SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5tvl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QVN_B_BO2B201_1 (PROTEASOME SUBUNIT BETA TYPE-2 PROTEASOME SUBUNIT BETA TYPE-1)	5tvl	FOLDASE PROTEIN PRSA (Streptococcus pneumoniae)	5 / 12	SER A 172 THR A 237 ALA A 113 ALA A 173 THR A 175	None	1.22A	4qvnV-5tvlA: undetectable 4qvnb-5tvlA: undetectable	4qvnV-5tvlA: 20.71 4qvnb-5tvlA: 22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QVN_N_BO2N201_1 (PROTEASOME SUBUNIT BETA TYPE-2 PROTEASOME SUBUNIT BETA TYPE-1)	5tvl	FOLDASE PROTEIN PRSA (Streptococcus pneumoniae)	5 / 12	SER A 172 THR A 237 ALA A 113 ALA A 173 THR A 175	None	1.21A	4qvnH-5tvlA: undetectable 4qvnN-5tvlA: undetectable	4qvnH-5tvlA: 20.71 4qvnN-5tvlA: 22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RP9_A_ASCA501_0 (ASCORBATE-SPECIFIC PERMEASE IIC COMPONENT ULAA)	5tvl	FOLDASE PROTEIN PRSA (Streptococcus pneumoniae)	5 / 12	TYR A 273 GLN A 247 ALA A 96 ILE A 37 PHE A 41	None	1.49A	4rp9A-5tvlA: undetectable	4rp9A-5tvlA: 18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6HWD_B_BO2B201_0 (PROTEASOME SUBUNIT BETA TYPE-1 PROTEASOME SUBUNIT BETA TYPE-2)	5tvl	FOLDASE PROTEIN PRSA (Streptococcus pneumoniae)	5 / 12	SER A 172 THR A 237 ALA A 113 ALA A 173 THR A 175	None	1.25A	6hwdV-5tvlA: undetectable 6hwdb-5tvlA: undetectable	6hwdV-5tvlA: 11.27 6hwdb-5tvlA: 15.27

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["4QVN_B_BO2B201_1","PROTEASOME SUBUNIT BETA TYPE-2;PROTEASOME SUBUNIT BETA TYPE-1","5tvl","FOLDASE PROTEIN PRSA","Streptococcus pneumoniae",5,"SER A 172;THR A 237;ALA A 113;ALA A 173;THR A 175","None","1.22A","4qvnV-5tvlA:undetectable;4qvnb-5tvlA:undetectable","4qvnV-5tvlA:20.71;4qvnb-5tvlA:22.26"],["4QVN_N_BO2N201_1","PROTEASOME SUBUNIT BETA TYPE-2;PROTEASOME SUBUNIT BETA TYPE-1","5tvl","FOLDASE PROTEIN PRSA","Streptococcus pneumoniae",5,"SER A 172;THR A 237;ALA A 113;ALA A 173;THR A 175","None","1.21A","4qvnH-5tvlA:undetectable;4qvnN-5tvlA:undetectable","4qvnH-5tvlA:20.71;4qvnN-5tvlA:22.26"],["4RP9_A_ASCA501_0","ASCORBATE-SPECIFIC PERMEASE IIC COMPONENT ULAA","5tvl","FOLDASE PROTEIN PRSA","Streptococcus pneumoniae",5,"TYR A 273;GLN A 247;ALA A  96;ILE A  37;PHE A  41","None","1.49A","4rp9A-5tvlA:undetectable","4rp9A-5tvlA:18.70"],["6HWD_B_BO2B201_0","PROTEASOME SUBUNIT BETA TYPE-1;PROTEASOME SUBUNIT BETA TYPE-2","5tvl","FOLDASE PROTEIN PRSA","Streptococcus pneumoniae",5,"SER A 172;THR A 237;ALA A 113;ALA A 173;THR A 175","None","1.25A","6hwdV-5tvlA:undetectable;6hwdb-5tvlA:undetectable","6hwdV-5tvlA:11.27;6hwdb-5tvlA:15.27"]]