SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5tvj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ8_A_CAMA503_0
(CYTOCHROME P450-CAM)
5tvj ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN

(Mycobacterium
tuberculosis)
5 / 9 PHE A 402
THR A  79
LEU A  69
GLY A 188
THR A 135
None
1.47A 1dz8A-5tvjA:
undetectable
1dz8A-5tvjA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ8_B_CAMB502_0
(CYTOCHROME P450-CAM)
5tvj ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN

(Mycobacterium
tuberculosis)
5 / 9 PHE A 402
THR A  79
LEU A  69
GLY A 188
THR A 135
None
1.49A 1dz8B-5tvjA:
undetectable
1dz8B-5tvjA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ9_B_CAMB502_0
(CYTOCHROME P450-CAM)
5tvj ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN

(Mycobacterium
tuberculosis)
5 / 9 PHE A 402
THR A  79
LEU A  69
GLY A 188
THR A 135
None
1.46A 1dz9B-5tvjA:
undetectable
1dz9B-5tvjA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK6_A_LNLA1201_1
(NON-SPECIFIC LIPID
TRANSFER PROTEIN)
5tvj ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN

(Mycobacterium
tuberculosis)
5 / 12 VAL A  71
ALA A 363
ALA A 134
LEU A 296
ALA A 116
None
1.00A 1fk6A-5tvjA:
undetectable
1fk6A-5tvjA:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_J_TRPJ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
5tvj ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN

(Mycobacterium
tuberculosis)
4 / 8 SER A  23
ALA A  22
GLY A  15
ALA A  21
None
0.66A 1gtnI-5tvjA:
undetectable
1gtnJ-5tvjA:
undetectable
1gtnI-5tvjA:
12.06
1gtnJ-5tvjA:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1871_0
(FPRA)
5tvj ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN

(Mycobacterium
tuberculosis)
4 / 7 PHE A  84
ALA A  20
PHE A  27
PHE A  17
7LF  A 502 (-4.0A)
None
None
None
1.16A 1lqtA-5tvjA:
undetectable
1lqtA-5tvjA:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_A_ACTA1428_0
(FPRA)
5tvj ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN

(Mycobacterium
tuberculosis)
4 / 7 PHE A  84
ALA A  20
PHE A  27
PHE A  17
7LF  A 502 (-4.0A)
None
None
None
1.17A 1lquA-5tvjA:
undetectable
1lquA-5tvjA:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RBP_A_RTLA183_0
(PLASMA
RETINOL-BINDING
PROTEIN PRECURSOR)
5tvj ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN

(Mycobacterium
tuberculosis)
5 / 12 ALA A 311
ALA A 391
ALA A 389
LEU A 382
GLN A 381
None
1.20A 1rbpA-5tvjA:
undetectable
1rbpA-5tvjA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)
5tvj ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN

(Mycobacterium
tuberculosis)
5 / 12 THR A 398
VAL A 115
LEU A  77
THR A  79
PHE A 402
GOL  A 503 (-3.9A)
None
None
None
None
1.20A 2jn3A-5tvjA:
undetectable
2jn3A-5tvjA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)
5tvj ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN

(Mycobacterium
tuberculosis)
4 / 6 THR A 288
ARG A 286
ASP A 229
THR A 231
None
1.16A 2okcB-5tvjA:
undetectable
2okcB-5tvjA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)
5tvj ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN

(Mycobacterium
tuberculosis)
4 / 6 THR A 288
ARG A 286
THR A 231
ASP A 211
None
1.11A 2okcB-5tvjA:
undetectable
2okcB-5tvjA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_A_RALA600_1
(ESTROGEN RECEPTOR)
5tvj ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN

(Mycobacterium
tuberculosis)
5 / 12 THR A 135
ALA A 363
LEU A 369
LEU A 296
PRO A  72
None
1.15A 2qxsA-5tvjA:
undetectable
2qxsA-5tvjA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN7_A_T44A1355_1
(THYROXINE-BINDING
GLOBULIN)
5tvj ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN

(Mycobacterium
tuberculosis)
5 / 10 LEU A 331
LEU A 321
LEU A 356
LEU A 305
ARG A 308
None
1.15A 2xn7A-5tvjA:
undetectable
2xn7B-5tvjA:
undetectable
2xn7A-5tvjA:
20.93
2xn7B-5tvjA:
7.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_D_ADND438_1
(ADENOSYLHOMOCYSTEINA
SE)
5tvj ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN

(Mycobacterium
tuberculosis)
5 / 12 LEU A 190
THR A  79
THR A 398
LEU A 361
PHE A 402
None
None
GOL  A 503 (-3.9A)
None
None
1.27A 3g1uD-5tvjA:
undetectable
3g1uD-5tvjA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)
5tvj ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN

(Mycobacterium
tuberculosis)
5 / 12 LEU A 383
ARG A 385
GLN A 381
ILE A 349
PHE A 317
None
1.03A 3gwvA-5tvjA:
undetectable
3gwvA-5tvjA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACHG301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)
5tvj ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN

(Mycobacterium
tuberculosis)
4 / 8 TYR A 360
THR A  70
ARG A 183
LEU A 190
None
CL  A 504 (-3.8A)
CL  A 504 (-3.9A)
None
1.18A 3wipG-5tvjA:
undetectable
3wipH-5tvjA:
undetectable
3wipG-5tvjA:
18.98
3wipH-5tvjA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTZ_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 8C8)
5tvj ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN

(Mycobacterium
tuberculosis)
4 / 6 PHE A 402
ALA A 399
LEU A 294
THR A 398
None
None
None
GOL  A 503 (-3.9A)
1.11A 4dtzB-5tvjA:
undetectable
4dtzB-5tvjA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)
5tvj ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN

(Mycobacterium
tuberculosis)
4 / 8 GLU A 180
ARG A 242
GLY A 189
ARG A 183
None
None
CL  A 504 (-4.7A)
CL  A 504 (-3.9A)
1.02A 4fgzA-5tvjA:
undetectable
4fgzB-5tvjA:
undetectable
4fgzA-5tvjA:
17.56
4fgzB-5tvjA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_0
(PUTATIVE
METHYLTRANSFERASE
NSUN4)
5tvj ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN

(Mycobacterium
tuberculosis)
5 / 12 GLY A 160
GLY A 159
LEU A 218
GLY A 222
LEU A 252
None
1.08A 4fzvA-5tvjA:
undetectable
4fzvA-5tvjA:
21.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JD6_A_TOYA501_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)
5tvj ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN

(Mycobacterium
tuberculosis)
7 / 9 PHE A  24
ASP A  26
ILE A  28
TRP A  36
SER A  83
TYR A 126
GLU A 203
7LF  A 502 ( 3.9A)
7LF  A 502 (-3.5A)
7LF  A 502 (-4.1A)
7LF  A 502 (-3.9A)
7LF  A 502 (-3.5A)
COA  A 501 (-4.0A)
None
0.93A 4jd6A-5tvjA:
61.2
4jd6A-5tvjA:
98.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JD6_A_TOYA501_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)
5tvj ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN

(Mycobacterium
tuberculosis)
7 / 9 PHE A  24
ASP A  26
ILE A  28
TRP A  36
SER A  83
VAL A  85
GLU A 203
7LF  A 502 ( 3.9A)
7LF  A 502 (-3.5A)
7LF  A 502 (-4.1A)
7LF  A 502 (-3.9A)
7LF  A 502 (-3.5A)
COA  A 501 (-3.8A)
None
0.62A 4jd6A-5tvjA:
61.2
4jd6A-5tvjA:
98.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JD6_A_TOYA501_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)
5tvj ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN

(Mycobacterium
tuberculosis)
7 / 9 PHE A  24
ASP A  26
TRP A  36
SER A  83
VAL A  85
GLU A 203
GLU A 401
7LF  A 502 ( 3.9A)
7LF  A 502 (-3.5A)
7LF  A 502 (-3.9A)
7LF  A 502 (-3.5A)
COA  A 501 (-3.8A)
None
7LF  A 502 (-3.3A)
0.75A 4jd6A-5tvjA:
61.2
4jd6A-5tvjA:
98.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JD6_B_TOYB501_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)
5tvj ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN

(Mycobacterium
tuberculosis)
7 / 9 PHE A  24
ASP A  26
ILE A  28
TRP A  36
SER A  83
TYR A 126
GLU A 203
7LF  A 502 ( 3.9A)
7LF  A 502 (-3.5A)
7LF  A 502 (-4.1A)
7LF  A 502 (-3.9A)
7LF  A 502 (-3.5A)
COA  A 501 (-4.0A)
None
0.90A 4jd6B-5tvjA:
61.2
4jd6B-5tvjA:
98.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JD6_B_TOYB501_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)
5tvj ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN

(Mycobacterium
tuberculosis)
7 / 9 PHE A  24
ASP A  26
ILE A  28
TRP A  36
SER A  83
VAL A  85
GLU A 203
7LF  A 502 ( 3.9A)
7LF  A 502 (-3.5A)
7LF  A 502 (-4.1A)
7LF  A 502 (-3.9A)
7LF  A 502 (-3.5A)
COA  A 501 (-3.8A)
None
0.59A 4jd6B-5tvjA:
61.2
4jd6B-5tvjA:
98.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JD6_B_TOYB501_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)
5tvj ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN

(Mycobacterium
tuberculosis)
7 / 9 PHE A  24
ASP A  26
TRP A  36
SER A  83
TYR A 126
GLU A 203
GLU A 401
7LF  A 502 ( 3.9A)
7LF  A 502 (-3.5A)
7LF  A 502 (-3.9A)
7LF  A 502 (-3.5A)
COA  A 501 (-4.0A)
None
7LF  A 502 (-3.3A)
1.00A 4jd6B-5tvjA:
61.2
4jd6B-5tvjA:
98.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JD6_B_TOYB501_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)
5tvj ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN

(Mycobacterium
tuberculosis)
7 / 9 PHE A  24
ASP A  26
TRP A  36
SER A  83
VAL A  85
GLU A 203
GLU A 401
7LF  A 502 ( 3.9A)
7LF  A 502 (-3.5A)
7LF  A 502 (-3.9A)
7LF  A 502 (-3.5A)
COA  A 501 (-3.8A)
None
7LF  A 502 (-3.3A)
0.68A 4jd6B-5tvjA:
61.2
4jd6B-5tvjA:
98.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_B_9TPB601_1
(SERUM ALBUMIN)
5tvj ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN

(Mycobacterium
tuberculosis)
5 / 12 PRO A 302
ALA A 330
LEU A 356
LEU A 359
GLY A 362
None
1.22A 4l9qB-5tvjA:
undetectable
4l9qB-5tvjA:
20.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QB9_E_PARE500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)
5tvj ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN

(Mycobacterium
tuberculosis)
5 / 12 SER A  83
LEU A 118
SER A 121
TYR A 126
ASP A 292
7LF  A 502 (-3.5A)
COA  A 501 ( 4.8A)
COA  A 501 ( 4.4A)
COA  A 501 (-4.0A)
None
0.75A 4qb9E-5tvjA:
50.7
4qb9E-5tvjA:
60.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1Y_B_LOCB502_1
(TUBULIN BETA CHAIN)
5tvj ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN

(Mycobacterium
tuberculosis)
5 / 12 LEU A 217
ALA A 255
MET A 262
ALA A 236
VAL A 238
None
0.97A 4x1yB-5tvjA:
undetectable
4x1yB-5tvjA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1Y_D_LOCD502_2
(TUBULIN BETA CHAIN)
5tvj ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN

(Mycobacterium
tuberculosis)
6 / 12 LEU A 217
LEU A 259
MET A 262
ALA A 236
VAL A 238
ILE A 265
None
1.38A 4x1yD-5tvjA:
undetectable
4x1yD-5tvjA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_2
(TUBULIN BETA CHAIN)
5tvj ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN

(Mycobacterium
tuberculosis)
6 / 11 LEU A 217
LEU A 259
MET A 262
ALA A 236
VAL A 238
ILE A 265
None
1.41A 4x20D-5tvjA:
undetectable
4x20D-5tvjA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_A_29SA601_1
(ESTROGEN RECEPTOR)
5tvj ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN

(Mycobacterium
tuberculosis)
5 / 12 THR A 135
ALA A 363
LEU A 369
LEU A 296
PRO A  72
None
1.20A 4xi3A-5tvjA:
undetectable
4xi3A-5tvjA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_D_29SD601_1
(ESTROGEN RECEPTOR)
5tvj ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN

(Mycobacterium
tuberculosis)
5 / 12 THR A 135
ALA A 363
LEU A 369
LEU A 296
PRO A  72
None
1.20A 4xi3D-5tvjA:
undetectable
4xi3D-5tvjA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)
5tvj ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN

(Mycobacterium
tuberculosis)
5 / 12 ILE A 349
LEU A 331
ALA A 311
GLY A 336
TYR A 310
None
0.81A 5uxdB-5tvjA:
undetectable
5uxdB-5tvjA:
25.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_A_ACTA816_0
(UNCHARACTERIZED
PROTEIN)
5tvj ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN

(Mycobacterium
tuberculosis)
3 / 3 ARG A 227
ARG A 230
ASP A 211
None
0.86A 6d8pA-5tvjA:
undetectable
6d8pA-5tvjA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA821_0
(GEPHYRIN)
5tvj ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN

(Mycobacterium
tuberculosis)
3 / 3 ARG A 297
PHE A 129
GLY A 130
None
0.79A 6fgdA-5tvjA:
undetectable
6fgdA-5tvjA:
23.29