SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5tv1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_G_AG2G7003_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 5tv1 BETA-ARRESTIN-2
(Bos
taurus) 		4 / 6 ASP A  70
LEU A  69
GLY A  65
ARG A  63
 None
 0.78A 1mt1G-5tv1A:
undetectable
1mt1J-5tv1A:
undetectable		 1mt1G-5tv1A:
10.59
1mt1J-5tv1A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_H_AG2H7012_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 5tv1 BETA-ARRESTIN-2
(Bos
taurus) 		4 / 6 ARG A  63
ASP A  70
LEU A  69
GLY A  65
 None
 0.79A 1n13H-5tv1A:
undetectable
1n13K-5tv1A:
undetectable		 1n13H-5tv1A:
17.41
1n13K-5tv1A:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_J_AG2J7013_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 5tv1 BETA-ARRESTIN-2
(Bos
taurus) 		4 / 7 ASP A  70
LEU A  69
GLY A  65
ARG A  63
 None
 0.81A 1n13G-5tv1A:
undetectable
1n13J-5tv1A:
undetectable		 1n13G-5tv1A:
10.59
1n13J-5tv1A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJF_B_ADNB2002_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 5tv1 BETA-ARRESTIN-2
(Bos
taurus) 		4 / 6 ARG A 323
ASN A 282
PRO A 277
ALA A 255
 None
 1.40A 2ejfB-5tv1A:
undetectable		 2ejfB-5tv1A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJG_A_ADNA1501_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 5tv1 BETA-ARRESTIN-2
(Bos
taurus) 		4 / 7 ARG A 323
ASN A 282
PRO A 277
ALA A 255
 None
 1.24A 2ejgA-5tv1A:
undetectable		 2ejgA-5tv1A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_E_AG2E671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 5tv1 BETA-ARRESTIN-2
(Bos
taurus) 		4 / 7 ARG A  63
ASP A  70
LEU A  69
GLY A  65
 None
 0.77A 2qqcD-5tv1A:
undetectable
2qqcE-5tv1A:
undetectable		 2qqcD-5tv1A:
17.41
2qqcE-5tv1A:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL4_A_ROCA100_2
(PROTEASE)		 5tv1 BETA-ARRESTIN-2
(Bos
taurus) 		5 / 9 ARG A 170
ASP A 144
ALA A  61
GLY A 317
ILE A 318
 None
 1.17A 3el4B-5tv1A:
undetectable		 3el4B-5tv1A:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RET_A_SALA201_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 5tv1 BETA-ARRESTIN-2
(Bos
taurus) 		5 / 10 VAL A 257
VAL A 219
ILE A 232
GLN A 259
ILE A 275
 None
 1.15A 3retA-5tv1A:
undetectable
3retB-5tv1A:
undetectable		 3retA-5tv1A:
15.92
3retB-5tv1A:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T8N_D_EDTD135_0
(STEROID
DELTA-ISOMERASE)		 5tv1 BETA-ARRESTIN-2
(Bos
taurus) 		5 / 11 THR A 137
GLY A 138
GLY A 133
PRO A 134
PRO A 132
 None
 1.33A 3t8nD-5tv1A:
undetectable
3t8nF-5tv1A:
undetectable		 3t8nD-5tv1A:
12.79
3t8nF-5tv1A:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA803_1
(CATALASE-PEROXIDASE)		 5tv1 BETA-ARRESTIN-2
(Bos
taurus) 		4 / 4 ASP A 291
THR A 129
VAL A 320
SER A 127
 None
 1.39A 3wxoA-5tv1A:
undetectable		 3wxoA-5tv1A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GRQ_C_AVLC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 5tv1 BETA-ARRESTIN-2
(Bos
taurus) 		4 / 7 PHE A 116
PRO A  37
GLN A 102
PHE A  28
 None
 1.31A 4grqA-5tv1A:
undetectable
4grqC-5tv1A:
undetectable		 4grqA-5tv1A:
14.47
4grqC-5tv1A:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP6_A_B40A601_1
(TRANSPORTER)		 5tv1 BETA-ARRESTIN-2
(Bos
taurus) 		4 / 5 ASP A  27
VAL A  38
ASP A  39
GLY A  24
 None
 1.08A 4xp6A-5tv1A:
undetectable		 4xp6A-5tv1A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T7B_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 5tv1 BETA-ARRESTIN-2
(Bos
taurus) 		4 / 6 PHE A 118
PRO A  37
VAL A  38
THR A  99
 None
 0.84A 5t7bA-5tv1A:
undetectable		 5t7bA-5tv1A:
18.63