SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5tva'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_J_CHDJ101_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5tva 6-CARBOXYHEXANOATE--
COA LIGASE
(Aquifex
aeolicus) 		4 / 6 LEU A  84
ARG A 201
THR A 203
LEU A 205
 None
 1.08A 2dysA-5tvaA:
undetectable
2dysJ-5tvaA:
undetectable		 2dysA-5tvaA:
19.00
2dysJ-5tvaA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5tva 6-CARBOXYHEXANOATE--
COA LIGASE
(Aquifex
aeolicus) 		4 / 6 LEU A  84
ARG A 201
THR A 203
LEU A 205
 None
 1.02A 2zxwA-5tvaA:
undetectable
2zxwJ-5tvaA:
undetectable		 2zxwA-5tvaA:
19.00
2zxwJ-5tvaA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5tva 6-CARBOXYHEXANOATE--
COA LIGASE
(Aquifex
aeolicus) 		4 / 6 LEU A  84
ARG A 201
THR A 203
LEU A 205
 None
 1.06A 3abmA-5tvaA:
undetectable
3abmJ-5tvaA:
undetectable		 3abmA-5tvaA:
19.00
3abmJ-5tvaA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_J_CHDJ60_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 5tva 6-CARBOXYHEXANOATE--
COA LIGASE
(Aquifex
aeolicus) 		4 / 6 LEU A  84
ARG A 201
THR A 203
LEU A 205
 None
 1.07A 3asnA-5tvaA:
undetectable
3asnJ-5tvaA:
undetectable		 3asnA-5tvaA:
19.00
3asnJ-5tvaA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 5tva 6-CARBOXYHEXANOATE--
COA LIGASE
(Aquifex
aeolicus) 		5 / 12 ALA A 177
ILE A 197
LEU A 179
ILE A 202
LEU A 205
 None
 1.15A 3k2hB-5tvaA:
undetectable		 3k2hB-5tvaA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		 5tva 6-CARBOXYHEXANOATE--
COA LIGASE
(Aquifex
aeolicus) 		5 / 9 LEU A 152
LEU A 158
ILE A 238
GLU A  35
VAL A 147
 None
 1.21A 3tmzA-5tvaA:
undetectable		 3tmzA-5tvaA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_B_08JB602_1
(CYTOCHROME P450 3A4)		 5tva 6-CARBOXYHEXANOATE--
COA LIGASE
(Aquifex
aeolicus) 		4 / 8 ALA A 115
ILE A 100
ALA A  97
LEU A 101
 AMP  A 301 (-3.7A)
None
None
None
 0.80A 5te8B-5tvaA:
undetectable		 5te8B-5tvaA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5tva 6-CARBOXYHEXANOATE--
COA LIGASE
(Aquifex
aeolicus) 		4 / 6 LEU A  84
ARG A 201
THR A 203
LEU A 205
 None
 1.01A 5x1fA-5tvaA:
undetectable
5x1fJ-5tvaA:
undetectable		 5x1fA-5tvaA:
19.00
5x1fJ-5tvaA:
14.29