SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5trp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5trp DH272 FAB HEAVY
CHAIN
(Homo
sapiens) 		4 / 5 GLY H 199
GLN H 201
VAL H 193
SER H 196
 None
 1.40A 1zzuB-5trpH:
undetectable		 1zzuB-5trpH:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZ7_A_CA4A1_2
(ANDROGEN RECEPTOR)		 5trp DH272 FAB HEAVY
CHAIN
(Homo
sapiens) 		4 / 6 TRP H  36
MET H  79
MET H  70
LEU H  81
 None
 1.41A 2oz7A-5trpH:
undetectable		 2oz7A-5trpH:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_A_PNNA302_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 5trp DH272 FAB HEAVY
CHAIN
(Homo
sapiens) 		4 / 6 LEU H 198
GLY H 199
ALA H 134
PRO H 135
 None
 0.48A 3huoA-5trpH:
undetectable		 3huoA-5trpH:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5trp DH272 FAB HEAVY
CHAIN
(Homo
sapiens) 		5 / 12 SER H 197
GLY H 143
THR H 144
ALA H 145
THR H 140
 None
 0.92A 4qvpH-5trpH:
undetectable
4qvpI-5trpH:
undetectable		 4qvpH-5trpH:
23.47
4qvpI-5trpH:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5trp DH272 FAB HEAVY
CHAIN
(Homo
sapiens) 		5 / 12 SER H 197
GLY H 143
THR H 144
ALA H 145
THR H 140
 None
 0.92A 4qvpV-5trpH:
undetectable
4qvpW-5trpH:
undetectable		 4qvpV-5trpH:
23.47
4qvpW-5trpH:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)		 5trp DH272 FAB HEAVY
CHAIN
(Homo
sapiens) 		5 / 11 SER H 197
GLY H 143
THR H 144
ALA H 145
THR H 140
 None
 0.96A 4qvvH-5trpH:
undetectable		 4qvvH-5trpH:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)		 5trp DH272 FAB HEAVY
CHAIN
(Homo
sapiens) 		5 / 11 SER H 197
GLY H 143
THR H 144
ALA H 145
THR H 140
 None
 0.95A 4qvvV-5trpH:
undetectable		 4qvvV-5trpH:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)		 5trp DH272 FAB HEAVY
CHAIN
(Homo
sapiens) 		5 / 11 SER H 197
GLY H 143
THR H 144
ALA H 145
THR H 140
 None
 0.96A 4qvyH-5trpH:
undetectable		 4qvyH-5trpH:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5trp DH272 FAB HEAVY
CHAIN
(Homo
sapiens) 		5 / 12 SER H 197
GLY H 143
THR H 144
ALA H 145
THR H 140
 None
 0.96A 4qvyV-5trpH:
undetectable
4qvyW-5trpH:
undetectable		 4qvyV-5trpH:
23.47
4qvyW-5trpH:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5trp DH272 FAB HEAVY
CHAIN
(Homo
sapiens) 		5 / 11 SER H 197
GLY H 143
THR H 144
ALA H 145
THR H 140
 None
 0.95A 4qw0H-5trpH:
undetectable
4qw0I-5trpH:
undetectable		 4qw0H-5trpH:
23.47
4qw0I-5trpH:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5trp DH272 FAB HEAVY
CHAIN
(Homo
sapiens) 		5 / 11 SER H 197
GLY H 143
THR H 144
ALA H 145
THR H 140
 None
 0.95A 4qw0V-5trpH:
undetectable
4qw0W-5trpH:
undetectable		 4qw0V-5trpH:
23.47
4qw0W-5trpH:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5trp DH272 FAB HEAVY
CHAIN
(Homo
sapiens) 		5 / 11 SER H 197
GLY H 143
THR H 144
ALA H 145
THR H 140
 None
 0.93A 5bxnH-5trpH:
undetectable
5bxnI-5trpH:
undetectable		 5bxnH-5trpH:
23.47
5bxnI-5trpH:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZ7_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5trp DH272 FAB HEAVY
CHAIN
(Homo
sapiens) 		5 / 12 SER H 197
GLY H 143
THR H 144
ALA H 145
THR H 140
 None
 0.94A 5cz7V-5trpH:
undetectable
5cz7W-5trpH:
undetectable		 5cz7V-5trpH:
23.47
5cz7W-5trpH:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)		 5trp DH272 FAB HEAVY
CHAIN
(Homo
sapiens) 		5 / 11 SER H 197
GLY H 143
THR H 144
ALA H 145
THR H 140
 None
 0.94A 5d0xV-5trpH:
undetectable		 5d0xV-5trpH:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5trp DH272 FAB HEAVY
CHAIN
(Homo
sapiens) 		5 / 12 SER H 197
GLY H 143
THR H 144
ALA H 145
THR H 140
 None
 0.91A 5l5fH-5trpH:
undetectable
5l5fI-5trpH:
undetectable		 5l5fH-5trpH:
23.47
5l5fI-5trpH:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5trp DH272 FAB HEAVY
CHAIN
(Homo
sapiens) 		5 / 12 SER H 197
GLY H 143
THR H 144
ALA H 145
THR H 140
 None
 0.92A 5l5fV-5trpH:
undetectable
5l5fW-5trpH:
undetectable		 5l5fV-5trpH:
23.47
5l5fW-5trpH:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_H_BO2H301_0
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5trp DH272 FAB HEAVY
CHAIN
(Homo
sapiens) 		5 / 12 SER H 197
GLY H 143
THR H 144
ALA H 145
THR H 140
 None
 1.04A 6hwdH-5trpH:
undetectable
6hwdI-5trpH:
undetectable		 6hwdH-5trpH:
17.26
6hwdI-5trpH:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_V_BO2V301_0
(PROTEASOME SUBUNIT
BETA TYPE-2)		 5trp DH272 FAB HEAVY
CHAIN
(Homo
sapiens) 		5 / 11 SER H 197
GLY H 143
THR H 144
ALA H 145
THR H 140
 None
 1.05A 6hwdV-5trpH:
undetectable		 6hwdV-5trpH:
17.26