SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ttk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_CCSA381_0
(ESTROGEN RECEPTOR)
5ttk AMINE OXIDASE
(Pseudomonas
putida)
4 / 5 HIS A 460
ALA A 466
SER A 469
HIS A 115
None
FAD  A 501 (-3.1A)
None
None
1.37A 1errA-5ttkA:
undetectable
1errB-5ttkA:
undetectable
1errA-5ttkA:
19.56
1errB-5ttkA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG2_A_ADNA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)
5ttk AMINE OXIDASE
(Pseudomonas
putida)
5 / 12 ILE A 448
GLY A 287
THR A 300
ALA A 301
VAL A  57
None
1.20A 1jg2A-5ttkA:
undetectable
1jg2A-5ttkA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S2A_A_IMNA2001_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)
5ttk AMINE OXIDASE
(Pseudomonas
putida)
5 / 12 TYR A 218
LEU A 234
HIS A 460
SER A 456
SER A 336
None
1.19A 1s2aA-5ttkA:
undetectable
1s2aA-5ttkA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_A_SAMA301_0
(RRNA
METHYLTRANSFERASE)
5ttk AMINE OXIDASE
(Pseudomonas
putida)
5 / 11 GLY A  65
GLY A  60
LEU A 449
ALA A 451
ALA A 473
None
FAD  A 501 (-3.1A)
None
None
None
1.03A 1x7pA-5ttkA:
2.6
1x7pB-5ttkA:
2.5
1x7pA-5ttkA:
20.40
1x7pB-5ttkA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_A_GBNA2414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)
5ttk AMINE OXIDASE
(Pseudomonas
putida)
4 / 8 GLY A  60
THR A  67
ALA A  68
ALA A  69
FAD  A 501 (-3.1A)
None
None
None
0.53A 2ej3A-5ttkA:
undetectable
2ej3A-5ttkA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEO_A_017A402_2
(PROTEASE)
5ttk AMINE OXIDASE
(Pseudomonas
putida)
5 / 12 LEU A 449
ALA A  68
GLY A  73
VAL A 303
VAL A 305
None
0.79A 2ieoB-5ttkA:
undetectable
2ieoB-5ttkA:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_2
(PROTEASE)
5ttk AMINE OXIDASE
(Pseudomonas
putida)
3 / 3 ARG A  85
VAL A  58
THR A 307
FAD  A 501 (-3.5A)
None
None
0.75A 2nmzA-5ttkA:
undetectable
2nmzA-5ttkA:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_1
(PROTEASE)
5ttk AMINE OXIDASE
(Pseudomonas
putida)
5 / 12 LEU A 449
ALA A  68
GLY A  73
VAL A 303
VAL A 305
None
0.81A 2nnkA-5ttkA:
undetectable
2nnkA-5ttkA:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_0
(SAM DEPENDENT
METHYLTRANSFERASE)
5ttk AMINE OXIDASE
(Pseudomonas
putida)
5 / 12 LEU A  88
VAL A  59
GLY A  60
GLY A  62
ALA A  84
None
FAD  A 501 (-4.7A)
FAD  A 501 (-3.1A)
FAD  A 501 (-3.5A)
FAD  A 501 (-3.3A)
1.38A 3dh0A-5ttkA:
undetectable
3dh0A-5ttkA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU9_A_478A401_2
(PROTEASE)
5ttk AMINE OXIDASE
(Pseudomonas
putida)
5 / 10 LEU A 449
ALA A  68
GLY A  73
VAL A 303
VAL A 305
None
0.87A 3nu9B-5ttkA:
undetectable
3nu9B-5ttkA:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QOW_A_SAMA417_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE)
5ttk AMINE OXIDASE
(Pseudomonas
putida)
5 / 12 GLY A 446
GLY A 302
VAL A 477
LYS A 290
PHE A  52
None
1.30A 3qowA-5ttkA:
1.6
3qowA-5ttkA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA5_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)
5ttk AMINE OXIDASE
(Pseudomonas
putida)
3 / 3 LYS A 165
SER A 204
GLN A 207
None
1.19A 3si7A-5ttkA:
undetectable
3si7A-5ttkA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_A_017A201_1
(PROTEASE)
5ttk AMINE OXIDASE
(Pseudomonas
putida)
5 / 12 LEU A 449
ALA A  68
GLY A  73
VAL A 303
VAL A 305
None
0.80A 3ucbA-5ttkA:
undetectable
3ucbA-5ttkA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_A_017A201_2
(PROTEASE)
5ttk AMINE OXIDASE
(Pseudomonas
putida)
5 / 12 LEU A 449
ALA A  68
GLY A  73
VAL A 303
VAL A 305
None
0.85A 3ucbB-5ttkA:
undetectable
3ucbB-5ttkA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UGR_A_IMNA2001_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)
5ttk AMINE OXIDASE
(Pseudomonas
putida)
5 / 12 TYR A 218
LEU A 234
HIS A 460
SER A 456
SER A 336
None
1.21A 3ugrA-5ttkA:
undetectable
3ugrA-5ttkA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_A_UEGA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)
5ttk AMINE OXIDASE
(Pseudomonas
putida)
5 / 11 GLY A  65
ALA A 473
GLY A 470
VAL A  58
CYH A  72
None
1.33A 4c5lA-5ttkA:
2.7
4c5lA-5ttkA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)
5ttk AMINE OXIDASE
(Pseudomonas
putida)
5 / 10 GLY A  65
ALA A 473
GLY A 470
VAL A  58
CYH A  72
None
1.30A 4c5lD-5ttkA:
2.7
4c5lD-5ttkA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)
5ttk AMINE OXIDASE
(Pseudomonas
putida)
5 / 10 GLY A  65
ALA A 473
GLY A 470
VAL A  58
CYH A  72
None
1.31A 4c5nD-5ttkA:
2.5
4c5nD-5ttkA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F84_A_SAMA501_0
(GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E)
5ttk AMINE OXIDASE
(Pseudomonas
putida)
5 / 12 GLY A  60
GLY A  62
VAL A 308
THR A 307
VAL A  57
FAD  A 501 (-3.1A)
FAD  A 501 (-3.5A)
FAD  A 501 (-4.1A)
None
None
1.23A 4f84A-5ttkA:
undetectable
4f84A-5ttkA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K17_B_OHBB701_0
(LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 16A)
5ttk AMINE OXIDASE
(Pseudomonas
putida)
4 / 5 GLU A 454
SER A 456
ARG A  91
SER A 469
None
None
FAD  A 501 (-3.9A)
None
1.43A 4k17B-5ttkA:
undetectable
4k17B-5ttkA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_B_HFGB703_0
(AMINOACYL-TRNA
SYNTHETASE)
5ttk AMINE OXIDASE
(Pseudomonas
putida)
5 / 12 LEU A 322
PHE A 318
GLU A 476
SER A 469
GLY A 474
None
1.09A 5f9zB-5ttkA:
undetectable
5f9zB-5ttkA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_F_SAMF501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)
5ttk AMINE OXIDASE
(Pseudomonas
putida)
5 / 10 GLY A  65
GLY A  60
VAL A 304
LEU A 449
ALA A 473
None
FAD  A 501 (-3.1A)
None
None
None
1.03A 5o96E-5ttkA:
undetectable
5o96F-5ttkA:
undetectable
5o96E-5ttkA:
20.51
5o96F-5ttkA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_H_SAMH501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)
5ttk AMINE OXIDASE
(Pseudomonas
putida)
5 / 10 GLY A  65
GLY A  60
VAL A 304
LEU A 449
ALA A 473
None
FAD  A 501 (-3.1A)
None
None
None
1.04A 5o96G-5ttkA:
undetectable
5o96H-5ttkA:
undetectable
5o96G-5ttkA:
20.51
5o96H-5ttkA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TRQ_B_ACTB307_0
(WELO5)
5ttk AMINE OXIDASE
(Pseudomonas
putida)
3 / 3 GLU A 119
HIS A 115
VAL A 467
None
0.84A 5trqB-5ttkA:
undetectable
5trqB-5ttkA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCP_A_BRLA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
5ttk AMINE OXIDASE
(Pseudomonas
putida)
3 / 3 GLY A 317
VAL A 308
MET A 306
None
FAD  A 501 (-4.1A)
None
0.62A 5ycpA-5ttkA:
undetectable
5ycpA-5ttkA:
12.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6C71_A_NCTA501_1
(AMINE OXIDASE)
5ttk AMINE OXIDASE
(Pseudomonas
putida)
5 / 10 TRP A 108
THR A 250
TRP A 427
ALA A 461
ASN A 462
FAD  A 501 (-4.8A)
None
None
None
FAD  A 501 (-3.8A)
0.74A 6c71A-5ttkA:
65.8
6c71A-5ttkA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6C71_A_NCTA501_1
(AMINE OXIDASE)
5ttk AMINE OXIDASE
(Pseudomonas
putida)
5 / 10 TYR A 218
GLU A 249
THR A 250
THR A 381
TRP A 427
None
1.47A 6c71A-5ttkA:
65.8
6c71A-5ttkA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6C71_A_NCTA501_1
(AMINE OXIDASE)
5ttk AMINE OXIDASE
(Pseudomonas
putida)
6 / 10 TYR A 218
THR A 250
THR A 381
TRP A 427
ALA A 461
ASN A 462
None
None
None
None
None
FAD  A 501 (-3.8A)
0.66A 6c71A-5ttkA:
65.8
6c71A-5ttkA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6C71_B_NCTB501_1
(AMINE OXIDASE)
5ttk AMINE OXIDASE
(Pseudomonas
putida)
4 / 8 TYR A 218
GLU A 249
THR A 381
TRP A 427
None
1.25A 6c71B-5ttkA:
64.7
6c71B-5ttkA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6C71_B_NCTB501_1
(AMINE OXIDASE)
5ttk AMINE OXIDASE
(Pseudomonas
putida)
4 / 8 TYR A 218
THR A 381
TRP A 427
ASN A 462
None
None
None
FAD  A 501 (-3.8A)
0.55A 6c71B-5ttkA:
64.7
6c71B-5ttkA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6C71_C_NCTC501_1
(AMINE OXIDASE)
5ttk AMINE OXIDASE
(Pseudomonas
putida)
5 / 10 TRP A 108
THR A 250
TRP A 427
ALA A 461
ASN A 462
FAD  A 501 (-4.8A)
None
None
None
FAD  A 501 (-3.8A)
0.72A 6c71C-5ttkA:
64.5
6c71C-5ttkA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6C71_C_NCTC501_1
(AMINE OXIDASE)
5ttk AMINE OXIDASE
(Pseudomonas
putida)
6 / 10 TYR A 218
THR A 250
THR A 381
TRP A 427
ALA A 461
ASN A 462
None
None
None
None
None
FAD  A 501 (-3.8A)
0.70A 6c71C-5ttkA:
64.5
6c71C-5ttkA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6C71_D_NCTD501_1
(AMINE OXIDASE)
5ttk AMINE OXIDASE
(Pseudomonas
putida)
6 / 9 LEU A 217
TYR A 218
GLU A 249
THR A 250
THR A 381
TRP A 427
None
1.44A 6c71D-5ttkA:
64.4
6c71D-5ttkA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6C71_D_NCTD501_1
(AMINE OXIDASE)
5ttk AMINE OXIDASE
(Pseudomonas
putida)
5 / 9 TYR A 218
THR A 250
THR A 381
TRP A 427
ASN A 462
None
None
None
None
FAD  A 501 (-3.8A)
0.77A 6c71D-5ttkA:
64.4
6c71D-5ttkA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_0
(PROTEASE)
5ttk AMINE OXIDASE
(Pseudomonas
putida)
5 / 12 LEU A 449
ALA A  68
GLY A  73
VAL A 303
VAL A 305
None
0.95A 6dh0A-5ttkA:
undetectable
6dh0A-5ttkA:
10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GSD_A_STRA401_0
(PROGESTERONE
5-BETA-REDUCTASE)
5ttk AMINE OXIDASE
(Pseudomonas
putida)
5 / 12 VAL A 396
ILE A 388
MET A 141
SER A 379
ILE A 382
None
0.94A 6gsdA-5ttkA:
3.3
6gsdA-5ttkA:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_K_BO2K301_0
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)
5ttk AMINE OXIDASE
(Pseudomonas
putida)
5 / 11 ALA A  68
ALA A 451
ALA A 473
GLY A  61
GLY A  60
None
None
None
FAD  A 501 ( 4.5A)
FAD  A 501 (-3.1A)
0.92A 6hwdK-5ttkA:
undetectable
6hwdL-5ttkA:
undetectable
6hwdK-5ttkA:
9.96
6hwdL-5ttkA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_Y_BO2Y301_0
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)
5ttk AMINE OXIDASE
(Pseudomonas
putida)
5 / 11 ALA A  68
ALA A 451
ALA A 473
GLY A  61
GLY A  60
None
None
None
FAD  A 501 ( 4.5A)
FAD  A 501 (-3.1A)
0.92A 6hwdY-5ttkA:
undetectable
6hwdZ-5ttkA:
undetectable
6hwdY-5ttkA:
9.96
6hwdZ-5ttkA:
14.59