SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5tuk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4G_B_ZMRB466_2
(NEURAMINIDASE)		 5tuk TETRACYCLINE
DESTRUCTASE TET(51)
(uncultured
bacterium) 		3 / 3 ASP A  47
ARG A  49
ILE A 374
 None
 0.90A 1a4gB-5tukA:
undetectable		 1a4gB-5tukA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_0
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)		 5tuk TETRACYCLINE
DESTRUCTASE TET(51)
(uncultured
bacterium) 		5 / 12 ALA A 285
PHE A 167
ARG A 163
GLY A 291
LEU A  32
 None
 1.23A 1kglA-5tukA:
undetectable		 1kglA-5tukA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_D_DIFD3701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5tuk TETRACYCLINE
DESTRUCTASE TET(51)
(uncultured
bacterium) 		5 / 10 TYR A 330
LEU A  32
VAL A  19
GLY A  16
ALA A  15
 None
None
None
None
FAD  A 402 (-3.5A)
 1.20A 1pxxD-5tukA:
undetectable		 1pxxD-5tukA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_1
(HEMK PROTEIN)		 5tuk TETRACYCLINE
DESTRUCTASE TET(51)
(uncultured
bacterium) 		3 / 3 ASP A 289
PHE A 271
ASN A 341
 FAD  A 402 (-3.0A)
None
None
 0.78A 1sg9B-5tukA:
undetectable		 1sg9B-5tukA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_B_SAMB600_0
(PCZA361.24)		 5tuk TETRACYCLINE
DESTRUCTASE TET(51)
(uncultured
bacterium) 		5 / 12 ALA A  15
GLY A  13
LEU A 108
SER A 302
GLY A 301
 FAD  A 402 (-3.5A)
FAD  A 402 (-3.2A)
None
FAD  A 402 (-3.4A)
FAD  A 402 (-3.0A)
 1.05A 3g2oB-5tukA:
undetectable		 3g2oB-5tukA:
25.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LBD_A_9CRA424_1
(RETINOIC ACID
RECEPTOR GAMMA)		 5tuk TETRACYCLINE
DESTRUCTASE TET(51)
(uncultured
bacterium) 		5 / 12 ALA A 155
ILE A  14
ARG A 105
ALA A 313
ILE A 153
 None
FAD  A 402 (-3.6A)
FAD  A 402 (-3.4A)
None
None
 0.98A 3lbdA-5tukA:
undetectable		 3lbdA-5tukA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UR0_C_SVRC516_1
(RNA-DEPENDENT RNA
POLYMERASE)		 5tuk TETRACYCLINE
DESTRUCTASE TET(51)
(uncultured
bacterium) 		5 / 9 PRO A  17
GLY A  11
ALA A  12
ARG A  40
LEU A  39
 None
FAD  A 402 (-3.2A)
FAD  A 402 (-4.9A)
FAD  A 402 (-3.0A)
None
 1.30A 3ur0C-5tukA:
undetectable		 3ur0C-5tukA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1001_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 5tuk TETRACYCLINE
DESTRUCTASE TET(51)
(uncultured
bacterium) 		3 / 3 ASP A 168
LYS A 169
ASP A 170
 None
 0.79A 4a7tA-5tukA:
undetectable		 4a7tA-5tukA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_B_20JB601_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 5tuk TETRACYCLINE
DESTRUCTASE TET(51)
(uncultured
bacterium) 		4 / 7 ASP A 265
SER A 185
ALA A 183
SER A 182
 None
None
FAD  A 402 ( 3.7A)
None
 1.22A 4lv9A-5tukA:
undetectable
4lv9B-5tukA:
undetectable		 4lv9A-5tukA:
21.00
4lv9B-5tukA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_A_MRVA1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 5tuk TETRACYCLINE
DESTRUCTASE TET(51)
(uncultured
bacterium) 		4 / 7 LEU A 174
THR A 272
THR A 162
MET A 165
 None
 1.07A 4mbsA-5tukA:
undetectable		 4mbsA-5tukA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZO1_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 5tuk TETRACYCLINE
DESTRUCTASE TET(51)
(uncultured
bacterium) 		5 / 12 ILE A 186
ALA A 217
LEU A 190
ASN A 188
PHE A 184
 None
GOL  A 401 ( 4.8A)
None
None
None
 1.33A 4zo1X-5tukA:
undetectable		 4zo1X-5tukA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_B_SAMB401_0
(PAVINE
N-METHYLTRANSFERASE)		 5tuk TETRACYCLINE
DESTRUCTASE TET(51)
(uncultured
bacterium) 		5 / 12 SER A 302
GLY A  16
GLY A  13
VAL A   9
ALA A 305
 FAD  A 402 (-3.4A)
None
FAD  A 402 (-3.2A)
None
FAD  A 402 ( 3.5A)
 1.10A 5kpcB-5tukA:
undetectable		 5kpcB-5tukA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE0_A_XINA401_2
(AP2-ASSOCIATED
PROTEIN KINASE 1)		 5tuk TETRACYCLINE
DESTRUCTASE TET(51)
(uncultured
bacterium) 		4 / 5 LEU A 112
VAL A 109
CYH A  20
CYH A 121
 None
 1.27A 5te0A-5tukA:
undetectable		 5te0A-5tukA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_G_CVIG301_1
(REGULATORY PROTEIN
TETR)		 5tuk TETRACYCLINE
DESTRUCTASE TET(51)
(uncultured
bacterium) 		4 / 7 GLY A  16
TYR A 267
ASP A 289
TYR A 292
 None
FAD  A 402 (-3.7A)
FAD  A 402 (-3.0A)
None
 1.21A 5vlmG-5tukA:
undetectable		 5vlmG-5tukA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_B_BEZB201_0
(NS3 PROTEASE)		 5tuk TETRACYCLINE
DESTRUCTASE TET(51)
(uncultured
bacterium) 		4 / 5 HIS A  44
ALA A 209
SER A 207
GLY A 220
 FAD  A 402 (-3.8A)
GOL  A 401 (-4.2A)
None
None
 1.29A 5yodB-5tukA:
undetectable		 5yodB-5tukA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0I_B_TA1B502_1
(TUBULIN BETA CHAIN)		 5tuk TETRACYCLINE
DESTRUCTASE TET(51)
(uncultured
bacterium) 		5 / 12 VAL A 287
LEU A 108
LEU A 306
ALA A 309
GLY A  11
 None
None
None
None
FAD  A 402 (-3.2A)
 1.06A 6b0iB-5tukA:
undetectable		 6b0iB-5tukA:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HZP_A_FVTA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)		 5tuk TETRACYCLINE
DESTRUCTASE TET(51)
(uncultured
bacterium) 		4 / 8 VAL A 348
GLN A 304
ASN A 341
ILE A 374
 None
 1.12A 6hzpA-5tukA:
undetectable		 6hzpA-5tukA:
22.38