SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5tvo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DB1_A_VDXA428_2
(VITAMIN D NUCLEAR
RECEPTOR)		 5tvo S-ADENOSYLMETHIONINE
DECARBOXYLASE
PROENZYME
(Trypanosoma
brucei) 		4 / 6 ILE A  98
ARG B  34
TYR A 274
VAL B  82
 None
None
None
PYR  A 401 (-3.7A)
 1.07A 1db1A-5tvoA:
undetectable		 1db1A-5tvoA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_A_STIA3_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5tvo S-ADENOSYLMETHIONINE
DECARBOXYLASE
PROENZYME
(Trypanosoma
brucei) 		4 / 5 TYR B  81
VAL A 232
ILE A 237
MET A  91
 None
 1.40A 1opjA-5tvoB:
undetectable		 1opjA-5tvoB:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q2H_B_ACTB501_0
(SECRETION CHAPERONE,
PHAGE-DISPLAY
DERIVED PEPTIDE)		 5tvo S-ADENOSYLMETHIONINE
DECARBOXYLASE
PROENZYME
(Trypanosoma
brucei) 		3 / 3 ARG A 223
SER A 229
TYR A 248
 None
 0.88A 2q2hA-5tvoA:
undetectable
2q2hB-5tvoA:
undetectable		 2q2hA-5tvoA:
19.12
2q2hB-5tvoA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_B_TRPB1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5tvo S-ADENOSYLMETHIONINE
DECARBOXYLASE
PROENZYME
(Trypanosoma
brucei) 		4 / 8 VAL A 119
ILE A 112
VAL A  95
VAL A  90
 None
 0.80A 3fi0B-5tvoA:
undetectable		 3fi0B-5tvoA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_G_TRPG1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5tvo S-ADENOSYLMETHIONINE
DECARBOXYLASE
PROENZYME
(Trypanosoma
brucei) 		4 / 8 VAL A 119
ILE A 112
VAL A  95
VAL A  90
 None
 0.73A 3fi0G-5tvoA:
undetectable		 3fi0G-5tvoA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_Q_TRPQ1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5tvo S-ADENOSYLMETHIONINE
DECARBOXYLASE
PROENZYME
(Trypanosoma
brucei) 		4 / 8 VAL A 119
ILE A 112
VAL A  95
VAL A  90
 None
 0.74A 3fi0Q-5tvoA:
undetectable		 3fi0Q-5tvoA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_H_TFPH202_1
(PROTEIN S100-A4)		 5tvo S-ADENOSYLMETHIONINE
DECARBOXYLASE
PROENZYME
(Trypanosoma
brucei) 		5 / 12 SER A 193
ILE A  98
PHE A 128
PHE A 304
ASP A 169
 None
 1.34A 3ko0G-5tvoA:
undetectable
3ko0H-5tvoA:
undetectable
3ko0I-5tvoA:
undetectable
3ko0J-5tvoA:
undetectable		 3ko0G-5tvoA:
16.79
3ko0H-5tvoA:
16.79
3ko0I-5tvoA:
16.79
3ko0J-5tvoA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_A_FUNA201_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 5tvo S-ADENOSYLMETHIONINE
DECARBOXYLASE
PROENZYME
(Trypanosoma
brucei) 		5 / 11 MET A 194
ILE A 261
VAL A 290
VAL A 231
ILE A 287
 None
 1.14A 3rf4A-5tvoA:
undetectable
3rf4C-5tvoA:
undetectable		 3rf4A-5tvoA:
19.37
3rf4C-5tvoA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_B_FUNB202_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 5tvo S-ADENOSYLMETHIONINE
DECARBOXYLASE
PROENZYME
(Trypanosoma
brucei) 		5 / 11 ILE A 287
MET A 194
ILE A 261
VAL A 290
VAL A 231
 None
 1.17A 3rf4A-5tvoA:
undetectable
3rf4B-5tvoA:
undetectable		 3rf4A-5tvoA:
19.37
3rf4B-5tvoA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_C_FUNC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 5tvo S-ADENOSYLMETHIONINE
DECARBOXYLASE
PROENZYME
(Trypanosoma
brucei) 		5 / 11 ILE A 287
MET A 194
ILE A 261
VAL A 290
VAL A 231
 None
 1.17A 3rf4B-5tvoA:
undetectable
3rf4C-5tvoA:
undetectable		 3rf4B-5tvoA:
19.37
3rf4C-5tvoA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_C_FUNC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 5tvo S-ADENOSYLMETHIONINE
DECARBOXYLASE
PROENZYME
(Trypanosoma
brucei) 		5 / 11 ILE A 287
SER A 273
ILE A 261
VAL A 290
VAL A 231
 None
 1.10A 3rf4B-5tvoA:
undetectable
3rf4C-5tvoA:
undetectable		 3rf4B-5tvoA:
19.37
3rf4C-5tvoA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1479_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 5tvo S-ADENOSYLMETHIONINE
DECARBOXYLASE
PROENZYME
(Trypanosoma
brucei) 		4 / 5 THR A  99
ILE A  98
GLU A 275
PHE A 271
 PYR  A 401 ( 4.4A)
None
None
None
 1.47A 4acbC-5tvoA:
undetectable		 4acbC-5tvoA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WQP_A_NCAA302_0
(PROBABLE
DEHYDROGENASE)		 5tvo S-ADENOSYLMETHIONINE
DECARBOXYLASE
PROENZYME
S-ADENOSYLMETHIONINE
DECARBOXYLASE
PROENZYME
(Trypanosoma
brucei;
Trypanosoma
brucei) 		4 / 8 SER B  84
MET A 212
TYR A 243
HIS B  68
 None
 1.39A 5wqpA-5tvoB:
undetectable		 5wqpA-5tvoB:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_2
(-)		 5tvo S-ADENOSYLMETHIONINE
DECARBOXYLASE
PROENZYME
(Trypanosoma
brucei) 		4 / 8 VAL A 303
TYR A 283
ASN A 277
GLU B  36
 None
 1.21A 6gneB-5tvoA:
undetectable		 6gneB-5tvoA:
20.79