SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5tum'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4G_B_ZMRB466_2
(NEURAMINIDASE)		 5tum TETRACYCLINE
DESTRUCTASE TET(56)
(Legionella
longbeachae) 		3 / 3 ASP A  47
ARG A  49
ILE A 374
 None
 0.58A 1a4gB-5tumA:
undetectable		 1a4gB-5tumA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_B_ADNB1502_1
(CLASS B ACID
PHOSPHATASE)		 5tum TETRACYCLINE
DESTRUCTASE TET(56)
(Legionella
longbeachae) 		4 / 7 PHE A 327
LEU A 316
THR A 328
TYR A 330
 None
 1.19A 1rmtB-5tumA:
undetectable		 1rmtB-5tumA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XL6_B_SPMB3001_1
(INWARD RECTIFIER
POTASSIUM CHANNEL)		 5tum TETRACYCLINE
DESTRUCTASE TET(56)
(Legionella
longbeachae) 		4 / 5 ALA A 313
ALA A 309
TYR A 310
GLN A 385
 None
 0.83A 1xl6A-5tumA:
undetectable
1xl6B-5tumA:
undetectable		 1xl6A-5tumA:
20.38
1xl6B-5tumA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3A_A_TOPA1190_1
(DIHYDROFOLATE
REDUCTASE)		 5tum TETRACYCLINE
DESTRUCTASE TET(56)
(Legionella
longbeachae) 		5 / 11 ILE A  55
ALA A 309
PHE A 306
THR A 115
ILE A 111
 None
 1.25A 2w3aA-5tumA:
undetectable		 2w3aA-5tumA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3A_B_TOPB1189_1
(DIHYDROFOLATE
REDUCTASE)		 5tum TETRACYCLINE
DESTRUCTASE TET(56)
(Legionella
longbeachae) 		5 / 10 ILE A  55
ALA A 309
PHE A 306
THR A 115
ILE A 111
 None
 1.22A 2w3aB-5tumA:
undetectable		 2w3aB-5tumA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 5tum TETRACYCLINE
DESTRUCTASE TET(56)
(Legionella
longbeachae) 		3 / 3 ASN A 209
ASP A 211
ARG A  49
 None
 0.91A 3k13A-5tumA:
undetectable		 3k13A-5tumA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 5tum TETRACYCLINE
DESTRUCTASE TET(56)
(Legionella
longbeachae) 		3 / 3 ASN A 209
ASP A 211
ARG A  49
 None
 0.91A 3k13C-5tumA:
undetectable		 3k13C-5tumA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_A_DSFA319_1
(GLR4197 PROTEIN)		 5tum TETRACYCLINE
DESTRUCTASE TET(56)
(Legionella
longbeachae) 		5 / 9 TYR A 149
ILE A 127
ILE A 162
VAL A 139
ILE A 284
 None
 1.49A 3p4wA-5tumA:
1.7		 3p4wA-5tumA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_A_SUEA1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 5tum TETRACYCLINE
DESTRUCTASE TET(56)
(Legionella
longbeachae) 		4 / 4 PHE A  28
TYR A 323
ILE A  33
LEU A  32
 None
 1.19A 3sudA-5tumA:
undetectable		 3sudA-5tumA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_C_SUEC1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 5tum TETRACYCLINE
DESTRUCTASE TET(56)
(Legionella
longbeachae) 		4 / 5 PHE A  28
TYR A 323
ILE A  33
LEU A  32
 None
 1.12A 3sueC-5tumA:
undetectable		 3sueC-5tumA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5tum TETRACYCLINE
DESTRUCTASE TET(56)
(Legionella
longbeachae) 		5 / 12 LEU A 112
ALA A 305
ILE A  61
ILE A  65
ALA A  52
 None
FAD  A 401 ( 3.1A)
None
None
None
 1.16A 4nkvA-5tumA:
undetectable		 4nkvA-5tumA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5tum TETRACYCLINE
DESTRUCTASE TET(56)
(Legionella
longbeachae) 		5 / 12 LEU A 112
ALA A 305
ILE A  61
ILE A  65
ALA A  52
 None
FAD  A 401 ( 3.1A)
None
None
None
 1.13A 4nkvC-5tumA:
undetectable		 4nkvC-5tumA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5tum TETRACYCLINE
DESTRUCTASE TET(56)
(Legionella
longbeachae) 		5 / 12 LEU A 112
ALA A 305
ILE A  61
ILE A  65
ALA A  52
 None
FAD  A 401 ( 3.1A)
None
None
None
 1.14A 4nkvD-5tumA:
undetectable		 4nkvD-5tumA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN)		 5tum TETRACYCLINE
DESTRUCTASE TET(56)
(Legionella
longbeachae) 		5 / 12 ARG A  49
GLY A 345
ALA A 372
MET A 373
PHE A 344
 None
 1.21A 4r29B-5tumA:
undetectable		 4r29B-5tumA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5tum TETRACYCLINE
DESTRUCTASE TET(56)
(Legionella
longbeachae) 		4 / 6 VAL A 152
MET A 165
ILE A 162
ASP A 156
 None
None
None
FAD  A 401 (-3.8A)
 1.19A 5iwuA-5tumA:
undetectable		 5iwuA-5tumA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_A_PFLA412_1
(PROTON-GATED ION
CHANNEL)		 5tum TETRACYCLINE
DESTRUCTASE TET(56)
(Legionella
longbeachae) 		5 / 10 TYR A 149
ILE A 127
ILE A 162
VAL A 139
ILE A 284
 None
 1.45A 5mzrA-5tumA:
1.7		 5mzrA-5tumA:
10.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_C_PFLC409_1
(PROTON-GATED ION
CHANNEL)		 5tum TETRACYCLINE
DESTRUCTASE TET(56)
(Legionella
longbeachae) 		5 / 10 TYR A 149
ILE A 127
ILE A 162
VAL A 139
ILE A 284
 None
 1.42A 5mzrC-5tumA:
1.5		 5mzrC-5tumA:
10.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 5tum TETRACYCLINE
DESTRUCTASE TET(56)
(Legionella
longbeachae) 		5 / 12 ILE A  51
GLY A  50
VAL A  48
TYR A 310
ILE A 311
 None
 0.96A 5n0sA-5tumA:
undetectable		 5n0sA-5tumA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 5tum TETRACYCLINE
DESTRUCTASE TET(56)
(Legionella
longbeachae) 		5 / 12 ILE A  51
GLY A  50
VAL A  48
TYR A 310
ILE A 311
 None
 0.94A 5n0tA-5tumA:
undetectable		 5n0tA-5tumA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 5tum TETRACYCLINE
DESTRUCTASE TET(56)
(Legionella
longbeachae) 		5 / 12 ILE A  51
GLY A  50
VAL A  48
TYR A 310
ILE A 311
 None
 0.95A 5n0wB-5tumA:
undetectable		 5n0wB-5tumA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4I_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 5tum TETRACYCLINE
DESTRUCTASE TET(56)
(Legionella
longbeachae) 		5 / 12 ILE A  51
GLY A  50
VAL A  48
TYR A 310
ILE A 311
 None
 0.96A 5n4iA-5tumA:
undetectable		 5n4iA-5tumA:
23.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TUI_B_CTCB405_0
(TETRACYCLINE
DESTRUCTASE TET(50))		 5tum TETRACYCLINE
DESTRUCTASE TET(56)
(Legionella
longbeachae) 		5 / 12 GLU A 102
PRO A 296
GLY A 299
PHE A 344
VAL A 348
 None
FAD  A 401 (-3.4A)
None
None
None
 0.66A 5tuiB-5tumA:
50.2		 5tuiB-5tumA:
79.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_G_CVIG301_1
(REGULATORY PROTEIN
TETR)		 5tum TETRACYCLINE
DESTRUCTASE TET(56)
(Legionella
longbeachae) 		4 / 7 GLY A  16
TYR A 267
ASP A 289
TYR A 292
 None
FAD  A 401 (-3.5A)
FAD  A 401 (-2.4A)
None
 1.19A 5vlmG-5tumA:
undetectable		 5vlmG-5tumA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IEY_A_CLMA401_0
(ESTERASE)		 5tum TETRACYCLINE
DESTRUCTASE TET(56)
(Legionella
longbeachae) 		5 / 11 ILE A   5
ALA A 326
LEU A 312
GLY A 314
PHE A  28
 None
 1.26A 6ieyA-5tumA:
undetectable
6ieyB-5tumA:
undetectable		 6ieyA-5tumA:
20.94
6ieyB-5tumA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MHT_D_SAMD328_0
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI)		 5tum TETRACYCLINE
DESTRUCTASE TET(56)
(Legionella
longbeachae) 		5 / 12 LEU A 304
GLY A 308
ASP A 107
ILE A 111
VAL A 287
 None
 1.12A 6mhtA-5tumA:
2.9		 6mhtA-5tumA:
22.70