SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5tsh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3003_1
(SERUM ALBUMIN)		 5tsh TYPE IV PILUS
BIOGENESIS ATPASE
PILB
(Geobacter
metallireducens) 		4 / 6 PHE A 383
ILE A 404
ALA A 352
MET A 368
 None
 1.09A 1hk2A-5tshA:
undetectable		 1hk2A-5tshA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_A_SAMA400_1
(UNCHARACTERIZED
PROTEIN TFU_2867)		 5tsh TYPE IV PILUS
BIOGENESIS ATPASE
PILB
(Geobacter
metallireducens) 		3 / 3 ASN A 433
ARG A 430
ASP A 423
 None
 0.80A 2qe6A-5tshA:
undetectable		 2qe6A-5tshA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_B_SAMB400_1
(UNCHARACTERIZED
PROTEIN TFU_2867)		 5tsh TYPE IV PILUS
BIOGENESIS ATPASE
PILB
(Geobacter
metallireducens) 		3 / 3 ASN A 433
ARG A 430
ASP A 423
 None
 0.79A 2qe6B-5tshA:
undetectable		 2qe6B-5tshA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T8N_D_EDTD135_0
(STEROID
DELTA-ISOMERASE)		 5tsh TYPE IV PILUS
BIOGENESIS ATPASE
PILB
(Geobacter
metallireducens) 		5 / 11 PRO A 425
THR A 324
GLY A 325
PRO A 326
ARG A 452
 None
 1.29A 3t8nD-5tshA:
undetectable
3t8nF-5tshA:
undetectable		 3t8nD-5tshA:
12.95
3t8nF-5tshA:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T8N_D_EDTD135_0
(STEROID
DELTA-ISOMERASE)		 5tsh TYPE IV PILUS
BIOGENESIS ATPASE
PILB
(Geobacter
metallireducens) 		5 / 11 THR A 324
GLY A 325
PRO A 326
ARG A 452
PRO A 425
 None
 1.27A 3t8nD-5tshA:
undetectable
3t8nF-5tshA:
undetectable		 3t8nD-5tshA:
12.95
3t8nF-5tshA:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_A_AZMA229_2
(CARBONIC ANHYDRASE)		 5tsh TYPE IV PILUS
BIOGENESIS ATPASE
PILB
(Geobacter
metallireducens) 		3 / 3 GLN A 365
PHE A 360
TYR A 336
 None
 0.91A 3ucjB-5tshA:
undetectable		 3ucjB-5tshA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_B_AZMB229_1
(CARBONIC ANHYDRASE)		 5tsh TYPE IV PILUS
BIOGENESIS ATPASE
PILB
(Geobacter
metallireducens) 		3 / 3 GLN A 365
PHE A 360
TYR A 336
 None
 0.93A 3ucjA-5tshA:
undetectable		 3ucjA-5tshA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CVT_B_ACTB200_0
(N5-CARBOXYAMINOIMIDA
ZOLE RIBONUCLEOTIDE
MUTASE)		 5tsh TYPE IV PILUS
BIOGENESIS ATPASE
PILB
(Geobacter
metallireducens) 		3 / 3 ASN A 526
ALA A 528
ARG A 532
 None
 0.70A 5cvtB-5tshA:
undetectable		 5cvtB-5tshA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_ACTA405_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 5tsh TYPE IV PILUS
BIOGENESIS ATPASE
PILB
(Geobacter
metallireducens) 		3 / 3 GLN A 544
THR A 541
ASP A 567
 None
 0.67A 5k9dA-5tshA:
undetectable		 5k9dA-5tshA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCN_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5tsh TYPE IV PILUS
BIOGENESIS ATPASE
PILB
(Geobacter
metallireducens) 		5 / 12 GLY A 340
LEU A 416
ILE A 349
LEU A 307
LEU A 300
 None
None
None
None
ANP  A 602 (-3.6A)
 1.01A 5ycnA-5tshA:
undetectable		 5ycnA-5tshA:
18.51