SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5trv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5trv DENOVO NTF2
(synthetic
construct) 		4 / 7 ILE A 106
PHE A  92
LYS A  35
GLY A  37
 None
 1.04A 3em0B-5trvA:
undetectable		 3em0B-5trvA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5trv DENOVO NTF2
(synthetic
construct) 		4 / 8 PHE A  41
VAL A  36
MET A  88
ILE A 106
 PEG  A 201 (-4.3A)
None
None
None
 0.94A 4a97C-5trvA:
undetectable		 4a97C-5trvA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5trv DENOVO NTF2
(synthetic
construct) 		5 / 8 PHE A  41
VAL A  36
MET A  88
ILE A 106
GLU A  46
 PEG  A 201 (-4.3A)
None
None
None
None
 1.34A 4a97G-5trvA:
undetectable		 4a97G-5trvA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_J_ZPCJ1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5trv DENOVO NTF2
(synthetic
construct) 		4 / 8 PHE A  41
VAL A  36
MET A  88
ILE A 106
 PEG  A 201 (-4.3A)
None
None
None
 1.01A 4a97I-5trvA:
undetectable		 4a97I-5trvA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IMA_D_ADND604_1
(PYRUVATE KINASE)		 5trv DENOVO NTF2
(synthetic
construct) 		3 / 3 ARG A  72
GLU A  70
ASN A  71
 None
 0.85A 4imaD-5trvA:
undetectable		 4imaD-5trvA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IP7_D_ADND604_1
(PYRUVATE KINASE
ISOZYMES L)		 5trv DENOVO NTF2
(synthetic
construct) 		3 / 3 ARG A  72
GLU A  70
ASN A  71
 None
 0.85A 4ip7D-5trvA:
undetectable		 4ip7D-5trvA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJC_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 5trv DENOVO NTF2
(synthetic
construct) 		4 / 7 LEU A  28
ILE A 106
MET A  88
MET A  50
 None
None
None
PEG  A 201 (-3.5A)
 0.89A 5ljcA-5trvA:
undetectable		 5ljcA-5trvA:
23.74