SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5tul'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_C_IPHC802_0
(PHENOL HYDROXYLASE)		 5tul TETRACYCLINE
DESTRUCTASE TET(55)
(uncultured
bacterium) 		5 / 10 GLY A 301
ILE A  46
ARG A 105
TYR A  44
GLY A 299
 None
None
PO4  A 401 (-3.2A)
None
None
 1.41A 1fohC-5tulA:
27.6		 1fohC-5tulA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_D_IPHD802_0
(PHENOL HYDROXYLASE)		 5tul TETRACYCLINE
DESTRUCTASE TET(55)
(uncultured
bacterium) 		5 / 10 ASP A  47
GLY A 299
ARG A 105
ILE A  46
GLY A 301
 None
None
PO4  A 401 (-3.2A)
None
None
 1.40A 1fohD-5tulA:
27.6		 1fohD-5tulA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_D_IPHD802_0
(PHENOL HYDROXYLASE)		 5tul TETRACYCLINE
DESTRUCTASE TET(55)
(uncultured
bacterium) 		5 / 10 GLY A 301
ILE A  46
ARG A 105
TYR A  44
GLY A 299
 None
None
PO4  A 401 (-3.2A)
None
None
 1.41A 1fohD-5tulA:
27.6		 1fohD-5tulA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HA2_A_SWFA3001_1
(SERUM ALBUMIN)		 5tul TETRACYCLINE
DESTRUCTASE TET(55)
(uncultured
bacterium) 		5 / 11 ALA A  18
LEU A 112
LEU A 306
LEU A  48
ILE A  46
 None
 1.06A 1ha2A-5tulA:
undetectable		 1ha2A-5tulA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_0
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)		 5tul TETRACYCLINE
DESTRUCTASE TET(55)
(uncultured
bacterium) 		5 / 12 ALA A 285
PHE A 167
ARG A 163
GLY A 291
LEU A  32
 None
 1.24A 1kglA-5tulA:
undetectable		 1kglA-5tulA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_A_STIA3_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5tul TETRACYCLINE
DESTRUCTASE TET(55)
(uncultured
bacterium) 		4 / 5 TYR A  26
VAL A  33
ILE A 119
MET A  59
 None
 1.17A 1opjA-5tulA:
undetectable		 1opjA-5tulA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_C_DIFC2701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5tul TETRACYCLINE
DESTRUCTASE TET(55)
(uncultured
bacterium) 		5 / 12 TYR A 292
LEU A  32
GLY A  16
ALA A  15
SER A  13
 None
None
None
PO4  A 401 (-3.5A)
PO4  A 401 (-3.5A)
 1.05A 1pxxC-5tulA:
undetectable		 1pxxC-5tulA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_D_DIFD3701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5tul TETRACYCLINE
DESTRUCTASE TET(55)
(uncultured
bacterium) 		5 / 10 TYR A 292
LEU A  32
GLY A  16
ALA A  15
SER A  13
 None
None
None
PO4  A 401 (-3.5A)
PO4  A 401 (-3.5A)
 1.06A 1pxxD-5tulA:
undetectable		 1pxxD-5tulA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_B_DESB459_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 5tul TETRACYCLINE
DESTRUCTASE TET(55)
(uncultured
bacterium) 		5 / 12 LEU A 306
LEU A 312
ALA A 313
LEU A  23
VAL A   9
 None
 0.97A 1s9pB-5tulA:
undetectable		 1s9pB-5tulA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_C_DESC500_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 5tul TETRACYCLINE
DESTRUCTASE TET(55)
(uncultured
bacterium) 		5 / 12 LEU A 306
LEU A 312
ALA A 313
LEU A  23
VAL A   9
 None
 0.96A 1s9pC-5tulA:
undetectable		 1s9pC-5tulA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KAW_A_SUZA91_1
(SEGMENT POLARITY
PROTEIN DISHEVELLED
HOMOLOG DVL-1)		 5tul TETRACYCLINE
DESTRUCTASE TET(55)
(uncultured
bacterium) 		5 / 11 GLY A  60
ILE A  61
SER A  64
VAL A 101
LEU A  48
 None
 0.98A 2kawA-5tulA:
undetectable		 2kawA-5tulA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_A_SNLA1001_2
(MINERALOCORTICOID
RECEPTOR)		 5tul TETRACYCLINE
DESTRUCTASE TET(55)
(uncultured
bacterium) 		4 / 5 LEU A 306
ALA A 309
LEU A  19
MET A 113
 None
 1.20A 2oaxA-5tulA:
undetectable		 2oaxA-5tulA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA508_0
(CHORISMATE SYNTHASE)		 5tul TETRACYCLINE
DESTRUCTASE TET(55)
(uncultured
bacterium) 		4 / 5 LEU A 286
ASP A 156
ALA A 290
ILE A 284
 None
 1.01A 2qhfA-5tulA:
undetectable		 2qhfA-5tulA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_E_SAME1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 5tul TETRACYCLINE
DESTRUCTASE TET(55)
(uncultured
bacterium) 		5 / 12 GLY A  16
ILE A 153
ALA A 309
THR A  39
GLU A  34
 None
 1.26A 2vdvE-5tulA:
2.1		 2vdvE-5tulA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_F_SAMF1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 5tul TETRACYCLINE
DESTRUCTASE TET(55)
(uncultured
bacterium) 		5 / 11 GLY A  16
ILE A 153
ALA A 309
THR A  39
GLU A  34
 None
 1.25A 2vdvF-5tulA:
2.2		 2vdvF-5tulA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_B_SAMB300_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 5tul TETRACYCLINE
DESTRUCTASE TET(55)
(uncultured
bacterium) 		5 / 12 LEU A 312
GLY A 288
GLY A 308
VAL A 337
ALA A 155
 None
PO4  A 401 (-3.3A)
None
None
PO4  A 401 (-4.5A)
 1.06A 3dh0B-5tulA:
undetectable		 3dh0B-5tulA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQT_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5tul TETRACYCLINE
DESTRUCTASE TET(55)
(uncultured
bacterium) 		4 / 7 TRP A 346
PHE A 343
GLU A 349
SER A 350
 None
 1.26A 3dqtA-5tulA:
undetectable
3dqtB-5tulA:
1.6		 3dqtA-5tulA:
23.08
3dqtB-5tulA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_C_SAMC301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 5tul TETRACYCLINE
DESTRUCTASE TET(55)
(uncultured
bacterium) 		5 / 12 TRP A 279
PRO A 383
GLY A 308
ILE A 153
LEU A 312
 None
 1.22A 3iv6C-5tulA:
undetectable		 3iv6C-5tulA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX1_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5tul TETRACYCLINE
DESTRUCTASE TET(55)
(uncultured
bacterium) 		4 / 8 TRP A 346
PHE A 343
GLU A 349
SER A 350
 None
 1.27A 3jx1A-5tulA:
undetectable
3jx1B-5tulA:
undetectable		 3jx1A-5tulA:
21.51
3jx1B-5tulA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5T_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 5tul TETRACYCLINE
DESTRUCTASE TET(55)
(uncultured
bacterium) 		4 / 7 SER A 350
TRP A 346
PHE A 343
GLU A 349
 None
 1.20A 3n5tA-5tulA:
undetectable
3n5tB-5tulA:
undetectable		 3n5tA-5tulA:
22.88
3n5tB-5tulA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N61_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE)		 5tul TETRACYCLINE
DESTRUCTASE TET(55)
(uncultured
bacterium) 		4 / 7 TRP A 346
PHE A 343
GLU A 349
SER A 350
 None
 1.24A 3n61A-5tulA:
undetectable
3n61B-5tulA:
undetectable		 3n61A-5tulA:
21.29
3n61B-5tulA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_B_URFB400_1
(URIDINE
PHOSPHORYLASE 1)		 5tul TETRACYCLINE
DESTRUCTASE TET(55)
(uncultured
bacterium) 		4 / 8 THR A 293
GLY A 157
ARG A  40
LEU A 158
 None
PO4  A 401 (-3.5A)
None
None
 0.91A 3nbqB-5tulA:
undetectable		 3nbqB-5tulA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_C_URFC400_1
(URIDINE
PHOSPHORYLASE 1)		 5tul TETRACYCLINE
DESTRUCTASE TET(55)
(uncultured
bacterium) 		4 / 8 THR A 293
GLY A 157
ARG A  40
LEU A 158
 None
PO4  A 401 (-3.5A)
None
None
 0.89A 3nbqC-5tulA:
undetectable		 3nbqC-5tulA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLY_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5tul TETRACYCLINE
DESTRUCTASE TET(55)
(uncultured
bacterium) 		4 / 8 TRP A 346
PHE A 343
GLU A 349
SER A 350
 None
 1.22A 3nlyA-5tulA:
undetectable
3nlyB-5tulA:
undetectable		 3nlyA-5tulA:
21.55
3nlyB-5tulA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQL_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5tul TETRACYCLINE
DESTRUCTASE TET(55)
(uncultured
bacterium) 		4 / 8 TRP A 346
PHE A 343
GLU A 349
SER A 350
 None
 1.23A 3rqlA-5tulA:
1.5
3rqlB-5tulA:
undetectable		 3rqlA-5tulA:
21.55
3rqlB-5tulA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_D_CVID301_0
(PUTATIVE REGULATORY
PROTEIN)		 5tul TETRACYCLINE
DESTRUCTASE TET(55)
(uncultured
bacterium) 		5 / 12 LEU A  19
CYH A  20
ILE A   7
ALA A 290
VAL A 137
 None
 1.12A 3vw1D-5tulA:
undetectable		 3vw1D-5tulA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_B_ACHB301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5tul TETRACYCLINE
DESTRUCTASE TET(55)
(uncultured
bacterium) 		4 / 8 TYR A  26
TYR A 310
TYR A 385
ARG A 328
 None
 1.49A 3wipB-5tulA:
undetectable
3wipC-5tulA:
undetectable		 3wipB-5tulA:
18.18
3wipC-5tulA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_C_PXLC300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 5tul TETRACYCLINE
DESTRUCTASE TET(55)
(uncultured
bacterium) 		4 / 8 GLY A 291
ASP A 289
GLY A 288
VAL A 337
 None
PO4  A 401 (-4.2A)
PO4  A 401 (-3.3A)
None
 0.88A 4c5nC-5tulA:
undetectable		 4c5nC-5tulA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CAP_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5tul TETRACYCLINE
DESTRUCTASE TET(55)
(uncultured
bacterium) 		4 / 8 TRP A 346
PHE A 343
GLU A 349
SER A 350
 None
 1.22A 4capA-5tulA:
undetectable
4capB-5tulA:
undetectable		 4capA-5tulA:
21.55
4capB-5tulA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_C_H4BC600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5tul TETRACYCLINE
DESTRUCTASE TET(55)
(uncultured
bacterium) 		4 / 8 SER A 350
TRP A 346
PHE A 343
GLU A 349
 None
 1.26A 4cx7C-5tulA:
undetectable
4cx7D-5tulA:
undetectable		 4cx7C-5tulA:
21.58
4cx7D-5tulA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D32_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5tul TETRACYCLINE
DESTRUCTASE TET(55)
(uncultured
bacterium) 		4 / 8 TRP A 346
PHE A 343
GLU A 349
SER A 350
 None
 1.23A 4d32A-5tulA:
undetectable
4d32B-5tulA:
undetectable		 4d32A-5tulA:
21.55
4d32B-5tulA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5J_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5tul TETRACYCLINE
DESTRUCTASE TET(55)
(uncultured
bacterium) 		4 / 7 TRP A 346
PHE A 343
GLU A 349
SER A 350
 None
 1.22A 4k5jA-5tulA:
undetectable
4k5jB-5tulA:
undetectable		 4k5jA-5tulA:
22.93
4k5jB-5tulA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8Z_A_BBIA402_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 5tul TETRACYCLINE
DESTRUCTASE TET(55)
(uncultured
bacterium) 		4 / 5 PHE A 223
HIS A 249
LEU A 199
PRO A 356
 None
 1.40A 4o8zA-5tulA:
2.9		 4o8zA-5tulA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRX_A_LURA706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5tul TETRACYCLINE
DESTRUCTASE TET(55)
(uncultured
bacterium) 		5 / 12 TYR A 292
LEU A  32
GLY A  16
ALA A  15
SER A  13
 None
None
None
PO4  A 401 (-3.5A)
PO4  A 401 (-3.5A)
 1.11A 4rrxA-5tulA:
undetectable		 4rrxA-5tulA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRX_B_LURB706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5tul TETRACYCLINE
DESTRUCTASE TET(55)
(uncultured
bacterium) 		5 / 12 TYR A 292
LEU A  32
GLY A  16
ALA A  15
SER A  13
 None
None
None
PO4  A 401 (-3.5A)
PO4  A 401 (-3.5A)
 1.11A 4rrxB-5tulA:
undetectable		 4rrxB-5tulA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_B_478B101_1
(HIV-1 PROTEASE)		 5tul TETRACYCLINE
DESTRUCTASE TET(55)
(uncultured
bacterium) 		5 / 11 LEU A 151
VAL A   9
GLY A 308
ILE A 311
ILE A 153
 None
 0.93A 4rvjA-5tulA:
undetectable		 4rvjA-5tulA:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_D_478D101_1
(HIV-1 PROTEASE)		 5tul TETRACYCLINE
DESTRUCTASE TET(55)
(uncultured
bacterium) 		5 / 11 LEU A 151
VAL A   9
GLY A 308
ILE A 311
ILE A 153
 None
 0.93A 4rvjC-5tulA:
undetectable		 4rvjC-5tulA:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V3Y_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5tul TETRACYCLINE
DESTRUCTASE TET(55)
(uncultured
bacterium) 		4 / 8 TRP A 346
PHE A 343
GLU A 349
SER A 350
 None
 1.22A 4v3yA-5tulA:
undetectable
4v3yB-5tulA:
undetectable		 4v3yA-5tulA:
21.55
4v3yB-5tulA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 5tul TETRACYCLINE
DESTRUCTASE TET(55)
(uncultured
bacterium) 		5 / 12 SER A 358
VAL A  78
ALA A 353
LEU A 205
THR A 197
 None
 1.23A 4x1kA-5tulA:
undetectable
4x1kB-5tulA:
undetectable		 4x1kA-5tulA:
23.11
4x1kB-5tulA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZO1_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 5tul TETRACYCLINE
DESTRUCTASE TET(55)
(uncultured
bacterium) 		5 / 12 ILE A 186
ALA A 217
LEU A 190
ASN A 188
PHE A 184
 None
 1.18A 4zo1X-5tulA:
undetectable		 4zo1X-5tulA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADL_B_H4BB600_1
(ENDOTHELIAL NITRIC
OXIDE SYNTHASE)		 5tul TETRACYCLINE
DESTRUCTASE TET(55)
(uncultured
bacterium) 		4 / 7 TRP A 346
PHE A 343
GLU A 349
SER A 350
 None
 1.21A 5adlA-5tulA:
undetectable
5adlB-5tulA:
undetectable		 5adlA-5tulA:
22.93
5adlB-5tulA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FJ3_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5tul TETRACYCLINE
DESTRUCTASE TET(55)
(uncultured
bacterium) 		4 / 7 TRP A 346
PHE A 343
GLU A 349
SER A 350
 None
 1.25A 5fj3A-5tulA:
undetectable
5fj3B-5tulA:
undetectable		 5fj3A-5tulA:
22.93
5fj3B-5tulA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5tul TETRACYCLINE
DESTRUCTASE TET(55)
(uncultured
bacterium) 		5 / 12 TYR A 292
LEU A  32
GLY A  16
ALA A  15
SER A  13
 None
None
None
PO4  A 401 (-3.5A)
PO4  A 401 (-3.5A)
 0.98A 5ikqA-5tulA:
undetectable		 5ikqA-5tulA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_B_JMSB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5tul TETRACYCLINE
DESTRUCTASE TET(55)
(uncultured
bacterium) 		5 / 12 TYR A 292
LEU A  32
GLY A  16
ALA A  15
SER A  13
 None
None
None
PO4  A 401 (-3.5A)
PO4  A 401 (-3.5A)
 1.02A 5ikqB-5tulA:
undetectable		 5ikqB-5tulA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA607_1
(PHIAB6 TAILSPIKE)		 5tul TETRACYCLINE
DESTRUCTASE TET(55)
(uncultured
bacterium) 		3 / 3 THR A  39
SER A  38
TYR A 123
 None
 0.88A 5jsdA-5tulA:
undetectable		 5jsdA-5tulA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_C_1GNC608_1
(PHIAB6 TAILSPIKE)		 5tul TETRACYCLINE
DESTRUCTASE TET(55)
(uncultured
bacterium) 		3 / 3 THR A  39
SER A  38
TYR A 123
 None
 0.88A 5jsdC-5tulA:
undetectable		 5jsdC-5tulA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_C_1GNC611_1
(PHIAB6 TAILSPIKE)		 5tul TETRACYCLINE
DESTRUCTASE TET(55)
(uncultured
bacterium) 		3 / 3 THR A  39
SER A  38
TYR A 123
 None
 0.89A 5jseC-5tulA:
undetectable		 5jseC-5tulA:
23.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TUI_B_CTCB405_0
(TETRACYCLINE
DESTRUCTASE TET(50))		 5tul TETRACYCLINE
DESTRUCTASE TET(55)
(uncultured
bacterium) 		6 / 12 GLU A 102
GLY A 220
PRO A 296
GLY A 299
PHE A 343
VAL A 347
 None
 0.40A 5tuiB-5tulA:
53.0		 5tuiB-5tulA:
62.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO7_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5tul TETRACYCLINE
DESTRUCTASE TET(55)
(uncultured
bacterium) 		4 / 8 SER A 350
TRP A 346
PHE A 343
GLU A 349
 None
 1.21A 5uo7A-5tulA:
undetectable
5uo7B-5tulA:
undetectable		 5uo7A-5tulA:
21.00
5uo7B-5tulA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO8_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5tul TETRACYCLINE
DESTRUCTASE TET(55)
(uncultured
bacterium) 		4 / 6 SER A 350
TRP A 346
PHE A 343
GLU A 349
 None
 1.26A 5uo8A-5tulA:
0.0
5uo8B-5tulA:
undetectable		 5uo8A-5tulA:
23.01
5uo8B-5tulA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_G_CVIG301_1
(REGULATORY PROTEIN
TETR)		 5tul TETRACYCLINE
DESTRUCTASE TET(55)
(uncultured
bacterium) 		4 / 7 GLY A  16
TYR A  44
ASP A 289
TYR A 292
 None
None
PO4  A 401 (-4.2A)
None
 1.18A 5vlmG-5tulA:
undetectable		 5vlmG-5tulA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV7_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5tul TETRACYCLINE
DESTRUCTASE TET(55)
(uncultured
bacterium) 		4 / 7 TRP A 346
PHE A 343
GLU A 349
SER A 350
 None
 1.26A 5vv7A-5tulA:
undetectable
5vv7B-5tulA:
1.6		 5vv7A-5tulA:
22.93
5vv7B-5tulA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_B_H4BB501_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5tul TETRACYCLINE
DESTRUCTASE TET(55)
(uncultured
bacterium) 		4 / 7 SER A 350
TRP A 346
PHE A 343
GLU A 349
 None
 1.25A 6av6A-5tulA:
undetectable
6av6B-5tulA:
undetectable		 6av6A-5tulA:
10.84
6av6B-5tulA:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_D_H4BD502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5tul TETRACYCLINE
DESTRUCTASE TET(55)
(uncultured
bacterium) 		4 / 7 TRP A 346
PHE A 343
GLU A 349
SER A 350
 None
 1.22A 6av6C-5tulA:
undetectable
6av6D-5tulA:
undetectable		 6av6C-5tulA:
10.84
6av6D-5tulA:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV7_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5tul TETRACYCLINE
DESTRUCTASE TET(55)
(uncultured
bacterium) 		4 / 7 SER A 350
TRP A 346
PHE A 343
GLU A 349
 None
 1.28A 6av7A-5tulA:
undetectable
6av7B-5tulA:
undetectable		 6av7A-5tulA:
10.84
6av7B-5tulA:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5tul TETRACYCLINE
DESTRUCTASE TET(55)
(uncultured
bacterium) 		4 / 5 LEU A 333
TYR A 329
ILE A 116
GLY A 291
 None
 1.08A 6hd6A-5tulA:
undetectable		 6hd6A-5tulA:
10.86