SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5tsq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZE_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 5tsq IUNH
(Leishmania
braziliensis) 		5 / 9 LEU A 112
LEU A 108
ILE A  33
THR A 122
ILE A   5
 None
 1.46A 1hzeA-5tsqA:
undetectable
1hzeB-5tsqA:
undetectable		 1hzeA-5tsqA:
17.63
1hzeB-5tsqA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZE_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 5tsq IUNH
(Leishmania
braziliensis) 		5 / 9 LEU A 112
LEU A 108
THR A  34
THR A 122
ILE A   5
 None
 1.47A 1hzeA-5tsqA:
undetectable
1hzeB-5tsqA:
undetectable		 1hzeA-5tsqA:
17.63
1hzeB-5tsqA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZE_B_RBFB99_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 5tsq IUNH
(Leishmania
braziliensis) 		5 / 9 THR A 122
ILE A   5
LEU A 112
LEU A 108
ILE A  33
 None
 1.46A 1hzeA-5tsqA:
undetectable
1hzeB-5tsqA:
undetectable		 1hzeA-5tsqA:
17.63
1hzeB-5tsqA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZE_B_RBFB99_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 5tsq IUNH
(Leishmania
braziliensis) 		5 / 9 THR A 122
ILE A   5
LEU A 112
LEU A 108
THR A  34
 None
 1.47A 1hzeA-5tsqA:
undetectable
1hzeB-5tsqA:
undetectable		 1hzeA-5tsqA:
17.63
1hzeB-5tsqA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		 5tsq IUNH
(Leishmania
braziliensis) 		3 / 3 ASP A 301
PHE A 296
VAL A 203
 None
 0.74A 1kijB-5tsqA:
undetectable		 1kijB-5tsqA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KXH_A_ACRA598_1
(ALPHA-AMYLASE)		 5tsq IUNH
(Leishmania
braziliensis) 		5 / 12 ALA A 105
VAL A  36
GLY A  66
ALA A 175
ILE A 169
 None
 1.21A 1kxhA-5tsqA:
undetectable		 1kxhA-5tsqA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_A_SALA710_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 5tsq IUNH
(Leishmania
braziliensis) 		4 / 7 VAL A 203
VAL A  17
LEU A  20
LEU A 222
 None
 0.83A 1pthA-5tsqA:
0.8		 1pthA-5tsqA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_B_SALB711_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 5tsq IUNH
(Leishmania
braziliensis) 		4 / 7 VAL A 203
VAL A  17
LEU A  20
LEU A 222
 None
 0.82A 1pthB-5tsqA:
0.7		 1pthB-5tsqA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_A_SAMA302_1
(HYPOTHETICAL PROTEIN
PH0226)		 5tsq IUNH
(Leishmania
braziliensis) 		4 / 4 TYR A 229
ARG A 233
ASP A 241
ASP A   8
 None
None
BDR  A 402 ( 2.5A)
None
 1.26A 1ve3A-5tsqA:
2.7		 1ve3A-5tsqA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_B_SAMB301_1
(HYPOTHETICAL PROTEIN
PH0226)		 5tsq IUNH
(Leishmania
braziliensis) 		4 / 4 TYR A 229
ARG A 233
ASP A 241
ASP A   8
 None
None
BDR  A 402 ( 2.5A)
None
 1.30A 1ve3B-5tsqA:
3.3		 1ve3B-5tsqA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_1
(ADENOSINE KINASE)		 5tsq IUNH
(Leishmania
braziliensis) 		6 / 12 ASP A  14
GLY A  12
ALA A  78
GLN A  80
GLY A 127
ASP A  10
 BDR  A 402 (-2.8A)
BDR  A 402 ( 4.9A)
None
None
CA  A 401 ( 4.2A)
CA  A 401 (-3.1A)
 1.40A 2pkkA-5tsqA:
undetectable		 2pkkA-5tsqA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKM_A_ADNA501_1
(ADENOSINE KINASE)		 5tsq IUNH
(Leishmania
braziliensis) 		6 / 12 ASP A  14
GLY A  12
ALA A  78
GLN A  80
GLY A 127
ASP A  10
 BDR  A 402 (-2.8A)
BDR  A 402 ( 4.9A)
None
None
CA  A 401 ( 4.2A)
CA  A 401 (-3.1A)
 1.38A 2pkmA-5tsqA:
5.5		 2pkmA-5tsqA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBL_A_CAMA517_0
(CYTOCHROME P450-CAM)		 5tsq IUNH
(Leishmania
braziliensis) 		4 / 7 LEU A  42
VAL A  45
THR A  46
ASP A   8
 None
 0.75A 2qblA-5tsqA:
undetectable		 2qblA-5tsqA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_C_X2NC1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 5tsq IUNH
(Leishmania
braziliensis) 		5 / 12 PHE A 180
VAL A 179
ALA A 165
THR A 194
MET A 188
 None
 1.20A 2x2nC-5tsqA:
undetectable		 2x2nC-5tsqA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID5_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 5tsq IUNH
(Leishmania
braziliensis) 		5 / 11 THR A 126
ASP A  54
ALA A  53
ILE A  63
GLN A  50
 CA  A 401 ( 4.9A)
None
None
None
None
 1.30A 3id5B-5tsqA:
3.4		 3id5B-5tsqA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID5_F_SAMF301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 5tsq IUNH
(Leishmania
braziliensis) 		5 / 11 THR A 126
ASP A  54
ALA A  53
ILE A  63
GLN A  50
 CA  A 401 ( 4.9A)
None
None
None
None
 1.30A 3id5F-5tsqA:
undetectable		 3id5F-5tsqA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_D_SAMD6735_0
(16S RRNA METHYLASE)		 5tsq IUNH
(Leishmania
braziliensis) 		6 / 12 PRO A  11
VAL A  45
ALA A  16
ALA A  18
LEU A 151
LEU A   7
 None
 1.44A 3p2kD-5tsqA:
undetectable		 3p2kD-5tsqA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5tsq IUNH
(Leishmania
braziliensis) 		6 / 12 ASP A 172
ARG A 137
ILE A 109
GLY A  66
ALA A 133
ALA A 135
 None
 1.34A 3sudC-5tsqA:
undetectable		 3sudC-5tsqA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_C_C2FC1410_0
(GLYCINE
N-METHYLTRANSFERASE)		 5tsq IUNH
(Leishmania
braziliensis) 		3 / 3 ARG A  76
PRO A  79
PHE A 167
 None
None
BDR  A 402 (-4.6A)
 1.01A 3thrC-5tsqA:
undetectable		 3thrC-5tsqA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TOP_A_ACRA1_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 5tsq IUNH
(Leishmania
braziliensis) 		5 / 12 ASP A 241
PRO A  11
ILE A 169
MET A 152
ASP A  10
 BDR  A 402 ( 2.5A)
None
None
BDR  A 402 ( 3.7A)
CA  A 401 (-3.1A)
 1.41A 3topA-5tsqA:
undetectable		 3topA-5tsqA:
16.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_A_OBNA1104_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 5tsq IUNH
(Leishmania
braziliensis) 		4 / 5 PRO A  11
ASP A  15
ILE A  33
VAL A 245
 None
CA  A 401 ( 2.2A)
None
None
 1.26A 4hytA-5tsqA:
4.7		 4hytA-5tsqA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5tsq IUNH
(Leishmania
braziliensis) 		5 / 9 THR A 274
ALA A 176
ALA A 175
GLY A 154
GLY A 153
 None
 1.19A 4qwuK-5tsqA:
undetectable
4qwuL-5tsqA:
undetectable		 4qwuK-5tsqA:
20.70
4qwuL-5tsqA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5tsq IUNH
(Leishmania
braziliensis) 		5 / 9 THR A 274
ALA A 176
ALA A 175
GLY A 154
GLY A 153
 None
 1.14A 4qwuY-5tsqA:
undetectable
4qwuZ-5tsqA:
undetectable		 4qwuY-5tsqA:
20.70
4qwuZ-5tsqA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_A_C2FA402_0
(THYMIDYLATE SYNTHASE)		 5tsq IUNH
(Leishmania
braziliensis) 		5 / 11 PHE A 224
ILE A  81
ASN A 160
LEU A 191
ASP A 241
 None
None
BDR  A 402 (-3.1A)
None
BDR  A 402 ( 2.5A)
 1.38A 5fctA-5tsqA:
undetectable		 5fctA-5tsqA:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 5tsq IUNH
(Leishmania
braziliensis) 		5 / 12 ILE A 169
GLY A 154
VAL A 290
ILE A 178
VAL A 179
 None
 1.08A 5n0tA-5tsqA:
undetectable		 5n0tA-5tsqA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_B_FFOB403_0
(THYMIDYLATE SYNTHASE)		 5tsq IUNH
(Leishmania
braziliensis) 		5 / 10 PHE A 224
ILE A  81
ASN A 160
LEU A 191
ASP A 241
 None
None
BDR  A 402 (-3.1A)
None
BDR  A 402 ( 2.5A)
 1.40A 6r2eB-5tsqA:
undetectable		 6r2eB-5tsqA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_C_FFOC404_0
(THYMIDYLATE SYNTHASE)		 5tsq IUNH
(Leishmania
braziliensis) 		5 / 10 PHE A 224
ILE A  81
ASN A 160
LEU A 191
ASP A 241
 None
None
BDR  A 402 (-3.1A)
None
BDR  A 402 ( 2.5A)
 1.40A 6r2eC-5tsqA:
undetectable		 6r2eC-5tsqA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_D_FFOD403_0
(THYMIDYLATE SYNTHASE)		 5tsq IUNH
(Leishmania
braziliensis) 		5 / 10 PHE A 224
ILE A  81
ASN A 160
LEU A 191
ASP A 241
 None
None
BDR  A 402 (-3.1A)
None
BDR  A 402 ( 2.5A)
 1.34A 6r2eD-5tsqA:
undetectable		 6r2eD-5tsqA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_F_FFOF403_0
(THYMIDYLATE SYNTHASE)		 5tsq IUNH
(Leishmania
braziliensis) 		5 / 11 PHE A 224
ILE A  81
ASN A 160
LEU A 191
ASP A 241
 None
None
BDR  A 402 (-3.1A)
None
BDR  A 402 ( 2.5A)
 1.36A 6r2eF-5tsqA:
undetectable		 6r2eF-5tsqA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_G_FFOG403_0
(THYMIDYLATE SYNTHASE)		 5tsq IUNH
(Leishmania
braziliensis) 		5 / 11 PHE A 224
ILE A  81
ASN A 160
LEU A 191
ASP A 241
 None
None
BDR  A 402 (-3.1A)
None
BDR  A 402 ( 2.5A)
 1.34A 6r2eG-5tsqA:
undetectable		 6r2eG-5tsqA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_H_FFOH403_0
(THYMIDYLATE SYNTHASE)		 5tsq IUNH
(Leishmania
braziliensis) 		5 / 12 PHE A 224
ILE A  81
ASN A 160
LEU A 191
ASP A 241
 None
None
BDR  A 402 (-3.1A)
None
BDR  A 402 ( 2.5A)
 1.29A 6r2eH-5tsqA:
undetectable		 6r2eH-5tsqA:
21.29