SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5tus'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_J_TRPJ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5tus RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		4 / 8 SER A 543
GLY A 502
ALA A 539
ILE A 599
 None
 0.80A 1c9sI-5tusA:
undetectable
1c9sJ-5tusA:
undetectable		 1c9sI-5tusA:
7.41
1c9sJ-5tusA:
7.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_U_TRPU81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5tus RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		4 / 8 GLY A 502
ALA A 539
ILE A 599
SER A 543
 None
 0.80A 1c9sU-5tusA:
undetectable
1c9sV-5tusA:
undetectable		 1c9sU-5tusA:
7.41
1c9sV-5tusA:
7.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_A_TRPA81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5tus RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		4 / 7 GLY A 502
ALA A 539
ILE A 599
SER A 543
 None
 0.72A 1gtnA-5tusA:
undetectable
1gtnK-5tusA:
undetectable		 1gtnA-5tusA:
7.41
1gtnK-5tusA:
7.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_F_TRPF81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5tus RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		4 / 8 SER A 543
GLY A 502
ALA A 539
ILE A 599
 None
 0.75A 1gtnE-5tusA:
undetectable
1gtnF-5tusA:
undetectable		 1gtnE-5tusA:
7.41
1gtnF-5tusA:
7.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IIU_A_RTLA176_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 5tus RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		5 / 11 LEU A 578
LEU A 527
ALA A 511
LEU A 466
HIS A 459
 None
 1.25A 1iiuA-5tusA:
undetectable		 1iiuA-5tusA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_A_AG2A7005_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 5tus RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		4 / 6 LEU A 645
ASP A 644
ILE A 513
ARG A 516
 None
 1.01A 1mt1A-5tusA:
undetectable
1mt1F-5tusA:
undetectable		 1mt1A-5tusA:
5.56
1mt1F-5tusA:
9.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_B_AG2B7001_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 5tus RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		4 / 6 ILE A 513
ARG A 516
LEU A 645
ASP A 644
 None
 1.01A 1mt1B-5tusA:
undetectable
1mt1C-5tusA:
undetectable		 1mt1B-5tusA:
9.47
1mt1C-5tusA:
5.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_L_AG2L7014_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 5tus RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		4 / 7 LEU A 645
ASP A 644
ILE A 513
ARG A 516
 None
 1.01A 1n13I-5tusA:
undetectable
1n13L-5tusA:
undetectable		 1n13I-5tusA:
5.56
1n13L-5tusA:
9.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_A_ADNA1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5tus RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		5 / 11 THR A 210
GLY A 177
MET A 170
GLU A 165
ILE A 178
 None
 1.02A 1odiA-5tusA:
undetectable		 1odiA-5tusA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_B_ADNB1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5tus RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		5 / 11 THR A 210
GLY A 177
MET A 170
GLU A 165
ILE A 178
 None
 1.10A 1odiB-5tusA:
undetectable		 1odiB-5tusA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_C_ADNC1238_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5tus RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		5 / 11 THR A 210
GLY A 177
MET A 170
GLU A 165
ILE A 178
 None
 1.10A 1odiC-5tusA:
undetectable		 1odiC-5tusA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_D_ADND1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5tus RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		5 / 11 THR A 210
GLY A 177
MET A 170
GLU A 165
ILE A 178
 None
 1.08A 1odiD-5tusA:
undetectable		 1odiD-5tusA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_E_ADNE1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5tus RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		5 / 11 THR A 210
GLY A 177
MET A 170
GLU A 165
ILE A 178
 None
 1.02A 1odiE-5tusA:
undetectable		 1odiE-5tusA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_F_ADNF1238_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5tus RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		5 / 11 THR A 210
GLY A 177
MET A 170
GLU A 165
ILE A 178
 None
 1.06A 1odiF-5tusA:
undetectable		 1odiF-5tusA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SGU_B_MK1B2632_2
(POL POLYPROTEIN)		 5tus RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		5 / 12 GLY A 558
ILE A 593
ILE A 588
GLY A 564
ILE A 565
 None
 0.88A 1sguB-5tusA:
undetectable		 1sguB-5tusA:
8.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TD2_A_PXLA288_1
(PYRIDOXAMINE KINASE)		 5tus RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		5 / 10 SER A 494
VAL A 443
ALA A 491
GLN A 237
VAL A 488
 None
 1.43A 1td2A-5tusA:
2.3		 1td2A-5tusA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_B_SAMB3141_1
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 5tus RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		3 / 3 HIS A 179
ASP A 482
ASN A 495
 None
 0.87A 1wg8B-5tusA:
undetectable		 1wg8B-5tusA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_A_715A801_2
(DIPEPTIDYL PEPTIDASE
IV)		 5tus RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		3 / 3 ARG A 256
SER A 373
TYR A 371
 TTP  A1601 (-3.2A)
None
None
 0.68A 1x70A-5tusA:
undetectable		 1x70A-5tusA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 5tus RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		5 / 12 ALA A  82
ARG A  21
ILE A  39
PHE A 146
PHE A 634
 None
 1.26A 1y0xX-5tusA:
undetectable		 1y0xX-5tusA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B60_B_RITB100_1
(GAG-POL POLYPROTEIN)		 5tus RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		5 / 12 GLY A 538
ALA A 539
ILE A 501
ALA A 447
ILE A 503
 None
 0.91A 2b60A-5tusA:
undetectable		 2b60A-5tusA:
9.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B60_B_RITB100_2
(GAG-POL POLYPROTEIN)		 5tus RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		5 / 11 GLY A 538
ALA A 539
ILE A 501
ALA A 447
ILE A 503
 None
 0.94A 2b60B-5tusA:
undetectable		 2b60B-5tusA:
9.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_B_NCAB1246_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 5tus RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		4 / 7 GLY A 735
SER A 707
SER A 705
GLU A 431
 None
 0.93A 2c8aB-5tusA:
undetectable		 2c8aB-5tusA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_D_NCAD1247_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 5tus RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		4 / 7 GLY A 735
SER A 707
SER A 705
GLU A 431
 None
 0.93A 2c8aD-5tusA:
undetectable		 2c8aD-5tusA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CPP_A_CAMA422_0
(CYTOCHROME P450-CAM)		 5tus RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		4 / 7 PHE A 198
THR A 189
LEU A 477
VAL A 174
 None
 1.06A 2cppA-5tusA:
undetectable		 2cppA-5tusA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_1
(CYTOCHROME P450 2C8)		 5tus RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		5 / 12 SER A 606
THR A 199
VAL A 174
ALA A 208
THR A 210
 None
 1.23A 2nniA-5tusA:
undetectable		 2nniA-5tusA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 5tus RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		4 / 7 ILE A 513
ARG A 516
LEU A 645
ASP A 644
 None
 1.05A 2qqcB-5tusA:
undetectable
2qqcC-5tusA:
undetectable		 2qqcB-5tusA:
9.78
2qqcC-5tusA:
5.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 5tus RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		4 / 7 LEU A 645
ASP A 644
ILE A 513
ARG A 516
 None
 1.01A 2qqcA-5tusA:
undetectable
2qqcF-5tusA:
undetectable		 2qqcA-5tusA:
5.69
2qqcF-5tusA:
9.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 5tus RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		4 / 7 LEU A 645
ASP A 644
ILE A 513
ARG A 516
 None
 0.98A 2qqcG-5tusA:
undetectable
2qqcJ-5tusA:
undetectable		 2qqcG-5tusA:
5.69
2qqcJ-5tusA:
9.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 5tus RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		4 / 7 LEU A 645
ASP A 644
ILE A 513
ARG A 516
 None
 1.01A 2qqcI-5tusA:
undetectable
2qqcL-5tusA:
undetectable		 2qqcI-5tusA:
5.69
2qqcL-5tusA:
9.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 5tus RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		4 / 7 LEU A 645
ASP A 644
ILE A 513
ARG A 516
 None
 0.99A 2qqdA-5tusA:
undetectable
2qqdE-5tusA:
undetectable		 2qqdA-5tusA:
6.27
2qqdE-5tusA:
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKF_A_AB1A501_1
(PROTEASE RETROPEPSIN)		 5tus RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		5 / 12 GLY A 538
ALA A 539
ILE A 501
ALA A 447
ILE A 503
 None
 0.83A 2rkfA-5tusA:
undetectable		 2rkfA-5tusA:
9.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BSZ_E_RTLE177_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 5tus RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		5 / 11 LEU A 508
ALA A 524
VAL A 505
GLN A 706
PHE A 519
 None
 1.26A 3bszE-5tusA:
undetectable		 3bszE-5tusA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HLW_B_CE3B304_1
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 5tus RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		4 / 5 ASN A 445
THR A 555
SER A 596
SER A 415
 None
 1.10A 3hlwB-5tusA:
undetectable		 3hlwB-5tusA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5tus RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		5 / 12 VAL A 473
LEU A 477
ILE A 535
GLY A 538
ALA A 539
 None
 1.11A 3kk6A-5tusA:
undetectable		 3kk6A-5tusA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_Y_BO2Y1403_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 5tus RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		6 / 12 THR A  40
ALA A  60
THR A  63
ALA A  65
ALA A  61
ALA A  37
 None
 1.41A 3mg0Y-5tusA:
undetectable
3mg0Z-5tusA:
undetectable		 3mg0Y-5tusA:
14.46
3mg0Z-5tusA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_B_RITB401_2
(SECRETED ASPARTIC
PROTEASE)		 5tus RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		4 / 7 TYR A 680
ILE A 513
THR A 682
THR A 621
 None
 1.08A 3tneB-5tusA:
undetectable		 3tneB-5tusA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9H_B_NCAB1164_0
(TANKYRASE-2)		 5tus RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		5 / 8 GLY A 727
ALA A 696
LYS A 693
TYR A 726
GLU A 697
 None
 1.49A 3u9hB-5tusA:
undetectable		 3u9hB-5tusA:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UAW_A_ADNA236_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 5tus RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		5 / 11 THR A 210
GLY A 177
MET A 170
GLU A 165
ILE A 178
 None
 1.00A 3uawA-5tusA:
undetectable		 3uawA-5tusA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UAY_A_ADNA236_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 5tus RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		5 / 10 THR A 210
GLY A 177
MET A 170
GLU A 165
ILE A 178
 None
 0.95A 3uayA-5tusA:
undetectable		 3uayA-5tusA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZMD_A_SALA201_1
(PUTATIVE
TRANSCRIPTIONAL
REGULATOR)		 5tus RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		4 / 8 ARG A 256
ARG A 381
GLU A 355
HIS A 305
 TTP  A1601 (-3.2A)
None
None
None
 1.50A 3zmdA-5tusA:
undetectable
3zmdB-5tusA:
undetectable		 3zmdA-5tusA:
14.65
3zmdB-5tusA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5tus RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		5 / 12 LEU A 508
LEU A 451
LEU A 466
ILE A 617
GLN A 706
 None
 1.18A 4f4dA-5tusA:
undetectable		 4f4dA-5tusA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KF9_A_ACTA407_0
(GLUTATHIONE
S-TRANSFERASE
PROTEIN)		 5tus RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		3 / 3 GLU A 440
ARG A 497
HIS A 498
 None
 0.72A 4kf9A-5tusA:
undetectable		 4kf9A-5tusA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KUO_A_RBFA500_1
(BLUE-LIGHT
PHOTORECEPTOR)		 5tus RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		5 / 12 LEU A 193
ASN A 452
ASN A 613
LEU A 611
GLN A 506
 None
 1.46A 4kuoA-5tusA:
undetectable		 4kuoA-5tusA:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_STRA301_2
(ANCESTRAL STEROID
RECEPTOR 2)		 5tus RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		4 / 8 TRP A 581
ALA A 700
THR A 470
VAL A 474
 None
 0.99A 4ltwA-5tusA:
undetectable		 4ltwA-5tusA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5)		 5tus RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		4 / 7 THR A  40
ALA A  60
THR A  63
ALA A  65
 None
 1.01A 4qw0K-5tusA:
undetectable		 4qw0K-5tusA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5)		 5tus RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		4 / 7 THR A  40
ALA A  60
THR A  63
ALA A  65
 None
 1.01A 4qw0Y-5tusA:
undetectable		 4qw0Y-5tusA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_0
(UNCHARACTERIZED
PROTEIN)		 5tus RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		5 / 12 ALA A 608
GLY A 507
ILE A 702
ALA A 600
GLY A 504
 None
 0.84A 4r29D-5tusA:
undetectable		 4r29D-5tusA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZ8_A_GCSA208_1
(GLUCANASE/CHITOSANAS
E)		 5tus RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		4 / 7 GLU A 541
TYR A 537
GLU A 468
ALA A 467
 None
 1.08A 4zz8A-5tusA:
undetectable		 4zz8A-5tusA:
10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E2I_A_DMEA605_1
(ACETYLCHOLINESTERASE)		 5tus RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		4 / 6 TYR A 568
ASP A 569
TYR A 536
TRP A 581
 None
 1.44A 5e2iA-5tusA:
undetectable		 5e2iA-5tusA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5tus RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		5 / 12 ILE A 480
ALA A 447
LEU A 205
THR A 189
ILE A 178
 None
 1.00A 5e8qA-5tusA:
undetectable		 5e8qA-5tusA:
11.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_G_FK5G201_1
(FK506-BINDING
PROTEIN 1)		 5tus RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		3 / 3 ILE A 669
PRO A 670
ILE A 672
 None
 0.31A 5hw8F-5tusA:
undetectable		 5hw8F-5tusA:
8.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_B_CVIB301_0
(REGULATORY PROTEIN
TETR)		 5tus RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		5 / 12 ALA A 392
LEU A 332
ILE A 334
VAL A 342
PHE A 725
 None
 0.98A 5vlmB-5tusA:
undetectable		 5vlmB-5tusA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_E_CVIE301_0
(REGULATORY PROTEIN
TETR)		 5tus RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		5 / 12 ALA A 392
LEU A 332
ILE A 334
VAL A 342
PHE A 725
 None
 1.09A 5vlmE-5tusA:
undetectable		 5vlmE-5tusA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_G_CVIG301_0
(REGULATORY PROTEIN
TETR)		 5tus RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		5 / 12 ALA A 392
LEU A 332
ILE A 334
VAL A 342
PHE A 725
 None
 1.20A 5vlmG-5tusA:
undetectable		 5vlmG-5tusA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA902_1
(MRNA CAPPING ENZYME
P5)		 5tus RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		3 / 3 TYR A 680
ASP A 675
ASP A 644
 None
 0.86A 5x6yA-5tusA:
undetectable		 5x6yA-5tusA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_A_DAHA60_1
(PUTATIVE CYTOCHROME
C)		 5tus RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		4 / 6 HIS A 179
ASN A 478
VAL A 473
LEU A 192
 None
 1.34A 5xdhA-5tusA:
undetectable
5xdhC-5tusA:
undetectable		 5xdhA-5tusA:
9.02
5xdhC-5tusA:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_C_DAHC60_1
(PUTATIVE CYTOCHROME
C)		 5tus RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		4 / 6 HIS A 179
ASN A 478
VAL A 473
LEU A 192
 None
 1.24A 5xdhA-5tusA:
undetectable
5xdhC-5tusA:
undetectable		 5xdhA-5tusA:
9.02
5xdhC-5tusA:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MXT_A_K5YA1401_0
(ENDOLYSIN, BETA-2
ADRENERGIC RECEPTOR
CHIMERA)		 5tus RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT
(Homo
sapiens) 		5 / 12 VAL A 443
HIS A 200
ILE A 483
ASN A 484
TYR A 486
 None
 1.34A 6mxtA-5tusA:
0.0		 6mxtA-5tusA:
20.82