SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5tu0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 5tu0 LMO2125 PROTEIN
(Listeria
monocytogenes) 		5 / 10 VAL A 113
VAL A  52
VAL A  42
ASN A 329
LEU A 321
 None
 1.16A 1fe2A-5tu0A:
undetectable		 1fe2A-5tu0A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_A_9CRA801_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5tu0 LMO2125 PROTEIN
(Listeria
monocytogenes) 		6 / 12 ILE A 265
ALA A 262
ALA A 263
LEU A 167
PHE A 185
LEU A 186
 None
 1.50A 1xlsA-5tu0A:
undetectable		 1xlsA-5tu0A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_B_9CRB802_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5tu0 LMO2125 PROTEIN
(Listeria
monocytogenes) 		6 / 12 ILE A 265
ALA A 262
ALA A 263
LEU A 167
PHE A 185
LEU A 186
 None
 1.49A 1xlsB-5tu0A:
undetectable		 1xlsB-5tu0A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_C_9CRC803_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5tu0 LMO2125 PROTEIN
(Listeria
monocytogenes) 		6 / 12 ILE A 265
ALA A 262
ALA A 263
LEU A 167
PHE A 185
LEU A 186
 None
 1.49A 1xlsC-5tu0A:
undetectable		 1xlsC-5tu0A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_D_9CRD804_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5tu0 LMO2125 PROTEIN
(Listeria
monocytogenes) 		6 / 12 ILE A 265
ALA A 262
ALA A 263
LEU A 167
PHE A 185
LEU A 186
 None
 1.50A 1xlsD-5tu0A:
undetectable		 1xlsD-5tu0A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA6_A_SCKA902_1
(ACETYLCHOLINESTERASE)		 5tu0 LMO2125 PROTEIN
(Listeria
monocytogenes) 		5 / 10 GLU A 165
ASN A 182
LEU A 198
LEU A 290
TYR A 202
 PGE  A 503 (-3.8A)
None
None
None
None
 1.48A 2ha6A-5tu0A:
undetectable		 2ha6A-5tu0A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA6_B_SCKB952_1
(ACETYLCHOLINESTERASE)		 5tu0 LMO2125 PROTEIN
(Listeria
monocytogenes) 		5 / 10 GLU A 165
ASN A 182
LEU A 198
LEU A 290
TYR A 202
 PGE  A 503 (-3.8A)
None
None
None
None
 1.47A 2ha6B-5tu0A:
undetectable		 2ha6B-5tu0A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y05_A_RALA801_1
(PROSTAGLANDIN
REDUCTASE 1)		 5tu0 LMO2125 PROTEIN
(Listeria
monocytogenes) 		4 / 8 VAL A 206
SER A 103
VAL A 413
TYR A 417
 None
 1.26A 2y05A-5tu0A:
undetectable
2y05B-5tu0A:
undetectable		 2y05A-5tu0A:
25.44
2y05B-5tu0A:
25.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_B_SAMB602_1
(HYPOTHETICAL PROTEIN)		 5tu0 LMO2125 PROTEIN
(Listeria
monocytogenes) 		3 / 3 GLU A 410
ASP A 216
TYR A 205
 None
 0.78A 2yvlB-5tu0A:
undetectable		 2yvlB-5tu0A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5tu0 LMO2125 PROTEIN
(Listeria
monocytogenes) 		5 / 12 ILE A 374
GLY A 211
ALA A 200
LEU A 219
VAL A 380
 None
 1.38A 3adsB-5tu0A:
undetectable		 3adsB-5tu0A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BRF_A_SORA2_0
(LIN-12 AND GLP-1
PHENOTYPE PROTEIN 1,
ISOFORM A)		 5tu0 LMO2125 PROTEIN
(Listeria
monocytogenes) 		3 / 3 LYS A  56
LYS A  49
VAL A  52
 None
 1.05A 3brfA-5tu0A:
undetectable		 3brfA-5tu0A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_1
(N,N-DIMETHYLTRANSFER
ASE)		 5tu0 LMO2125 PROTEIN
(Listeria
monocytogenes) 		3 / 3 TYR A 148
GLU A 143
ASP A  99
 None
MAL  A 501 ( 4.2A)
MAL  A 501 (-3.8A)
 0.86A 3bxoA-5tu0A:
undetectable		 3bxoA-5tu0A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_B_SAMB238_1
(N,N-DIMETHYLTRANSFER
ASE)		 5tu0 LMO2125 PROTEIN
(Listeria
monocytogenes) 		3 / 3 TYR A 148
GLU A 143
ASP A  99
 None
MAL  A 501 ( 4.2A)
MAL  A 501 (-3.8A)
 0.89A 3bxoB-5tu0A:
undetectable		 3bxoB-5tu0A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TOP_A_ACRA1_2
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 5tu0 LMO2125 PROTEIN
(Listeria
monocytogenes) 		4 / 5 ILE A 253
TRP A 239
TRP A 234
THR A 289
 None
None
PGE  A 503 (-3.8A)
None
 1.38A 3topA-5tu0A:
undetectable		 3topA-5tu0A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TOP_B_ACRB1_2
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 5tu0 LMO2125 PROTEIN
(Listeria
monocytogenes) 		4 / 5 PRO A 288
ILE A 253
TRP A 239
TRP A 234
 None
None
None
PGE  A 503 (-3.8A)
 1.35A 3topB-5tu0A:
undetectable		 3topB-5tu0A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_0
(MNMC2)		 5tu0 LMO2125 PROTEIN
(Listeria
monocytogenes) 		5 / 12 GLY A 197
GLY A 204
TYR A 205
PHE A 299
LEU A 145
 None
 1.12A 3vywC-5tu0A:
undetectable		 3vywC-5tu0A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_C_STRC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5tu0 LMO2125 PROTEIN
(Listeria
monocytogenes) 		4 / 5 ILE A 141
ASP A 335
GLU A 339
VAL A 361
 None
 1.21A 4nkxC-5tu0A:
undetectable		 4nkxC-5tu0A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_D_STRD601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5tu0 LMO2125 PROTEIN
(Listeria
monocytogenes) 		4 / 5 ILE A 141
ASP A 335
GLU A 339
VAL A 361
 None
 1.20A 4nkxD-5tu0A:
undetectable		 4nkxD-5tu0A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_1
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 5tu0 LMO2125 PROTEIN
(Listeria
monocytogenes) 		3 / 3 SER A 271
TYR A 275
ASP A 250
 None
 0.83A 4rp8C-5tu0A:
1.2		 4rp8C-5tu0A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZO1_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 5tu0 LMO2125 PROTEIN
(Listeria
monocytogenes) 		5 / 12 ILE A 141
ALA A 342
ARG A 347
ALA A 300
MET A  74
 None
 1.49A 4zo1X-5tu0A:
undetectable		 4zo1X-5tu0A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5tu0 LMO2125 PROTEIN
(Listeria
monocytogenes) 		4 / 6 GLY A 304
ILE A 362
ARG A 347
TYR A 365
 None
 1.10A 5iwuA-5tu0A:
undetectable		 5iwuA-5tu0A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 5tu0 LMO2125 PROTEIN
(Listeria
monocytogenes) 		3 / 3 ALA A 249
GLN A 244
THR A 190
 None
 0.70A 5n0oA-5tu0A:
undetectable		 5n0oA-5tu0A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0R_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 5tu0 LMO2125 PROTEIN
(Listeria
monocytogenes) 		4 / 4 SER A 248
ALA A 249
GLN A 244
THR A 190
 None
 1.21A 5n0rA-5tu0A:
1.2		 5n0rA-5tu0A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 5tu0 LMO2125 PROTEIN
(Listeria
monocytogenes) 		4 / 4 SER A 248
ALA A 249
GLN A 244
THR A 190
 None
 1.18A 5n0sA-5tu0A:
undetectable		 5n0sA-5tu0A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 5tu0 LMO2125 PROTEIN
(Listeria
monocytogenes) 		4 / 4 SER A 248
ALA A 249
GLN A 244
THR A 190
 None
 1.18A 5n0wA-5tu0A:
undetectable		 5n0wA-5tu0A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 5tu0 LMO2125 PROTEIN
(Listeria
monocytogenes) 		4 / 5 SER A 248
ALA A 249
GLN A 244
THR A 190
 None
 1.16A 5n0wB-5tu0A:
undetectable		 5n0wB-5tu0A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 5tu0 LMO2125 PROTEIN
(Listeria
monocytogenes) 		4 / 4 SER A 248
ALA A 249
GLN A 244
THR A 190
 None
 1.17A 5n0xA-5tu0A:
1.3		 5n0xA-5tu0A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4I_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 5tu0 LMO2125 PROTEIN
(Listeria
monocytogenes) 		4 / 5 SER A 248
ALA A 249
GLN A 244
THR A 190
 None
 1.16A 5n4iA-5tu0A:
undetectable		 5n4iA-5tu0A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TQR_B_SAMB8009_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2, POLYCOMB
PROTEIN SUZ12)		 5tu0 LMO2125 PROTEIN
(Listeria
monocytogenes) 		5 / 10 LEU A 154
GLY A 283
TYR A 282
VAL A 146
TYR A 275
 None
 1.32A 5tqrB-5tu0A:
undetectable		 5tqrB-5tu0A:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_A_RBFA502_1
(RIBOFLAVIN LYASE)		 5tu0 LMO2125 PROTEIN
(Listeria
monocytogenes) 		5 / 12 GLY A 137
ALA A 138
SER A 311
VAL A  93
THR A 325
 None
 0.95A 5w4zA-5tu0A:
undetectable		 5w4zA-5tu0A:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_B_RBFB502_1
(RIBOFLAVIN LYASE)		 5tu0 LMO2125 PROTEIN
(Listeria
monocytogenes) 		5 / 12 GLY A 137
ALA A 138
SER A 311
VAL A  93
THR A 325
 None
 0.96A 5w4zB-5tu0A:
undetectable		 5w4zB-5tu0A:
10.62