SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ttx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3M_A_DLUA398_1
(PFV INTEGRASE)		 5ttx HYDROGENASE 2
MATURATION PEPTIDASE
(Thaumarchaeota
archaeon
SCGC
AB-539-E09) 		4 / 8 ASP A  19
GLY A  18
PRO A  73
GLU A 139
 None
 0.94A 3s3mA-5ttxA:
undetectable		 3s3mA-5ttxA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3N_A_DLUA398_1
(PFV INTEGRASE)		 5ttx HYDROGENASE 2
MATURATION PEPTIDASE
(Thaumarchaeota
archaeon
SCGC
AB-539-E09) 		4 / 8 ASP A  19
GLY A  18
PRO A  73
GLU A 139
 None
 0.87A 3s3nA-5ttxA:
undetectable		 3s3nA-5ttxA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5ttx HYDROGENASE 2
MATURATION PEPTIDASE
(Thaumarchaeota
archaeon
SCGC
AB-539-E09) 		5 / 11 LEU A  55
PHE A 109
VAL A 120
LEU A  81
PHE A  63
 None
 1.14A 3w67A-5ttxA:
undetectable		 3w67A-5ttxA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_A_BEZA201_0
(HYDROXYNITRILE LYASE)		 5ttx HYDROGENASE 2
MATURATION PEPTIDASE
(Thaumarchaeota
archaeon
SCGC
AB-539-E09) 		5 / 9 VAL A 120
VAL A  61
PHE A  63
ILE A  49
LEU A 116
 None
 1.50A 5e4dA-5ttxA:
undetectable		 5e4dA-5ttxA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 5ttx HYDROGENASE 2
MATURATION PEPTIDASE
(Thaumarchaeota
archaeon
SCGC
AB-539-E09) 		5 / 12 PHE A  63
ILE A 123
ASP A 149
LEU A   8
ALA A  10
 None
 0.98A 5h5fA-5ttxA:
undetectable		 5h5fA-5ttxA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA302_1
(CHITOSANASE)		 5ttx HYDROGENASE 2
MATURATION PEPTIDASE
(Thaumarchaeota
archaeon
SCGC
AB-539-E09) 		4 / 7 ARG A  25
ASP A  28
ASP A  43
GLY A  23
 None
 1.08A 5hwaA-5ttxA:
undetectable		 5hwaA-5ttxA:
20.63