SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5tv2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_D_TRPD81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5tv2 ELONGATION FACTOR G
(Vibrio
vulnificus) 		4 / 7 THR A 256
VAL A 110
GLY A 108
ILE A  13
 None
 0.71A 1gtnC-5tv2A:
undetectable
1gtnD-5tv2A:
undetectable		 1gtnC-5tv2A:
11.89
1gtnD-5tv2A:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KAW_A_SUZA91_1
(SEGMENT POLARITY
PROTEIN DISHEVELLED
HOMOLOG DVL-1)		 5tv2 ELONGATION FACTOR G
(Vibrio
vulnificus) 		5 / 11 GLY A  14
ILE A  15
ILE A  30
LEU A 279
VAL A 282
 None
 1.03A 2kawA-5tv2A:
undetectable		 2kawA-5tv2A:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_F_SNLF6001_1
(MINERALOCORTICOID
RECEPTOR)		 5tv2 ELONGATION FACTOR G
(Vibrio
vulnificus) 		5 / 12 LEU A 263
ALA A 264
LEU A 222
LEU A 171
PHE A 140
 None
 1.32A 2oaxF-5tv2A:
undetectable		 2oaxF-5tv2A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 5tv2 ELONGATION FACTOR G
(Vibrio
vulnificus) 		3 / 3 ASP A 399
ASN A 397
THR A 394
 None
 0.74A 2pymB-5tv2A:
undetectable		 2pymB-5tv2A:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_2
(PROGESTERONE
RECEPTOR)		 5tv2 ELONGATION FACTOR G
(Vibrio
vulnificus) 		4 / 7 LEU A 222
ASN A 221
GLU A 217
LEU A 214
 None
 0.95A 2w8yA-5tv2A:
undetectable		 2w8yA-5tv2A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		 5tv2 ELONGATION FACTOR G
(Vibrio
vulnificus) 		5 / 12 VAL A 182
CYH A 266
ILE A 169
ILE A 158
VAL A 119
 None
 1.44A 3g8iA-5tv2A:
undetectable		 3g8iA-5tv2A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 5tv2 ELONGATION FACTOR G
(Vibrio
vulnificus) 		5 / 12 GLU A 284
GLU A 245
VAL A 167
ASP A 184
ILE A 169
 None
 1.46A 3jb3A-5tv2A:
undetectable		 3jb3A-5tv2A:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5tv2 ELONGATION FACTOR G
(Vibrio
vulnificus) 		4 / 7 TYR A  10
ARG A 335
ASN A  12
GLU A   8
 None
 1.01A 4a97E-5tv2A:
undetectable		 4a97E-5tv2A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_B_0LAB602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		 5tv2 ELONGATION FACTOR G
(Vibrio
vulnificus) 		4 / 6 LEU A 103
LEU A 106
ILE A  13
THR A  89
 None
 0.80A 4do3B-5tv2A:
undetectable		 4do3B-5tv2A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_A_ADNA401_1
(APH(2'')-ID)		 5tv2 ELONGATION FACTOR G
(Vibrio
vulnificus) 		5 / 10 ALA A 281
ILE A 248
LEU A 222
ILE A 186
ASP A 184
 None
 1.25A 4dtaA-5tv2A:
undetectable		 4dtaA-5tv2A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_2
(PROTEASE)		 5tv2 ELONGATION FACTOR G
(Vibrio
vulnificus) 		5 / 12 ALA A 382
GLY A 385
GLY A 329
VAL A 389
ILE A 322
 None
 0.87A 4q5mA-5tv2A:
undetectable		 4q5mA-5tv2A:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UXQ_A_0LIA1752_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 5tv2 ELONGATION FACTOR G
(Vibrio
vulnificus) 		4 / 7 VAL A 182
MET A  75
ARG A  11
ILE A  30
 None
 0.78A 4uxqA-5tv2A:
undetectable		 4uxqA-5tv2A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_B_RTZB602_1
(CYTOCHROME P450 2D6)		 5tv2 ELONGATION FACTOR G
(Vibrio
vulnificus) 		5 / 12 GLY A 385
LEU A 386
ALA A 323
VAL A 389
PHE A 358
 None
 1.01A 4wnwB-5tv2A:
undetectable		 4wnwB-5tv2A:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_B_FK5B201_1
(FK506-BINDING
PROTEIN 1)		 5tv2 ELONGATION FACTOR G
(Vibrio
vulnificus) 		5 / 11 ASP A 291
ARG A 253
VAL A  84
ILE A   7
ILE A 290
 None
 1.29A 5hw8B-5tv2A:
undetectable		 5hw8B-5tv2A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BZO_C_FI8C1201_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 5tv2 ELONGATION FACTOR G
(Vibrio
vulnificus) 		5 / 12 ILE A 322
THR A 390
THR A 394
VAL A 402
GLU A  98
 None
 1.37A 6bzoC-5tv2A:
undetectable		 6bzoC-5tv2A:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F32_B_ACTB602_0
(AMINE OXIDASE LKCE)		 5tv2 ELONGATION FACTOR G
(Vibrio
vulnificus) 		4 / 6 VAL A 351
LYS A 352
VAL A 389
THR A 390
 None
 1.14A 6f32B-5tv2A:
undetectable		 6f32B-5tv2A:
20.78