SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5tuc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ULV_A_ACRA3000_2 (GLUCODEXTRANASE)	5tuc	SUS TBC1D15 GAP DOMAIN (Sus scrofa)	4 / 5	GLN A 323 TRP A 348 LEU A 334 TRP A 305	None	1.24A	1ulvA-5tucA: undetectable	1ulvA-5tucA: 13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2A7Q_A_CFBA328_2 (DEOXYCYTIDINE KINASE)	5tuc	SUS TBC1D15 GAP DOMAIN (Sus scrofa)	4 / 4	ILE A 528 ASP A 582 LEU A 548 ARG A 335	None	1.33A	2a7qA-5tucA: undetectable	2a7qA-5tucA: 21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BJW_F_SVRF509_3 (PHOSPHOLIPASE A2)	5tuc	SUS TBC1D15 GAP DOMAIN (Sus scrofa)	4 / 7	VAL A 318 LYS A 322 ILE A 325 GLY A 329	None	0.72A	3bjwF-5tucA: undetectable	3bjwF-5tucA: 14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BJW_H_SVRH511_3 (PHOSPHOLIPASE A2)	5tuc	SUS TBC1D15 GAP DOMAIN (Sus scrofa)	4 / 7	VAL A 318 LYS A 322 ILE A 325 GLY A 329	None	0.72A	3bjwH-5tucA: undetectable	3bjwH-5tucA: 14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OLL_A_ESTA600_1 (ESTROGEN RECEPTOR BETA)	5tuc	SUS TBC1D15 GAP DOMAIN (Sus scrofa)	5 / 10	LEU A 488 LEU A 492 GLU A 554 ARG A 291 LEU A 508	None	1.40A	3ollA-5tucA: undetectable	3ollA-5tucA: 22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OLL_B_ESTB600_1 (ESTROGEN RECEPTOR BETA)	5tuc	SUS TBC1D15 GAP DOMAIN (Sus scrofa)	5 / 9	LEU A 488 LEU A 492 GLU A 554 ARG A 291 LEU A 508	None	1.40A	3ollB-5tucA: 0.0	3ollB-5tucA: 22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3QL6_A_NIMA614_1 (LACTOPEROXIDASE)	5tuc	SUS TBC1D15 GAP DOMAIN (Sus scrofa)	4 / 7	GLN A 323 GLU A 584 ARG A 327 PHE A 544	None	1.41A	3ql6A-5tucA: undetectable	3ql6A-5tucA: 19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WNU_A_QDNA602_1 (CYTOCHROME P450 2D6)	5tuc	SUS TBC1D15 GAP DOMAIN (Sus scrofa)	5 / 11	GLY A 438 LEU A 516 GLN A 437 LEU A 393 PHE A 512	None	1.18A	4wnuA-5tucA: undetectable	4wnuA-5tucA: 21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6I0Y_A_TRPA3001_0 (23S RIBOSOMAL RNA TRYPTOPHANASE OPERON LEADER PEPTIDE)	5tuc	SUS TBC1D15 GAP DOMAIN (Sus scrofa)	3 / 3	TRP A 373 ILE A 422 ASP A 421	None	0.83A	6i0y7-5tucA: undetectable	6i0y7-5tucA: 4.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6MN1_A_LLLA302_0 (AMINOGLYCOSIDE N(3)-ACETYLTRANSFERA SE)	5tuc	SUS TBC1D15 GAP DOMAIN (Sus scrofa)	5 / 10	TYR A 435 ASP A 397 GLY A 438 ASP A 421 SER A 444	None	1.29A	6mn1A-5tucA: undetectable	6mn1A-5tucA: 14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6MN1_B_LLLB302_0 (AMINOGLYCOSIDE N(3)-ACETYLTRANSFERA SE)	5tuc	SUS TBC1D15 GAP DOMAIN (Sus scrofa)	5 / 10	TYR A 435 ASP A 397 GLY A 438 ASP A 421 SER A 444	None	1.25A	6mn1B-5tucA: undetectable	6mn1B-5tucA: 14.24

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1ULV_A_ACRA3000_2","GLUCODEXTRANASE","5tuc","SUS TBC1D15 GAP DOMAIN","Sus scrofa",4,"GLN A 323;TRP A 348;LEU A 334;TRP A 305","None","1.24A","1ulvA-5tucA:undetectable","1ulvA-5tucA:13.37"],["2A7Q_A_CFBA328_2","DEOXYCYTIDINE KINASE","5tuc","SUS TBC1D15 GAP DOMAIN","Sus scrofa",4,"ILE A 528;ASP A 582;LEU A 548;ARG A 335","None","1.33A","2a7qA-5tucA:undetectable","2a7qA-5tucA:21.53"],["3BJW_F_SVRF509_3","PHOSPHOLIPASE A2","5tuc","SUS TBC1D15 GAP DOMAIN","Sus scrofa",4,"VAL A 318;LYS A 322;ILE A 325;GLY A 329","None","0.72A","3bjwF-5tucA:undetectable","3bjwF-5tucA:14.61"],["3BJW_H_SVRH511_3","PHOSPHOLIPASE A2","5tuc","SUS TBC1D15 GAP DOMAIN","Sus scrofa",4,"VAL A 318;LYS A 322;ILE A 325;GLY A 329","None","0.72A","3bjwH-5tucA:undetectable","3bjwH-5tucA:14.61"],["3OLL_A_ESTA600_1","ESTROGEN RECEPTOR BETA","5tuc","SUS TBC1D15 GAP DOMAIN","Sus scrofa",5,"LEU A 488;LEU A 492;GLU A 554;ARG A 291;LEU A 508","None","1.40A","3ollA-5tucA:undetectable","3ollA-5tucA:22.06"],["3OLL_B_ESTB600_1","ESTROGEN RECEPTOR BETA","5tuc","SUS TBC1D15 GAP DOMAIN","Sus scrofa",5,"LEU A 488;LEU A 492;GLU A 554;ARG A 291;LEU A 508","None","1.40A","3ollB-5tucA:0.0","3ollB-5tucA:22.06"],["3QL6_A_NIMA614_1","LACTOPEROXIDASE","5tuc","SUS TBC1D15 GAP DOMAIN","Sus scrofa",4,"GLN A 323;GLU A 584;ARG A 327;PHE A 544","None","1.41A","3ql6A-5tucA:undetectable","3ql6A-5tucA:19.73"],["4WNU_A_QDNA602_1","CYTOCHROME P450 2D6","5tuc","SUS TBC1D15 GAP DOMAIN","Sus scrofa",5,"GLY A 438;LEU A 516;GLN A 437;LEU A 393;PHE A 512","None","1.18A","4wnuA-5tucA:undetectable","4wnuA-5tucA:21.34"],["6I0Y_A_TRPA3001_0","23S RIBOSOMAL RNA;TRYPTOPHANASE OPERON LEADER PEPTIDE","5tuc","SUS TBC1D15 GAP DOMAIN","Sus scrofa",3,"TRP A 373;ILE A 422;ASP A 421","None","0.83A","6i0y7-5tucA:undetectable","6i0y7-5tucA:4.48"],["6MN1_A_LLLA302_0","AMINOGLYCOSIDE N(3)-ACETYLTRANSFERASE","5tuc","SUS TBC1D15 GAP DOMAIN","Sus scrofa",5,"TYR A 435;ASP A 397;GLY A 438;ASP A 421;SER A 444","None","1.29A","6mn1A-5tucA:undetectable","6mn1A-5tucA:14.24"],["6MN1_B_LLLB302_0","AMINOGLYCOSIDE N(3)-ACETYLTRANSFERASE","5tuc","SUS TBC1D15 GAP DOMAIN","Sus scrofa",5,"TYR A 435;ASP A 397;GLY A 438;ASP A 421;SER A 444","None","1.25A","6mn1B-5tucA:undetectable","6mn1B-5tucA:14.24"]]