SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5tuy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PNL_B_PACB559_0
(PENICILLIN
AMIDOHYDROLASE)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		4 / 8 SER A1108
PHE A1138
ILE A1099
ASN A1106
 None
 0.96A 1pnlA-5tuyA:
undetectable
1pnlB-5tuyA:
undetectable		 1pnlA-5tuyA:
19.42
1pnlB-5tuyA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H21_A_SAMA801_0
(RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		5 / 10 GLY A1049
SER A1084
ASN A1112
HIS A1113
TYR A1154
 SAM  A1505 ( 3.9A)
SAM  A1505 (-3.8A)
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
 0.52A 2h21A-5tuyA:
6.0		 2h21A-5tuyA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H21_B_SAMB802_0
(RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		5 / 11 GLY A1049
SER A1084
ASN A1112
HIS A1113
TYR A1154
 SAM  A1505 ( 3.9A)
SAM  A1505 (-3.8A)
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
 0.54A 2h21B-5tuyA:
6.4		 2h21B-5tuyA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H21_C_SAMC803_0
(RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		5 / 11 GLY A1049
SER A1084
ASN A1112
HIS A1113
TYR A1154
 SAM  A1505 ( 3.9A)
SAM  A1505 (-3.8A)
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
 0.50A 2h21C-5tuyA:
6.1		 2h21C-5tuyA:
21.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2R3A_A_SAMA304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		5 / 12 GLY A1049
TRP A1050
HIS A1113
TYR A1154
CYH A1168
 SAM  A1505 ( 3.9A)
None
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
ZN  A1504 (-2.2A)
 1.42A 2r3aA-5tuyA:
28.1		 2r3aA-5tuyA:
35.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2R3A_A_SAMA304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		7 / 12 GLY A1049
TRP A1050
TYR A1085
HIS A1113
TYR A1154
CYH A1168
CYH A1170
 SAM  A1505 ( 3.9A)
None
SAM  A1505 (-4.0A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
ZN  A1504 (-2.2A)
ZN  A1504 (-2.2A)
 0.41A 2r3aA-5tuyA:
28.1		 2r3aA-5tuyA:
35.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WB9_A_CYSA301_0
(GLUTATHIONE
TRANSFERASE SIGMA
CLASS)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		4 / 5 GLY A1105
ARG A1109
TYR A 950
TYR A 952
 None
 1.48A 2wb9A-5tuyA:
undetectable		 2wb9A-5tuyA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YOE_C_FL7C1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		4 / 8 GLY A1105
ASN A1106
ILE A1119
VAL A1032
 None
 0.75A 2yoeB-5tuyA:
undetectable
2yoeC-5tuyA:
undetectable		 2yoeB-5tuyA:
21.64
2yoeC-5tuyA:
21.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OOI_A_SAMA237_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		5 / 12 GLY A1049
TRP A1050
ASN A1112
HIS A1113
CYH A1170
 SAM  A1505 ( 3.9A)
None
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
ZN  A1504 (-2.2A)
 1.23A 3ooiA-5tuyA:
19.1		 3ooiA-5tuyA:
30.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OOI_A_SAMA237_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		5 / 12 GLY A1049
TRP A1050
HIS A1113
TYR A1154
CYH A1168
 SAM  A1505 ( 3.9A)
None
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
ZN  A1504 (-2.2A)
 1.37A 3ooiA-5tuyA:
19.1		 3ooiA-5tuyA:
30.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OOI_A_SAMA237_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		8 / 12 GLY A1049
TRP A1050
TYR A1085
ASN A1112
HIS A1113
TYR A1154
CYH A1168
CYH A1170
 SAM  A1505 ( 3.9A)
None
SAM  A1505 (-4.0A)
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
ZN  A1504 (-2.2A)
ZN  A1504 (-2.2A)
 0.35A 3ooiA-5tuyA:
19.1		 3ooiA-5tuyA:
30.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OOI_A_SAMA237_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		5 / 12 GLY A1051
TYR A1085
HIS A1113
TYR A1154
CYH A1170
 None
SAM  A1505 (-4.0A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
ZN  A1504 (-2.2A)
 1.43A 3ooiA-5tuyA:
19.1		 3ooiA-5tuyA:
30.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OPE_A_SAMA7_0
(PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		5 / 12 GLY A1049
TRP A1050
ASN A1112
HIS A1113
CYH A1170
 SAM  A1505 ( 3.9A)
None
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
ZN  A1504 (-2.2A)
 1.26A 3opeA-5tuyA:
17.9		 3opeA-5tuyA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OPE_A_SAMA7_0
(PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		7 / 12 GLY A1049
TRP A1050
TYR A1085
ASN A1112
HIS A1113
TYR A1154
CYH A1168
 SAM  A1505 ( 3.9A)
None
SAM  A1505 (-4.0A)
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
ZN  A1504 (-2.2A)
 0.41A 3opeA-5tuyA:
17.9		 3opeA-5tuyA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OPE_B_SAMB8_0
(PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		5 / 9 GLY A1049
TRP A1050
TYR A1085
ASN A1112
TYR A1154
 SAM  A1505 ( 3.9A)
None
SAM  A1505 (-4.0A)
SAM  A1505 (-3.4A)
SAM  A1505 (-4.9A)
 0.46A 3opeB-5tuyA:
17.5		 3opeB-5tuyA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_A_SAMA6734_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		6 / 12 GLY A1049
TYR A1085
ASN A1112
HIS A1113
LEU A1114
TYR A1154
 SAM  A1505 ( 3.9A)
SAM  A1505 (-4.0A)
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
None
SAM  A1505 (-4.9A)
 1.23A 3qxyA-5tuyA:
7.1		 3qxyA-5tuyA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_A_SAMA484_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		5 / 11 GLY A1049
TYR A1085
ASN A1112
LEU A1114
TYR A1154
 SAM  A1505 ( 3.9A)
SAM  A1505 (-4.0A)
SAM  A1505 (-3.4A)
None
SAM  A1505 (-4.9A)
 1.07A 3rc0A-5tuyA:
6.6		 3rc0A-5tuyA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_B_SAMB480_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		6 / 12 GLY A1049
TYR A1085
ASN A1112
HIS A1113
LEU A1114
TYR A1154
 SAM  A1505 ( 3.9A)
SAM  A1505 (-4.0A)
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
None
SAM  A1505 (-4.9A)
 1.25A 3rc0B-5tuyA:
6.9		 3rc0B-5tuyA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_A_SAMA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		6 / 12 SER A1084
ASN A1112
HIS A1113
TYR A1154
CYH A1168
CYH A1170
 SAM  A1505 (-3.8A)
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
ZN  A1504 (-2.2A)
ZN  A1504 (-2.2A)
 1.30A 3s8pA-5tuyA:
9.2		 3s8pA-5tuyA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_B_SAMB500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		5 / 12 SER A1084
HIS A1113
TYR A1154
CYH A1168
CYH A1170
 SAM  A1505 (-3.8A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
ZN  A1504 (-2.2A)
ZN  A1504 (-2.2A)
 1.38A 3s8pB-5tuyA:
7.3		 3s8pB-5tuyA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOA_A_ACRA1587_2
(TREHALOSE
SYNTHASE/AMYLASE
TRES)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		3 / 3 ARG A1132
PHE A1133
PRO A1134
 None
 0.73A 3zoaB-5tuyA:
undetectable		 3zoaB-5tuyA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_A_SAMA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		6 / 12 SER A1084
ASN A1112
HIS A1113
TYR A1154
CYH A1168
CYH A1170
 SAM  A1505 (-3.8A)
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
ZN  A1504 (-2.2A)
ZN  A1504 (-2.2A)
 1.26A 4bupA-5tuyA:
9.0		 4bupA-5tuyA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_B_SAMB500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		5 / 12 SER A1084
HIS A1113
TYR A1154
CYH A1168
CYH A1170
 SAM  A1505 (-3.8A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
ZN  A1504 (-2.2A)
ZN  A1504 (-2.2A)
 1.35A 4bupB-5tuyA:
4.5		 4bupB-5tuyA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_I_SPMI202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		4 / 7 ASN A1106
GLU A1066
GLU A 955
GLU A 931
 None
 1.32A 4r87I-5tuyA:
undetectable		 4r87I-5tuyA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNM_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		6 / 12 GLY A1049
TRP A1050
ASN A1112
HIS A1113
TYR A1154
CYH A1168
 SAM  A1505 ( 3.9A)
None
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
ZN  A1504 (-2.2A)
 0.45A 4ynmA-5tuyA:
18.2		 4ynmA-5tuyA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNM_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		6 / 12 GLY A1049
TRP A1050
ASN A1112
HIS A1113
TYR A1154
CYH A1170
 SAM  A1505 ( 3.9A)
None
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
ZN  A1504 (-2.2A)
 1.21A 4ynmA-5tuyA:
18.2		 4ynmA-5tuyA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNM_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		6 / 12 GLY A1049
TRP A1050
ASN A1112
HIS A1113
TYR A1154
CYH A1170
 SAM  A1505 ( 3.9A)
None
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
ZN  A1504 (-2.2A)
 1.21A 4ynmB-5tuyA:
18.0		 4ynmB-5tuyA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNM_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		7 / 12 GLY A1049
TRP A1050
TYR A1085
ASN A1112
HIS A1113
TYR A1154
CYH A1168
 SAM  A1505 ( 3.9A)
None
SAM  A1505 (-4.0A)
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
ZN  A1504 (-2.2A)
 0.32A 4ynmB-5tuyA:
18.0		 4ynmB-5tuyA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNM_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		5 / 12 GLY A1051
TYR A1085
HIS A1113
TYR A1154
CYH A1168
 None
SAM  A1505 (-4.0A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
ZN  A1504 (-2.2A)
 1.43A 4ynmB-5tuyA:
18.0		 4ynmB-5tuyA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNP_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		7 / 12 GLY A1049
TRP A1050
TYR A1085
HIS A1113
TYR A1154
CYH A1168
CYH A1170
 SAM  A1505 ( 3.9A)
None
SAM  A1505 (-4.0A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
ZN  A1504 (-2.2A)
ZN  A1504 (-2.2A)
 0.47A 4ynpA-5tuyA:
18.0		 4ynpA-5tuyA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNP_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		6 / 12 GLY A1049
TRP A1050
TYR A1085
HIS A1113
TYR A1154
CYH A1170
 SAM  A1505 ( 3.9A)
None
SAM  A1505 (-4.0A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
ZN  A1504 (-2.2A)
 1.39A 4ynpA-5tuyA:
18.0		 4ynpA-5tuyA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNP_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		5 / 12 GLY A1051
TYR A1085
HIS A1113
TYR A1154
CYH A1170
 None
SAM  A1505 (-4.0A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
ZN  A1504 (-2.2A)
 1.09A 4ynpA-5tuyA:
18.0		 4ynpA-5tuyA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNP_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		5 / 12 GLY A1051
TYR A1085
HIS A1113
TYR A1154
CYH A1170
 None
SAM  A1505 (-4.0A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
ZN  A1504 (-2.2A)
 1.46A 4ynpA-5tuyA:
18.0		 4ynpA-5tuyA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNP_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		5 / 10 GLY A1049
TRP A1050
ASN A1112
HIS A1113
CYH A1170
 SAM  A1505 ( 3.9A)
None
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
ZN  A1504 (-2.2A)
 1.05A 4ynpB-5tuyA:
17.9		 4ynpB-5tuyA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNP_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		7 / 10 GLY A1049
TRP A1050
TYR A1085
ASN A1112
HIS A1113
TYR A1154
CYH A1168
 SAM  A1505 ( 3.9A)
None
SAM  A1505 (-4.0A)
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
ZN  A1504 (-2.2A)
 0.45A 4ynpB-5tuyA:
17.9		 4ynpB-5tuyA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNP_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		5 / 10 GLY A1051
TYR A1085
HIS A1113
TYR A1154
CYH A1168
 None
SAM  A1505 (-4.0A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
ZN  A1504 (-2.2A)
 1.47A 4ynpB-5tuyA:
17.9		 4ynpB-5tuyA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPA_A_SAMA3004_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		5 / 12 GLY A1049
TRP A1050
ASN A1112
HIS A1113
CYH A1170
 SAM  A1505 ( 3.9A)
None
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
ZN  A1504 (-2.2A)
 1.18A 4ypaA-5tuyA:
18.6		 4ypaA-5tuyA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPA_A_SAMA3004_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		7 / 12 GLY A1049
TRP A1050
TYR A1085
ASN A1112
HIS A1113
TYR A1154
CYH A1168
 SAM  A1505 ( 3.9A)
None
SAM  A1505 (-4.0A)
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
ZN  A1504 (-2.2A)
 0.36A 4ypaA-5tuyA:
18.6		 4ypaA-5tuyA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPA_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		6 / 12 GLY A1049
TRP A1050
ASN A1112
HIS A1113
TYR A1154
CYH A1168
 SAM  A1505 ( 3.9A)
None
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
ZN  A1504 (-2.2A)
 0.29A 4ypaB-5tuyA:
18.2		 4ypaB-5tuyA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPA_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		6 / 12 GLY A1049
TRP A1050
ASN A1112
HIS A1113
TYR A1154
CYH A1170
 SAM  A1505 ( 3.9A)
None
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
ZN  A1504 (-2.2A)
 1.12A 4ypaB-5tuyA:
18.2		 4ypaB-5tuyA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPA_C_SAMC2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		5 / 12 GLY A1049
TRP A1050
ASN A1112
HIS A1113
CYH A1170
 SAM  A1505 ( 3.9A)
None
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
ZN  A1504 (-2.2A)
 1.15A 4ypaC-5tuyA:
18.6		 4ypaC-5tuyA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPA_C_SAMC2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		6 / 12 GLY A1049
TRP A1050
ASN A1112
HIS A1113
TYR A1154
CYH A1168
 SAM  A1505 ( 3.9A)
None
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
ZN  A1504 (-2.2A)
 0.37A 4ypaC-5tuyA:
18.6		 4ypaC-5tuyA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPA_D_SAMD2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		5 / 12 GLY A1049
TRP A1050
ASN A1112
HIS A1113
CYH A1170
 SAM  A1505 ( 3.9A)
None
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
ZN  A1504 (-2.2A)
 1.10A 4ypaD-5tuyA:
18.4		 4ypaD-5tuyA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPA_D_SAMD2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		7 / 12 GLY A1049
TRP A1050
TYR A1085
ASN A1112
HIS A1113
TYR A1154
CYH A1168
 SAM  A1505 ( 3.9A)
None
SAM  A1505 (-4.0A)
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
ZN  A1504 (-2.2A)
 0.31A 4ypaD-5tuyA:
18.4		 4ypaD-5tuyA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPE_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		6 / 12 GLY A1049
TRP A1050
ASN A1112
HIS A1113
TYR A1154
CYH A1170
 SAM  A1505 ( 3.9A)
None
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
ZN  A1504 (-2.2A)
 1.23A 4ypeA-5tuyA:
18.7		 4ypeA-5tuyA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPE_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		7 / 12 GLY A1049
TRP A1050
TYR A1085
ASN A1112
HIS A1113
TYR A1154
CYH A1168
 SAM  A1505 ( 3.9A)
None
SAM  A1505 (-4.0A)
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
ZN  A1504 (-2.2A)
 0.45A 4ypeA-5tuyA:
18.7		 4ypeA-5tuyA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPE_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		5 / 11 GLY A1049
TRP A1050
ASN A1112
HIS A1113
CYH A1170
 SAM  A1505 ( 3.9A)
None
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
ZN  A1504 (-2.2A)
 1.19A 4ypeB-5tuyA:
18.4		 4ypeB-5tuyA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPE_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		7 / 11 GLY A1049
TRP A1050
TYR A1085
ASN A1112
HIS A1113
TYR A1154
CYH A1168
 SAM  A1505 ( 3.9A)
None
SAM  A1505 (-4.0A)
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
ZN  A1504 (-2.2A)
 0.30A 4ypeB-5tuyA:
18.4		 4ypeB-5tuyA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPU_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		6 / 12 GLY A1049
TRP A1050
ASN A1112
HIS A1113
TYR A1154
CYH A1170
 SAM  A1505 ( 3.9A)
None
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
ZN  A1504 (-2.2A)
 1.24A 4ypuA-5tuyA:
18.3		 4ypuA-5tuyA:
27.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPU_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		7 / 12 GLY A1049
TRP A1050
TYR A1085
ASN A1112
HIS A1113
TYR A1154
CYH A1168
 SAM  A1505 ( 3.9A)
None
SAM  A1505 (-4.0A)
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
ZN  A1504 (-2.2A)
 0.37A 4ypuA-5tuyA:
18.3		 4ypuA-5tuyA:
27.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPU_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		6 / 11 GLY A1049
TRP A1050
TYR A1085
ASN A1112
HIS A1113
TYR A1154
 SAM  A1505 ( 3.9A)
None
SAM  A1505 (-4.0A)
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
 0.48A 4ypuB-5tuyA:
17.4		 4ypuB-5tuyA:
27.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_DIFA601_1
(SERUM ALBUMIN)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		5 / 9 LEU A1086
ASP A1074
ALA A1077
VAL A1079
GLU A1070
 7L6  A1506 (-4.2A)
None
7L6  A1506 (-3.6A)
None
None
 1.45A 4zbrA-5tuyA:
undetectable		 4zbrA-5tuyA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CPR_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		5 / 12 PHE A1110
HIS A1113
TYR A1154
CYH A1168
CYH A1170
 None
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
ZN  A1504 (-2.2A)
ZN  A1504 (-2.2A)
 1.38A 5cprB-5tuyA:
8.0		 5cprB-5tuyA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_A_IPHA101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		4 / 4 CYH A1065
LEU A1150
LEU A1040
ALA A1054
 None
 0.98A 5hpuA-5tuyA:
undetectable
5hpuB-5tuyA:
undetectable		 5hpuA-5tuyA:
9.68
5hpuB-5tuyA:
8.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JHN_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		5 / 12 GLY A1051
TYR A1085
HIS A1113
TYR A1154
PHE A1158
 None
SAM  A1505 (-4.0A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
7L6  A1506 (-4.3A)
 1.09A 5jhnA-5tuyA:
26.4		 5jhnA-5tuyA:
97.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JHN_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		6 / 12 MET A1048
GLY A1049
TRP A1050
ASN A1112
HIS A1113
CYH A1170
 SAM  A1505 (-3.4A)
SAM  A1505 ( 3.9A)
None
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
ZN  A1504 (-2.2A)
 1.34A 5jhnA-5tuyA:
26.4		 5jhnA-5tuyA:
97.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JHN_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		12 / 12 MET A1048
GLY A1049
TRP A1050
SER A1084
TYR A1085
ASN A1112
HIS A1113
TYR A1154
PHE A1158
LYS A1162
PHE A1166
CYH A1168
 SAM  A1505 (-3.4A)
SAM  A1505 ( 3.9A)
None
SAM  A1505 (-3.8A)
SAM  A1505 (-4.0A)
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
7L6  A1506 (-4.3A)
7L6  A1506 ( 4.6A)
SAM  A1505 (-4.3A)
ZN  A1504 (-2.2A)
 0.41A 5jhnA-5tuyA:
26.4		 5jhnA-5tuyA:
97.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JHN_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		5 / 12 GLY A1051
TYR A1085
HIS A1113
TYR A1154
PHE A1158
 None
SAM  A1505 (-4.0A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
7L6  A1506 (-4.3A)
 1.03A 5jhnB-5tuyA:
41.3		 5jhnB-5tuyA:
97.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JHN_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		12 / 12 MET A1048
GLY A1049
TRP A1050
SER A1084
TYR A1085
ASN A1112
HIS A1113
TYR A1154
PHE A1158
PHE A1166
CYH A1168
GLN A1169
 SAM  A1505 (-3.4A)
SAM  A1505 ( 3.9A)
None
SAM  A1505 (-3.8A)
SAM  A1505 (-4.0A)
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
7L6  A1506 (-4.3A)
SAM  A1505 (-4.3A)
ZN  A1504 (-2.2A)
None
 0.38A 5jhnB-5tuyA:
41.3		 5jhnB-5tuyA:
97.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JIN_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		12 / 12 MET A1048
GLY A1049
TRP A1050
SER A1084
TYR A1085
HIS A1113
TYR A1154
PHE A1158
LYS A1162
PHE A1166
CYH A1168
GLN A1169
 SAM  A1505 (-3.4A)
SAM  A1505 ( 3.9A)
None
SAM  A1505 (-3.8A)
SAM  A1505 (-4.0A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
7L6  A1506 (-4.3A)
7L6  A1506 ( 4.6A)
SAM  A1505 (-4.3A)
ZN  A1504 (-2.2A)
None
 0.44A 5jinA-5tuyA:
26.3		 5jinA-5tuyA:
97.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JIN_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		12 / 12 MET A1048
TRP A1050
SER A1084
TYR A1085
ASN A1112
HIS A1113
TYR A1154
PHE A1158
LYS A1162
PHE A1166
CYH A1168
GLN A1169
 SAM  A1505 (-3.4A)
None
SAM  A1505 (-3.8A)
SAM  A1505 (-4.0A)
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
7L6  A1506 (-4.3A)
7L6  A1506 ( 4.6A)
SAM  A1505 (-4.3A)
ZN  A1504 (-2.2A)
None
 0.46A 5jinB-5tuyA:
41.2		 5jinB-5tuyA:
97.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JIY_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		6 / 12 MET A1048
GLY A1049
TRP A1050
ASN A1112
HIS A1113
CYH A1170
 SAM  A1505 (-3.4A)
SAM  A1505 ( 3.9A)
None
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
ZN  A1504 (-2.2A)
 1.34A 5jiyA-5tuyA:
41.8		 5jiyA-5tuyA:
97.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JIY_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		12 / 12 MET A1048
GLY A1049
TRP A1050
SER A1084
TYR A1085
ASN A1112
HIS A1113
TYR A1154
PHE A1158
LYS A1162
PHE A1166
CYH A1168
 SAM  A1505 (-3.4A)
SAM  A1505 ( 3.9A)
None
SAM  A1505 (-3.8A)
SAM  A1505 (-4.0A)
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
7L6  A1506 (-4.3A)
7L6  A1506 ( 4.6A)
SAM  A1505 (-4.3A)
ZN  A1504 (-2.2A)
 0.42A 5jiyA-5tuyA:
41.8		 5jiyA-5tuyA:
97.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JIY_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		6 / 12 MET A1048
GLY A1049
TRP A1050
ASN A1112
HIS A1113
CYH A1170
 SAM  A1505 (-3.4A)
SAM  A1505 ( 3.9A)
None
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
ZN  A1504 (-2.2A)
 1.39A 5jiyB-5tuyA:
41.1		 5jiyB-5tuyA:
97.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JIY_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		12 / 12 MET A1048
GLY A1049
TRP A1050
SER A1084
TYR A1085
ASN A1112
HIS A1113
TYR A1154
PHE A1158
LYS A1162
PHE A1166
CYH A1168
 SAM  A1505 (-3.4A)
SAM  A1505 ( 3.9A)
None
SAM  A1505 (-3.8A)
SAM  A1505 (-4.0A)
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
7L6  A1506 (-4.3A)
7L6  A1506 ( 4.6A)
SAM  A1505 (-4.3A)
ZN  A1504 (-2.2A)
 0.44A 5jiyB-5tuyA:
41.1		 5jiyB-5tuyA:
97.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JJ0_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		12 / 12 MET A1048
GLY A1049
TRP A1050
SER A1084
TYR A1085
HIS A1113
TYR A1154
PHE A1158
LYS A1162
PHE A1166
CYH A1168
GLN A1169
 SAM  A1505 (-3.4A)
SAM  A1505 ( 3.9A)
None
SAM  A1505 (-3.8A)
SAM  A1505 (-4.0A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
7L6  A1506 (-4.3A)
7L6  A1506 ( 4.6A)
SAM  A1505 (-4.3A)
ZN  A1504 (-2.2A)
None
 0.44A 5jj0A-5tuyA:
26.5		 5jj0A-5tuyA:
97.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JJ0_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		12 / 12 MET A1048
GLY A1049
TRP A1050
SER A1084
ASN A1112
HIS A1113
TYR A1154
PHE A1158
LYS A1162
PHE A1166
CYH A1168
GLN A1169
 SAM  A1505 (-3.4A)
SAM  A1505 ( 3.9A)
None
SAM  A1505 (-3.8A)
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
7L6  A1506 (-4.3A)
7L6  A1506 ( 4.6A)
SAM  A1505 (-4.3A)
ZN  A1504 (-2.2A)
None
 0.44A 5jj0B-5tuyA:
41.1		 5jj0B-5tuyA:
97.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKL_B_SAMB8009_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN,HISTONE H3.1
PEPTIDE,ZINC FINGER
DOMAIN-CONTAINING
PROTEIN)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		5 / 12 GLY A1049
ASN A1112
HIS A1113
TYR A1154
PHE A1158
 SAM  A1505 ( 3.9A)
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
7L6  A1506 (-4.3A)
 0.61A 5kklB-5tuyA:
4.1		 5kklB-5tuyA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSU_A_SAMA1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		6 / 12 GLY A1049
TRP A1050
TYR A1085
HIS A1113
CYH A1168
CYH A1170
 SAM  A1505 ( 3.9A)
None
SAM  A1505 (-4.0A)
SAM  A1505 (-4.7A)
ZN  A1504 (-2.2A)
ZN  A1504 (-2.2A)
 0.38A 5lsuA-5tuyA:
19.8		 5lsuA-5tuyA:
28.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSU_B_SAMB1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		5 / 12 GLY A1049
TRP A1050
TYR A1085
HIS A1113
CYH A1170
 SAM  A1505 ( 3.9A)
None
SAM  A1505 (-4.0A)
SAM  A1505 (-4.7A)
ZN  A1504 (-2.2A)
 0.39A 5lsuB-5tuyA:
19.5		 5lsuB-5tuyA:
28.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSU_B_SAMB1304_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		3 / 3 ASN A1112
TYR A1154
CYH A1168
 SAM  A1505 (-3.4A)
SAM  A1505 (-4.9A)
ZN  A1504 (-2.2A)
 0.21A 5lsuB-5tuyA:
19.5		 5lsuB-5tuyA:
28.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5T0K_A_SAMA1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		5 / 12 GLY A1051
TYR A1085
HIS A1113
TYR A1154
PHE A1158
 None
SAM  A1505 (-4.0A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
7L6  A1506 (-4.3A)
 1.06A 5t0kA-5tuyA:
41.4		 5t0kA-5tuyA:
99.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5T0K_A_SAMA1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		12 / 12 MET A1048
GLY A1049
TRP A1050
SER A1084
TYR A1085
ASN A1112
HIS A1113
TYR A1154
PHE A1158
PHE A1166
CYH A1168
GLN A1169
 SAM  A1505 (-3.4A)
SAM  A1505 ( 3.9A)
None
SAM  A1505 (-3.8A)
SAM  A1505 (-4.0A)
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
7L6  A1506 (-4.3A)
SAM  A1505 (-4.3A)
ZN  A1504 (-2.2A)
None
 0.36A 5t0kA-5tuyA:
41.4		 5t0kA-5tuyA:
99.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5T0K_B_SAMB1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		12 / 12 MET A1048
GLY A1049
TRP A1050
SER A1084
ASN A1112
HIS A1113
TYR A1154
PHE A1158
LYS A1162
PHE A1166
CYH A1168
GLN A1169
 SAM  A1505 (-3.4A)
SAM  A1505 ( 3.9A)
None
SAM  A1505 (-3.8A)
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
7L6  A1506 (-4.3A)
7L6  A1506 ( 4.6A)
SAM  A1505 (-4.3A)
ZN  A1504 (-2.2A)
None
 0.44A 5t0kB-5tuyA:
38.5		 5t0kB-5tuyA:
99.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5T0M_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		12 / 12 MET A1048
TRP A1050
SER A1084
TYR A1085
ASN A1112
HIS A1113
TYR A1154
PHE A1158
LYS A1162
PHE A1166
CYH A1168
GLN A1169
 SAM  A1505 (-3.4A)
None
SAM  A1505 (-3.8A)
SAM  A1505 (-4.0A)
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
7L6  A1506 (-4.3A)
7L6  A1506 ( 4.6A)
SAM  A1505 (-4.3A)
ZN  A1504 (-2.2A)
None
 0.43A 5t0mA-5tuyA:
41.1		 5t0mA-5tuyA:
99.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5T0M_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		5 / 12 GLY A1051
TYR A1085
HIS A1113
TYR A1154
PHE A1158
 None
SAM  A1505 (-4.0A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
7L6  A1506 (-4.3A)
 1.10A 5t0mB-5tuyA:
41.5		 5t0mB-5tuyA:
99.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5T0M_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		12 / 12 MET A1048
GLY A1049
TRP A1050
SER A1084
TYR A1085
ASN A1112
HIS A1113
TYR A1154
PHE A1158
PHE A1166
CYH A1168
GLN A1169
 SAM  A1505 (-3.4A)
SAM  A1505 ( 3.9A)
None
SAM  A1505 (-3.8A)
SAM  A1505 (-4.0A)
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
7L6  A1506 (-4.3A)
SAM  A1505 (-4.3A)
ZN  A1504 (-2.2A)
None
 0.34A 5t0mB-5tuyA:
41.5		 5t0mB-5tuyA:
99.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TEG_B_SAMB401_0
(HISTONE H4 MUTANT
PEPTIDE WITH
H4K20NORLEUCINE
N-LYSINE
METHYLTRANSFERASE
KMT5A)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		5 / 10 GLY A1049
TYR A1085
ASN A1112
HIS A1113
TYR A1154
 SAM  A1505 ( 3.9A)
SAM  A1505 (-4.0A)
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
 0.23A 5tegB-5tuyA:
12.8
5tegE-5tuyA:
undetectable		 5tegB-5tuyA:
23.38
5tegE-5tuyA:
4.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TQR_B_SAMB8009_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2, POLYCOMB
PROTEIN SUZ12)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		5 / 10 GLY A1049
TYR A1085
ASN A1112
HIS A1113
TYR A1154
 SAM  A1505 ( 3.9A)
SAM  A1505 (-4.0A)
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
 0.35A 5tqrB-5tuyA:
3.2		 5tqrB-5tuyA:
14.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TTF_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		6 / 11 MET A1048
GLY A1049
TRP A1050
ASN A1112
HIS A1113
CYH A1170
 SAM  A1505 (-3.4A)
SAM  A1505 ( 3.9A)
None
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
ZN  A1504 (-2.2A)
 1.31A 5ttfA-5tuyA:
42.0		 5ttfA-5tuyA:
99.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TTF_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		11 / 11 MET A1048
GLY A1049
TRP A1050
SER A1084
TYR A1085
ASN A1112
HIS A1113
TYR A1154
PHE A1158
PHE A1166
CYH A1168
 SAM  A1505 (-3.4A)
SAM  A1505 ( 3.9A)
None
SAM  A1505 (-3.8A)
SAM  A1505 (-4.0A)
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
7L6  A1506 (-4.3A)
SAM  A1505 (-4.3A)
ZN  A1504 (-2.2A)
 0.21A 5ttfA-5tuyA:
42.0		 5ttfA-5tuyA:
99.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TTF_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		12 / 12 MET A1048
GLY A1049
TRP A1050
SER A1084
TYR A1085
ASN A1112
HIS A1113
TYR A1154
PHE A1158
PHE A1166
CYH A1168
GLN A1169
 SAM  A1505 (-3.4A)
SAM  A1505 ( 3.9A)
None
SAM  A1505 (-3.8A)
SAM  A1505 (-4.0A)
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
7L6  A1506 (-4.3A)
SAM  A1505 (-4.3A)
ZN  A1504 (-2.2A)
None
 0.22A 5ttfB-5tuyA:
42.1		 5ttfB-5tuyA:
99.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TTF_C_SAMC1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		10 / 12 MET A1048
GLY A1049
TRP A1050
ASN A1112
HIS A1113
TYR A1154
PHE A1158
TRP A1159
CYH A1168
GLN A1169
 SAM  A1505 (-3.4A)
SAM  A1505 ( 3.9A)
None
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
7L6  A1506 (-4.3A)
None
ZN  A1504 (-2.2A)
None
 0.71A 5ttfC-5tuyA:
41.7		 5ttfC-5tuyA:
99.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TTF_C_SAMC1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		11 / 12 MET A1048
GLY A1049
TRP A1050
SER A1084
ASN A1112
HIS A1113
TYR A1154
PHE A1158
TRP A1159
PHE A1166
CYH A1168
 SAM  A1505 (-3.4A)
SAM  A1505 ( 3.9A)
None
SAM  A1505 (-3.8A)
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
7L6  A1506 (-4.3A)
None
SAM  A1505 (-4.3A)
ZN  A1504 (-2.2A)
 0.43A 5ttfC-5tuyA:
41.7		 5ttfC-5tuyA:
99.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TTF_D_SAMD1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		6 / 11 MET A1048
GLY A1049
TRP A1050
ASN A1112
HIS A1113
CYH A1170
 SAM  A1505 (-3.4A)
SAM  A1505 ( 3.9A)
None
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
ZN  A1504 (-2.2A)
 1.39A 5ttfD-5tuyA:
41.2		 5ttfD-5tuyA:
99.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TTF_D_SAMD1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		11 / 11 MET A1048
GLY A1049
TRP A1050
SER A1084
TYR A1085
ASN A1112
HIS A1113
TYR A1154
PHE A1158
PHE A1166
CYH A1168
 SAM  A1505 (-3.4A)
SAM  A1505 ( 3.9A)
None
SAM  A1505 (-3.8A)
SAM  A1505 (-4.0A)
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
7L6  A1506 (-4.3A)
SAM  A1505 (-4.3A)
ZN  A1504 (-2.2A)
 0.36A 5ttfD-5tuyA:
41.2		 5ttfD-5tuyA:
99.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TTG_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		6 / 12 GLY A1051
TYR A1085
HIS A1113
TYR A1154
PHE A1158
CYH A1168
 None
SAM  A1505 (-4.0A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
7L6  A1506 (-4.3A)
ZN  A1504 (-2.2A)
 1.34A 5ttgA-5tuyA:
39.7		 5ttgA-5tuyA:
79.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TTG_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		6 / 12 MET A1048
GLY A1049
TRP A1050
ASN A1112
HIS A1113
CYH A1170
 SAM  A1505 (-3.4A)
SAM  A1505 ( 3.9A)
None
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
ZN  A1504 (-2.2A)
 1.31A 5ttgA-5tuyA:
39.7		 5ttgA-5tuyA:
79.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TTG_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		11 / 12 MET A1048
GLY A1049
TRP A1050
SER A1084
TYR A1085
ASN A1112
HIS A1113
TYR A1154
PHE A1158
PHE A1166
CYH A1168
 SAM  A1505 (-3.4A)
SAM  A1505 ( 3.9A)
None
SAM  A1505 (-3.8A)
SAM  A1505 (-4.0A)
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
7L6  A1506 (-4.3A)
SAM  A1505 (-4.3A)
ZN  A1504 (-2.2A)
 0.33A 5ttgA-5tuyA:
39.7		 5ttgA-5tuyA:
79.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TTG_B_SAMB1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		6 / 11 GLY A1051
TYR A1085
HIS A1113
TYR A1154
PHE A1158
CYH A1168
 None
SAM  A1505 (-4.0A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
7L6  A1506 (-4.3A)
ZN  A1504 (-2.2A)
 1.33A 5ttgB-5tuyA:
24.5		 5ttgB-5tuyA:
79.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TTG_B_SAMB1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		6 / 11 MET A1048
GLY A1049
TRP A1050
ASN A1112
HIS A1113
CYH A1170
 SAM  A1505 (-3.4A)
SAM  A1505 ( 3.9A)
None
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
ZN  A1504 (-2.2A)
 1.32A 5ttgB-5tuyA:
24.5		 5ttgB-5tuyA:
79.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TTG_B_SAMB1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		11 / 11 MET A1048
GLY A1049
TRP A1050
SER A1084
TYR A1085
ASN A1112
HIS A1113
TYR A1154
PHE A1158
PHE A1166
CYH A1168
 SAM  A1505 (-3.4A)
SAM  A1505 ( 3.9A)
None
SAM  A1505 (-3.8A)
SAM  A1505 (-4.0A)
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
7L6  A1506 (-4.3A)
SAM  A1505 (-4.3A)
ZN  A1504 (-2.2A)
 0.36A 5ttgB-5tuyA:
24.5		 5ttgB-5tuyA:
79.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TUY_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		8 / 12 MET A1048
GLY A1049
TRP A1050
ASN A1112
HIS A1113
TYR A1154
CYH A1170
GLN A1169
 SAM  A1505 (-3.4A)
SAM  A1505 ( 3.9A)
None
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
ZN  A1504 (-2.2A)
None
 1.47A 5tuyA-5tuyA:
45.9		 5tuyA-5tuyA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TUY_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		12 / 12 MET A1048
GLY A1049
TRP A1050
SER A1084
TYR A1085
ASN A1112
HIS A1113
TYR A1154
PHE A1158
PHE A1166
CYH A1168
GLN A1169
 SAM  A1505 (-3.4A)
SAM  A1505 ( 3.9A)
None
SAM  A1505 (-3.8A)
SAM  A1505 (-4.0A)
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
7L6  A1506 (-4.3A)
SAM  A1505 (-4.3A)
ZN  A1504 (-2.2A)
None
 0.00A 5tuyA-5tuyA:
45.9		 5tuyA-5tuyA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TUY_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		12 / 12 MET A1048
GLY A1049
TRP A1050
SER A1084
TYR A1085
ASN A1112
HIS A1113
TYR A1154
PHE A1158
PHE A1166
CYH A1168
GLN A1169
 SAM  A1505 (-3.4A)
SAM  A1505 ( 3.9A)
None
SAM  A1505 (-3.8A)
SAM  A1505 (-4.0A)
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
7L6  A1506 (-4.3A)
SAM  A1505 (-4.3A)
ZN  A1504 (-2.2A)
None
 0.16A 5tuyB-5tuyA:
42.4		 5tuyB-5tuyA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TUZ_A_SAMA3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		6 / 12 MET A1048
GLY A1049
TRP A1050
ASN A1112
HIS A1113
CYH A1170
 SAM  A1505 (-3.4A)
SAM  A1505 ( 3.9A)
None
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
ZN  A1504 (-2.2A)
 1.32A 5tuzA-5tuyA:
25.2		 5tuzA-5tuyA:
79.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TUZ_A_SAMA3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		6 / 12 MET A1048
GLY A1049
TRP A1050
HIS A1113
TYR A1154
CYH A1168
 SAM  A1505 (-3.4A)
SAM  A1505 ( 3.9A)
None
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
ZN  A1504 (-2.2A)
 1.46A 5tuzA-5tuyA:
25.2		 5tuzA-5tuyA:
79.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TUZ_A_SAMA3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		11 / 12 MET A1048
GLY A1049
TRP A1050
SER A1084
ASN A1112
HIS A1113
TYR A1154
PHE A1158
PHE A1166
CYH A1168
CYH A1170
 SAM  A1505 (-3.4A)
SAM  A1505 ( 3.9A)
None
SAM  A1505 (-3.8A)
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
7L6  A1506 (-4.3A)
SAM  A1505 (-4.3A)
ZN  A1504 (-2.2A)
ZN  A1504 (-2.2A)
 0.37A 5tuzA-5tuyA:
25.2		 5tuzA-5tuyA:
79.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TUZ_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		6 / 12 MET A1048
GLY A1049
TRP A1050
ASN A1112
HIS A1113
CYH A1170
 SAM  A1505 (-3.4A)
SAM  A1505 ( 3.9A)
None
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
ZN  A1504 (-2.2A)
 1.34A 5tuzB-5tuyA:
24.8		 5tuzB-5tuyA:
79.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TUZ_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		11 / 12 MET A1048
GLY A1049
TRP A1050
SER A1084
TYR A1085
ASN A1112
HIS A1113
TYR A1154
PHE A1158
PHE A1166
CYH A1168
 SAM  A1505 (-3.4A)
SAM  A1505 ( 3.9A)
None
SAM  A1505 (-3.8A)
SAM  A1505 (-4.0A)
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
7L6  A1506 (-4.3A)
SAM  A1505 (-4.3A)
ZN  A1504 (-2.2A)
 0.31A 5tuzB-5tuyA:
24.8		 5tuzB-5tuyA:
79.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UPD_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD3)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		8 / 11 GLY A1049
TRP A1050
TYR A1085
ASN A1112
HIS A1113
TYR A1154
CYH A1168
CYH A1170
 SAM  A1505 ( 3.9A)
None
SAM  A1505 (-4.0A)
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
ZN  A1504 (-2.2A)
ZN  A1504 (-2.2A)
 0.41A 5updA-5tuyA:
19.4		 5updA-5tuyA:
30.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB309_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		3 / 3 TYR A 950
ALA A 927
TYR A 952
 None
 0.80A 5uunB-5tuyA:
undetectable		 5uunB-5tuyA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V21_A_SAMA1804_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		5 / 12 GLY A1049
TRP A1050
ASN A1112
HIS A1113
CYH A1170
 SAM  A1505 ( 3.9A)
None
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
ZN  A1504 (-2.2A)
 1.10A 5v21A-5tuyA:
18.4		 5v21A-5tuyA:
28.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V21_A_SAMA1804_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		7 / 12 GLY A1049
TRP A1050
TYR A1085
ASN A1112
HIS A1113
TYR A1154
CYH A1168
 SAM  A1505 ( 3.9A)
None
SAM  A1505 (-4.0A)
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
ZN  A1504 (-2.2A)
 0.47A 5v21A-5tuyA:
18.4		 5v21A-5tuyA:
28.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V9I_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		12 / 12 MET A1048
GLY A1049
TRP A1050
SER A1084
TYR A1085
ASN A1112
HIS A1113
TYR A1154
PHE A1158
PHE A1166
CYH A1168
GLN A1169
 SAM  A1505 (-3.4A)
SAM  A1505 ( 3.9A)
None
SAM  A1505 (-3.8A)
SAM  A1505 (-4.0A)
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
7L6  A1506 (-4.3A)
SAM  A1505 (-4.3A)
ZN  A1504 (-2.2A)
None
 0.25A 5v9iA-5tuyA:
41.3		 5v9iA-5tuyA:
99.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V9I_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		6 / 11 MET A1048
GLY A1049
TRP A1050
ASN A1112
HIS A1113
CYH A1170
 SAM  A1505 (-3.4A)
SAM  A1505 ( 3.9A)
None
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
ZN  A1504 (-2.2A)
 1.35A 5v9iB-5tuyA:
41.5		 5v9iB-5tuyA:
99.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V9I_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		11 / 11 MET A1048
GLY A1049
TRP A1050
SER A1084
TYR A1085
ASN A1112
HIS A1113
TYR A1154
PHE A1158
PHE A1166
CYH A1168
 SAM  A1505 (-3.4A)
SAM  A1505 ( 3.9A)
None
SAM  A1505 (-3.8A)
SAM  A1505 (-4.0A)
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
7L6  A1506 (-4.3A)
SAM  A1505 (-4.3A)
ZN  A1504 (-2.2A)
 0.26A 5v9iB-5tuyA:
41.5		 5v9iB-5tuyA:
99.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V9I_C_SAMC1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		6 / 11 MET A1048
GLY A1049
TRP A1050
ASN A1112
HIS A1113
CYH A1170
 SAM  A1505 (-3.4A)
SAM  A1505 ( 3.9A)
None
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
ZN  A1504 (-2.2A)
 1.37A 5v9iC-5tuyA:
41.0		 5v9iC-5tuyA:
99.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V9I_C_SAMC1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		11 / 11 MET A1048
GLY A1049
TRP A1050
SER A1084
TYR A1085
ASN A1112
HIS A1113
TYR A1154
PHE A1158
PHE A1166
CYH A1168
 SAM  A1505 (-3.4A)
SAM  A1505 ( 3.9A)
None
SAM  A1505 (-3.8A)
SAM  A1505 (-4.0A)
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
7L6  A1506 (-4.3A)
SAM  A1505 (-4.3A)
ZN  A1504 (-2.2A)
 0.35A 5v9iC-5tuyA:
41.0		 5v9iC-5tuyA:
99.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V9I_D_SAMD1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		8 / 12 MET A1048
GLY A1049
TRP A1050
HIS A1113
TYR A1154
TRP A1159
CYH A1168
GLN A1169
 SAM  A1505 (-3.4A)
SAM  A1505 ( 3.9A)
None
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
None
ZN  A1504 (-2.2A)
None
 0.79A 5v9iD-5tuyA:
41.0		 5v9iD-5tuyA:
99.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V9I_D_SAMD1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		11 / 12 MET A1048
GLY A1049
TRP A1050
SER A1084
TYR A1085
HIS A1113
TYR A1154
PHE A1158
TRP A1159
PHE A1166
CYH A1168
 SAM  A1505 (-3.4A)
SAM  A1505 ( 3.9A)
None
SAM  A1505 (-3.8A)
SAM  A1505 (-4.0A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
7L6  A1506 (-4.3A)
None
SAM  A1505 (-4.3A)
ZN  A1504 (-2.2A)
 0.43A 5v9iD-5tuyA:
41.0		 5v9iD-5tuyA:
99.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V9J_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		6 / 12 GLY A1051
TYR A1085
HIS A1113
TYR A1154
PHE A1158
CYH A1168
 None
SAM  A1505 (-4.0A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
7L6  A1506 (-4.3A)
ZN  A1504 (-2.2A)
 1.38A 5v9jA-5tuyA:
39.9		 5v9jA-5tuyA:
79.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V9J_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		6 / 12 MET A1048
GLY A1049
TRP A1050
ASN A1112
HIS A1113
CYH A1170
 SAM  A1505 (-3.4A)
SAM  A1505 ( 3.9A)
None
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
ZN  A1504 (-2.2A)
 1.30A 5v9jA-5tuyA:
39.9		 5v9jA-5tuyA:
79.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V9J_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		11 / 12 MET A1048
GLY A1049
TRP A1050
SER A1084
TYR A1085
ASN A1112
HIS A1113
TYR A1154
PHE A1158
PHE A1166
CYH A1168
 SAM  A1505 (-3.4A)
SAM  A1505 ( 3.9A)
None
SAM  A1505 (-3.8A)
SAM  A1505 (-4.0A)
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
7L6  A1506 (-4.3A)
SAM  A1505 (-4.3A)
ZN  A1504 (-2.2A)
 0.31A 5v9jA-5tuyA:
39.9		 5v9jA-5tuyA:
79.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V9J_B_SAMB1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		6 / 12 GLY A1051
TYR A1085
HIS A1113
TYR A1154
PHE A1158
CYH A1168
 None
SAM  A1505 (-4.0A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
7L6  A1506 (-4.3A)
ZN  A1504 (-2.2A)
 1.34A 5v9jB-5tuyA:
40.2		 5v9jB-5tuyA:
79.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V9J_B_SAMB1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		6 / 12 MET A1048
GLY A1049
TRP A1050
ASN A1112
HIS A1113
CYH A1170
 SAM  A1505 (-3.4A)
SAM  A1505 ( 3.9A)
None
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
ZN  A1504 (-2.2A)
 1.32A 5v9jB-5tuyA:
40.2		 5v9jB-5tuyA:
79.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V9J_B_SAMB1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		11 / 12 MET A1048
GLY A1049
TRP A1050
SER A1084
TYR A1085
ASN A1112
HIS A1113
TYR A1154
PHE A1158
PHE A1166
CYH A1168
 SAM  A1505 (-3.4A)
SAM  A1505 ( 3.9A)
None
SAM  A1505 (-3.8A)
SAM  A1505 (-4.0A)
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
7L6  A1506 (-4.3A)
SAM  A1505 (-4.3A)
ZN  A1504 (-2.2A)
 0.33A 5v9jB-5tuyA:
40.2		 5v9jB-5tuyA:
79.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VSC_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		12 / 12 MET A1048
GLY A1049
TRP A1050
SER A1084
TYR A1085
ASN A1112
HIS A1113
TYR A1154
PHE A1158
PHE A1166
CYH A1168
GLN A1169
 SAM  A1505 (-3.4A)
SAM  A1505 ( 3.9A)
None
SAM  A1505 (-3.8A)
SAM  A1505 (-4.0A)
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
7L6  A1506 (-4.3A)
SAM  A1505 (-4.3A)
ZN  A1504 (-2.2A)
None
 0.21A 5vscA-5tuyA:
41.6		 5vscA-5tuyA:
97.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VSC_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		12 / 12 MET A1048
GLY A1049
TRP A1050
SER A1084
TYR A1085
ASN A1112
HIS A1113
TYR A1154
PHE A1158
PHE A1166
CYH A1168
GLN A1169
 SAM  A1505 (-3.4A)
SAM  A1505 ( 3.9A)
None
SAM  A1505 (-3.8A)
SAM  A1505 (-4.0A)
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
7L6  A1506 (-4.3A)
SAM  A1505 (-4.3A)
ZN  A1504 (-2.2A)
None
 0.23A 5vscB-5tuyA:
26.1		 5vscB-5tuyA:
97.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VSD_A_SAMA3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		6 / 12 MET A1048
GLY A1049
TRP A1050
ASN A1112
HIS A1113
CYH A1170
 SAM  A1505 (-3.4A)
SAM  A1505 ( 3.9A)
None
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
ZN  A1504 (-2.2A)
 1.30A 5vsdA-5tuyA:
24.9		 5vsdA-5tuyA:
79.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VSD_A_SAMA3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		11 / 12 MET A1048
GLY A1049
TRP A1050
SER A1084
ASN A1112
HIS A1113
TYR A1154
PHE A1158
TRP A1159
PHE A1166
CYH A1168
 SAM  A1505 (-3.4A)
SAM  A1505 ( 3.9A)
None
SAM  A1505 (-3.8A)
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
7L6  A1506 (-4.3A)
None
SAM  A1505 (-4.3A)
ZN  A1504 (-2.2A)
 0.34A 5vsdA-5tuyA:
24.9		 5vsdA-5tuyA:
79.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VSD_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		6 / 12 GLY A1051
TYR A1085
HIS A1113
TYR A1154
PHE A1158
CYH A1168
 None
SAM  A1505 (-4.0A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
7L6  A1506 (-4.3A)
ZN  A1504 (-2.2A)
 1.36A 5vsdB-5tuyA:
24.9		 5vsdB-5tuyA:
79.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VSD_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		6 / 12 MET A1048
GLY A1049
TRP A1050
ASN A1112
HIS A1113
CYH A1170
 SAM  A1505 (-3.4A)
SAM  A1505 ( 3.9A)
None
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
ZN  A1504 (-2.2A)
 1.32A 5vsdB-5tuyA:
24.9		 5vsdB-5tuyA:
79.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VSD_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		11 / 12 MET A1048
GLY A1049
TRP A1050
SER A1084
TYR A1085
ASN A1112
HIS A1113
TYR A1154
PHE A1158
PHE A1166
CYH A1168
 SAM  A1505 (-3.4A)
SAM  A1505 ( 3.9A)
None
SAM  A1505 (-3.8A)
SAM  A1505 (-4.0A)
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
7L6  A1506 (-4.3A)
SAM  A1505 (-4.3A)
ZN  A1504 (-2.2A)
 0.34A 5vsdB-5tuyA:
24.9		 5vsdB-5tuyA:
79.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VSE_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		12 / 12 MET A1048
GLY A1049
TRP A1050
SER A1084
TYR A1085
ASN A1112
HIS A1113
TYR A1154
PHE A1158
PHE A1166
CYH A1168
GLN A1169
 SAM  A1505 (-3.4A)
SAM  A1505 ( 3.9A)
None
SAM  A1505 (-3.8A)
SAM  A1505 (-4.0A)
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
7L6  A1506 (-4.3A)
SAM  A1505 (-4.3A)
ZN  A1504 (-2.2A)
None
 0.24A 5vseA-5tuyA:
41.9		 5vseA-5tuyA:
99.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VSE_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		12 / 12 MET A1048
GLY A1049
TRP A1050
SER A1084
TYR A1085
ASN A1112
HIS A1113
TYR A1154
PHE A1158
PHE A1166
CYH A1168
GLN A1169
 SAM  A1505 (-3.4A)
SAM  A1505 ( 3.9A)
None
SAM  A1505 (-3.8A)
SAM  A1505 (-4.0A)
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
7L6  A1506 (-4.3A)
SAM  A1505 (-4.3A)
ZN  A1504 (-2.2A)
None
 0.22A 5vseB-5tuyA:
41.6		 5vseB-5tuyA:
99.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VSF_A_SAMA3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		6 / 12 MET A1048
GLY A1049
TRP A1050
ASN A1112
HIS A1113
CYH A1170
 SAM  A1505 (-3.4A)
SAM  A1505 ( 3.9A)
None
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
ZN  A1504 (-2.2A)
 1.31A 5vsfA-5tuyA:
25.2		 5vsfA-5tuyA:
79.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VSF_A_SAMA3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		11 / 12 MET A1048
GLY A1049
TRP A1050
SER A1084
ASN A1112
HIS A1113
TYR A1154
PHE A1158
TRP A1159
PHE A1166
CYH A1168
 SAM  A1505 (-3.4A)
SAM  A1505 ( 3.9A)
None
SAM  A1505 (-3.8A)
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
7L6  A1506 (-4.3A)
None
SAM  A1505 (-4.3A)
ZN  A1504 (-2.2A)
 0.35A 5vsfA-5tuyA:
25.2		 5vsfA-5tuyA:
79.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VSF_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		6 / 12 MET A1048
GLY A1049
TRP A1050
ASN A1112
HIS A1113
CYH A1170
 SAM  A1505 (-3.4A)
SAM  A1505 ( 3.9A)
None
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
ZN  A1504 (-2.2A)
 1.31A 5vsfB-5tuyA:
40.0		 5vsfB-5tuyA:
79.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VSF_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		11 / 12 MET A1048
GLY A1049
TRP A1050
SER A1084
TYR A1085
ASN A1112
HIS A1113
TYR A1154
PHE A1158
PHE A1166
CYH A1168
 SAM  A1505 (-3.4A)
SAM  A1505 ( 3.9A)
None
SAM  A1505 (-3.8A)
SAM  A1505 (-4.0A)
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
7L6  A1506 (-4.3A)
SAM  A1505 (-4.3A)
ZN  A1504 (-2.2A)
 0.28A 5vsfB-5tuyA:
40.0		 5vsfB-5tuyA:
79.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5K_A_SAMA805_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH6)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		7 / 12 GLY A1049
TRP A1050
ASN A1112
HIS A1113
TYR A1154
CYH A1168
CYH A1170
 SAM  A1505 ( 3.9A)
None
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
ZN  A1504 (-2.2A)
ZN  A1504 (-2.2A)
 0.36A 6a5kA-5tuyA:
6.8		 6a5kA-5tuyA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5K_A_SAMA805_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH6)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		6 / 12 GLY A1049
TRP A1050
ASN A1112
HIS A1113
TYR A1154
CYH A1170
 SAM  A1505 ( 3.9A)
None
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
ZN  A1504 (-2.2A)
 1.29A 6a5kA-5tuyA:
6.8		 6a5kA-5tuyA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5K_A_SAMA805_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH6)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		5 / 12 GLY A1051
HIS A1113
TYR A1154
CYH A1168
CYH A1170
 None
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
ZN  A1504 (-2.2A)
ZN  A1504 (-2.2A)
 1.17A 6a5kA-5tuyA:
6.8		 6a5kA-5tuyA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5M_A_SAMA805_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH6)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		5 / 12 GLY A1049
TRP A1050
HIS A1113
TYR A1154
CYH A1168
 SAM  A1505 ( 3.9A)
None
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
ZN  A1504 (-2.2A)
 1.40A 6a5mA-5tuyA:
28.3		 6a5mA-5tuyA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5M_A_SAMA805_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH6)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		8 / 12 GLY A1049
TRP A1050
TYR A1085
ASN A1112
HIS A1113
TYR A1154
CYH A1168
CYH A1170
 SAM  A1505 ( 3.9A)
None
SAM  A1505 (-4.0A)
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
ZN  A1504 (-2.2A)
ZN  A1504 (-2.2A)
 0.45A 6a5mA-5tuyA:
28.3		 6a5mA-5tuyA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AGO_A_SAMA2301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		6 / 11 GLY A1049
TRP A1050
ASN A1112
HIS A1113
TYR A1154
CYH A1168
 SAM  A1505 ( 3.9A)
None
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
ZN  A1504 (-2.2A)
 1.36A 6agoA-5tuyA:
18.0		 6agoA-5tuyA:
26.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AGO_A_SAMA2301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		7 / 11 GLY A1049
TRP A1050
ASN A1112
HIS A1113
TYR A1154
CYH A1168
CYH A1170
 SAM  A1505 ( 3.9A)
None
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
ZN  A1504 (-2.2A)
ZN  A1504 (-2.2A)
 0.80A 6agoA-5tuyA:
18.0		 6agoA-5tuyA:
26.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AGO_A_SAMA2301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		7 / 11 GLY A1049
TYR A1085
ASN A1112
HIS A1113
TYR A1154
CYH A1168
CYH A1170
 SAM  A1505 ( 3.9A)
SAM  A1505 (-4.0A)
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
ZN  A1504 (-2.2A)
ZN  A1504 (-2.2A)
 0.89A 6agoA-5tuyA:
18.0		 6agoA-5tuyA:
26.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6BP4_A_SAMA505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		6 / 12 GLY A1049
TRP A1050
ARG A1109
HIS A1113
TYR A1154
CYH A1170
 SAM  A1505 ( 3.9A)
None
None
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
ZN  A1504 (-2.2A)
 0.74A 6bp4A-5tuyA:
27.5		 6bp4A-5tuyA:
35.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6BP4_B_SAMB505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		5 / 12 GLY A1035
TYR A 996
CYH A1027
CYH A1017
GLY A1000
 None
None
ZN  A1501 (-1.9A)
ZN  A1501 ( 2.1A)
None
 1.18A 6bp4B-5tuyA:
27.5		 6bp4B-5tuyA:
35.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6BP4_B_SAMB505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		7 / 12 GLY A1049
TRP A1050
TYR A1085
HIS A1113
TYR A1154
CYH A1168
CYH A1170
 SAM  A1505 ( 3.9A)
None
SAM  A1505 (-4.0A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
ZN  A1504 (-2.2A)
ZN  A1504 (-2.2A)
 0.41A 6bp4B-5tuyA:
27.5		 6bp4B-5tuyA:
35.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6BP4_B_SAMB505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		6 / 12 GLY A1049
TRP A1050
TYR A1085
HIS A1113
TYR A1154
CYH A1170
 SAM  A1505 ( 3.9A)
None
SAM  A1505 (-4.0A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
ZN  A1504 (-2.2A)
 1.37A 6bp4B-5tuyA:
27.5		 6bp4B-5tuyA:
35.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6BP4_B_SAMB505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		5 / 12 GLY A1051
TYR A1085
HIS A1113
TYR A1154
CYH A1170
 None
SAM  A1505 (-4.0A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
ZN  A1504 (-2.2A)
 1.45A 6bp4B-5tuyA:
27.5		 6bp4B-5tuyA:
35.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CEN_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD3)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		8 / 11 GLY A1049
TRP A1050
TYR A1085
ASN A1112
HIS A1113
TYR A1154
CYH A1168
CYH A1170
 SAM  A1505 ( 3.9A)
None
SAM  A1505 (-4.0A)
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
ZN  A1504 (-2.2A)
ZN  A1504 (-2.2A)
 0.42A 6cenA-5tuyA:
19.6		 6cenA-5tuyA:
29.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CHG_C_SAMC1101_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-4 SPECIFIC)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		5 / 12 TRP A1050
TYR A1085
PHE A1110
ASN A1112
HIS A1113
 None
SAM  A1505 (-4.0A)
None
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
 0.37A 6chgC-5tuyA:
8.7		 6chgC-5tuyA:
29.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6INE_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		5 / 12 GLY A1049
ASN A1112
HIS A1113
GLN A1169
CYH A1170
 SAM  A1505 ( 3.9A)
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
None
ZN  A1504 (-2.2A)
 1.37A 6ineA-5tuyA:
17.6		 6ineA-5tuyA:
27.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6INE_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		5 / 12 GLY A1049
TRP A1050
ASN A1112
HIS A1113
CYH A1170
 SAM  A1505 ( 3.9A)
None
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
ZN  A1504 (-2.2A)
 1.26A 6ineA-5tuyA:
17.6		 6ineA-5tuyA:
27.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6INE_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		7 / 12 GLY A1049
TRP A1050
ASN A1112
HIS A1113
TYR A1154
CYH A1168
CYH A1170
 SAM  A1505 ( 3.9A)
None
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
ZN  A1504 (-2.2A)
ZN  A1504 (-2.2A)
 0.31A 6ineA-5tuyA:
17.6		 6ineA-5tuyA:
27.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6INE_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2
(Homo
sapiens) 		5 / 12 GLY A1049
TRP A1050
HIS A1113
TYR A1154
CYH A1168
 SAM  A1505 ( 3.9A)
None
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
ZN  A1504 (-2.2A)
 1.38A 6ineA-5tuyA:
17.6		 6ineA-5tuyA:
27.43