SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5tw7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AO8_A_MTXA170_1
(DIHYDROFOLATE
REDUCTASE)		 5tw7 GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]
(Neisseria
gonorrhoeae) 		5 / 12 ASP A 418
PHE A 421
THR A 440
LEU A 488
ALA A 470
 None
 1.09A 1ao8A-5tw7A:
undetectable		 1ao8A-5tw7A:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BZF_A_TMQA170_1
(DIHYDROFOLATE
REDUCTASE)		 5tw7 GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]
(Neisseria
gonorrhoeae) 		5 / 12 ASP A 418
PHE A 421
THR A 440
LEU A 488
ALA A 470
 None
 1.04A 1bzfA-5tw7A:
undetectable		 1bzfA-5tw7A:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		 5tw7 GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]
(Neisseria
gonorrhoeae) 		5 / 11 ALA A 380
LEU A 381
LEU A 377
LEU A 366
ALA A 207
 None
 0.85A 1h9zA-5tw7A:
undetectable		 1h9zA-5tw7A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HA2_A_SWFA3001_1
(SERUM ALBUMIN)		 5tw7 GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]
(Neisseria
gonorrhoeae) 		5 / 11 ALA A 380
LEU A 381
LEU A 377
LEU A 366
ALA A 207
 None
 0.89A 1ha2A-5tw7A:
undetectable		 1ha2A-5tw7A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPV_B_478B200_1
(HIV-1 PROTEASE)		 5tw7 GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]
(Neisseria
gonorrhoeae) 		5 / 9 LEU A 383
GLY A 227
VAL A 374
ILE A 327
GLY A 325
 None
 0.87A 1hpvA-5tw7A:
undetectable		 1hpvA-5tw7A:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7F_A_BCZA801_1
(NEURAMINIDASE)		 5tw7 GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]
(Neisseria
gonorrhoeae) 		3 / 3 ARG A 256
ARG A 375
ARG A 401
 None
 0.92A 1l7fA-5tw7A:
undetectable		 1l7fA-5tw7A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7H_A_BCZA801_1
(NEURAMINIDASE)		 5tw7 GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]
(Neisseria
gonorrhoeae) 		3 / 3 ARG A 256
ARG A 375
ARG A 401
 None
 0.94A 1l7hA-5tw7A:
undetectable		 1l7hA-5tw7A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_I_BEZI518_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 5tw7 GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]
(Neisseria
gonorrhoeae) 		4 / 7 ILE A  50
GLY A  49
PHE A  45
ASN A  46
 None
 0.92A 1oniG-5tw7A:
undetectable
1oniI-5tw7A:
undetectable		 1oniG-5tw7A:
16.83
1oniI-5tw7A:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OQ5_A_CELA701_2
(CARBONIC ANHYDRASE
II)		 5tw7 GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]
(Neisseria
gonorrhoeae) 		4 / 4 HIS A  89
VAL A  59
THR A  68
LEU A   9
 None
 1.49A 1oq5A-5tw7A:
undetectable		 1oq5A-5tw7A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YOE_C_FL7C1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5tw7 GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]
(Neisseria
gonorrhoeae) 		4 / 8 ASN A 185
GLY A 180
ILE A   8
VAL A  28
 None
 0.74A 2yoeB-5tw7A:
undetectable
2yoeC-5tw7A:
undetectable		 2yoeB-5tw7A:
19.55
2yoeC-5tw7A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D4S_A_TIMA401_2
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		 5tw7 GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]
(Neisseria
gonorrhoeae) 		3 / 3 THR A  16
SER A  53
PHE A 103
 None
 0.70A 3d4sA-5tw7A:
undetectable		 3d4sA-5tw7A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_A_J3ZA2_1
(ESTROGEN RECEPTOR)		 5tw7 GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]
(Neisseria
gonorrhoeae) 		5 / 12 LEU A 439
THR A 440
ALA A 482
LEU A 488
LEU A 425
 None
 1.10A 3hm1A-5tw7A:
undetectable		 3hm1A-5tw7A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5tw7 GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]
(Neisseria
gonorrhoeae) 		4 / 6 VAL A  77
ILE A  42
MET A  87
ARG A  24
 None
 1.14A 3ms9A-5tw7A:
undetectable		 3ms9A-5tw7A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 5tw7 GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]
(Neisseria
gonorrhoeae) 		5 / 12 LEU A 183
ILE A  51
GLY A 167
GLY A  79
ILE A  80
 None
 1.24A 3uj7B-5tw7A:
2.3		 3uj7B-5tw7A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UUU_A_SAMA1546_0
(CYSTATHIONINE
BETA-SYNTHASE)		 5tw7 GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]
(Neisseria
gonorrhoeae) 		5 / 11 LEU A 222
GLN A 324
ALA A 323
ILE A 306
ASP A 310
 None
 1.34A 4uuuA-5tw7A:
undetectable
4uuuB-5tw7A:
undetectable		 4uuuA-5tw7A:
16.82
4uuuB-5tw7A:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_2
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 5tw7 GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]
(Neisseria
gonorrhoeae) 		4 / 4 VAL A 500
LEU A 414
ASN A 504
ASP A 463
 None
 1.26A 5vcyA-5tw7A:
undetectable		 5vcyA-5tw7A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_C_CVIC301_1
(REGULATORY PROTEIN
TETR)		 5tw7 GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]
(Neisseria
gonorrhoeae) 		4 / 7 GLN A 244
GLY A 216
ILE A 211
TRP A 321
 None
 1.12A 5vlmC-5tw7A:
undetectable		 5vlmC-5tw7A:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_A_ACTA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5tw7 GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]
(Neisseria
gonorrhoeae) 		3 / 3 GLN A 214
TRP A 321
VAL A 220
 None
 0.71A 6auuA-5tw7A:
undetectable		 6auuA-5tw7A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH6_A_017A104_0
(PROTEASE)		 5tw7 GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]
(Neisseria
gonorrhoeae) 		5 / 12 LEU A 383
GLY A 227
VAL A 374
ILE A 327
GLY A 325
 None
 0.88A 6dh6A-5tw7A:
undetectable		 6dh6A-5tw7A:
10.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G1P_B_ACTB403_0
(ADP-RIBOSYLHYDROLASE
LIKE 2)		 5tw7 GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]
(Neisseria
gonorrhoeae) 		3 / 3 PHE A 444
ARG A 256
GLN A 442
 None
 1.14A 6g1pB-5tw7A:
undetectable		 6g1pB-5tw7A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_B_LLLB301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5tw7 GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]
(Neisseria
gonorrhoeae) 		4 / 7 ASP A 475
ARG A  21
GLU A  25
CYH A  30
 None
 1.34A 6mn5B-5tw7A:
undetectable		 6mn5B-5tw7A:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_E_LLLE301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5tw7 GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]
(Neisseria
gonorrhoeae) 		4 / 7 ASP A 475
ARG A  21
GLU A  25
CYH A  30
 None
 1.17A 6mn5E-5tw7A:
undetectable		 6mn5E-5tw7A:
11.93