SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5tth'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GAH_A_ACRA497_2
(GLUCOAMYLASE-471)		 5tth C-TERMINAL
SPYCATCHER FUSION OF
WILDTYPE ZEBRAFISH
TNF
RECEPTOR-ASSOCIATED
PROTEIN 1
(Danio
rerio;
Streptococcus
pyogenes) 		4 / 6 ALA A 695
SER A 488
ARG A 634
LEU A 697
 None
 1.22A 1gahA-5tthA:
undetectable		 1gahA-5tthA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GRM_B_DVAB6_0
(GRAMICIDIN A)		 5tth C-TERMINAL
SPYCATCHER FUSION OF
WILDTYPE ZEBRAFISH
TNF
RECEPTOR-ASSOCIATED
PROTEIN 1
(Streptococcus
pyogenes;
Danio
rerio) 		3 / 3 ALA A 480
VAL A 475
TRP A 398
 None
 0.97A 1grmB-5tthA:
undetectable		 1grmB-5tthA:
3.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_C_ACTC2294_0
(GLYCINE
N-METHYLTRANSFERASE)		 5tth C-TERMINAL
SPYCATCHER FUSION OF
WILDTYPE ZEBRAFISH
TNF
RECEPTOR-ASSOCIATED
PROTEIN 1
(Streptococcus
pyogenes;
Danio
rerio) 		4 / 7 TRP A 314
TYR A 381
ASN A 294
TYR A 332
 None
 1.41A 1kiaC-5tthA:
undetectable		 1kiaC-5tthA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_D_ACTD3294_0
(GLYCINE
N-METHYLTRANSFERASE)		 5tth C-TERMINAL
SPYCATCHER FUSION OF
WILDTYPE ZEBRAFISH
TNF
RECEPTOR-ASSOCIATED
PROTEIN 1
(Streptococcus
pyogenes;
Danio
rerio) 		4 / 7 TRP A 314
TYR A 381
ASN A 294
TYR A 332
 None
 1.42A 1kiaD-5tthA:
undetectable		 1kiaD-5tthA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_B_ACTB1294_0
(GLYCINE
N-METHYLTRANSFERASE)		 5tth C-TERMINAL
SPYCATCHER FUSION OF
WILDTYPE ZEBRAFISH
TNF
RECEPTOR-ASSOCIATED
PROTEIN 1
(Streptococcus
pyogenes;
Danio
rerio) 		4 / 7 TRP A 314
TYR A 381
ASN A 294
TYR A 332
 None
 1.41A 1nbhB-5tthA:
0.9		 1nbhB-5tthA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_ACTD3294_0
(GLYCINE
N-METHYLTRANSFERASE)		 5tth C-TERMINAL
SPYCATCHER FUSION OF
WILDTYPE ZEBRAFISH
TNF
RECEPTOR-ASSOCIATED
PROTEIN 1
(Streptococcus
pyogenes;
Danio
rerio) 		4 / 7 TRP A 314
TYR A 381
ASN A 294
TYR A 332
 None
 1.41A 1nbhD-5tthA:
0.9		 1nbhD-5tthA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OIP_A_VIVA1278_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5tth C-TERMINAL
SPYCATCHER FUSION OF
WILDTYPE ZEBRAFISH
TNF
RECEPTOR-ASSOCIATED
PROTEIN 1
(Streptococcus
pyogenes;
Danio
rerio) 		5 / 12 ILE A 213
ILE A 158
LEU A 160
ILE A 128
ILE A 300
 None
 1.06A 1oipA-5tthA:
2.0		 1oipA-5tthA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1001_0
(ALDEHYDE
DEHYDROGENASE A)		 5tth C-TERMINAL
SPYCATCHER FUSION OF
WILDTYPE ZEBRAFISH
TNF
RECEPTOR-ASSOCIATED
PROTEIN 1
(Streptococcus
pyogenes;
Danio
rerio) 		4 / 7 LEU A 270
ILE A 268
ASN A 134
PHE A 220
 None
None
MG  A 903 ( 2.6A)
None
 0.87A 2opxA-5tthA:
undetectable		 2opxA-5tthA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRL_A_DXTA1211_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 5tth C-TERMINAL
SPYCATCHER FUSION OF
WILDTYPE ZEBRAFISH
TNF
RECEPTOR-ASSOCIATED
PROTEIN 1
(Danio
rerio;
Streptococcus
pyogenes) 		5 / 12 PHE A 636
THR A 610
VAL A 609
LEU A 657
ILE A 625
 None
 1.12A 2xrlA-5tthA:
undetectable		 2xrlA-5tthA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_0
(CYTOCHROME P450 2R1)		 5tth C-TERMINAL
SPYCATCHER FUSION OF
WILDTYPE ZEBRAFISH
TNF
RECEPTOR-ASSOCIATED
PROTEIN 1
(Streptococcus
pyogenes;
Danio
rerio) 		5 / 12 THR A 162
PHE A 127
VAL A 226
VAL A 296
ILE A 300
 None
 1.22A 3dl9A-5tthA:
undetectable		 3dl9A-5tthA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5tth C-TERMINAL
SPYCATCHER FUSION OF
WILDTYPE ZEBRAFISH
TNF
RECEPTOR-ASSOCIATED
PROTEIN 1
(Streptococcus
pyogenes;
Danio
rerio) 		5 / 12 ILE A 426
ASP A 393
ILE A 394
ARG A 355
SER A 408
 None
 1.10A 4iv0B-5tthA:
undetectable		 4iv0B-5tthA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 5tth C-TERMINAL
SPYCATCHER FUSION OF
WILDTYPE ZEBRAFISH
TNF
RECEPTOR-ASSOCIATED
PROTEIN 1
(Danio
rerio;
Streptococcus
pyogenes) 		4 / 7 ASN A 690
GLU A 685
TYR A 688
ARG A 608
 None
 1.04A 4mi4B-5tthA:
1.2
4mi4C-5tthA:
undetectable		 4mi4B-5tthA:
14.98
4mi4C-5tthA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 5tth C-TERMINAL
SPYCATCHER FUSION OF
WILDTYPE ZEBRAFISH
TNF
RECEPTOR-ASSOCIATED
PROTEIN 1
(Danio
rerio;
Streptococcus
pyogenes) 		4 / 8 ASN A 690
GLU A 685
TYR A 688
ARG A 608
 None
 1.03A 4mj8B-5tthA:
undetectable
4mj8C-5tthA:
undetectable		 4mj8B-5tthA:
13.40
4mj8C-5tthA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_B_ADNB501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 5tth C-TERMINAL
SPYCATCHER FUSION OF
WILDTYPE ZEBRAFISH
TNF
RECEPTOR-ASSOCIATED
PROTEIN 1
(Danio
rerio;
Streptococcus
pyogenes) 		3 / 3 PRO A 491
LEU A 490
GLN A 495
 None
 0.67A 4pevB-5tthA:
undetectable		 4pevB-5tthA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_F_FK5F201_1
(FK506-BINDING
PROTEIN 1)		 5tth C-TERMINAL
SPYCATCHER FUSION OF
WILDTYPE ZEBRAFISH
TNF
RECEPTOR-ASSOCIATED
PROTEIN 1
(Danio
rerio;
Streptococcus
pyogenes) 		5 / 12 VAL A 288
ILE A 300
ILE A 158
PHE A 169
ILE A 213
 None
 1.06A 5hw8B-5tthA:
undetectable
5hw8F-5tthA:
undetectable
5hw8G-5tthA:
undetectable		 5hw8B-5tthA:
10.45
5hw8F-5tthA:
10.45
5hw8G-5tthA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_H_RITH602_2
(CYTOCHROME P450 3A5)		 5tth C-TERMINAL
SPYCATCHER FUSION OF
WILDTYPE ZEBRAFISH
TNF
RECEPTOR-ASSOCIATED
PROTEIN 1
(Danio
rerio;
Streptococcus
pyogenes) 		4 / 5 ARG A 464
PHE A 456
LEU A 482
LEU A 540
 None
 1.21A 5veuH-5tthA:
undetectable		 5veuH-5tthA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AK3_A_P2EA1201_0
(PROSTAGLANDIN E2
RECEPTOR EP3
SUBTYPE,SOLUBLE
CYTOCHROME B562)		 5tth C-TERMINAL
SPYCATCHER FUSION OF
WILDTYPE ZEBRAFISH
TNF
RECEPTOR-ASSOCIATED
PROTEIN 1
(Streptococcus
pyogenes;
Danio
rerio) 		5 / 12 THR A 470
THR A 469
VAL A 468
THR A 550
LEU A 483
 None
 1.45A 6ak3A-5tthA:
undetectable		 6ak3A-5tthA:
7.78