SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5tru'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA350_2
(PROTEIN (ADENOSINE
KINASE))		 5tru CYTOTOXIC
T-LYMPHOCYTE PROTEIN
4
(Homo
sapiens) 		3 / 3 LEU c  79
SER c  72
ASN c  75
 None
 0.81A 1bx4A-5truc:
undetectable		 1bx4A-5truc:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_A_STIA3_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5tru CYTOTOXIC
T-LYMPHOCYTE PROTEIN
4
(Homo
sapiens) 		4 / 5 TYR c  25
VAL c  46
ILE c 108
MET c  99
 None
 1.44A 1opjA-5truc:
undetectable		 1opjA-5truc:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_A_PAUA301_0
(TYPE III
PANTOTHENATE KINASE)		 5tru CYTOTOXIC
T-LYMPHOCYTE PROTEIN
4
(Homo
sapiens) 		5 / 12 VAL c   5
TYR c 104
LEU c 106
GLY c 107
THR c  37
 None
 1.30A 4o5fA-5truc:
undetectable
4o5fB-5truc:
undetectable		 4o5fA-5truc:
17.69
4o5fB-5truc:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)		 5tru CYTOTOXIC
T-LYMPHOCYTE PROTEIN
4
(Homo
sapiens) 		5 / 12 VAL c   5
TYR c 104
LEU c 106
GLY c 107
THR c  37
 None
 1.27A 4o5fA-5truc:
undetectable
4o5fB-5truc:
undetectable		 4o5fA-5truc:
17.69
4o5fB-5truc:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_A_PAUA302_0
(TYPE III
PANTOTHENATE KINASE)		 5tru CYTOTOXIC
T-LYMPHOCYTE PROTEIN
4
(Homo
sapiens) 		5 / 12 VAL c   5
TYR c 104
LEU c 106
GLY c 107
THR c  37
 None
 1.30A 5b8hA-5truc:
undetectable
5b8hB-5truc:
undetectable		 5b8hA-5truc:
19.08
5b8hB-5truc:
19.08