SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5tub'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C7V_C_MTXC1272_1
(PTERIDINE REDUCTASE)		 5tub SHARK TBC1D15
GTPASE-ACTIVATING
PROTEIN
(Squalimorphii) 		5 / 12 PHE A 383
PRO A 384
ASP A 492
TYR A 382
GLU A 390
 None
 1.47A 2c7vC-5tubA:
undetectable		 2c7vC-5tubA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_2
(PROTEASE RETROPEPSIN)		 5tub SHARK TBC1D15
GTPASE-ACTIVATING
PROTEIN
(Squalimorphii) 		3 / 3 ARG A 333
THR A 574
VAL A 571
 None
 0.95A 2q64A-5tubA:
undetectable		 2q64A-5tubA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZGW_A_ADNA1301_1
(BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 5tub SHARK TBC1D15
GTPASE-ACTIVATING
PROTEIN
(Squalimorphii) 		4 / 7 ARG A 333
GLU A 622
ALA A 627
ALA A 588
 None
 1.14A 2zgwA-5tubA:
undetectable		 2zgwA-5tubA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB202_1
(PROTEIN S100-A4)		 5tub SHARK TBC1D15
GTPASE-ACTIVATING
PROTEIN
(Squalimorphii) 		3 / 3 GLU A 509
LEU A 470
ASP A 469
 None
 0.39A 3ko0A-5tubA:
1.9		 3ko0A-5tubA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5tub SHARK TBC1D15
GTPASE-ACTIVATING
PROTEIN
(Squalimorphii) 		5 / 12 GLN A 579
GLY A 649
ARG A 328
ILE A 585
ALA A 627
 None
 1.01A 3sudC-5tubA:
undetectable		 3sudC-5tubA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEO_A_ACRA1001_2
(ALPHA-GLUCOSIDASE)		 5tub SHARK TBC1D15
GTPASE-ACTIVATING
PROTEIN
(Squalimorphii) 		4 / 6 TRP A 573
ILE A 362
TRP A 376
TRP A 385
 None
 1.44A 3weoA-5tubA:
undetectable		 3weoA-5tubA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_B_BRLB501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5tub SHARK TBC1D15
GTPASE-ACTIVATING
PROTEIN
(Squalimorphii) 		4 / 6 ILE A 473
GLY A 475
ILE A 483
LEU A 470
 None
 0.77A 4o8fB-5tubA:
undetectable		 4o8fB-5tubA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_B_CHDB102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5tub SHARK TBC1D15
GTPASE-ACTIVATING
PROTEIN
(Squalimorphii) 		5 / 11 LEU A 648
LEU A 525
ALA A 627
LEU A 584
TYR A 631
 None
 1.13A 4wg0B-5tubA:
undetectable
4wg0C-5tubA:
undetectable
4wg0D-5tubA:
undetectable		 4wg0B-5tubA:
3.17
4wg0C-5tubA:
3.17
4wg0D-5tubA:
3.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_D_CHDD102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5tub SHARK TBC1D15
GTPASE-ACTIVATING
PROTEIN
(Squalimorphii) 		5 / 11 LEU A 648
LEU A 525
ALA A 627
LEU A 584
TYR A 631
 None
 1.14A 4wg0D-5tubA:
undetectable
4wg0E-5tubA:
undetectable
4wg0F-5tubA:
undetectable		 4wg0D-5tubA:
3.17
4wg0E-5tubA:
3.17
4wg0F-5tubA:
3.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_F_CHDF103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5tub SHARK TBC1D15
GTPASE-ACTIVATING
PROTEIN
(Squalimorphii) 		5 / 11 LEU A 648
LEU A 525
ALA A 627
LEU A 584
TYR A 631
 None
 1.15A 4wg0F-5tubA:
undetectable
4wg0G-5tubA:
undetectable
4wg0H-5tubA:
undetectable		 4wg0F-5tubA:
3.17
4wg0G-5tubA:
3.17
4wg0H-5tubA:
3.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_H_CHDH103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5tub SHARK TBC1D15
GTPASE-ACTIVATING
PROTEIN
(Squalimorphii) 		5 / 11 LEU A 648
LEU A 525
ALA A 627
LEU A 584
TYR A 631
 None
 1.16A 4wg0H-5tubA:
undetectable
4wg0I-5tubA:
undetectable
4wg0J-5tubA:
undetectable		 4wg0H-5tubA:
3.17
4wg0I-5tubA:
3.17
4wg0J-5tubA:
3.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_I_CHDI103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5tub SHARK TBC1D15
GTPASE-ACTIVATING
PROTEIN
(Squalimorphii) 		5 / 11 ALA A 627
LEU A 584
TYR A 631
LEU A 525
LEU A 648
 None
 1.16A 4wg0G-5tubA:
undetectable
4wg0H-5tubA:
undetectable
4wg0I-5tubA:
undetectable		 4wg0G-5tubA:
3.17
4wg0H-5tubA:
3.17
4wg0I-5tubA:
3.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_J_CHDJ103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5tub SHARK TBC1D15
GTPASE-ACTIVATING
PROTEIN
(Squalimorphii) 		5 / 11 LEU A 648
LEU A 525
ALA A 627
LEU A 584
TYR A 631
 None
 1.17A 4wg0J-5tubA:
undetectable
4wg0K-5tubA:
undetectable
4wg0L-5tubA:
undetectable		 4wg0J-5tubA:
3.17
4wg0K-5tubA:
3.17
4wg0L-5tubA:
3.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_K_CHDK103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5tub SHARK TBC1D15
GTPASE-ACTIVATING
PROTEIN
(Squalimorphii) 		5 / 11 ALA A 627
LEU A 584
TYR A 631
LEU A 525
LEU A 648
 None
 1.15A 4wg0I-5tubA:
undetectable
4wg0J-5tubA:
undetectable
4wg0K-5tubA:
undetectable		 4wg0I-5tubA:
3.17
4wg0J-5tubA:
3.17
4wg0K-5tubA:
3.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_M_CHDM103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5tub SHARK TBC1D15
GTPASE-ACTIVATING
PROTEIN
(Squalimorphii) 		5 / 11 ALA A 627
LEU A 584
TYR A 631
LEU A 525
LEU A 648
 None
 1.14A 4wg0K-5tubA:
undetectable
4wg0L-5tubA:
undetectable
4wg0M-5tubA:
undetectable		 4wg0K-5tubA:
3.17
4wg0L-5tubA:
3.17
4wg0M-5tubA:
3.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KI6_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 5tub SHARK TBC1D15
GTPASE-ACTIVATING
PROTEIN
(Squalimorphii) 		4 / 5 CYH A 632
GLN A 633
PRO A 329
ILE A 331
 None
 1.28A 5ki6A-5tubA:
undetectable		 5ki6A-5tubA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I0Y_A_TRPA3001_0
(23S RIBOSOMAL RNA
TRYPTOPHANASE OPERON
LEADER PEPTIDE)		 5tub SHARK TBC1D15
GTPASE-ACTIVATING
PROTEIN
(Squalimorphii) 		3 / 3 TRP A 410
ILE A 459
ASP A 458
 None
 0.85A 6i0y7-5tubA:
undetectable		 6i0y7-5tubA:
5.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN1_A_LLLA302_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE)		 5tub SHARK TBC1D15
GTPASE-ACTIVATING
PROTEIN
(Squalimorphii) 		5 / 10 TYR A 472
ASP A 434
GLY A 475
ASP A 458
SER A 481
 None
 1.30A 6mn1A-5tubA:
undetectable		 6mn1A-5tubA:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N7F_A_RBFA502_0
(PUTATIVE GLUTATHIONE
REDUCTASE (GR))		 5tub SHARK TBC1D15
GTPASE-ACTIVATING
PROTEIN
(Squalimorphii) 		4 / 7 TYR A 536
ASN A 600
GLU A 606
GLY A 603
 None
 0.90A 6n7fA-5tubA:
undetectable		 6n7fA-5tubA:
13.84