SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5tt0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1NBI_A_SAMA293_0 (GLYCINE N-METHYLTRANSFERASE)	5tt0	OXIDOREDUCTASE, SHORT CHAIN DEHYDROGENASE/REDUCT ASE FAMILY (Burkholderia thailandensis)	5 / 12	TYR A 145 ILE A 16 GLY A 132 ALA A 150 GLY A 176	EDO A 310 (-4.2A) None None None EDO A 309 ( 4.1A)	1.01A	1nbiA-5tt0A: 8.4	1nbiA-5tt0A: 23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1NBI_B_SAMB1293_0 (GLYCINE N-METHYLTRANSFERASE)	5tt0	OXIDOREDUCTASE, SHORT CHAIN DEHYDROGENASE/REDUCT ASE FAMILY (Burkholderia thailandensis)	5 / 12	TYR A 145 ILE A 16 GLY A 132 ALA A 150 GLY A 176	EDO A 310 (-4.2A) None None None EDO A 309 ( 4.1A)	1.01A	1nbiB-5tt0A: 8.4	1nbiB-5tt0A: 23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2BM9_E_SAME301_0 (CEPHALOSPORIN HYDROXYLASE CMCI)	5tt0	OXIDOREDUCTASE, SHORT CHAIN DEHYDROGENASE/REDUCT ASE FAMILY (Burkholderia thailandensis)	5 / 12	GLY A 11 ASP A 35 ASN A 81 ALA A 82 ALA A 108	SO4 A 301 ( 3.7A) EDO A 305 (-3.5A) None EDO A 305 ( 3.6A) None	1.00A	2bm9E-5tt0A: 5.6	2bm9E-5tt0A: 23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2BM9_F_SAMF301_0 (CEPHALOSPORIN HYDROXYLASE CMCI)	5tt0	OXIDOREDUCTASE, SHORT CHAIN DEHYDROGENASE/REDUCT ASE FAMILY (Burkholderia thailandensis)	5 / 12	GLY A 11 ASP A 35 ASN A 81 ALA A 82 ALA A 108	SO4 A 301 ( 3.7A) EDO A 305 (-3.5A) None EDO A 305 ( 3.6A) None	0.83A	2bm9F-5tt0A: undetectable	2bm9F-5tt0A: 23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ZZM_A_SAMA401_1 (UNCHARACTERIZED PROTEIN MJ0883)	5tt0	OXIDOREDUCTASE, SHORT CHAIN DEHYDROGENASE/REDUCT ASE FAMILY (Burkholderia thailandensis)	3 / 3	ARG A 74 ASP A 68 ASN A 72	None EDO A 307 ( 4.5A) None	0.84A	2zzmA-5tt0A: 6.9	2zzmA-5tt0A: 21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3N8Y_A_DIFA701_1 (PROSTAGLANDIN G/H SYNTHASE 1)	5tt0	OXIDOREDUCTASE, SHORT CHAIN DEHYDROGENASE/REDUCT ASE FAMILY (Burkholderia thailandensis)	5 / 11	VAL A 53 LEU A 25 ILE A 9 ALA A 12 LEU A 41	None EDO A 306 (-3.6A) None None None	1.13A	3n8yA-5tt0A: undetectable	3n8yA-5tt0A: 17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3UBO_B_ADNB353_2 (ADENOSINE KINASE)	5tt0	OXIDOREDUCTASE, SHORT CHAIN DEHYDROGENASE/REDUCT ASE FAMILY (Burkholderia thailandensis)	4 / 5	SER A 133 ILE A 16 TYR A 145 GLY A 176	EDO A 310 ( 4.0A) None EDO A 310 (-4.2A) EDO A 309 ( 4.1A)	1.01A	3uboB-5tt0A: 6.4	3uboB-5tt0A: 23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FO4_A_MOAA502_1 (INOSINE 5'-MONOPHOSPHATE DEHYDROGENASE)	5tt0	OXIDOREDUCTASE, SHORT CHAIN DEHYDROGENASE/REDUCT ASE FAMILY (Burkholderia thailandensis)	4 / 8	ASP A 222 SER A 221 THR A 7 GLY A 126	None EDO A 304 (-4.6A) None None	0.98A	4fo4A-5tt0A: undetectable	4fo4A-5tt0A: 23.51

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1NBI_A_SAMA293_0","GLYCINE N-METHYLTRANSFERASE","5tt0","OXIDOREDUCTASE, SHORT CHAIN DEHYDROGENASE\/REDUCTASE FAMILY","Burkholderia thailandensis",5,"TYR A 145;ILE A  16;GLY A 132;ALA A 150;GLY A 176","EDO A 310 (-4.2A);None;None;None;EDO A 309 ( 4.1A)","1.01A","1nbiA-5tt0A:8.4","1nbiA-5tt0A:23.00"],["1NBI_B_SAMB1293_0","GLYCINE N-METHYLTRANSFERASE","5tt0","OXIDOREDUCTASE, SHORT CHAIN DEHYDROGENASE\/REDUCTASE FAMILY","Burkholderia thailandensis",5,"TYR A 145;ILE A  16;GLY A 132;ALA A 150;GLY A 176","EDO A 310 (-4.2A);None;None;None;EDO A 309 ( 4.1A)","1.01A","1nbiB-5tt0A:8.4","1nbiB-5tt0A:23.00"],["2BM9_E_SAME301_0","CEPHALOSPORIN HYDROXYLASE CMCI","5tt0","OXIDOREDUCTASE, SHORT CHAIN DEHYDROGENASE\/REDUCTASE FAMILY","Burkholderia thailandensis",5,"GLY A  11;ASP A  35;ASN A  81;ALA A  82;ALA A 108","SO4 A 301 ( 3.7A);EDO A 305 (-3.5A);None;EDO A 305 ( 3.6A);None","1.00A","2bm9E-5tt0A:5.6","2bm9E-5tt0A:23.57"],["2BM9_F_SAMF301_0","CEPHALOSPORIN HYDROXYLASE CMCI","5tt0","OXIDOREDUCTASE, SHORT CHAIN DEHYDROGENASE\/REDUCTASE FAMILY","Burkholderia thailandensis",5,"GLY A  11;ASP A  35;ASN A  81;ALA A  82;ALA A 108","SO4 A 301 ( 3.7A);EDO A 305 (-3.5A);None;EDO A 305 ( 3.6A);None","0.83A","2bm9F-5tt0A:undetectable","2bm9F-5tt0A:23.57"],["2ZZM_A_SAMA401_1","UNCHARACTERIZED PROTEIN MJ0883","5tt0","OXIDOREDUCTASE, SHORT CHAIN DEHYDROGENASE\/REDUCTASE FAMILY","Burkholderia thailandensis",3,"ARG A  74;ASP A  68;ASN A  72","None;EDO A 307 ( 4.5A);None","0.84A","2zzmA-5tt0A:6.9","2zzmA-5tt0A:21.26"],["3N8Y_A_DIFA701_1","PROSTAGLANDIN G\/H SYNTHASE 1","5tt0","OXIDOREDUCTASE, SHORT CHAIN DEHYDROGENASE\/REDUCTASE FAMILY","Burkholderia thailandensis",5,"VAL A  53;LEU A  25;ILE A   9;ALA A  12;LEU A  41","None;EDO A 306 (-3.6A);None;None;None","1.13A","3n8yA-5tt0A:undetectable","3n8yA-5tt0A:17.60"],["3UBO_B_ADNB353_2","ADENOSINE KINASE","5tt0","OXIDOREDUCTASE, SHORT CHAIN DEHYDROGENASE\/REDUCTASE FAMILY","Burkholderia thailandensis",4,"SER A 133;ILE A  16;TYR A 145;GLY A 176","EDO A 310 ( 4.0A);None;EDO A 310 (-4.2A);EDO A 309 ( 4.1A)","1.01A","3uboB-5tt0A:6.4","3uboB-5tt0A:23.51"],["4FO4_A_MOAA502_1","INOSINE 5'-MONOPHOSPHATE DEHYDROGENASE","5tt0","OXIDOREDUCTASE, SHORT CHAIN DEHYDROGENASE\/REDUCTASE FAMILY","Burkholderia thailandensis",4,"ASP A 222;SER A 221;THR A   7;GLY A 126","None;EDO A 304 (-4.6A);None;None","0.98A","4fo4A-5tt0A:undetectable","4fo4A-5tt0A:23.51"]]