SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5tu4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BRP_A_RTLA183_0
(RETINOL BINDING
PROTEIN)		 5tu4 PAGF
PRENYLTRANSFERASE
(Planktothrix
agardhii) 		5 / 12 LEU A 120
MET A 137
GLY A 123
PHE A  37
LEU A 104
 None
 1.34A 1brpA-5tu4A:
undetectable		 1brpA-5tu4A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKP_A_NVPA999_1
(HIV-1 RT, A-CHAIN)		 5tu4 PAGF
PRENYLTRANSFERASE
(Planktothrix
agardhii) 		5 / 11 PRO A 232
LEU A 234
VAL A 203
LEU A 279
TYR A 236
 None
 1.33A 1fkpA-5tu4A:
undetectable		 1fkpA-5tu4A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWC_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 5tu4 PAGF
PRENYLTRANSFERASE
(Planktothrix
agardhii) 		5 / 11 PRO A 232
LEU A 234
VAL A 203
LEU A 279
TYR A 236
 None
 1.40A 1lwcA-5tu4A:
undetectable		 1lwcA-5tu4A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CC8_A_RBFA1067_1
(VNG1446H)		 5tu4 PAGF
PRENYLTRANSFERASE
(Planktothrix
agardhii) 		3 / 3 PHE A 221
VAL A 203
TRP A 204
 None
 0.90A 2cc8A-5tu4A:
undetectable		 2cc8A-5tu4A:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CCB_A_RBFA1067_1
(VNG1446H)		 5tu4 PAGF
PRENYLTRANSFERASE
(Planktothrix
agardhii) 		3 / 3 PHE A 221
VAL A 203
TRP A 204
 None
 0.91A 2ccbA-5tu4A:
undetectable		 2ccbA-5tu4A:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNC_B_CLUB809_1
(COPPER AMINE
OXIDASE, LIVER
ISOZYME)		 5tu4 PAGF
PRENYLTRANSFERASE
(Planktothrix
agardhii) 		4 / 6 ALA A  52
TYR A 292
TYR A 261
HIS A  22
 None
 1.43A 2pncB-5tu4A:
undetectable		 2pncB-5tu4A:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD2_A_CHDA2_0
(FERROCHELATASE)		 5tu4 PAGF
PRENYLTRANSFERASE
(Planktothrix
agardhii) 		4 / 8 LEU A 289
ARG A 283
PRO A 214
SER A 218
 None
 1.09A 2qd2A-5tu4A:
undetectable		 2qd2A-5tu4A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU9_B_SPMB700_1
(POLYAMINE OXIDASE)		 5tu4 PAGF
PRENYLTRANSFERASE
(Planktothrix
agardhii) 		4 / 7 GLU A  51
TYR A 186
TYR A 235
TYR A 292
 B1C  A 403 (-2.9A)
DST  A 401 (-4.3A)
DST  A 401 (-3.4A)
None
 1.18A 3ku9B-5tu4A:
undetectable		 3ku9B-5tu4A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		 5tu4 PAGF
PRENYLTRANSFERASE
(Planktothrix
agardhii) 		4 / 8 PRO A  33
PRO A  30
GLN A  23
GLU A  29
 None
 1.09A 3oyaA-5tu4A:
undetectable		 3oyaA-5tu4A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_1
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 5tu4 PAGF
PRENYLTRANSFERASE
(Planktothrix
agardhii) 		4 / 6 GLY A 224
THR A 223
LEU A 234
GLU A 184
 None
 0.95A 3ps9A-5tu4A:
undetectable		 3ps9A-5tu4A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DR2_A_PARA1609_1
(16S RRNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		 5tu4 PAGF
PRENYLTRANSFERASE
(Planktothrix
agardhii) 		3 / 3 TYR A 176
ARG A 127
SER A 133
 None
 1.07A 4dr2I-5tu4A:
undetectable
4dr2J-5tu4A:
0.2		 4dr2I-5tu4A:
18.94
4dr2J-5tu4A:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5tu4 PAGF
PRENYLTRANSFERASE
(Planktothrix
agardhii) 		5 / 11 VAL A  97
PHE A  87
PHE A  37
LEU A 126
VAL A  95
 None
 1.46A 4eilA-5tu4A:
undetectable		 4eilA-5tu4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5tu4 PAGF
PRENYLTRANSFERASE
(Planktothrix
agardhii) 		5 / 10 VAL A  97
PHE A  88
SER A 134
LEU A 126
VAL A  95
 None
 1.41A 4eilB-5tu4A:
undetectable		 4eilB-5tu4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_C_FOLC703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5tu4 PAGF
PRENYLTRANSFERASE
(Planktothrix
agardhii) 		5 / 11 VAL A  97
SER A 134
PHE A  37
LEU A 126
VAL A  95
 None
 1.09A 4eilC-5tu4A:
undetectable		 4eilC-5tu4A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_F_BEZF501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 5tu4 PAGF
PRENYLTRANSFERASE
(Planktothrix
agardhii) 		4 / 8 ASN A 231
ALA A 275
TYR A 235
ARG A 288
 None
None
DST  A 401 (-3.4A)
DST  A 401 (-4.3A)
 1.03A 4ijiF-5tu4A:
undetectable		 4ijiF-5tu4A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_A_8PRA603_1
(TRANSPORTER)		 5tu4 PAGF
PRENYLTRANSFERASE
(Planktothrix
agardhii) 		5 / 12 VAL A 168
ALA A 187
PHE A 107
SER A 226
GLY A 224
 None
 1.24A 4mm4A-5tu4A:
undetectable		 4mm4A-5tu4A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_1
(TRANSPORTER)		 5tu4 PAGF
PRENYLTRANSFERASE
(Planktothrix
agardhii) 		5 / 12 VAL A 168
ALA A 187
PHE A 107
SER A 226
GLY A 224
 None
 1.22A 4mm4B-5tu4A:
undetectable		 4mm4B-5tu4A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		 5tu4 PAGF
PRENYLTRANSFERASE
(Planktothrix
agardhii) 		5 / 9 VAL A 168
ALA A 187
GLY A 172
SER A 226
GLY A 224
 None
 1.33A 4mm5A-5tu4A:
undetectable		 4mm5A-5tu4A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_A_29QA603_1
(TRANSPORTER)		 5tu4 PAGF
PRENYLTRANSFERASE
(Planktothrix
agardhii) 		5 / 9 VAL A 168
ALA A 187
GLY A 172
SER A 226
GLY A 224
 None
 1.33A 4mmeA-5tu4A:
undetectable		 4mmeA-5tu4A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_A_29QA603_1
(TRANSPORTER)		 5tu4 PAGF
PRENYLTRANSFERASE
(Planktothrix
agardhii) 		5 / 9 VAL A 168
ALA A 187
GLY A 172
SER A 226
GLY A 224
 None
 1.37A 4mmfA-5tu4A:
undetectable		 4mmfA-5tu4A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PUO_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 5tu4 PAGF
PRENYLTRANSFERASE
(Planktothrix
agardhii) 		5 / 9 PRO A 232
LEU A 234
VAL A 203
LEU A 279
TYR A 236
 None
 1.39A 4puoA-5tu4A:
0.7		 4puoA-5tu4A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_A_BQ1A1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 5tu4 PAGF
PRENYLTRANSFERASE
(Planktothrix
agardhii) 		3 / 3 GLU A 188
ALA A 187
PHE A 222
 B1C  A 403 ( 4.2A)
None
DST  A 401 ( 4.5A)
 0.68A 4v1fA-5tu4A:
undetectable		 4v1fA-5tu4A:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_C_BQ1C1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 5tu4 PAGF
PRENYLTRANSFERASE
(Planktothrix
agardhii) 		3 / 3 GLU A 188
ALA A 187
PHE A 222
 B1C  A 403 ( 4.2A)
None
DST  A 401 ( 4.5A)
 0.66A 4v1fC-5tu4A:
undetectable		 4v1fC-5tu4A:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4N_C_ACTC201_0
(NITROGEN REGULATORY
PROTEIN P-II)		 5tu4 PAGF
PRENYLTRANSFERASE
(Planktothrix
agardhii) 		4 / 5 VAL A  91
VAL A  97
GLY A  96
PHE A 177
 None
 1.06A 5d4nA-5tu4A:
1.4
5d4nC-5tu4A:
1.4		 5d4nA-5tu4A:
19.27
5d4nC-5tu4A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_B_0HKB1201_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 5tu4 PAGF
PRENYLTRANSFERASE
(Planktothrix
agardhii) 		3 / 3 ASP A 193
ASN A 200
PHE A 207
 None
 0.76A 5dsgB-5tu4A:
undetectable		 5dsgB-5tu4A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 5tu4 PAGF
PRENYLTRANSFERASE
(Planktothrix
agardhii) 		5 / 12 ILE A  19
LEU A  34
GLU A  51
PHE A  66
HIS A 138
 None
None
B1C  A 403 (-2.9A)
None
B1C  A 403 ( 3.5A)
 1.21A 5k7uA-5tu4A:
undetectable		 5k7uA-5tu4A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIG_A_EDTA501_0
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 5tu4 PAGF
PRENYLTRANSFERASE
(Planktothrix
agardhii) 		4 / 6 THR A 253
ASN A 251
ILE A 287
GLU A 278
 None
 1.22A 5uigA-5tu4A:
undetectable		 5uigA-5tu4A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 5tu4 PAGF
PRENYLTRANSFERASE
(Planktothrix
agardhii) 		4 / 6 PHE A  70
LEU A 120
ALA A 122
GLN A  75
 None
 1.07A 6b89B-5tu4A:
undetectable		 6b89B-5tu4A:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 5tu4 PAGF
PRENYLTRANSFERASE
(Planktothrix
agardhii) 		4 / 7 PHE A  70
LEU A 120
ALA A 122
GLN A  75
 None
 1.27A 6b89A-5tu4A:
undetectable		 6b89A-5tu4A:
13.55