SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5tuf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA154_1
(CALMODULIN)		 5tuf TETRACYCLINE
DESTRUCTASE TET(50)
(uncultured
bacterium) 		4 / 7 LEU A 297
MET A 222
LEU A 205
GLU A 200
 None
 1.00A 1linA-5tufA:
undetectable		 1linA-5tufA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5tuf TETRACYCLINE
DESTRUCTASE TET(50)
(uncultured
bacterium) 		5 / 12 ALA A 291
TYR A 330
PHE A 167
GLY A 288
ILE A 287
 None
None
None
FAD  A 405 (-3.2A)
None
 1.30A 2dcfA-5tufA:
undetectable		 2dcfA-5tufA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA508_0
(CHORISMATE SYNTHASE)		 5tuf TETRACYCLINE
DESTRUCTASE TET(50)
(uncultured
bacterium) 		4 / 5 LEU A 286
ASP A 156
ALA A 290
ILE A 284
 None
 1.04A 2qhfA-5tufA:
undetectable		 2qhfA-5tufA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM7_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5tuf TETRACYCLINE
DESTRUCTASE TET(50)
(uncultured
bacterium) 		5 / 10 ALA A 291
TYR A 330
PHE A 167
GLY A 288
ILE A 287
 None
None
None
FAD  A 405 (-3.2A)
None
 1.30A 2zm7A-5tufA:
undetectable		 2zm7A-5tufA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMA_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5tuf TETRACYCLINE
DESTRUCTASE TET(50)
(uncultured
bacterium) 		5 / 11 ALA A 291
TYR A 330
PHE A 167
GLY A 288
ILE A 287
 None
None
None
FAD  A 405 (-3.2A)
None
 1.31A 2zmaA-5tufA:
undetectable		 2zmaA-5tufA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_A_SAMA301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 5tuf TETRACYCLINE
DESTRUCTASE TET(50)
(uncultured
bacterium) 		5 / 12 TRP A 279
PRO A 385
GLY A 308
ILE A 153
LEU A 312
 None
 1.26A 3iv6A-5tufA:
2.8		 3iv6A-5tufA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_C_SAMC301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 5tuf TETRACYCLINE
DESTRUCTASE TET(50)
(uncultured
bacterium) 		5 / 12 TRP A 279
PRO A 385
GLY A 308
ILE A 153
LEU A 312
 None
 1.19A 3iv6C-5tufA:
2.7		 3iv6C-5tufA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_D_MXMD606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5tuf TETRACYCLINE
DESTRUCTASE TET(50)
(uncultured
bacterium) 		5 / 12 ILE A  51
LEU A 334
LEU A 384
TRP A 279
ALA A 309
 None
 1.31A 4m11D-5tufA:
undetectable		 4m11D-5tufA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_A_MRVA1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 5tuf TETRACYCLINE
DESTRUCTASE TET(50)
(uncultured
bacterium) 		4 / 7 LEU A 174
THR A 272
THR A 162
MET A 165
 None
 1.08A 4mbsA-5tufA:
undetectable		 4mbsA-5tufA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN)		 5tuf TETRACYCLINE
DESTRUCTASE TET(50)
(uncultured
bacterium) 		5 / 12 ARG A  49
GLY A 345
ALA A 373
MET A 374
PHE A 344
 FAD  A 405 ( 4.6A)
None
None
None
None
 1.11A 4r29B-5tufA:
0.8		 4r29B-5tufA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZO1_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 5tuf TETRACYCLINE
DESTRUCTASE TET(50)
(uncultured
bacterium) 		5 / 12 ILE A 186
ALA A 217
LEU A 190
ASN A 188
PHE A 184
 None
 1.30A 4zo1X-5tufA:
undetectable		 4zo1X-5tufA:
23.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TUI_B_CTCB405_0
(TETRACYCLINE
DESTRUCTASE TET(50))		 5tuf TETRACYCLINE
DESTRUCTASE TET(50)
(uncultured
bacterium) 		12 / 12 GLY A  94
PHE A  95
GLU A 102
VAL A 181
LEU A 198
THR A 207
GLY A 220
PRO A 296
GLY A 299
PHE A 344
VAL A 348
ILE A 371
 None
SO4  A 403 ( 4.8A)
None
FAD  A 405 ( 4.9A)
None
None
None
FAD  A 405 ( 4.2A)
SO4  A 403 ( 3.5A)
None
None
None
 0.40A 5tuiB-5tufA:
60.9		 5tuiB-5tufA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TUI_B_CTCB405_1
(TETRACYCLINE
DESTRUCTASE TET(50))		 5tuf TETRACYCLINE
DESTRUCTASE TET(50)
(uncultured
bacterium) 		5 / 5 ASP A  47
ARG A  49
ARG A  96
LEU A 205
MET A 222
 FAD  A 405 (-3.0A)
FAD  A 405 ( 4.6A)
None
None
None
 0.71A 5tuiB-5tufA:
60.9		 5tuiB-5tufA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V5Z_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5tuf TETRACYCLINE
DESTRUCTASE TET(50)
(uncultured
bacterium) 		3 / 3 GLY A  16
THR A   2
PRO A  30
 None
 0.62A 5v5zA-5tufA:
undetectable		 5v5zA-5tufA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA902_0
(MRNA CAPPING ENZYME
P5)		 5tuf TETRACYCLINE
DESTRUCTASE TET(50)
(uncultured
bacterium) 		5 / 12 GLY A  11
ALA A 290
PRO A  17
VAL A  39
PHE A 123
 FAD  A 405 (-3.3A)
None
None
None
None
 1.23A 5x6yA-5tufA:
undetectable		 5x6yA-5tufA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IEY_A_CLMA401_0
(ESTERASE)		 5tuf TETRACYCLINE
DESTRUCTASE TET(50)
(uncultured
bacterium) 		5 / 11 ILE A   5
ALA A 326
LEU A 312
GLY A 314
PHE A  28
 None
 1.25A 6ieyA-5tufA:
undetectable
6ieyB-5tufA:
undetectable		 6ieyA-5tufA:
21.93
6ieyB-5tufA:
21.93