SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5tw1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A27_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacteriu
m
smegmatis)
5 / 12 VAL C 414
GLY C 383
MET C 387
LEU C 384
VAL C 126
None
1.40A 1a27A-5tw1C:
undetectable
1a27A-5tw1C:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYR_A_TOPA407_1
(DIHYDROFOLATE
REDUCTASE)
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacteriu
m
smegmatis)
5 / 11 ILE C 748
ALA C 750
GLU C 758
ILE C 764
PRO C 765
None
1.02A 1dyrA-5tw1C:
undetectable
1dyrA-5tw1C:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4007_1
(SERUM ALBUMIN)
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacteriu
m
smegmatis)
4 / 8 LEU C 437
ASN C 434
LEU C1022
LEU C 706
None
1.08A 1e7cA-5tw1C:
undetectable
1e7cA-5tw1C:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EUP_A_ASDA452_1
(CYTOCHROME P450ERYF)
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacteriu
m
smegmatis)
4 / 8 PHE C 148
ILE C 380
LEU C  55
LEU C  81
None
0.80A 1eupA-5tw1C:
undetectable
1eupA-5tw1C:
17.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I6V_C_RFPC1640_1
(DNA-DIRECTED RNA
POLYMERASE)
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacteriu
m
smegmatis)
10 / 12 ARG C 164
GLN C 426
LEU C 427
GLN C 429
ASP C 432
ARG C 604
HIS C 442
ARG C 445
SER C 447
ILE C 488
None
1.04A 1i6vC-5tw1C:
37.2
1i6vC-5tw1C:
50.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I6V_C_RFPC1640_1
(DNA-DIRECTED RNA
POLYMERASE)
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacteriu
m
smegmatis)
7 / 12 GLN C 429
PHE C 430
ARG C 604
HIS C 442
ARG C 445
SER C 447
ILE C 488
None
1.35A 1i6vC-5tw1C:
37.2
1i6vC-5tw1C:
50.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_I_BEZI518_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacteriu
m
smegmatis)
4 / 7 GLY C  92
PRO C  86
ASN C 132
ASN C 133
None
0.81A 1oniG-5tw1C:
undetectable
1oniI-5tw1C:
undetectable
1oniG-5tw1C:
8.45
1oniI-5tw1C:
8.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_A_SAMA301_1
(HEMK PROTEIN)
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacteriu
m
smegmatis)
4 / 4 THR C 962
GLY C 702
ASP C 695
ALA C 705
None
1.24A 1sg9A-5tw1C:
undetectable
1sg9A-5tw1C:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U1J_A_C2FA773_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacteriu
m
smegmatis)
4 / 8 LYS C 114
ASN C 434
SER C 669
ARG C 664
None
1.27A 1u1jA-5tw1C:
undetectable
1u1jA-5tw1C:
22.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YNN_C_RFPC1120_1
(DNA-DIRECTED RNA
POLYMERASE BETA
CHAIN)
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacteriu
m
smegmatis)
11 / 12 ARG C 164
GLN C 426
GLN C 429
ASP C 432
ARG C 604
HIS C 442
ARG C 445
SER C 447
LEU C 449
PRO C 480
ILE C 488
None
1.11A 1ynnC-5tw1C:
40.7
1ynnC-5tw1C:
50.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YNN_C_RFPC1120_1
(DNA-DIRECTED RNA
POLYMERASE BETA
CHAIN)
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacteriu
m
smegmatis)
6 / 12 GLN C 429
PHE C 430
HIS C 442
ARG C 445
PRO C 480
ILE C 488
None
1.04A 1ynnC-5tw1C:
40.7
1ynnC-5tw1C:
50.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A68_C_RBTC8001_1
(DNA-DIRECTED RNA
POLYMERASE BETA
CHAIN
RNA POLYMERASE SIGMA
FACTOR RPOD)
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacteriu
m
smegmatis)
8 / 11 ARG C 164
GLN C 426
GLN C 429
ASP C 432
HIS C 442
ARG C 445
SER C 447
PRO C 480
None
0.70A 2a68C-5tw1C:
39.0
2a68F-5tw1C:
1.3
2a68C-5tw1C:
50.41
2a68F-5tw1C:
18.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A68_C_RBTC8001_1
(DNA-DIRECTED RNA
POLYMERASE BETA
CHAIN
RNA POLYMERASE SIGMA
FACTOR RPOD)
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacteriu
m
smegmatis)
8 / 11 ARG C 164
GLN C 426
GLN C 429
ASP C 432
HIS C 442
SER C 447
PRO C 480
ILE C 488
None
0.83A 2a68C-5tw1C:
39.0
2a68F-5tw1C:
1.3
2a68C-5tw1C:
50.41
2a68F-5tw1C:
18.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A68_C_RBTC8001_1
(DNA-DIRECTED RNA
POLYMERASE BETA
CHAIN
RNA POLYMERASE SIGMA
FACTOR RPOD)
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacteriu
m
smegmatis)
6 / 11 GLN C 429
PHE C 430
ASP C 432
HIS C 442
ARG C 445
PRO C 480
None
0.92A 2a68C-5tw1C:
39.0
2a68F-5tw1C:
1.3
2a68C-5tw1C:
50.41
2a68F-5tw1C:
18.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A68_M_RBTM8002_1
(DNA-DIRECTED RNA
POLYMERASE BETA
CHAIN)
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacteriu
m
smegmatis)
10 / 11 ARG C 164
GLN C 426
GLN C 429
PHE C 430
ASP C 432
HIS C 442
ARG C 445
SER C 447
PRO C 480
ILE C 488
None
0.88A 2a68M-5tw1C:
38.2
2a68M-5tw1C:
50.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A68_M_RBTM8002_1
(DNA-DIRECTED RNA
POLYMERASE BETA
CHAIN)
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacteriu
m
smegmatis)
5 / 11 GLN C 169
HIS C 442
ARG C 445
PRO C 480
ILE C 488
None
1.08A 2a68M-5tw1C:
38.2
2a68M-5tw1C:
50.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A68_M_RBTM8002_1
(DNA-DIRECTED RNA
POLYMERASE BETA
CHAIN)
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacteriu
m
smegmatis)
6 / 11 GLN C 426
ARG C 445
SER C 447
PRO C 480
ILE C 488
ASN C 601
None
1.04A 2a68M-5tw1C:
38.2
2a68M-5tw1C:
50.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A69_C_RPTC8001_1
(DNA-DIRECTED RNA
POLYMERASE BETA
CHAIN
RNA POLYMERASE SIGMA
FACTOR RPOD)
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacteriu
m
smegmatis)
9 / 11 ARG C 164
GLN C 426
GLN C 429
ASP C 432
HIS C 442
ARG C 445
SER C 447
PRO C 480
ILE C 488
None
0.76A 2a69C-5tw1C:
38.0
2a69F-5tw1C:
1.3
2a69C-5tw1C:
50.41
2a69F-5tw1C:
18.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A69_C_RPTC8001_1
(DNA-DIRECTED RNA
POLYMERASE BETA
CHAIN
RNA POLYMERASE SIGMA
FACTOR RPOD)
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacteriu
m
smegmatis)
5 / 11 GLN C 169
HIS C 442
ARG C 445
PRO C 480
ILE C 488
None
1.28A 2a69C-5tw1C:
38.0
2a69F-5tw1C:
1.3
2a69C-5tw1C:
50.41
2a69F-5tw1C:
18.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A69_C_RPTC8001_1
(DNA-DIRECTED RNA
POLYMERASE BETA
CHAIN
RNA POLYMERASE SIGMA
FACTOR RPOD)
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacteriu
m
smegmatis)
7 / 11 GLN C 429
PHE C 430
ASP C 432
HIS C 442
ARG C 445
PRO C 480
ILE C 488
None
0.97A 2a69C-5tw1C:
38.0
2a69F-5tw1C:
1.3
2a69C-5tw1C:
50.41
2a69F-5tw1C:
18.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A69_M_RPTM8002_1
(DNA-DIRECTED RNA
POLYMERASE BETA
CHAIN)
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacteriu
m
smegmatis)
8 / 12 ARG C 164
GLN C 426
GLN C 429
ASP C 432
ARG C 604
HIS C 442
ARG C 445
ILE C 488
None
1.20A 2a69M-5tw1C:
39.0
2a69M-5tw1C:
50.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A69_M_RPTM8002_1
(DNA-DIRECTED RNA
POLYMERASE BETA
CHAIN)
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacteriu
m
smegmatis)
9 / 12 GLN C 426
GLN C 429
ASP C 432
ARG C 604
HIS C 442
ARG C 445
SER C 447
ILE C 488
ASN C 601
None
1.23A 2a69M-5tw1C:
39.0
2a69M-5tw1C:
50.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A69_M_RPTM8002_1
(DNA-DIRECTED RNA
POLYMERASE BETA
CHAIN)
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacteriu
m
smegmatis)
5 / 12 GLN C 426
GLN C 429
ASP C 432
HIS C 442
GLU C 481
None
1.41A 2a69M-5tw1C:
39.0
2a69M-5tw1C:
50.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_2
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacteriu
m
smegmatis)
4 / 6 ARG C 301
GLN C 377
ASN C 378
LEU C 124
None
1.12A 2nyrA-5tw1C:
undetectable
2nyrA-5tw1C:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacteriu
m
smegmatis)
4 / 6 GLY C  57
GLY C 373
PHE C 148
PHE C 103
None
0.99A 2qx6A-5tw1C:
undetectable
2qx6B-5tw1C:
undetectable
2qx6A-5tw1C:
11.77
2qx6B-5tw1C:
11.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacteriu
m
smegmatis)
4 / 6 GLY C  75
GLY C 373
PHE C 148
PHE C 103
None
0.79A 2qx6A-5tw1C:
undetectable
2qx6B-5tw1C:
undetectable
2qx6A-5tw1C:
11.77
2qx6B-5tw1C:
11.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RK8_A_PPFA3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacteriu
m
smegmatis)
4 / 8 HIS C 467
SER C 469
ASP C 360
ALA C 524
None
1.41A 2rk8A-5tw1C:
undetectable
2rk8A-5tw1C:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_A_D16A309_1
(THYMIDYLATE SYNTHASE)
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacteriu
m
smegmatis)
4 / 7 ILE C 627
LEU C  44
GLY C  43
TYR C 494
None
0.84A 2tsrA-5tw1C:
undetectable
2tsrA-5tw1C:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A9E_B_REAB1_1
(RETINOIC ACID
RECEPTOR ALPHA)
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacteriu
m
smegmatis)
5 / 11 ILE C 376
PHE C  52
SER C  51
PHE C 148
VAL C 126
None
1.19A 3a9eB-5tw1C:
undetectable
3a9eB-5tw1C:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC507_2
(PHOSPHOLIPASE A2)
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacteriu
m
smegmatis)
4 / 6 VAL C 860
VAL C 843
ARG C 842
ARG C 846
None
1.13A 3bjwF-5tw1C:
undetectable
3bjwF-5tw1C:
7.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_B_SAMB238_1
(N,N-DIMETHYLTRANSFER
ASE)
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacteriu
m
smegmatis)
3 / 3 TYR C 569
GLU C 504
ASP C  50
None
0.85A 3bxoB-5tw1C:
undetectable
3bxoB-5tw1C:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_1
(MODIFICATION
METHYLASE HHAI)
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacteriu
m
smegmatis)
3 / 3 GLU C 420
SER C 428
VAL C 166
None
0.73A 3eeoA-5tw1C:
undetectable
3eeoA-5tw1C:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUU_A_ADNA0_1
(DIMETHYLADENOSINE
TRANSFERASE)
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacteriu
m
smegmatis)
5 / 12 VAL C 687
GLY C 639
ASP C 655
ASP C 636
ALA C 635
None
0.93A 3fuuA-5tw1C:
undetectable
3fuuA-5tw1C:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacteriu
m
smegmatis)
4 / 7 LEU C 908
GLN C 603
LEU C 609
LEU C 710
None
0.91A 3g8iA-5tw1C:
undetectable
3g8iA-5tw1C:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R0L_D_ACTD127_0
(PHOSPHOLIPASE A2 CB)
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacteriu
m
smegmatis)
4 / 5 PHE C 364
ILE C 503
GLY C 472
HIS C 470
None
1.22A 3r0lD-5tw1C:
undetectable
3r0lD-5tw1C:
6.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_A_C2FA1100_0
(GLYCINE
N-METHYLTRANSFERASE)
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacteriu
m
smegmatis)
4 / 6 SER C 612
LEU C 706
MET C 704
THR C 699
None
1.40A 3thrB-5tw1C:
undetectable
3thrB-5tw1C:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacteriu
m
smegmatis)
5 / 12 ILE C 418
ALA C 417
LEU C  77
LEU C  55
PHE C 422
None
1.01A 3uvvA-5tw1C:
undetectable
3uvvA-5tw1C:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3A_A_ADNA500_2
(SUGAR KINASE PROTEIN)
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacteriu
m
smegmatis)
4 / 4 SER C1036
TYR C1094
GLY C1038
PRO C1047
None
1.48A 4e3aA-5tw1C:
undetectable
4e3aA-5tw1C:
15.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_B_ASWB1301_1
(DNA TOPOISOMERASE
2-BETA)
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacteriu
m
smegmatis)
4 / 7 ILE C 585
PRO C 586
GLU C 924
GLN C 700
None
0.70A 4g0uB-5tw1C:
undetectable
4g0uB-5tw1C:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_B_D16B402_1
(THYMIDYLATE SYNTHASE)
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacteriu
m
smegmatis)
4 / 7 ILE C 627
LEU C  44
GLY C  43
TYR C 494
None
0.85A 4iqqB-5tw1C:
undetectable
4iqqB-5tw1C:
14.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KMU_C_RFPC1401_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacteriu
m
smegmatis)
10 / 12 GLN C 426
GLN C 429
ASP C 432
HIS C 442
ARG C 445
SER C 447
ARG C 456
PRO C 480
ASN C 484
ILE C 488
None
0.93A 4kmuC-5tw1C:
39.7
4kmuC-5tw1C:
45.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KMU_C_RFPC1401_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacteriu
m
smegmatis)
10 / 12 GLN C 426
GLN C 429
ASP C 432
HIS C 442
ARG C 445
SER C 447
PRO C 480
ASN C 484
ILE C 488
ARG C 604
None
1.16A 4kmuC-5tw1C:
39.7
4kmuC-5tw1C:
45.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KMU_C_RFPC1401_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacteriu
m
smegmatis)
10 / 12 GLN C 426
GLN C 429
HIS C 442
ARG C 445
SER C 447
LEU C 449
ARG C 456
PRO C 480
ASN C 484
ILE C 488
None
0.94A 4kmuC-5tw1C:
39.7
4kmuC-5tw1C:
45.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KMU_C_RFPC1401_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacteriu
m
smegmatis)
10 / 12 GLN C 426
GLN C 429
HIS C 442
ARG C 445
SER C 447
LEU C 449
PRO C 480
ASN C 484
ILE C 488
ARG C 604
None
1.19A 4kmuC-5tw1C:
39.7
4kmuC-5tw1C:
45.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KMU_H_RFPH1401_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacteriu
m
smegmatis)
7 / 12 ARG C 445
SER C 447
LEU C 449
ARG C 456
PRO C 480
ASN C 484
ILE C 488
None
1.24A 4kmuH-5tw1C:
35.0
4kmuH-5tw1C:
45.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KMU_H_RFPH1401_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacteriu
m
smegmatis)
8 / 12 ASP C 432
HIS C 442
SER C 447
LEU C 449
ARG C 456
PRO C 480
ASN C 484
ILE C 488
None
0.98A 4kmuH-5tw1C:
35.0
4kmuH-5tw1C:
45.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KMU_H_RFPH1401_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacteriu
m
smegmatis)
9 / 12 GLN C 426
GLN C 429
ASP C 432
HIS C 442
SER C 447
PRO C 480
ASN C 484
ILE C 488
ARG C 604
None
1.35A 4kmuH-5tw1C:
35.0
4kmuH-5tw1C:
45.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KMU_H_RFPH1401_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacteriu
m
smegmatis)
9 / 12 GLN C 429
ASP C 432
HIS C 442
SER C 447
LEU C 449
PRO C 480
ASN C 484
ILE C 488
ARG C 604
None
1.32A 4kmuH-5tw1C:
35.0
4kmuH-5tw1C:
45.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_1
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacteriu
m
smegmatis)
3 / 3 SER C 173
TYR C 177
ASP C 525
None
0.90A 4rp8C-5tw1C:
1.4
4rp8C-5tw1C:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_C_29SC601_2
(ESTROGEN RECEPTOR)
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacteriu
m
smegmatis)
4 / 6 LEU C 190
ASP C 179
GLU C 180
ILE C 248
None
1.09A 4xi3C-5tw1C:
undetectable
4xi3C-5tw1C:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_ACTA605_0
(SERUM ALBUMIN)
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
OMEGA

(Mycolicibacteriu
m
smegmatis)
4 / 6 TYR E  65
GLY E  77
GLU E  95
ARG E  57
None
1.09A 4zbqA-5tw1E:
undetectable
4zbqA-5tw1E:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B6I_A_ADNA302_1
(FLUORINASE)
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacteriu
m
smegmatis)
4 / 7 ASP C 695
THR C 699
PRO C 697
SER C 612
None
1.34A 5b6iA-5tw1C:
undetectable
5b6iA-5tw1C:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CP4_A_CAMA422_0
(CYTOCHROME P450CAM)
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacteriu
m
smegmatis)
5 / 9 LEU C 980
VAL C 993
GLY C 997
THR C1015
VAL C 712
None
1.40A 5cp4A-5tw1C:
undetectable
5cp4A-5tw1C:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWZ_B_BEZB301_0
(14-3-3 PROTEIN
ZETA/DELTA)
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacteriu
m
smegmatis)
3 / 3 MET C 577
GLN C 576
ARG C 575
None
0.90A 5ewzB-5tw1C:
undetectable
5ewzB-5tw1C:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacteriu
m
smegmatis)
3 / 3 ARG C 813
ILE C 815
PHE C 816
None
0.67A 5kirA-5tw1C:
undetectable
5kirA-5tw1C:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M35_B_BEZB302_0
(14-3-3 PROTEIN
ZETA/DELTA)
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacteriu
m
smegmatis)
3 / 3 MET C 577
GLN C 576
ARG C 575
None
1.00A 5m35B-5tw1C:
undetectable
5m35B-5tw1C:
12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M36_A_BEZA303_0
(14-3-3 PROTEIN
ZETA/DELTA)
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacteriu
m
smegmatis)
3 / 3 MET C 577
GLN C 576
ARG C 575
None
1.06A 5m36A-5tw1C:
undetectable
5m36A-5tw1C:
12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_A_D16A402_1
(THYMIDYLATE SYNTHASE)
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacteriu
m
smegmatis)
4 / 7 ILE C 627
LEU C  44
GLY C  43
TYR C 494
None
0.87A 5nooA-5tw1C:
undetectable
5nooA-5tw1C:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_A_TESA503_1
(-)
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacteriu
m
smegmatis)
5 / 9 LEU C 710
VAL C 904
ILE C 889
LEU C 876
PRO C 896
None
1.23A 5og9A-5tw1C:
undetectable
5og9A-5tw1C:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA405_0
(THIOREDOXIN
REDUCTASE)
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacteriu
m
smegmatis)
3 / 3 GLY C 920
LEU C 923
HIS C 590
None
0.65A 5u63A-5tw1C:
undetectable
5u63A-5tw1C:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_B_ACTB405_0
(THIOREDOXIN
REDUCTASE)
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacteriu
m
smegmatis)
3 / 3 GLY C 920
LEU C 923
HIS C 590
None
0.63A 5u63B-5tw1C:
undetectable
5u63B-5tw1C:
14.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UAC_C_RFPC3001_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacteriu
m
smegmatis)
9 / 12 GLN C 426
ASP C 432
HIS C 442
ARG C 445
SER C 447
LEU C 449
ARG C 456
PRO C 480
ILE C 488
None
0.92A 5uacC-5tw1C:
39.9
5uacC-5tw1C:
45.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UAC_C_RFPC3001_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacteriu
m
smegmatis)
9 / 12 GLN C 426
ASP C 432
HIS C 442
ARG C 445
SER C 447
LEU C 449
PRO C 480
ILE C 488
ARG C 604
None
1.19A 5uacC-5tw1C:
39.9
5uacC-5tw1C:
45.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UAC_C_RFPC3001_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacteriu
m
smegmatis)
9 / 12 GLN C 426
GLN C 429
ASP C 432
HIS C 442
ARG C 445
SER C 447
ARG C 456
PRO C 480
ILE C 488
None
0.82A 5uacC-5tw1C:
39.9
5uacC-5tw1C:
45.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UAC_C_RFPC3001_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacteriu
m
smegmatis)
9 / 12 GLN C 426
GLN C 429
ASP C 432
HIS C 442
ARG C 445
SER C 447
PRO C 480
ILE C 488
ARG C 604
None
1.11A 5uacC-5tw1C:
39.9
5uacC-5tw1C:
45.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UAC_C_RFPC3001_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacteriu
m
smegmatis)
9 / 12 GLN C 429
PHE C 430
ASP C 432
HIS C 442
ARG C 445
SER C 447
ARG C 456
PRO C 480
ILE C 488
None
0.93A 5uacC-5tw1C:
39.9
5uacC-5tw1C:
45.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UAC_C_RFPC3001_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacteriu
m
smegmatis)
9 / 12 GLN C 429
PHE C 430
ASP C 432
HIS C 442
ARG C 445
SER C 447
PRO C 480
ILE C 488
ARG C 604
None
1.16A 5uacC-5tw1C:
39.9
5uacC-5tw1C:
45.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UAH_C_RFPC3001_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacteriu
m
smegmatis)
10 / 12 ARG C 164
GLN C 426
LEU C 427
GLN C 429
ARG C 445
SER C 447
LEU C 449
ARG C 456
PRO C 480
ILE C 488
None
0.90A 5uahC-5tw1C:
36.8
5uahC-5tw1C:
45.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UAH_C_RFPC3001_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacteriu
m
smegmatis)
10 / 12 ARG C 164
GLN C 426
LEU C 427
GLN C 429
ARG C 445
SER C 447
LEU C 449
PRO C 480
ILE C 488
ARG C 604
None
1.08A 5uahC-5tw1C:
36.8
5uahC-5tw1C:
45.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UH6_C_RFPC1201_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacteriu
m
smegmatis)
8 / 12 ASP C 432
HIS C 442
ARG C 445
SER C 447
ARG C 456
ASN C 484
ILE C 488
HIS C 671
None
1.08A 5uh6C-5tw1C:
50.5
5uh6C-5tw1C:
91.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UH6_C_RFPC1201_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacteriu
m
smegmatis)
10 / 12 GLN C 426
LEU C 427
GLN C 429
ASP C 432
HIS C 442
ARG C 445
SER C 447
ASN C 484
ILE C 488
ARG C 604
None
1.24A 5uh6C-5tw1C:
50.5
5uh6C-5tw1C:
91.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UH6_C_RFPC1201_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacteriu
m
smegmatis)
10 / 12 GLN C 426
LEU C 427
GLN C 429
ASP C 432
HIS C 442
ARG C 445
SER C 447
ASN C 484
ILE C 488
HIS C 671
None
0.68A 5uh6C-5tw1C:
50.5
5uh6C-5tw1C:
91.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UHB_C_RFPC1201_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacteriu
m
smegmatis)
10 / 12 GLN C 426
LEU C 427
GLN C 429
HIS C 442
ARG C 445
SER C 447
PRO C 480
ASN C 484
ILE C 488
ARG C 604
None
1.37A 5uhbC-5tw1C:
51.1
5uhbC-5tw1C:
91.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UHB_C_RFPC1201_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacteriu
m
smegmatis)
10 / 12 GLN C 426
LEU C 427
GLN C 429
HIS C 442
ARG C 445
SER C 447
PRO C 480
ASN C 484
ILE C 488
HIS C 671
None
0.82A 5uhbC-5tw1C:
51.1
5uhbC-5tw1C:
91.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UHB_C_RFPC1201_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacteriu
m
smegmatis)
8 / 12 HIS C 442
ARG C 445
SER C 447
ARG C 456
PRO C 480
ASN C 484
ILE C 488
HIS C 671
None
1.12A 5uhbC-5tw1C:
51.1
5uhbC-5tw1C:
91.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UHC_C_RFPC1201_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacteriu
m
smegmatis)
10 / 12 GLN C 426
LEU C 427
GLN C 429
HIS C 442
ARG C 445
SER C 447
PRO C 480
ASN C 484
ILE C 488
ARG C 604
None
1.29A 5uhcC-5tw1C:
49.5
5uhcC-5tw1C:
91.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UHC_C_RFPC1201_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacteriu
m
smegmatis)
10 / 12 GLN C 426
LEU C 427
GLN C 429
HIS C 442
ARG C 445
SER C 447
PRO C 480
ASN C 484
ILE C 488
HIS C 671
None
0.79A 5uhcC-5tw1C:
49.5
5uhcC-5tw1C:
91.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UHC_C_RFPC1201_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacteriu
m
smegmatis)
8 / 12 HIS C 442
ARG C 445
SER C 447
ARG C 456
PRO C 480
ASN C 484
ILE C 488
HIS C 671
None
1.15A 5uhcC-5tw1C:
49.5
5uhcC-5tw1C:
91.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UHD_C_RFPC1201_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacteriu
m
smegmatis)
10 / 12 GLN C 426
LEU C 427
GLN C 429
HIS C 442
ARG C 445
SER C 447
PRO C 480
ASN C 484
ILE C 488
ARG C 604
None
1.27A 5uhdC-5tw1C:
50.4
5uhdC-5tw1C:
91.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UHD_C_RFPC1201_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacteriu
m
smegmatis)
10 / 12 GLN C 426
LEU C 427
GLN C 429
HIS C 442
ARG C 445
SER C 447
PRO C 480
ASN C 484
ILE C 488
HIS C 671
None
0.71A 5uhdC-5tw1C:
50.4
5uhdC-5tw1C:
91.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UHD_C_RFPC1201_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacteriu
m
smegmatis)
8 / 12 HIS C 442
ARG C 445
SER C 447
ARG C 456
PRO C 480
ASN C 484
ILE C 488
HIS C 671
None
1.11A 5uhdC-5tw1C:
50.4
5uhdC-5tw1C:
91.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UHG_C_RFPC1201_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacteriu
m
smegmatis)
10 / 12 GLN C 429
ASP C 432
HIS C 442
ARG C 445
SER C 447
ARG C 456
PRO C 480
ASN C 484
ILE C 488
HIS C 671
None
1.09A 5uhgC-5tw1C:
50.5
5uhgC-5tw1C:
91.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UHG_C_RFPC1201_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacteriu
m
smegmatis)
10 / 12 LEU C 427
GLN C 429
ASP C 432
HIS C 442
ARG C 445
SER C 447
PRO C 480
ASN C 484
ILE C 488
HIS C 671
None
0.81A 5uhgC-5tw1C:
50.5
5uhgC-5tw1C:
91.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UHG_C_RFPC1201_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacteriu
m
smegmatis)
9 / 12 LEU C 427
GLN C 429
HIS C 442
ARG C 445
SER C 447
PRO C 480
ASN C 484
ILE C 488
ARG C 604
None
1.38A 5uhgC-5tw1C:
50.5
5uhgC-5tw1C:
91.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6BZO_C_FI8C1201_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacteriu
m
smegmatis)
7 / 12 MET C1042
ILE C1043
THR C1044
GLN C1045
THR C1087
VAL C1088
VAL C1091
None
0.93A 6bzoC-5tw1C:
43.8
6bzoC-5tw1C:
90.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6BZO_C_FI8C1201_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacteriu
m
smegmatis)
5 / 12 VAL C1091
GLU C1110
SER C1111
VAL C1114
GLU C1118
None
1.14A 6bzoC-5tw1C:
43.8
6bzoC-5tw1C:
90.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacteriu
m
smegmatis)
4 / 8 ILE C1043
THR C1044
THR C1087
ARG C1090
None
0.93A 6c06C-5tw1C:
32.9
6c06C-5tw1C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacteriu
m
smegmatis)
4 / 8 THR C1044
GLN C1045
THR C1087
ARG C1090
None
1.05A 6c06C-5tw1C:
32.9
6c06C-5tw1C:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6CCV_C_RFPC1205_1
(-)
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacteriu
m
smegmatis)
11 / 12 GLN C 426
GLN C 429
ASP C 432
HIS C 442
ARG C 445
SER C 447
LEU C 449
ARG C 456
PRO C 480
ILE C 488
HIS C 671
None
0.81A 6ccvC-5tw1C:
49.5
6ccvC-5tw1C:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6CCV_C_RFPC1205_1
(-)
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacteriu
m
smegmatis)
10 / 12 GLN C 426
GLN C 429
ASP C 432
HIS C 442
ARG C 445
SER C 447
LEU C 449
PRO C 480
ILE C 488
ARG C 604
None
1.40A 6ccvC-5tw1C:
49.5
6ccvC-5tw1C:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6FBV_D_FI8D1904_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacteriu
m
smegmatis)
4 / 8 ILE C1043
GLN C1045
THR C1087
LYS C1092
None
1.09A 6fbvC-5tw1C:
44.1
6fbvC-5tw1C:
91.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6FBV_D_FI8D1904_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacteriu
m
smegmatis)
4 / 8 ILE C1043
GLN C1045
THR C1087
VAL C1088
None
0.95A 6fbvC-5tw1C:
44.1
6fbvC-5tw1C:
91.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FN9_A_BEZA302_0
(14-3-3 PROTEIN
ZETA/DELTA)
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacteriu
m
smegmatis)
3 / 3 MET C 577
GLN C 576
ARG C 575
None
1.03A 6fn9A-5tw1C:
undetectable
6fn9A-5tw1C:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNA_B_BEZB302_0
(14-3-3 PROTEIN
ZETA/DELTA)
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacteriu
m
smegmatis)
3 / 3 MET C 577
GLN C 576
ARG C 575
None
1.03A 6fnaB-5tw1C:
undetectable
6fnaB-5tw1C:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNB_A_BEZA301_0
(14-3-3 PROTEIN
ZETA/DELTA)
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacteriu
m
smegmatis)
3 / 3 MET C 577
GLN C 576
ARG C 575
None
1.03A 6fnbA-5tw1C:
undetectable
6fnbA-5tw1C:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_Q_PCFQ202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacteriu
m
smegmatis)
4 / 6 TYR C 863
ILE C 839
ALA C 667
ARG C 668
None
1.06A 6hu9m-5tw1C:
undetectable
6hu9q-5tw1C:
undetectable
6hu9m-5tw1C:
19.23
6hu9q-5tw1C:
8.00