SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5trw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3002_1
(SERUM ALBUMIN)		 5trw PYRIDOXAL KINASE
PDXY
(Paraburkholderia
xenovorans) 		4 / 8 GLN A  89
TYR A 109
LEU A 131
SER A  81
 None
 1.18A 1hk2A-5trwA:
undetectable		 1hk2A-5trwA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_0
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)		 5trw PYRIDOXAL KINASE
PDXY
(Paraburkholderia
xenovorans) 		5 / 12 ALA A 141
PRO A 144
GLY A 174
ILE A 171
LEU A 196
 NHE  A 402 ( 4.0A)
None
None
None
None
 1.25A 1kglA-5trwA:
undetectable		 1kglA-5trwA:
17.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TD2_A_PXLA288_1
(PYRIDOXAMINE KINASE)		 5trw PYRIDOXAL KINASE
PDXY
(Paraburkholderia
xenovorans) 		6 / 10 ALA A  17
HIS A  44
GLN A  46
TYR A  83
VAL A 218
ASP A 222
 None
 0.69A 1td2A-5trwA:
44.0		 1td2A-5trwA:
54.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TD2_A_PXLA288_1
(PYRIDOXAMINE KINASE)		 5trw PYRIDOXAL KINASE
PDXY
(Paraburkholderia
xenovorans) 		8 / 10 SER A  10
VAL A  12
ALA A  17
HIS A  44
THR A  45
GLN A  46
VAL A 218
ASP A 222
 None
 0.25A 1td2A-5trwA:
44.0		 1td2A-5trwA:
54.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TD2_B_PXLB289_1
(PYRIDOXAMINE KINASE)		 5trw PYRIDOXAL KINASE
PDXY
(Paraburkholderia
xenovorans) 		7 / 9 ALA A  17
HIS A  44
THR A  45
TYR A  83
VAL A 114
VAL A 218
ASP A 222
 None
 0.79A 1td2B-5trwA:
44.0		 1td2B-5trwA:
54.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TD2_B_PXLB289_1
(PYRIDOXAMINE KINASE)		 5trw PYRIDOXAL KINASE
PDXY
(Paraburkholderia
xenovorans) 		7 / 9 SER A  10
ALA A  17
HIS A  44
THR A  45
VAL A 114
VAL A 218
ASP A 222
 None
 0.58A 1td2B-5trwA:
44.0		 1td2B-5trwA:
54.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		 5trw PYRIDOXAL KINASE
PDXY
(Paraburkholderia
xenovorans) 		6 / 12 ARG A 168
ILE A 157
LEU A 149
GLY A 154
ALA A 166
VAL A 164
 None
 1.34A 2oc8A-5trwA:
undetectable		 2oc8A-5trwA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_1
(WNT INHIBITORY
FACTOR 1)		 5trw PYRIDOXAL KINASE
PDXY
(Paraburkholderia
xenovorans) 		4 / 6 ARG A  27
MET A  26
PRO A  25
VAL A 138
 CL  A 404 (-4.5A)
None
None
None
 1.15A 2ygoA-5trwA:
undetectable		 2ygoA-5trwA:
15.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FHX_A_PXLA313_1
(PYRIDOXAL KINASE)		 5trw PYRIDOXAL KINASE
PDXY
(Paraburkholderia
xenovorans) 		4 / 4 SER A  10
HIS A  44
THR A  45
VAL A 218
 None
 0.73A 3fhxA-5trwA:
38.5		 3fhxA-5trwA:
34.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FHX_B_PXLB313_1
(PYRIDOXAL KINASE)		 5trw PYRIDOXAL KINASE
PDXY
(Paraburkholderia
xenovorans) 		6 / 8 VAL A  39
PHE A  41
HIS A  44
THR A  45
TYR A  83
VAL A 218
 None
 0.46A 3fhxB-5trwA:
38.1		 3fhxB-5trwA:
34.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_E_TOPE200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 5trw PYRIDOXAL KINASE
PDXY
(Paraburkholderia
xenovorans) 		5 / 10 LEU A 160
LEU A 196
VAL A 198
ILE A 157
LEU A 149
 None
 1.16A 3fl9E-5trwA:
undetectable		 3fl9E-5trwA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KM6_B_EAAB222_1
(GLUTATHIONE
S-TRANSFERASE P)		 5trw PYRIDOXAL KINASE
PDXY
(Paraburkholderia
xenovorans) 		5 / 9 VAL A 218
GLN A  46
VAL A  39
ASN A  19
GLY A  18
 None
 1.39A 3km6B-5trwA:
undetectable		 3km6B-5trwA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_A_PXLA400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 5trw PYRIDOXAL KINASE
PDXY
(Paraburkholderia
xenovorans) 		5 / 11 HIS A  44
GLN A  46
TYR A  83
VAL A 114
ASP A 222
 None
 0.87A 3mbhA-5trwA:
33.6		 3mbhA-5trwA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_B_PXLB400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 5trw PYRIDOXAL KINASE
PDXY
(Paraburkholderia
xenovorans) 		5 / 12 HIS A  44
GLN A  46
TYR A  83
VAL A 114
ASP A 222
 None
 0.85A 3mbhB-5trwA:
33.4		 3mbhB-5trwA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_C_PXLC400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 5trw PYRIDOXAL KINASE
PDXY
(Paraburkholderia
xenovorans) 		5 / 12 HIS A  44
GLN A  46
TYR A  83
VAL A 114
ASP A 222
 None
 0.81A 3mbhC-5trwA:
33.7		 3mbhC-5trwA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_C_PXLC400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 5trw PYRIDOXAL KINASE
PDXY
(Paraburkholderia
xenovorans) 		5 / 12 HIS A  44
THR A  45
GLN A  46
VAL A 114
ASP A 222
 None
 0.72A 3mbhC-5trwA:
33.7		 3mbhC-5trwA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_D_PXLD400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 5trw PYRIDOXAL KINASE
PDXY
(Paraburkholderia
xenovorans) 		5 / 12 HIS A  44
GLN A  46
TYR A  83
VAL A 114
ASP A 222
 None
 0.83A 3mbhD-5trwA:
33.4		 3mbhD-5trwA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_E_PXLE400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 5trw PYRIDOXAL KINASE
PDXY
(Paraburkholderia
xenovorans) 		5 / 12 HIS A  44
GLN A  46
TYR A  83
VAL A 114
ASP A 222
 None
 0.83A 3mbhE-5trwA:
33.4		 3mbhE-5trwA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_E_PXLE400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 5trw PYRIDOXAL KINASE
PDXY
(Paraburkholderia
xenovorans) 		5 / 12 HIS A  44
THR A  45
GLN A  46
VAL A 114
ASP A 222
 None
 0.71A 3mbhE-5trwA:
33.4		 3mbhE-5trwA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_F_PXLF400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 5trw PYRIDOXAL KINASE
PDXY
(Paraburkholderia
xenovorans) 		5 / 11 HIS A  44
GLN A  46
TYR A  83
VAL A 114
ASP A 222
 None
 0.82A 3mbhF-5trwA:
33.5		 3mbhF-5trwA:
24.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EOH_A_TEPA402_1
(PYRIDOXAL KINASE)		 5trw PYRIDOXAL KINASE
PDXY
(Paraburkholderia
xenovorans) 		4 / 5 GLY A  18
THR A  45
VAL A 218
ASP A 222
 None
 0.40A 4eohA-5trwA:
37.8		 4eohA-5trwA:
34.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EOH_A_TEPA402_1
(PYRIDOXAL KINASE)		 5trw PYRIDOXAL KINASE
PDXY
(Paraburkholderia
xenovorans) 		4 / 5 SER A  10
THR A  45
VAL A 218
ASP A 222
 None
 0.72A 4eohA-5trwA:
37.8		 4eohA-5trwA:
34.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EOH_B_TEPB402_1
(PYRIDOXAL KINASE)		 5trw PYRIDOXAL KINASE
PDXY
(Paraburkholderia
xenovorans) 		5 / 5 SER A  10
HIS A  44
TYR A  83
VAL A 218
ASP A 222
 None
 0.69A 4eohB-5trwA:
37.7		 4eohB-5trwA:
34.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA3_L_ACTL301_0
(C2095 HEAVY CHAIN
C2095 LIGHT CHAIN)		 5trw PYRIDOXAL KINASE
PDXY
(Paraburkholderia
xenovorans) 		3 / 3 PRO A  35
ASN A  37
HIS A  11
 None
 0.93A 4ma3H-5trwA:
undetectable
4ma3L-5trwA:
undetectable		 4ma3H-5trwA:
21.26
4ma3L-5trwA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8Z_A_BBIA402_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 5trw PYRIDOXAL KINASE
PDXY
(Paraburkholderia
xenovorans) 		4 / 5 PHE A 242
PHE A 228
LEU A 223
PRO A  25
 None
 1.45A 4o8zA-5trwA:
5.1		 4o8zA-5trwA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 5trw PYRIDOXAL KINASE
PDXY
(Paraburkholderia
xenovorans) 		4 / 6 LEU A 149
ASN A 145
PRO A 144
ARG A 133
 None
CL  A 405 (-3.4A)
None
SO4  A 403 (-3.7A)
 1.45A 4yv5B-5trwA:
undetectable		 4yv5B-5trwA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 5trw PYRIDOXAL KINASE
PDXY
(Paraburkholderia
xenovorans) 		4 / 6 LEU A 149
ASN A 145
PRO A 144
ARG A 133
 None
CL  A 405 (-3.4A)
None
SO4  A 403 (-3.7A)
 1.45A 4yv5A-5trwA:
undetectable		 4yv5A-5trwA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_H_ACTH612_0
(NADH DEHYDROGENASE,
PUTATIVE)		 5trw PYRIDOXAL KINASE
PDXY
(Paraburkholderia
xenovorans) 		3 / 3 ARG A  27
PRO A  35
ASN A  37
 CL  A 404 (-4.5A)
None
None
 1.02A 5jwaA-5trwA:
3.2
5jwaH-5trwA:
3.1		 5jwaA-5trwA:
18.01
5jwaH-5trwA:
18.01