SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5tv7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2XAD_E_GCSE710_1 (N-ACYL GLM PEUDO-TEICOPLANIN DEACETYLASE TEICOPLANIN)	5tv7	PUTATIVE PEPTIDOGLYCAN-BINDIN G/HYDROLYSING PROTEIN (Clostridioides difficile)	4 / 8	HIS A 66 SER A 159 ILE A 73 ASP A 157	CME A 70 ( 3.6A) CME A 70 ( 3.0A) CME A 70 ( 4.3A) None	1.02A	2xadA-5tv7A: undetectable	2xadA-5tv7A: 18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2XAD_F_GCSF710_1 (N-ACYL GLM PEUDO-TEICOPLANIN DEACETYLASE TEICOPLANIN)	5tv7	PUTATIVE PEPTIDOGLYCAN-BINDIN G/HYDROLYSING PROTEIN (Clostridioides difficile)	4 / 8	HIS A 66 SER A 159 ILE A 73 ASP A 157	CME A 70 ( 3.6A) CME A 70 ( 3.0A) CME A 70 ( 4.3A) None	1.05A	2xadB-5tv7A: undetectable	2xadB-5tv7A: 18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2XAD_G_GCSG710_1 (N-ACYL GLM PEUDO-TEICOPLANIN DEACETYLASE TEICOPLANIN)	5tv7	PUTATIVE PEPTIDOGLYCAN-BINDIN G/HYDROLYSING PROTEIN (Clostridioides difficile)	4 / 8	HIS A 66 SER A 159 ILE A 73 ASP A 157	CME A 70 ( 3.6A) CME A 70 ( 3.0A) CME A 70 ( 4.3A) None	1.03A	2xadC-5tv7A: undetectable	2xadC-5tv7A: 18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2XAD_H_GCSH710_1 (N-ACYL GLM PEUDO-TEICOPLANIN DEACETYLASE TEICOPLANIN)	5tv7	PUTATIVE PEPTIDOGLYCAN-BINDIN G/HYDROLYSING PROTEIN (Clostridioides difficile)	4 / 8	HIS A 66 SER A 159 ILE A 73 ASP A 157	CME A 70 ( 3.6A) CME A 70 ( 3.0A) CME A 70 ( 4.3A) None	1.03A	2xadD-5tv7A: undetectable	2xadD-5tv7A: 18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3EEY_E_SAME300_0 (PUTATIVE RRNA METHYLASE)	5tv7	PUTATIVE PEPTIDOGLYCAN-BINDIN G/HYDROLYSING PROTEIN (Clostridioides difficile)	5 / 12	GLY A 134 ILE A 182 GLY A 181 GLN A 172 THR A 187	None HGA A 301 (-3.9A) None HGA A 301 ( 4.6A) HGA A 301 (-3.6A)	1.18A	3eeyE-5tv7A: undetectable	3eeyE-5tv7A: 19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3EEY_F_SAMF300_0 (PUTATIVE RRNA METHYLASE)	5tv7	PUTATIVE PEPTIDOGLYCAN-BINDIN G/HYDROLYSING PROTEIN (Clostridioides difficile)	5 / 12	GLY A 134 ILE A 182 GLY A 181 GLN A 172 THR A 187	None HGA A 301 (-3.9A) None HGA A 301 ( 4.6A) HGA A 301 (-3.6A)	1.19A	3eeyF-5tv7A: undetectable	3eeyF-5tv7A: 19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ACB_C_DXCC1477_0 (TRANSLATION ELONGATION FACTOR SELB)	5tv7	PUTATIVE PEPTIDOGLYCAN-BINDIN G/HYDROLYSING PROTEIN (Clostridioides difficile)	4 / 6	THR A 127 GLY A 184 ILE A 131 LEU A 191	None HGA A 301 (-3.3A) None None	1.04A	4acbC-5tv7A: undetectable	4acbC-5tv7A: 17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4MME_B_29QB603_1 (TRANSPORTER)	5tv7	PUTATIVE PEPTIDOGLYCAN-BINDIN G/HYDROLYSING PROTEIN (Clostridioides difficile)	5 / 9	VAL A 168 ALA A 167 GLY A 134 PHE A 160 SER A 162	None	0.95A	4mmeB-5tv7A: undetectable	4mmeB-5tv7A: 15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6HLP_A_GAWA1501_0 (SUBSTANCE-P RECEPTOR,SUBSTANCE-P RECEPTOR)	5tv7	PUTATIVE PEPTIDOGLYCAN-BINDIN G/HYDROLYSING PROTEIN (Clostridioides difficile)	5 / 12	ILE A 117 ILE A 125 VAL A 106 ILE A 115 TRP A 188	None	1.20A	6hlpA-5tv7A: undetectable	6hlpA-5tv7A: 15.77

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2XAD_E_GCSE710_1","N-ACYL GLM PEUDO-TEICOPLANIN DEACETYLASE;TEICOPLANIN","5tv7","PUTATIVE PEPTIDOGLYCAN-BINDING\/HYDROLYSING PROTEIN","Clostridioides difficile",4,"HIS A  66;SER A 159;ILE A  73;ASP A 157","CME A  70 ( 3.6A);CME A  70 ( 3.0A);CME A  70 ( 4.3A);None","1.02A","2xadA-5tv7A:undetectable","2xadA-5tv7A:18.15"],["2XAD_F_GCSF710_1","N-ACYL GLM PEUDO-TEICOPLANIN DEACETYLASE;TEICOPLANIN","5tv7","PUTATIVE PEPTIDOGLYCAN-BINDING\/HYDROLYSING PROTEIN","Clostridioides difficile",4,"HIS A  66;SER A 159;ILE A  73;ASP A 157","CME A  70 ( 3.6A);CME A  70 ( 3.0A);CME A  70 ( 4.3A);None","1.05A","2xadB-5tv7A:undetectable","2xadB-5tv7A:18.15"],["2XAD_G_GCSG710_1","N-ACYL GLM PEUDO-TEICOPLANIN DEACETYLASE;TEICOPLANIN","5tv7","PUTATIVE PEPTIDOGLYCAN-BINDING\/HYDROLYSING PROTEIN","Clostridioides difficile",4,"HIS A  66;SER A 159;ILE A  73;ASP A 157","CME A  70 ( 3.6A);CME A  70 ( 3.0A);CME A  70 ( 4.3A);None","1.03A","2xadC-5tv7A:undetectable","2xadC-5tv7A:18.15"],["2XAD_H_GCSH710_1","N-ACYL GLM PEUDO-TEICOPLANIN DEACETYLASE;TEICOPLANIN","5tv7","PUTATIVE PEPTIDOGLYCAN-BINDING\/HYDROLYSING PROTEIN","Clostridioides difficile",4,"HIS A  66;SER A 159;ILE A  73;ASP A 157","CME A  70 ( 3.6A);CME A  70 ( 3.0A);CME A  70 ( 4.3A);None","1.03A","2xadD-5tv7A:undetectable","2xadD-5tv7A:18.15"],["3EEY_E_SAME300_0","PUTATIVE RRNA METHYLASE","5tv7","PUTATIVE PEPTIDOGLYCAN-BINDING\/HYDROLYSING PROTEIN","Clostridioides difficile",5,"GLY A 134;ILE A 182;GLY A 181;GLN A 172;THR A 187","None;HGA A 301 (-3.9A);None;HGA A 301 ( 4.6A);HGA A 301 (-3.6A)","1.18A","3eeyE-5tv7A:undetectable","3eeyE-5tv7A:19.23"],["3EEY_F_SAMF300_0","PUTATIVE RRNA METHYLASE","5tv7","PUTATIVE PEPTIDOGLYCAN-BINDING\/HYDROLYSING PROTEIN","Clostridioides difficile",5,"GLY A 134;ILE A 182;GLY A 181;GLN A 172;THR A 187","None;HGA A 301 (-3.9A);None;HGA A 301 ( 4.6A);HGA A 301 (-3.6A)","1.19A","3eeyF-5tv7A:undetectable","3eeyF-5tv7A:19.23"],["4ACB_C_DXCC1477_0","TRANSLATION ELONGATION FACTOR SELB","5tv7","PUTATIVE PEPTIDOGLYCAN-BINDING\/HYDROLYSING PROTEIN","Clostridioides difficile",4,"THR A 127;GLY A 184;ILE A 131;LEU A 191","None;HGA A 301 (-3.3A);None;None","1.04A","4acbC-5tv7A:undetectable","4acbC-5tv7A:17.23"],["4MME_B_29QB603_1","TRANSPORTER","5tv7","PUTATIVE PEPTIDOGLYCAN-BINDING\/HYDROLYSING PROTEIN","Clostridioides difficile",5,"VAL A 168;ALA A 167;GLY A 134;PHE A 160;SER A 162","None","0.95A","4mmeB-5tv7A:undetectable","4mmeB-5tv7A:15.67"],["6HLP_A_GAWA1501_0","SUBSTANCE-P RECEPTOR,SUBSTANCE-P RECEPTOR","5tv7","PUTATIVE PEPTIDOGLYCAN-BINDING\/HYDROLYSING PROTEIN","Clostridioides difficile",5,"ILE A 117;ILE A 125;VAL A 106;ILE A 115;TRP A 188","None","1.20A","6hlpA-5tv7A:undetectable","6hlpA-5tv7A:15.77"]]