SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5tsc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_C_BEZC505_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 5tsc UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		4 / 6 TYR A 365
ILE A  35
GLU A  34
PHE A 348
 None
 1.14A 1oniA-5tscA:
undetectable
1oniC-5tscA:
undetectable		 1oniA-5tscA:
15.22
1oniC-5tscA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_E_BEZE509_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 5tsc UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		4 / 7 TYR A 365
ILE A  35
GLU A  34
PHE A 348
 None
 1.05A 1oniD-5tscA:
undetectable
1oniE-5tscA:
undetectable		 1oniD-5tscA:
15.22
1oniE-5tscA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA502_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 5tsc UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		3 / 3 LEU A 339
HIS A  12
LYS A  16
 None
 1.13A 1y7iA-5tscA:
undetectable		 1y7iA-5tscA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZB7_A_NCAA901_0
(PROSTAGLANDIN
REDUCTASE 2)		 5tsc UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		4 / 5 TYR A 280
ILE A 235
LEU A 113
LEU A 109
 None
 1.04A 2zb7A-5tscA:
undetectable		 2zb7A-5tscA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BMC_C_FOLC270_0
(PTERIDINE REDUCTASE)		 5tsc UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		5 / 12 SER A  78
PHE A 233
PHE A 304
LEU A 248
PRO A 250
 None
 1.50A 3bmcC-5tscA:
undetectable		 3bmcC-5tscA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR4_X_PNTX101_0
(PROTEIN S100-B)		 5tsc UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		3 / 3 CYH A 177
HIS A 178
PHE A 181
 None
 0.90A 3cr4X-5tscA:
undetectable		 3cr4X-5tscA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_B_H3PB552_1
(GLUTAMATE
DEHYDROGENASE)		 5tsc UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		3 / 3 TYR A 198
TYR A 192
ILE A 193
 None
 0.70A 3eteA-5tscA:
undetectable
3eteB-5tscA:
undetectable		 3eteA-5tscA:
21.92
3eteB-5tscA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJW_A_SRYA2001_2
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5tsc UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		4 / 6 GLU A  34
ILE A  35
GLU A  80
VAL A 345
 None
 0.94A 4ejwB-5tscA:
undetectable		 4ejwB-5tscA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 5tsc UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		4 / 7 THR A 234
VAL A 345
GLN A 340
GLU A 336
 None
 1.10A 5tudA-5tscA:
undetectable		 5tudA-5tscA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5tsc UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		5 / 9 GLY A 111
LEU A 119
ILE A 281
GLY A 106
LEU A 102
 None
 0.95A 5vkqC-5tscA:
undetectable
5vkqD-5tscA:
undetectable		 5vkqC-5tscA:
14.22
5vkqD-5tscA:
14.22