SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5tvd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APX_A_Z80A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 5tvd TM16
(Trichuris
muris) 		5 / 12 VAL A   7
LEU A  45
GLU A  40
ALA A  31
PHE A 124
 None
 1.34A 3apxA-5tvdA:
undetectable		 3apxA-5tvdA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_H_BEZH501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 5tvd TM16
(Trichuris
muris) 		4 / 7 ASN A  43
ALA A  39
VAL A  50
TYR A  33
 None
 1.08A 4ijiH-5tvdA:
undetectable		 4ijiH-5tvdA:
25.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M5M_A_DX4A401_0
(2-AMINO-4-HYDROXY-6-
HYDROXYMETHYLDIHYDRO
PTERIDINE
PYROPHOSPHOKINASE)		 5tvd TM16
(Trichuris
muris) 		4 / 8 GLY A 150
THR A  71
LEU A  90
PHE A 152
 None
 1.21A 4m5mA-5tvdA:
undetectable		 4m5mA-5tvdA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1Y_B_LOCB502_1
(TUBULIN BETA CHAIN)		 5tvd TM16
(Trichuris
muris) 		5 / 12 CYH A  29
LEU A  28
LEU A  56
ALA A  31
VAL A 126
 None
 0.95A 4x1yB-5tvdA:
undetectable		 4x1yB-5tvdA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_B_LOCB502_1
(TUBULIN BETA CHAIN)		 5tvd TM16
(Trichuris
muris) 		5 / 12 CYH A  29
LEU A  28
LEU A  56
ALA A  31
VAL A 126
 None
 0.89A 4x20B-5tvdA:
undetectable		 4x20B-5tvdA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JI0_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5tvd TM16
(Trichuris
muris) 		5 / 11 GLN A 173
LEU A 171
LEU A  45
CYH A  29
LEU A  28
 None
 0.89A 5ji0A-5tvdA:
undetectable		 5ji0A-5tvdA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PHH_A_LDPA414_1
(LYSINE-SPECIFIC
DEMETHYLASE 4D)		 5tvd TM16
(Trichuris
muris) 		4 / 6 ALA A 174
LEU A  45
TYR A  33
SER A 111
 None
 0.94A 5phhA-5tvdA:
undetectable		 5phhA-5tvdA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_2
(SIALIDASE)		 5tvd TM16
(Trichuris
muris) 		4 / 6 ASP A 137
LEU A  90
SER A 106
PHE A 152
 None
 1.11A 6ekuA-5tvdA:
undetectable		 6ekuA-5tvdA:
13.00