SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ttd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_B_DVAB8_0
(GRAMICIDIN A)		 5ttd MALTOSE-BINDING
PERIPLASMIC
PROTEIN,PILIN
ISOPEPTIDE LINKAGE
DOMAIN PROTEIN
(Escherichia
coli;
Streptococcus
pyogenes) 		3 / 3 TRP A 164
VAL A 265
TRP A 346
 None
None
MLR  A 501 (-3.9A)
 1.30A 1c4dA-5ttdA:
undetectable
1c4dB-5ttdA:
undetectable		 1c4dA-5ttdA:
2.55
1c4dB-5ttdA:
2.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_2
(ISOLEUCYL-TRNA
SYNTHETASE)		 5ttd MALTOSE-BINDING
PERIPLASMIC
PROTEIN,PILIN
ISOPEPTIDE LINKAGE
DOMAIN PROTEIN
(Escherichia
coli;
Streptococcus
pyogenes) 		3 / 3 GLU A 117
TRP A 236
LYS A 279
 MLR  A 501 (-2.8A)
MLR  A 501 ( 4.6A)
None
 1.30A 1qu2A-5ttdA:
undetectable		 1qu2A-5ttdA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2888_0
(AMINOMETHYLTRANSFERA
SE)		 5ttd MALTOSE-BINDING
PERIPLASMIC
PROTEIN,PILIN
ISOPEPTIDE LINKAGE
DOMAIN PROTEIN
(Escherichia
coli;
Streptococcus
pyogenes) 		5 / 10 LEU A 198
LEU A 201
ILE A 167
GLU A 159
LEU A 157
 None
None
None
MLR  A 501 (-2.8A)
None
 1.21A 1wopA-5ttdA:
undetectable		 1wopA-5ttdA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_C_VIAC903_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5ttd MALTOSE-BINDING
PERIPLASMIC
PROTEIN,PILIN
ISOPEPTIDE LINKAGE
DOMAIN PROTEIN
(Escherichia
coli;
Streptococcus
pyogenes) 		5 / 12 LEU A 268
ILE A 114
VAL A 103
LEU A  82
ILE A  85
 None
 1.12A 2h42C-5ttdA:
undetectable		 2h42C-5ttdA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 5ttd MALTOSE-BINDING
PERIPLASMIC
PROTEIN,PILIN
ISOPEPTIDE LINKAGE
DOMAIN PROTEIN
(Escherichia
coli;
Streptococcus
pyogenes) 		4 / 8 THR A  99
LEU A 291
ASP A 293
GLU A 117
 None
None
None
MLR  A 501 (-2.8A)
 0.98A 2zw9A-5ttdA:
undetectable		 2zw9A-5ttdA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6H_A_MXDA551_1
(PROSTACYCLIN
SYNTHASE)		 5ttd MALTOSE-BINDING
PERIPLASMIC
PROTEIN,PILIN
ISOPEPTIDE LINKAGE
DOMAIN PROTEIN
(Escherichia
coli;
Streptococcus
pyogenes) 		4 / 6 ALA A 194
LEU A 198
ALA A 352
THR A 351
 None
 0.89A 3b6hA-5ttdA:
undetectable		 3b6hA-5ttdA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6H_B_MXDB551_1
(PROSTACYCLIN
SYNTHASE)		 5ttd MALTOSE-BINDING
PERIPLASMIC
PROTEIN,PILIN
ISOPEPTIDE LINKAGE
DOMAIN PROTEIN
(Escherichia
coli;
Streptococcus
pyogenes) 		4 / 6 ALA A 194
LEU A 198
ALA A 352
THR A 351
 None
 0.92A 3b6hB-5ttdA:
undetectable		 3b6hB-5ttdA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC507_1
(PHOSPHOLIPASE A2)		 5ttd MALTOSE-BINDING
PERIPLASMIC
PROTEIN,PILIN
ISOPEPTIDE LINKAGE
DOMAIN PROTEIN
(Escherichia
coli;
Streptococcus
pyogenes) 		4 / 7 VAL A 116
GLY A 306
PRO A 235
LYS A 311
 None
 0.73A 3bjwC-5ttdA:
undetectable		 3bjwC-5ttdA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_A_BEZA302_0
(DISULFIDE
INTERCHANGE PROTEIN)		 5ttd MALTOSE-BINDING
PERIPLASMIC
PROTEIN,PILIN
ISOPEPTIDE LINKAGE
DOMAIN PROTEIN
(Escherichia
coli;
Streptococcus
pyogenes) 		4 / 6 PRO A 132
LEU A 153
ALA A 229
PRO A 131
 None
 1.32A 3gv1A-5ttdA:
undetectable
3gv1C-5ttdA:
undetectable		 3gv1A-5ttdA:
12.83
3gv1C-5ttdA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_B_BEZB301_0
(DISULFIDE
INTERCHANGE PROTEIN)		 5ttd MALTOSE-BINDING
PERIPLASMIC
PROTEIN,PILIN
ISOPEPTIDE LINKAGE
DOMAIN PROTEIN
(Escherichia
coli;
Streptococcus
pyogenes) 		4 / 6 LEU A 153
ALA A 229
PRO A 131
PRO A 132
 None
 1.30A 3gv1A-5ttdA:
undetectable
3gv1B-5ttdA:
undetectable		 3gv1A-5ttdA:
12.83
3gv1B-5ttdA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 5ttd MALTOSE-BINDING
PERIPLASMIC
PROTEIN,PILIN
ISOPEPTIDE LINKAGE
DOMAIN PROTEIN
(Escherichia
coli;
Streptococcus
pyogenes) 		3 / 3 ARG A 481
ASP A 460
ASP A 484
 None
 0.88A 3jb2A-5ttdA:
undetectable		 3jb2A-5ttdA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 5ttd MALTOSE-BINDING
PERIPLASMIC
PROTEIN,PILIN
ISOPEPTIDE LINKAGE
DOMAIN PROTEIN
(Escherichia
coli;
Streptococcus
pyogenes) 		3 / 3 ARG A 481
ASP A 460
ASP A 484
 None
 0.84A 3jb3A-5ttdA:
undetectable		 3jb3A-5ttdA:
18.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JYR_A_ACRA371_1
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)		 5ttd MALTOSE-BINDING
PERIPLASMIC
PROTEIN,PILIN
ISOPEPTIDE LINKAGE
DOMAIN PROTEIN
(Escherichia
coli;
Streptococcus
pyogenes) 		10 / 12 ASP A  20
LYS A  21
GLU A  50
GLU A  51
ALA A  69
ASP A  71
ARG A  72
GLU A 117
PRO A 160
TRP A 236
 MLR  A 501 (-3.0A)
MLR  A 501 (-2.5A)
MLR  A 501 (-3.9A)
MLR  A 501 (-3.8A)
MLR  A 501 (-3.3A)
MLR  A 501 (-2.8A)
MLR  A 501 (-3.6A)
MLR  A 501 (-2.8A)
MLR  A 501 (-3.6A)
MLR  A 501 ( 4.6A)
 0.35A 3jyrA-5ttdA:
61.3		 3jyrA-5ttdA:
66.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JYR_A_ACRA371_2
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)		 5ttd MALTOSE-BINDING
PERIPLASMIC
PROTEIN,PILIN
ISOPEPTIDE LINKAGE
DOMAIN PROTEIN
(Escherichia
coli;
Streptococcus
pyogenes) 		6 / 7 ASN A  18
TRP A  68
GLU A 159
TYR A 161
MET A 336
TRP A 346
 MLR  A 501 (-4.2A)
MLR  A 501 (-4.4A)
MLR  A 501 (-2.8A)
MLR  A 501 (-3.9A)
MLR  A 501 ( 4.4A)
MLR  A 501 (-3.9A)
 0.22A 3jyrA-5ttdA:
61.3		 3jyrA-5ttdA:
66.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JYR_A_ACRA371_2
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)		 5ttd MALTOSE-BINDING
PERIPLASMIC
PROTEIN,PILIN
ISOPEPTIDE LINKAGE
DOMAIN PROTEIN
(Escherichia
coli;
Streptococcus
pyogenes) 		6 / 7 ASN A  18
TRP A  68
TYR A 161
MET A 336
TRP A 346
ARG A 350
 MLR  A 501 (-4.2A)
MLR  A 501 (-4.4A)
MLR  A 501 (-3.9A)
MLR  A 501 ( 4.4A)
MLR  A 501 (-3.9A)
MLR  A 501 (-4.8A)
 0.58A 3jyrA-5ttdA:
61.3		 3jyrA-5ttdA:
66.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_DIFB585_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5ttd MALTOSE-BINDING
PERIPLASMIC
PROTEIN,PILIN
ISOPEPTIDE LINKAGE
DOMAIN PROTEIN
(Escherichia
coli;
Streptococcus
pyogenes) 		5 / 12 VAL A 202
LEU A 166
GLY A 193
ALA A 194
LEU A 367
 None
 1.01A 3n8yB-5ttdA:
undetectable		 3n8yB-5ttdA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_B_RTZB1_1
(CYTOCHROME P450 2D6)		 5ttd MALTOSE-BINDING
PERIPLASMIC
PROTEIN,PILIN
ISOPEPTIDE LINKAGE
DOMAIN PROTEIN
(Escherichia
coli;
Streptococcus
pyogenes) 		5 / 12 PHE A 162
GLY A 306
LEU A 305
GLU A 117
ALA A 237
 None
None
None
MLR  A 501 (-2.8A)
None
 0.85A 3tbgB-5ttdA:
undetectable		 3tbgB-5ttdA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD1_1
(CYTOCHROME P450 2D6)		 5ttd MALTOSE-BINDING
PERIPLASMIC
PROTEIN,PILIN
ISOPEPTIDE LINKAGE
DOMAIN PROTEIN
(Escherichia
coli;
Streptococcus
pyogenes) 		5 / 12 PHE A 162
GLY A 306
LEU A 305
GLU A 117
ALA A 237
 None
None
None
MLR  A 501 (-2.8A)
None
 0.84A 3tbgD-5ttdA:
undetectable		 3tbgD-5ttdA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VWQ_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5ttd MALTOSE-BINDING
PERIPLASMIC
PROTEIN,PILIN
ISOPEPTIDE LINKAGE
DOMAIN PROTEIN
(Escherichia
coli;
Streptococcus
pyogenes) 		5 / 12 ALA A 237
TYR A  23
TYR A 216
ASN A 240
GLY A 234
 None
 1.35A 3vwqA-5ttdA:
undetectable		 3vwqA-5ttdA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_D_SAMD401_1
(MNMC2)		 5ttd MALTOSE-BINDING
PERIPLASMIC
PROTEIN,PILIN
ISOPEPTIDE LINKAGE
DOMAIN PROTEIN
(Escherichia
coli;
Streptococcus
pyogenes) 		4 / 5 GLU A 314
ASP A 320
ASP A 293
ASN A 300
 None
 1.40A 3vywD-5ttdA:
undetectable		 3vywD-5ttdA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 5ttd MALTOSE-BINDING
PERIPLASMIC
PROTEIN,PILIN
ISOPEPTIDE LINKAGE
DOMAIN PROTEIN
(Escherichia
coli;
Streptococcus
pyogenes) 		5 / 12 THR A 457
PHE A 459
ILE A 490
SER A 488
PHE A 492
 None
 1.39A 4c49B-5ttdA:
undetectable		 4c49B-5ttdA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_B_NPSB602_1
(SERUM ALBUMIN)		 5ttd MALTOSE-BINDING
PERIPLASMIC
PROTEIN,PILIN
ISOPEPTIDE LINKAGE
DOMAIN PROTEIN
(Escherichia
coli;
Streptococcus
pyogenes) 		5 / 9 ALA A 270
ALA A 111
LEU A 109
LEU A 268
VAL A 267
 None
 1.16A 4or0B-5ttdA:
undetectable		 4or0B-5ttdA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_A_RBFA502_1
(RIBOFLAVIN LYASE)		 5ttd MALTOSE-BINDING
PERIPLASMIC
PROTEIN,PILIN
ISOPEPTIDE LINKAGE
DOMAIN PROTEIN
(Escherichia
coli;
Streptococcus
pyogenes) 		6 / 12 ALA A 348
ALA A 344
GLY A 172
ALA A 194
PHE A 175
VAL A 187
 None
 1.40A 5w4zA-5ttdA:
undetectable		 5w4zA-5ttdA:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_B_RBFB502_1
(RIBOFLAVIN LYASE)		 5ttd MALTOSE-BINDING
PERIPLASMIC
PROTEIN,PILIN
ISOPEPTIDE LINKAGE
DOMAIN PROTEIN
(Escherichia
coli;
Streptococcus
pyogenes) 		6 / 12 ALA A 348
ALA A 344
GLY A 172
ALA A 194
PHE A 175
VAL A 187
 None
 1.43A 5w4zB-5ttdA:
undetectable		 5w4zB-5ttdA:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BM5_A_SAMA1301_0
(METHIONINE SYNTHASE)		 5ttd MALTOSE-BINDING
PERIPLASMIC
PROTEIN,PILIN
ISOPEPTIDE LINKAGE
DOMAIN PROTEIN
(Escherichia
coli;
Streptococcus
pyogenes) 		5 / 11 PRO A 139
GLU A 136
PRO A 260
ALA A 169
PRO A 165
 None
 1.46A 6bm5A-5ttdA:
undetectable		 6bm5A-5ttdA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_A_AQ4A602_0
(CYTOCHROME P450 1A1)		 5ttd MALTOSE-BINDING
PERIPLASMIC
PROTEIN,PILIN
ISOPEPTIDE LINKAGE
DOMAIN PROTEIN
(Escherichia
coli;
Streptococcus
pyogenes) 		5 / 12 SER A 407
PHE A 432
LEU A 473
ASP A 409
ILE A 414
 None
 1.31A 6dwnA-5ttdA:
undetectable		 6dwnA-5ttdA:
11.07