SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ts5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AX9_A_EDRA999_1
(ACETYLCHOLINESTERASE)		 5ts5 AMINE OXIDASE
(Bothrops
atrox) 		4 / 8 GLY A 238
GLU A 235
PHE A 362
HIS A 360
 None
 0.96A 1ax9A-5ts5A:
undetectable		 1ax9A-5ts5A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AX9_A_EDRA999_1
(ACETYLCHOLINESTERASE)		 5ts5 AMINE OXIDASE
(Bothrops
atrox) 		4 / 8 GLY A 239
GLU A 235
PHE A 362
HIS A 360
 None
 0.92A 1ax9A-5ts5A:
undetectable		 1ax9A-5ts5A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM4_A_DXCA1002_0
(MAJOR POLLEN
ALLERGEN BET V 1-L)		 5ts5 AMINE OXIDASE
(Bothrops
atrox) 		5 / 12 ILE A 408
TYR A 357
VAL A 393
ILE A 327
SER A 415
 None
 1.17A 1fm4A-5ts5A:
undetectable		 1fm4A-5ts5A:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_B_HISB450_0
(HISTIDYL-TRNA
SYNTHETASE)		 5ts5 AMINE OXIDASE
(Bothrops
atrox) 		5 / 12 GLU A 167
TYR A 180
TYR A 188
GLY A 193
TYR A 183
 None
 1.19A 1httB-5ts5A:
2.5		 1httB-5ts5A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE9_A_VDXA500_2
(VITAMIN D3 RECEPTOR)		 5ts5 AMINE OXIDASE
(Bothrops
atrox) 		4 / 4 LEU A  91
ILE A 430
ARG A 322
TRP A 420
 None
FAD  A 501 (-4.6A)
None
FAD  A 501 (-4.3A)
 1.39A 1ie9A-5ts5A:
undetectable		 1ie9A-5ts5A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG4_A_SAMA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 5ts5 AMINE OXIDASE
(Bothrops
atrox) 		4 / 8 GLY A  87
ARG A  71
ILE A 430
ASP A 423
 FAD  A 501 (-3.9A)
FAD  A 501 (-3.9A)
FAD  A 501 (-4.6A)
None
 0.85A 1jg4A-5ts5A:
3.7		 1jg4A-5ts5A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S8F_B_BEZB1503_0
(RAS-RELATED PROTEIN
RAB-9A)		 5ts5 AMINE OXIDASE
(Bothrops
atrox) 		4 / 6 GLU A  93
LEU A  91
ARG A 232
PHE A 233
 None
 1.04A 1s8fB-5ts5A:
undetectable		 1s8fB-5ts5A:
16.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TDN_A_LEUA487_0
(L-AMINO ACID OXIDASE)		 5ts5 AMINE OXIDASE
(Bothrops
atrox) 		7 / 7 ARG A  90
ASN A 208
HIS A 223
PHE A 227
TYR A 372
ILE A 430
TRP A 465
 None
None
None
None
None
FAD  A 501 (-4.6A)
FAD  A 501 (-4.8A)
 0.30A 1tdnA-5ts5A:
61.2		 1tdnA-5ts5A:
89.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TDN_A_LEUA487_0
(L-AMINO ACID OXIDASE)		 5ts5 AMINE OXIDASE
(Bothrops
atrox) 		4 / 7 ARG A  90
HIS A 223
PHE A 227
ILE A 374
 None
 0.91A 1tdnA-5ts5A:
61.2		 1tdnA-5ts5A:
89.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TDN_A_LEUA487_0
(L-AMINO ACID OXIDASE)		 5ts5 AMINE OXIDASE
(Bothrops
atrox) 		4 / 7 ASN A 208
HIS A 223
PHE A 227
TYR A 356
 None
 1.46A 1tdnA-5ts5A:
61.2		 1tdnA-5ts5A:
89.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACK_A_EDRA999_1
(ACETYLCHOLINESTERASE)		 5ts5 AMINE OXIDASE
(Bothrops
atrox) 		4 / 7 GLY A 238
GLU A 235
PHE A 362
HIS A 360
 None
 0.91A 2ackA-5ts5A:
undetectable		 2ackA-5ts5A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACK_A_EDRA999_1
(ACETYLCHOLINESTERASE)		 5ts5 AMINE OXIDASE
(Bothrops
atrox) 		4 / 7 GLY A 239
GLU A 235
PHE A 362
HIS A 360
 None
 0.88A 2ackA-5ts5A:
undetectable		 2ackA-5ts5A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B9E_A_SAMA1201_0
(NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2)		 5ts5 AMINE OXIDASE
(Bothrops
atrox) 		5 / 12 GLY A  87
ASN A  85
LEU A 422
ASP A 423
PHE A 381
 FAD  A 501 (-3.9A)
None
None
None
None
 1.31A 2b9eA-5ts5A:
2.6		 2b9eA-5ts5A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRE_B_CHDB701_0
(FERROCHELATASE)		 5ts5 AMINE OXIDASE
(Bothrops
atrox) 		3 / 3 LYS A 124
GLY A 198
PRO A 197
 None
 0.95A 2hreB-5ts5A:
undetectable		 2hreB-5ts5A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3M_B_FOLB1188_0
(DIHYDROFOLATE
REDUCTASE)		 5ts5 AMINE OXIDASE
(Bothrops
atrox) 		5 / 12 ALA A 199
GLU A 148
GLN A 162
LEU A 161
TYR A 213
 None
 1.17A 2w3mB-5ts5A:
undetectable		 2w3mB-5ts5A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XNR_A_ACTA1001_0
(NUCLEAR
POLYADENYLATED
RNA-BINDING PROTEIN
3)		 5ts5 AMINE OXIDASE
(Bothrops
atrox) 		3 / 3 SER A 113
ARG A  90
GLN A 114
 None
 0.94A 2xnrA-5ts5A:
undetectable		 2xnrA-5ts5A:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_A_Y00A601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 5ts5 AMINE OXIDASE
(Bothrops
atrox) 		5 / 12 LEU A 195
VAL A 200
VAL A 165
ASN A   5
TYR A 188
 None
 1.40A 2y00A-5ts5A:
undetectable		 2y00A-5ts5A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_B_Y00B601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 5ts5 AMINE OXIDASE
(Bothrops
atrox) 		5 / 12 LEU A 195
VAL A 200
VAL A 165
ASN A   5
TYR A 188
 None
 1.40A 2y00B-5ts5A:
undetectable		 2y00B-5ts5A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y01_B_Y00B601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 5ts5 AMINE OXIDASE
(Bothrops
atrox) 		5 / 12 LEU A 195
VAL A 200
VAL A 165
ASN A   5
TYR A 188
 None
 1.43A 2y01B-5ts5A:
undetectable		 2y01B-5ts5A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZLC_A_VDXA500_2
(VITAMIN D3 RECEPTOR)		 5ts5 AMINE OXIDASE
(Bothrops
atrox) 		4 / 5 LEU A  91
ILE A 430
ARG A 322
TRP A 420
 None
FAD  A 501 (-4.6A)
None
FAD  A 501 (-4.3A)
 1.43A 2zlcA-5ts5A:
undetectable		 2zlcA-5ts5A:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_B_XRAB233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5ts5 AMINE OXIDASE
(Bothrops
atrox) 		5 / 11 VAL A 215
PHE A  11
TYR A 229
ASN A   5
GLU A 209
 None
 1.48A 3owxA-5ts5A:
2.9
3owxB-5ts5A:
3.0		 3owxA-5ts5A:
19.20
3owxB-5ts5A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S43_A_478A401_1
(PROTEASE)		 5ts5 AMINE OXIDASE
(Bothrops
atrox) 		5 / 9 ILE A 369
GLY A 390
ILE A 392
ILE A 400
ILE A 355
 None
 0.97A 3s43A-5ts5A:
undetectable		 3s43A-5ts5A:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5ts5 AMINE OXIDASE
(Bothrops
atrox) 		3 / 3 THR A 431
VAL A 319
GLU A 219
 None
 0.74A 3v4tA-5ts5A:
undetectable
3v4tD-5ts5A:
undetectable		 3v4tA-5ts5A:
22.94
3v4tD-5ts5A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJZ_A_BEZA1001_0
(BENZOATE-COENZYME A
LIGASE)		 5ts5 AMINE OXIDASE
(Bothrops
atrox) 		4 / 8 ALA A 455
GLY A 473
ALA A  48
GLY A  45
 None
 0.68A 4zjzA-5ts5A:
undetectable		 4zjzA-5ts5A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)		 5ts5 AMINE OXIDASE
(Bothrops
atrox) 		5 / 12 GLY A  40
SER A  44
VAL A 273
THR A 274
ALA A 299
 FAD  A 501 (-3.2A)
FAD  A 501 (-2.5A)
None
None
None
 1.04A 5kocA-5ts5A:
3.0		 5kocA-5ts5A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NKN_A_LOCA201_1
(NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN)		 5ts5 AMINE OXIDASE
(Bothrops
atrox) 		5 / 12 GLY A 373
ARG A 322
PHE A 354
THR A 347
TYR A 121
 None
 1.46A 5nknA-5ts5A:
undetectable		 5nknA-5ts5A:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5ts5 AMINE OXIDASE
(Bothrops
atrox) 		4 / 5 ILE A 264
PHE A 304
ARG A 301
THR A 295
 None
None
None
FAD  A 501 (-4.6A)
 1.10A 5z84N-5ts5A:
undetectable
5z84W-5ts5A:
undetectable		 5z84N-5ts5A:
21.14
5z84W-5ts5A:
8.44