-5tr9A:
undetectable		 3sueD-5tr9A:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_A_ADNA401_1
(ADENOSINE KINASE,
PUTATIVE)		 5tr9 FERREDOXIN-NADP
REDUCTASE
(Neisseria
gonorrhoeae) 		5 / 12 ILE A 231
LEU A 245
THR A 241
LEU A 209
GLY A 129
 None
None
None
None
EDO  A 304 (-3.3A)
 0.88A 3uq6A-5tr9A:
4.3		 3uq6A-5tr9A:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5tr9 FERREDOXIN-NADP
REDUCTASE
(Neisseria
gonorrhoeae) 		5 / 11 ALA A 170
GLY A 199
ASN A 196
ASN A 166
HIS A 155
 None
None
None
None
CL  A 307 (-4.1A)
 1.30A 4e47A-5tr9A:
undetectable		 4e47A-5tr9A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_C_NCTC501_1
(CYTOCHROME P450 2A6)		 5tr9 FERREDOXIN-NADP
REDUCTASE
(Neisseria
gonorrhoeae) 		4 / 5 PHE A 165
PHE A  80
ILE A 132
GLY A 129
 None
None
None
EDO  A 304 (-3.3A)
 1.01A 4ejjC-5tr9A:
undetectable		 4ejjC-5tr9A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5tr9 FERREDOXIN-NADP
REDUCTASE
(Neisseria
gonorrhoeae) 		5 / 12 LEU A 136
LEU A 139
ILE A 132
SER A 184
THR A 150
 None
 0.85A 4f4dB-5tr9A:
3.7		 4f4dB-5tr9A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5tr9 FERREDOXIN-NADP
REDUCTASE
(Neisseria
gonorrhoeae) 		5 / 11 ALA A 170
GLY A 199
ASN A 196
ASN A 166
HIS A 155
 None
None
None
None
CL  A 307 (-4.1A)
 1.30A 4jdsA-5tr9A:
undetectable		 4jdsA-5tr9A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_B_SAMB401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5tr9 FERREDOXIN-NADP
REDUCTASE
(Neisseria
gonorrhoeae) 		5 / 11 ALA A 170
GLY A 199
ASN A 196
ASN A 166
HIS A 155
 None
None
None
None
CL  A 307 (-4.1A)
 1.29A 4jdsB-5tr9A:
undetectable		 4jdsB-5tr9A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_D_SAMD401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5tr9 FERREDOXIN-NADP
REDUCTASE
(Neisseria
gonorrhoeae) 		5 / 11 ALA A 170
GLY A 199
ASN A 196
ASN A 166
HIS A 155
 None
None
None
None
CL  A 307 (-4.1A)
 1.32A 4jdsD-5tr9A:
undetectable		 4jdsD-5tr9A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4D_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 5tr9 FERREDOXIN-NADP
REDUCTASE
(Neisseria
gonorrhoeae) 		4 / 8 TYR A 250
THR A 227
THR A 241
LEU A 222
 None
 1.09A 4l4dA-5tr9A:
undetectable		 4l4dA-5tr9A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5tr9 FERREDOXIN-NADP
REDUCTASE
(Neisseria
gonorrhoeae) 		4 / 7 ILE A 132
GLY A 131
PHE A 148
PHE A 229
 None
 0.82A 5hieA-5tr9A:
undetectable		 5hieA-5tr9A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 5tr9 FERREDOXIN-NADP
REDUCTASE
(Neisseria
gonorrhoeae) 		5 / 12 SER A 226
MET A 248
PHE A 229
LEU A 126
VAL A 124
 None
 1.02A 5tudA-5tr9A:
undetectable		 5tudA-5tr9A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 5tr9 FERREDOXIN-NADP
REDUCTASE
(Neisseria
gonorrhoeae) 		5 / 12 SER A 226
MET A 248
PHE A 229
LEU A 126
VAL A 124
 None
 1.07A 5tudD-5tr9A:
undetectable		 5tudD-5tr9A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW4_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 5tr9 FERREDOXIN-NADP
REDUCTASE
(Neisseria
gonorrhoeae) 		5 / 9 GLY A 131
ALA A 133
CYH A 232
GLY A 233
GLU A 264
 None
FAD  A 301 ( 3.7A)
None
None
FAD  A 301 ( 4.6A)
 0.68A 5vw4A-5tr9A:
21.3		 5vw4A-5tr9A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW4_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 5tr9 FERREDOXIN-NADP
REDUCTASE
(Neisseria
gonorrhoeae) 		5 / 9 SER A  67
GLY A 131
ALA A 133
CYH A 232
GLU A 264
 FAD  A 301 (-3.9A)
None
FAD  A 301 ( 3.7A)
None
FAD  A 301 ( 4.6A)
 0.62A 5vw4A-5tr9A:
21.3		 5vw4A-5tr9A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW4_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 5tr9 FERREDOXIN-NADP
REDUCTASE
(Neisseria
gonorrhoeae) 		5 / 9 SER A  67
GLY A 131
ALA A 133
CYH A 232
GLY A 266
 FAD  A 301 (-3.9A)
None
FAD  A 301 ( 3.7A)
None
FAD  A 301 (-4.9A)
 0.96A 5vw4A-5tr9A:
21.3		 5vw4A-5tr9A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW5_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 5tr9 FERREDOXIN-NADP
REDUCTASE
(Neisseria
gonorrhoeae) 		4 / 8 GLY A 131
CYH A 232
GLY A 233
GLU A 264
 None
None
None
FAD  A 301 ( 4.6A)
 0.65A 5vw5A-5tr9A:
21.5		 5vw5A-5tr9A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW5_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 5tr9 FERREDOXIN-NADP
REDUCTASE
(Neisseria
gonorrhoeae) 		4 / 8 SER A  67
GLY A 131
CYH A 232
GLU A 264
 FAD  A 301 (-3.9A)
None
None
FAD  A 301 ( 4.6A)
 0.66A 5vw5A-5tr9A:
21.5		 5vw5A-5tr9A:
25.00